El sistema de la proteína C activada en el cuadro séptico

Autores:: Escobar Soto, Carlos Hugo

Tipo de recurso:: Article of journal

Fecha de publicación:: 2011

Institución:: Fundación Universitaria de Ciencias de la Salud - FUCS

Repositorio:: Repositorio Digital Institucional ReDi

Idioma:: spa

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network_acronym_str	FUCS2
network_name_str	Repositorio Digital Institucional ReDi
repository_id_str
dc.title.spa.fl_str_mv	El sistema de la proteína C activada en el cuadro séptico
dc.title.translated.eng.fl_str_mv	The effects of activated protein C on the sepsis syndrome
title	El sistema de la proteína C activada en el cuadro séptico
spellingShingle	El sistema de la proteína C activada en el cuadro séptico proteína C sepsis morbimortalidad vitamina K apoptosis protein C sepsis morbidity/mortality vitamin K apoptosis
title_short	El sistema de la proteína C activada en el cuadro séptico
title_full	El sistema de la proteína C activada en el cuadro séptico
title_fullStr	El sistema de la proteína C activada en el cuadro séptico
title_full_unstemmed	El sistema de la proteína C activada en el cuadro séptico
title_sort	El sistema de la proteína C activada en el cuadro séptico
dc.creator.fl_str_mv	Escobar Soto, Carlos Hugo
dc.contributor.author.spa.fl_str_mv	Escobar Soto, Carlos Hugo
dc.subject.spa.fl_str_mv	proteína C sepsis morbimortalidad vitamina K apoptosis
topic	proteína C sepsis morbimortalidad vitamina K apoptosis protein C sepsis morbidity/mortality vitamin K apoptosis
dc.subject.eng.fl_str_mv	protein C sepsis morbidity/mortality vitamin K apoptosis
publishDate	2011
dc.date.accessioned.none.fl_str_mv	2011-03-01 00:00:00 2022-02-21T20:38:39Z
dc.date.issued.none.fl_str_mv	2011-03-01
dc.date.available.none.fl_str_mv	2011-03-01 00:00:00 2022-02-21T20:38:39Z
dc.type.spa.fl_str_mv	Artículo de revista
dc.type.eng.fl_str_mv	Journal article
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dc.identifier.doi.none.fl_str_mv	10.31260/RepertMedCir.v20.n1.2011.667
dc.identifier.issn.none.fl_str_mv	0121-7372
dc.identifier.uri.none.fl_str_mv	https://repositorio.fucsalud.edu.co/handle/001/2555
dc.identifier.eissn.none.fl_str_mv	2462-991X
dc.identifier.url.none.fl_str_mv	https://doi.org/10.31260/RepertMedCir.v20.n1.2011.667
identifier_str_mv	10.31260/RepertMedCir.v20.n1.2011.667 0121-7372 2462-991X
url	https://repositorio.fucsalud.edu.co/handle/001/2555 https://doi.org/10.31260/RepertMedCir.v20.n1.2011.667
dc.language.iso.spa.fl_str_mv	spa
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dc.relation.references.spa.fl_str_mv	Angus D, Linde-Zwirble, Lidicker J, Clemont G, Carcillo J, Pinsky M. Epidemiology ofsevere sepsis in the United States: analysis ofincidence, outcome, and associated costs ofcare. Crit Care Med. 2001; 29: 1303-1 O. 2. Martín G, ManninoD, Eaton S, Moss M. Tbe epidemiology ofsepsis in the United States from 1979 through 2000. N Eng!J Med. 2003; 348: 1546-54. 3. Riedemann N, Guo R, Ward P. The enigma ofsepsis. J Clin Invest. 2003; 112:460--67. 4. Hotchkiss RS, Karl IE. Toe pathophysiology and treatment of sepsis. N Engl J Med. 2003; 348:138 50. 5. Riedemann NC, Guo R, Ward PA. Novel strategies for the treatrnent of sepsis. Nat Med. 2003; 9:517-24. 6. Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N. Insight into sepsis therapeutic design based on the apoptotic death pathway. J Pharmacol Sci. [serie en Internet]. 2010 [citado 2011 Feb 1]; 114 (4):[aprox. 12 p.]. Disponible en: http://www.jstage.jst.go.jp/article/jphs/advpub/O/ advpub_l0l1100472/_article 7. Yan S, BrandtT, CorrellN, Um S, BourdageJ. Evaluation ofanti-activated protein C antibody development in patients with severe sepsis form four clinical studies with drotrecogin alpha (activated).J Thromb Haemost. 2009 Nov;7(11):1787-94. Tang B, McLean A, Dawes I, et al. Gene-expression profiling of gram positive and gram-negative sepsis in critically ill patients. Crit Care Med. 2008; 36 (4): 1125 28. 9. Fitting C, Dhawan S, Cavaillon J. Compartmentalisation ofendotoxin tolerance. JinfectDis 2004; 189: 1295-1303. 10. Bemard G, Margolis B, Shaines H, Ely E, Wheeler A, Levy H, et al. Extended evaluation ofrecombinan! human activated protein C United States trial (ENHANCE US): a single arm, phase 3B, multicenter study ofdrotrecogin alfa (Activated) in severe sepsis. CHEST. 2004; 125 (4): 2206- 16. 11. Martín G, Brunkhorst FM, Janes JM, et al. The intemational PROGRESS registry ofpatients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care 2009; 13: RI03. 12. Zeni F, FreemanB, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med. 1997; 25: 1095-11OO. 13. Natanson C, Esposito CJ, Banks SM. The sirens' songs of confirmatory sepsis trials: selection bias and sampling error. Crit Care Med. 1998; 26: 1927-31. 14. Marshall JC. Clinical trials ofmediator-directed therapy in sepsis: what have we leamed?. Intensive Care Med. 2000;26 Suppl 1:S75-83. 15. Mosnier L, Zlokovic B and Griffm J. The cytoprotective protein c pathway. Blood. 2006; 109 (8): 3161 72. 16. Griffin J, FemándezA, Gale A and Mosnier L. Activated protein C. JThromb Haemost. 2007; 5 (Suppl Í): 73-80. 17. Esmon C. The endothelial cell protein C receptor. Thromb Haemost. 2000; 83: 639-43. 18. Liaw P, Mather T, Oganesyan N, Ferrell G, Esmon C. Identification ofthe protein C/activated protein C binding sites on the endothelial cell protein C receptor. lmplications for a novel mode of ligand recognition by a major histocompatibility complex class 1- type receptor. JBiol Chem 2001; 276: 8364-70. 19. Ni Ainle F, O'Donnell J, Johnson J, Brown L, Gleeson E, Smith O, et al. Activated protein C N-Linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol. Chem. 2011 Jan 14; 286(2):1323-30. 20. Mosnier L, Yang X, Griffin J. Activated protein C mutan! with minimal antiocoagulant activity, normal cytoprotective activity, and preservation of thrombinactivablefibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007; 282 (45): 33022-33. 21. Bae J, YangL, Manithody Ch, et al. Engineering a disulfide bond to stabilize the calcium-binding loop ofactivated protein C eliminates its anticoagulant but not its protective signaling properties. J Biol Chem. 2007; 282 (12): 9251-59. 22. MosnierL, Zampolli A, Kerschen E, Schuepbach R, Benerjee Y, Femández J, et al. Hyperantithrombotic, noncytoprotective Glul 49Ala-activated c mutant. Blood. 2009; 113 (23): 5970-78. 23. Kerschen E, Femandez J, CooleyB, et al. Endotoxemia and sepsismortality reduction by non-anticoagulant-activated protein C. J Exp Med. 2004; 1O: 2439-48. 24. Douglas A, Rafferty H, Hodgkins P, Nagra A, Foulds N, Morgan M, et al. Persistent fetal vasculature and severe protein C deficiency. Mol Syndromol. 201O; 1 (2): 82-6. 25. Allaart C, P oort S, Rosendaal F, Reitsma P, Bertina R, Briet E. Increased risk ofvenous thrombosis in carriers ofhereditary protein C deficiency defect. Lancet. 1993; 341: 134-38. 26. Millar D, JohansenB, Bemtorp E, Minford A, Bolton-Maggs P, Wensley R, et al. Molecular genetic analysis ofsevere protein C deficiency. Hum. Genet. 2000; 106: 646-53. 27. Lay A, Liang Z, Rosen E, Castellino F. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest. 2005; 115: 1552-61. 28. Weiler, H. Regulation ofinflammation by the protein C system. Crit Care Med. 2010; 38 (2): S18-S25. 29. Mosnier L and Griffin J. Protein C anticoagulant activity in relation to anti inflammatory and antiapoptotic activities. FrontBiosci. 2006; 11: 2381- 99. 30. MosnierL, ZlokovicB and Griffin J. The cytoprotective protein C pathway. Blood. 2006; 109 (8): 3161-72. 31. Seeley S, Covic L, Jacques S, et al. Structural basis for thrombin activation ofa protease-activated receptor: inhibition ofa intramolecular liganding. 2003; 10: 1033-1041. 32. Hartmut W. Regulation ofinflammation by the protein C system. Crit Care Med. 201O, 38 (2): S18-S25. 33. Seeley S, Covic L, Jacques S, et al. Structural basis for thrombin activation ofa protease-activated receptor: lnhibition ofa intramolecular liganding. 2003; 10: 1033-41. 34. Coughlin S. Thrombin signaling and protease activated receptors. Nature. 2000; 407: 258-64. 35. Griffin C, Srinivasan Y, Zheng Y, Huang, W and Cougblin S. A role for thrombin receptor signaling in endotelial cells during embryonic development. Science. 2001; 293: 1666-70. 36. Even-Ram S, Uziely B, Cohen P, et al. Thrombin receptor over expression in malignan! and physiological invasion processes. Nat. Med. 1998; 4: 909-14. 37. Zain J, Huang Y, FengX,Nierodzik M, Li J and Karpat-kin S. Concentration dependent dual effect ofthrombin on impaired growth/apoptosis or rnitogenesis in tumor cells. Blood 2000; 95: 3133-38. 38. Boire A, Covic L, Agarwal A, et al. PAR! is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 2005; 120: 303-13. 39. Ludeman M, Kataoka H, Srinivasan Y, et al. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005; 280: 13122-28. 40. Coughlin SR, Camerer E. PARticipation in inflammation. J Clin Invest. 2003; 111: 25-27. 41. Ludeman M, Kataoka H, Srinivasan Y, et al. PAR! cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005; 280:13122-28. 42. Riewald M, Ruf W. Protease-activated receptor-! signaling by activated protein C in cytokine perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005; 280: 19808-14. 43. Franscini N, Bachli E, Blau N, et al. Gene expression profiling ofinflamed human endotbelial cells and influence ofactivated protein C. Circulation. 2004; 110: 2903-09. 44. Pereira C,Bacbil E, Schaer D, Schoedon G. Transcriptome analysis revelaled unique genes as targets for the anti-inflamatory action ofactivated protein e in human macrophages. PLoS One. 2010; 5 (10): el 5352. 45. Joyce D, Gelbert L, Ciaccia A, DeHoffB and Grinnell B. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001; 276: 11199-203. 46. Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 1996; 87: 642-47. 47. Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PARl-dependent sphingosine 1-phosphate receptor-] crossactivation. Blood. 2005; 105: 3178-84. 48. NickJ,ColdrenC, Geraci M, Poch K, Fouty B, O'Brien J, et al. Recombinan! human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition ofneutrophil chemotaxis. Blood. 2004; 104: 3878-85. 49. Niessen F, Furlan-Freguia C, Fernández J, Mosnier L, Castellino F, Weiler H, et al. Endogenous EPCR/aPC-PAR-1 signalling prevents inflammation induced vascular leakage and lethaly. Blood. 2009; 113 (12): 2859-66. 50. Cheng T, Liu D, GriffinJH, et al. ActivatedproteinC blocks p53-mediated apoptosis in ischemic human brainendothelium and is neuroprotective. Nat Med. 2003; 9: 338-42. 51. Stephenson D, Toltl L, Beaudin S and Liaw P. Modulation ofmonocyte function by activated protein C, a natural anticoagulant.J Immunol. 2006; 177: 2115-22. 52. Hotchkiss R, Chang K, Swanson P, Tinsley K, Hui J, Klender P, et al. Caspase inhibitors improve survival in sepsis: a critica! role offte lymphocyte. Nat Immunol. 2000; 1: 496-501. 53. McVerry B, GarcíaJ. Endothelial cell barrier regulation by sphingosine 1- phosphate. J Cell Biocbem. Mosnier L and GriflinJ 2004; 92: 1075-85. 54. Burridge K, Wennerberg K. Rho and Rae take center stage. Cell. 2004; 116: 167-79. 55. Singleton P, Dudek S,Chiang E and GarcíaJ. Regulation ofspbingosine 1- phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by SI PI receptor, PI3 kinase, Tiam 1 /Rac1, and alpha-actinin. FASEB J. 2005; 19: 1646-56.
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dc.relation.citationedition.spa.fl_str_mv	Núm. 1 , Año 2011 : Enero – Marzo
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spelling	Escobar Soto, Carlos Hugo87d8802bb264701803587c56766c01b53002011-03-01 00:00:002022-02-21T20:38:39Z2011-03-012011-03-01 00:00:002022-02-21T20:38:39ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Saludhttps://revistas.fucsalud.edu.co/index.php/repertorio/article/view/667proteína Csepsismorbimortalidadvitamina Kapoptosisprotein Csepsismorbidity/mortalityvitamin KapoptosisEl sistema de la proteína C activada en el cuadro sépticoThe effects of activated protein C on the sepsis syndromeapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/coar/version/c_970fb48d4fbd8a8510.31260/RepertMedCir.v20.n1.2011.6670121-7372https://repositorio.fucsalud.edu.co/handle/001/25552462-991Xhttps://doi.org/10.31260/RepertMedCir.v20.n1.2011.667spaAngus D, Linde-Zwirble, Lidicker J, Clemont G, Carcillo J, Pinsky M. Epidemiology ofsevere sepsis in the United States: analysis ofincidence, outcome, and associated costs ofcare. Crit Care Med. 2001; 29: 1303-1 O. 2. Martín G, ManninoD, Eaton S, Moss M. Tbe epidemiology ofsepsis in the United States from 1979 through 2000. N Eng!J Med. 2003; 348: 1546-54. 3. Riedemann N, Guo R, Ward P. The enigma ofsepsis. J Clin Invest. 2003; 112:460--67. 4. Hotchkiss RS, Karl IE. Toe pathophysiology and treatment of sepsis. N Engl J Med. 2003; 348:138 50. 5. Riedemann NC, Guo R, Ward PA. Novel strategies for the treatrnent of sepsis. Nat Med. 2003; 9:517-24. 6. Hattori Y, Takano K, Teramae H, Yamamoto S, Yokoo H, Matsuda N. Insight into sepsis therapeutic design based on the apoptotic death pathway. J Pharmacol Sci. [serie en Internet]. 2010 [citado 2011 Feb 1]; 114 (4):[aprox. 12 p.]. Disponible en: http://www.jstage.jst.go.jp/article/jphs/advpub/O/ advpub_l0l1100472/_article 7. Yan S, BrandtT, CorrellN, Um S, BourdageJ. Evaluation ofanti-activated protein C antibody development in patients with severe sepsis form four clinical studies with drotrecogin alpha (activated).J Thromb Haemost. 2009 Nov;7(11):1787-94. Tang B, McLean A, Dawes I, et al. Gene-expression profiling of gram positive and gram-negative sepsis in critically ill patients. Crit Care Med. 2008; 36 (4): 1125 28. 9. Fitting C, Dhawan S, Cavaillon J. Compartmentalisation ofendotoxin tolerance. JinfectDis 2004; 189: 1295-1303. 10. Bemard G, Margolis B, Shaines H, Ely E, Wheeler A, Levy H, et al. Extended evaluation ofrecombinan! human activated protein C United States trial (ENHANCE US): a single arm, phase 3B, multicenter study ofdrotrecogin alfa (Activated) in severe sepsis. CHEST. 2004; 125 (4): 2206- 16. 11. Martín G, Brunkhorst FM, Janes JM, et al. The intemational PROGRESS registry ofpatients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care 2009; 13: RI03. 12. Zeni F, FreemanB, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med. 1997; 25: 1095-11OO. 13. Natanson C, Esposito CJ, Banks SM. The sirens' songs of confirmatory sepsis trials: selection bias and sampling error. Crit Care Med. 1998; 26: 1927-31. 14. Marshall JC. Clinical trials ofmediator-directed therapy in sepsis: what have we leamed?. Intensive Care Med. 2000;26 Suppl 1:S75-83. 15. Mosnier L, Zlokovic B and Griffm J. The cytoprotective protein c pathway. Blood. 2006; 109 (8): 3161 72. 16. Griffin J, FemándezA, Gale A and Mosnier L. Activated protein C. JThromb Haemost. 2007; 5 (Suppl Í): 73-80. 17. Esmon C. The endothelial cell protein C receptor. Thromb Haemost. 2000; 83: 639-43. 18. Liaw P, Mather T, Oganesyan N, Ferrell G, Esmon C. Identification ofthe protein C/activated protein C binding sites on the endothelial cell protein C receptor. lmplications for a novel mode of ligand recognition by a major histocompatibility complex class 1- type receptor. JBiol Chem 2001; 276: 8364-70. 19. Ni Ainle F, O'Donnell J, Johnson J, Brown L, Gleeson E, Smith O, et al. Activated protein C N-Linked glycans modulate cytoprotective signaling function on endothelial cells. J Biol. Chem. 2011 Jan 14; 286(2):1323-30. 20. Mosnier L, Yang X, Griffin J. Activated protein C mutan! with minimal antiocoagulant activity, normal cytoprotective activity, and preservation of thrombinactivablefibrinolysis inhibitor-dependent cytoprotective functions. J Biol Chem. 2007; 282 (45): 33022-33. 21. Bae J, YangL, Manithody Ch, et al. Engineering a disulfide bond to stabilize the calcium-binding loop ofactivated protein C eliminates its anticoagulant but not its protective signaling properties. J Biol Chem. 2007; 282 (12): 9251-59. 22. MosnierL, Zampolli A, Kerschen E, Schuepbach R, Benerjee Y, Femández J, et al. Hyperantithrombotic, noncytoprotective Glul 49Ala-activated c mutant. Blood. 2009; 113 (23): 5970-78. 23. Kerschen E, Femandez J, CooleyB, et al. Endotoxemia and sepsismortality reduction by non-anticoagulant-activated protein C. J Exp Med. 2004; 1O: 2439-48. 24. Douglas A, Rafferty H, Hodgkins P, Nagra A, Foulds N, Morgan M, et al. Persistent fetal vasculature and severe protein C deficiency. Mol Syndromol. 201O; 1 (2): 82-6. 25. Allaart C, P oort S, Rosendaal F, Reitsma P, Bertina R, Briet E. Increased risk ofvenous thrombosis in carriers ofhereditary protein C deficiency defect. Lancet. 1993; 341: 134-38. 26. Millar D, JohansenB, Bemtorp E, Minford A, Bolton-Maggs P, Wensley R, et al. Molecular genetic analysis ofsevere protein C deficiency. Hum. Genet. 2000; 106: 646-53. 27. Lay A, Liang Z, Rosen E, Castellino F. Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest. 2005; 115: 1552-61. 28. Weiler, H. Regulation ofinflammation by the protein C system. Crit Care Med. 2010; 38 (2): S18-S25. 29. Mosnier L and Griffin J. Protein C anticoagulant activity in relation to anti inflammatory and antiapoptotic activities. FrontBiosci. 2006; 11: 2381- 99. 30. MosnierL, ZlokovicB and Griffin J. The cytoprotective protein C pathway. Blood. 2006; 109 (8): 3161-72. 31. Seeley S, Covic L, Jacques S, et al. Structural basis for thrombin activation ofa protease-activated receptor: inhibition ofa intramolecular liganding. 2003; 10: 1033-1041. 32. Hartmut W. Regulation ofinflammation by the protein C system. Crit Care Med. 201O, 38 (2): S18-S25. 33. Seeley S, Covic L, Jacques S, et al. Structural basis for thrombin activation ofa protease-activated receptor: lnhibition ofa intramolecular liganding. 2003; 10: 1033-41. 34. Coughlin S. Thrombin signaling and protease activated receptors. Nature. 2000; 407: 258-64. 35. Griffin C, Srinivasan Y, Zheng Y, Huang, W and Cougblin S. A role for thrombin receptor signaling in endotelial cells during embryonic development. Science. 2001; 293: 1666-70. 36. Even-Ram S, Uziely B, Cohen P, et al. Thrombin receptor over expression in malignan! and physiological invasion processes. Nat. Med. 1998; 4: 909-14. 37. Zain J, Huang Y, FengX,Nierodzik M, Li J and Karpat-kin S. Concentration dependent dual effect ofthrombin on impaired growth/apoptosis or rnitogenesis in tumor cells. Blood 2000; 95: 3133-38. 38. Boire A, Covic L, Agarwal A, et al. PAR! is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell. 2005; 120: 303-13. 39. Ludeman M, Kataoka H, Srinivasan Y, et al. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005; 280: 13122-28. 40. Coughlin SR, Camerer E. PARticipation in inflammation. J Clin Invest. 2003; 111: 25-27. 41. Ludeman M, Kataoka H, Srinivasan Y, et al. PAR! cleavage and signaling in response to activated protein C and thrombin. J Biol Chem. 2005; 280:13122-28. 42. Riewald M, Ruf W. Protease-activated receptor-! signaling by activated protein C in cytokine perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem. 2005; 280: 19808-14. 43. Franscini N, Bachli E, Blau N, et al. Gene expression profiling ofinflamed human endotbelial cells and influence ofactivated protein C. Circulation. 2004; 110: 2903-09. 44. Pereira C,Bacbil E, Schaer D, Schoedon G. Transcriptome analysis revelaled unique genes as targets for the anti-inflamatory action ofactivated protein e in human macrophages. PLoS One. 2010; 5 (10): el 5352. 45. Joyce D, Gelbert L, Ciaccia A, DeHoffB and Grinnell B. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem. 2001; 276: 11199-203. 46. Murakami K, Okajima K, Uchiba M, et al. Activated protein C attenuates endotoxin-induced pulmonary vascular injury by inhibiting activated leukocytes in rats. Blood. 1996; 87: 642-47. 47. Feistritzer C, Riewald M. Endothelial barrier protection by activated protein C through PARl-dependent sphingosine 1-phosphate receptor-] crossactivation. Blood. 2005; 105: 3178-84. 48. NickJ,ColdrenC, Geraci M, Poch K, Fouty B, O'Brien J, et al. Recombinan! human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition ofneutrophil chemotaxis. Blood. 2004; 104: 3878-85. 49. Niessen F, Furlan-Freguia C, Fernández J, Mosnier L, Castellino F, Weiler H, et al. Endogenous EPCR/aPC-PAR-1 signalling prevents inflammation induced vascular leakage and lethaly. Blood. 2009; 113 (12): 2859-66. 50. Cheng T, Liu D, GriffinJH, et al. ActivatedproteinC blocks p53-mediated apoptosis in ischemic human brainendothelium and is neuroprotective. Nat Med. 2003; 9: 338-42. 51. Stephenson D, Toltl L, Beaudin S and Liaw P. Modulation ofmonocyte function by activated protein C, a natural anticoagulant.J Immunol. 2006; 177: 2115-22. 52. Hotchkiss R, Chang K, Swanson P, Tinsley K, Hui J, Klender P, et al. Caspase inhibitors improve survival in sepsis: a critica! role offte lymphocyte. Nat Immunol. 2000; 1: 496-501. 53. McVerry B, GarcíaJ. Endothelial cell barrier regulation by sphingosine 1- phosphate. J Cell Biocbem. Mosnier L and GriflinJ 2004; 92: 1075-85. 54. Burridge K, Wennerberg K. Rho and Rae take center stage. Cell. 2004; 116: 167-79. 55. Singleton P, Dudek S,Chiang E and GarcíaJ. Regulation ofspbingosine 1- phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by SI PI receptor, PI3 kinase, Tiam 1 /Rac1, and alpha-actinin. FASEB J. 2005; 19: 1646-56.https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/667/713Núm. 1 , Año 2011 : Enero – Marzo1711220Revista Repertorio de Medicina y Cirugíainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2PublicationOREORE.xmltext/xml2494https://repositorio.fucsalud.edu.co/bitstreams/6d3f021b-d81c-437f-8b7a-4b47d5e5841a/downloada76741798179011d0066f9bfbb5185fcMD51001/2555oai:repositorio.fucsalud.edu.co:001/25552024-02-02 13:11:23.967https://creativecommons.org/licenses/by-nc-sa/4.0/metadata.onlyhttps://repositorio.fucsalud.edu.coRepositorio Digital de la Fundación Universitaria de Ciencias de la Saludredi@fucsalud.edu.co

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