Efficacy and safety of oral low-dose glucocorticoids in patients with estrogen-dependent primary osteoarthritis

Estrogen-dependent osteoarthritis (EDPOA) is a disease of perimenopausal-age women. Their manifestations are polyarticular pain with common co-morbidities (carpal tunnel syndrome, insomnia, fatigue, depression, and fibromyalgia). Based on dual role of glucocorticoids, its trophic action on the chondrocyte and its anti-inflammatory effect, we conducted a prospective interventional cohort study where we evaluate the efficacy and safety of oral low-dose GC in one hundred women with EDPOA. The pain intensity, number of tender joints as well as impact in co-morbidities were analyzed. We conclude that the use of low-dose GC in patients with EDPOA can be an effective and a safe therapeutic option. © 2013 Springer-Verlag.

• Autores: Cañas, Carlos Alberto; Bonilla-Abadía, Fabio; Izquierdo, Jorge H.; Cepeda, Magda C.; Coronel Restrepo, Nicolás; Osorio, Carlos J.
• Tipo de recurso: Article of investigation
• Fecha de publicación: 2014
• Institución: Universidad ICESI
• Repositorio: Repositorio ICESI
• Idioma: eng
• OAI Identifier: oai:repository.icesi.edu.co:10906/78521
• Acceso en línea: http://www.scopus.com/inward/record.url?eid=2-s2.0-84901291205&partnerID=tZOtx3y1; http://hdl.handle.net/10906/78521; http://dx.doi.org/10.1007/s00296-012-2603-1
• Palabra clave: Ciencias socio biomédicas; Esteroides; Steroids; Biomedical sciences; Medical sciences; Menopausia; Menopause
• Rights: openAccess
• License: https://creativecommons.org/licenses/by-nc-nd/4.0/