Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock

Purpose. To evaluate the prognostic value of the Cv-aCO2/Da-vO2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. Methods. Prospective observational study in a 60-bed mixed ICU. One hundred and thirty-five patients with septic shock were included. The resus...

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Autores:: Bermúdez, William F.
Ospina Tascón, Gusatvo Adolfo
Umaña, Mauricio
De Backer, Daniel P.
Arango Dávila, César Augusto
Salazar, Blanca C.
Granados, Marcela
Bruhn, Alejandro R.
Hernández, Glenn P.
Bautista Rincón. Diego F.

Tipo de recurso:: Article of investigation

Fecha de publicación:: 2015

Institución:: Universidad ICESI

Repositorio:: Repositorio ICESI

Idioma:: eng

Description
Summary:	Purpose. To evaluate the prognostic value of the Cv-aCO2/Da-vO2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. Methods. Prospective observational study in a 60-bed mixed ICU. One hundred and thirty-five patients with septic shock were included. The resuscitation protocol targeted mean arterial pressure, pulse pressure variations or central venous pressure, mixed venous oxygen saturation, and lactate levels. Patients were classified into four groups according to lactate levels and Cv-aCO2/Da-vO2 ratio at 6 h of resuscitation (T6): group 1, lactate ≥2.0 mmol/L and Cv-aCO2/Da-vO2 >1.0; group 2, lactate ≥2.0 mmol/L and Cv-aCO2/Da-vO2 ≤1.0; group 3, lactate <2.0 mmol/L and Cv-aCO2/Da-vO2 >1.0; and group 4, lactate <2.0 mmol/L and Cv-aCO2/Da-vO2 ≤1.0.

Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O2 content difference ratio as markers of resuscitation in patients with septic shock

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