Cutaneous Perivascular Epithelioid Cell Tumor of Gynecologic Origin Metastatic to Skin, Lung, Stomach, and Brain

Regarding the first case report recently published by Navale et al1 about a skin perivascular epithelioid cell tumor (PEComa) with focal melanin pigmentation, we wish to present another exceptional case of a malignant uterine PEComa metastatic to skin and lung, gastric lymph-vascular invasion, and brain dissemination, which was also initially misdiagnosed as skin melanoma because of the presence of epithelioid features and the expression of some melanocytic markers. Our patient was a 62-year-old woman, who presented with abnormal uterine bleeding that prompted hysterectomy 3 years ago. An extrainstitutional pathology report on the surgical specimen revealed a lesion compatible with a uterine leiomyosarcoma that was managed with adjuvant radiotherapy. At the 2-year clinical follow-up, the patient presented with a mass on the posterior region of the neck, which required undergoing surgical excision. The pathology study features were compatible with a malignant melanoma. Other reassessment and follow-up studies evidenced a compromise of the lung, with histopathological diagnosis of metastatic melanoma. A year ago, the patient presented with a new pigmented lesion on the right cheek. Once again, the biopsy study revealed a melanoma.

• Autores: Morales, Samuel D.; Parra-Medina, Rafael
• Tipo de recurso: Article of journal
• Fecha de publicación: 2017
• Institución: Fundación Universitaria de Ciencias de la Salud - FUCS
• Repositorio: Repositorio Digital Institucional ReDi
• Idioma: eng
• OAI Identifier: oai:repositorio.fucsalud.edu.co:001/1693
• Acceso en línea: https://repositorio.fucsalud.edu.co/handle/001/1693
• Palabra clave: Células epitelioides; Cerebro; Estómago; Pulmón; Piel
• Rights: openAccess
• License: Atribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)