Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología

Autores:
Reyna Villasmil, Eduardo
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
Repositorio:
Repositorio Digital Institucional ReDi
Idioma:
spa
OAI Identifier:
oai:repositorio.fucsalud.edu.co:001/3083
Acceso en línea:
https://repositorio.fucsalud.edu.co/handle/001/3083
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279
Palabra clave:
Oncología
Medicina de precisión
Prevención
Diagnóstico
Tratamiento.
Medicina
Medicina de precisión
Oncology
Precision medicine
Prevention
Diagnosis
Treatment
Rights
openAccess
License
Revista Repertorio de Medicina y Cirugía - 2020
id FUCS2_c6820f020c308df8bcd485c4d5f8fadb
oai_identifier_str oai:repositorio.fucsalud.edu.co:001/3083
network_acronym_str FUCS2
network_name_str Repositorio Digital Institucional ReDi
repository_id_str
dc.title.spa.fl_str_mv Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
dc.title.translated.eng.fl_str_mv Usefulness of precision medicine in improving prevention, treatment and prognosis in oncology
title Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
spellingShingle Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
Oncología
Medicina de precisión
Prevención
Diagnóstico
Tratamiento.
Medicina
Medicina de precisión
Oncology
Precision medicine
Prevention
Diagnosis
Treatment
title_short Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
title_full Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
title_fullStr Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
title_full_unstemmed Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
title_sort Utilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncología
dc.creator.fl_str_mv Reyna Villasmil, Eduardo
dc.contributor.author.spa.fl_str_mv Reyna Villasmil, Eduardo
dc.subject.spa.fl_str_mv Oncología
Medicina de precisión
Prevención
Diagnóstico
Tratamiento.
Medicina
Medicina de precisión
topic Oncología
Medicina de precisión
Prevención
Diagnóstico
Tratamiento.
Medicina
Medicina de precisión
Oncology
Precision medicine
Prevention
Diagnosis
Treatment
dc.subject.eng.fl_str_mv Oncology
Precision medicine
Prevention
Diagnosis
Treatment
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-04-06 16:33:03
2022-06-29T19:39:36Z
dc.date.issued.none.fl_str_mv 2020-04-06
dc.date.available.none.fl_str_mv 2020-04-06 16:33:03
2022-06-29T19:39:36Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.eng.fl_str_mv Journal article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.content.spa.fl_str_mv Text
dc.type.redcol.spa.fl_str_mv http://purl.org/redcol/resource_type/ARTREV
dc.type.coarversion.spa.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.issn.none.fl_str_mv 0121-7372
dc.identifier.uri.none.fl_str_mv https://repositorio.fucsalud.edu.co/handle/001/3083
dc.identifier.eissn.none.fl_str_mv 2462-991X
dc.identifier.url.none.fl_str_mv https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279
identifier_str_mv 0121-7372
2462-991X
url https://repositorio.fucsalud.edu.co/handle/001/3083
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279
dc.language.iso.spa.fl_str_mv spa
language spa
dc.relation.references.spa.fl_str_mv Santos-Cortez RLP, Bhutta MF, Earl JP, Hafrén L, Jennings M, Mell JC, Pichichero ME, Ryan AF, Tateossian H, Ehrlich GD. Panel 3: Genomics, precision medicine and targeted therapies. Int J Pediatr Otorhinolaryngol. 2020;130 Suppl 1(Suppl 1):109835. doi: 10.1016/j.ijporl.2019.109835. 2. Amekyeh H, Tarlochan F, Billa N. Practicality of 3D printed personalized medicines in therapeutics. Front Pharmacol. 2021;12:646836. doi: 10.3389/fphar.2021.646836. 3. Hebar A, Valent P, Selzer E. The impact of molecular targets in cancer drug development: major hurdles and future strategies. Expert Rev Clin Pharmacol. 2013;6(1):23-34. doi: 10.1586/ecp.12.71. 4. Yu Z, Song M, Chouchane L, Ma X. Functional genomic analysis of breast cancer metastasis: implications for diagnosis and therapy. Cancers (Basel). 2021;13(13):3276. doi: 10.3390/cancers13133276. 5. Huebner T, Scholl C, Steffens M. Cytogenetic and biochemical genetic techniques for personalized drug therapy in Europe. Diagnostics (Basel). 2021;11(7):1169. doi: 10.3390/diagnostics11071169. 6. Norrie JL, Nityanandam A, Lai K, Chen X, Wilson M, Stewart E, Griffiths L, Jin H, Wu G, Orr B, Tran Q, Allen S, Reilly C, Zhou X, Zhang J, Newman K, Johnson D, Brennan R, Dyer MA. Retinoblastoma from human stem cell-derived retinal organoids. Nat Commun. 2021;12(1):4535. doi: 10.1038/s41467-021-24781-7. 7. Heck JE, Huang X, Calkins KL, Sun Y, Olsen J, Ritz B, Hansen J. Phototherapy and childhood cancer: Shared risk factors. Int J Cancer. 2020;146(7):2059-2062. doi: 10.1002/ijc.32701. 8. Houlston R. Identification of low-penetrance alleles associated with colon cancer risk. Med Sci (Paris). 2009;25 Spec No 1:39-41. doi: 10.1051/medsci/2009251s39. 9. Capellini A, Williams M, Onel K, Huang KL. The functional hallmarks of cancer predisposition genes. Cancer Manag Res. 2021;13:4351-4357. doi: 10.2147/CMAR.S311548. 10. Bharucha PP, Chiu KE, François FM, Scott JL, Khorjekar GR, Tirada NP. Genetic testing and screening recommendations for patients with hereditary breast cancer. Radiographics. 2020;40(4):913-936. doi: 10.1148/rg.2020190181. 11. Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC. Functional genomic characterization of cancer genomes. Cold Spring Harb Symp Quant Biol. 2016;81:237-246. doi: 10.1101/sqb.2016.81.031070. 12. Kutkowska J, Strzadala L, Rapak A. Synergistic activity of sorafenib and betulinic acid against clonogenic activity of non-small cell lung cancer cells. Cancer Sci. 2017;108(11):2265-2272. doi: 10.1111/cas.13386. 13. Chen L, Liu S, Tao Y. Regulating tumor suppressor genes: post-translational modifications. Signal Transduct Target Ther. 2020;5(1):90. doi: 10.1038/s41392-020-0196-9. 14. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. 15. Gisselsson D, Egnell R. Cancer - An insurgency of clones. Trends Cancer. 2017;3(2):73-75. doi: 10.1016/j.trecan.2016.11.010. 16. Soltanian S, Matin MM. Cancer stem cells and cancer therapy. Tumour Biol. 2011;32(3):425-40. doi: 10.1007/s13277-011-0155-8. 17. Beijnen JH, Schellens JH. Personalized medicine in oncology: a personal view with myths and facts. Curr Clin Pharmacol. 2010;5(3):141-7. doi: 10.2174/157488410791498789. 18. Vishwakarma R, McManus KJ. Chromosome instability; Implications in cancer development, progression, and clinical outcomes. Cancers (Basel). 2020;12(4):824. doi: 10.3390/cancers12040824. 19. Mainor CB, Isaacs C. Risk Management for BRCA1/BRCA2 mutation carriers without and with breast cancer. Curr Breast Cancer Rep. 2020;12(2):66-74. doi: 10.1007/s12609-019-00350-2. 20. Lewis KM. Identifying hereditary cancer: genetic counseling and cancer risk assessment. Curr Probl Cancer. 2014;38(6):216-25. doi: 10.1016/j.currproblcancer.2014.10.002. 21. McClellan J, King MC. Genetic heterogeneity in human disease. Cell. 2010;141(2):210-7. doi: 10.1016/j.cell.2010.03.032. 22. Tian H, Gao Z, Li H, Zhang B, Wang G, Zhang Q, Pei D, Zheng J. DNA damage response--a double-edged sword in cancer prevention and cancer therapy. Cancer Lett. 2015;358(1):8-16. doi: 10.1016/j.canlet.2014.12.038. 23. Szczerba E, Kamińska K, Mierzwa T, Misiek M, Kowalewski J, Lewandowska MA. BRCA1/2 mutation detection in the tumor tissue from selected polish patients with breast cancer using Next Generation Sequencing. Genes (Basel). 2021;12(4):519. doi: 10.3390/genes12040519. 24. Landrum MJ, Chitipiralla S, Brown GR, Chen C, Gu B, Hart J, Hoffman D, Jang W, Kaur K, Liu C, Lyoshin V, Maddipatla Z, Maiti R, Mitchell J, O'Leary N, Riley GR, Shi W, Zhou G, Schneider V, Maglott D, Holmes JB, Kattman BL. ClinVar: improvements to accessing data. Nucleic Acids Res. 2020;48(D1):D835-D844. doi: 10.1093/nar/gkz972. 25. Dumbrava EI, Meric-Bernstam F. Personalized cancer therapy-leveraging a knowledge base for clinical decision-making. Cold Spring Harb Mol Case Stud. 2018;4(2):a001578. doi: 10.1101/mcs.a001578. 26. Hughes E, Tshiaba P, Wagner S, Judkins T, Rosenthal E, Roa B, Gallagher S, Meek S, Dalton K, Hedegard W, Adami CA, Grear DF, Domchek SM, Garber J, Lancaster JM, Weitzel JN, Kurian AW, Lanchbury JS, Gutin A, Robson ME. Integrating clinical and polygenic factors to predict breast cancer risk in women undergoing genetic testing. JCO Precis Oncol. 2021;5:PO.20.00246. doi: 10.1200/PO.20.00246. 27. Qiu J, Xu J, Zhang K, Gu W, Nie L, Wang G, Luo Y. Refining cancer management using integrated liquid biopsy. Theranostics. 2020;10(5):2374-2384. doi: 10.7150/thno.40677. 28. Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P. Molecular pathology of tumors of the central nervous system. Ann Oncol. 2019;30(8):1265-1278. doi: 10.1093/annonc/mdz164. 29. Elkamhawy A, Lu Q, Nada H, Woo J, Quan G, Lee K. The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer. Int J Mol Sci. 2021;22(12):6535. doi: 10.3390/ijms22126535. 30. Krzyszczyk P, Acevedo A, Davidoff EJ, Timmins LM, Marrero-Berrios I, Patel M, White C, Lowe C, Sherba JJ, Hartmanshenn C, O'Neill KM, Balter ML, Fritz ZR, Androulakis IP, Schloss RS, Yarmush ML. The growing role of precision and personalized medicine for cancer treatment. Technology (Singap World Sci). 2018;6(3-4):79-100. doi: 10.1142/S2339547818300020. 31. Helgadottir H, Rocha Trocoli Drakensjö I, Girnita A. Personalized medicine in malignant melanoma: Towards patient tailored treatment. Front Oncol. 2018;8:202. doi: 10.3389/fonc.2018.00202. 32. Afrăsânie VA, Marinca MV, Alexa-Stratulat T, Gafton B, Păduraru M, Adavidoaiei AM, Miron L, Rusu C. KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician. Radiol Oncol. 2019;53(3):265-274. doi: 10.2478/raon-2019-0033. 33. von Manstein V, Yang CM, Richter D, Delis N, Vafaizadeh V, Groner B. Resistance of cancer cells to targeted therapies through the activation of compensating signaling loops. Curr Signal Transduct Ther. 2013;8(3):193-202. doi: 10.2174/1574362409666140206221931. 34. Vieira AF, Schmitt F. An update on breast cancer multigene prognostic tests-emergent clinical biomarkers. Front Med (Lausanne). 2018;5:248. doi: 10.3389/fmed.2018.00248. 35. Schildgen V, Warm M, Brockmann M, Schildgen O. Oncotype DX Breast Cancer recurrence score resists inter-assay reproducibility with RT2-Profiler Multiplex RT-PCR. Sci Rep. 2019;9(1):20266. doi: 10.1038/s41598-019-56910-0.
dc.relation.bitstream.none.fl_str_mv https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1279/1861
dc.relation.citationedition.spa.fl_str_mv : Pre-Print
dc.relation.ispartofjournal.spa.fl_str_mv Revista Repertorio de Medicina y Cirugía
dc.rights.spa.fl_str_mv Revista Repertorio de Medicina y Cirugía - 2020
dc.rights.accessrights.spa.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.spa.fl_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.coar.spa.fl_str_mv http://purl.org/coar/access_right/c_abf2
rights_invalid_str_mv Revista Repertorio de Medicina y Cirugía - 2020
https://creativecommons.org/licenses/by-nc-sa/4.0/
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.mimetype.spa.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Sociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Salud
dc.source.spa.fl_str_mv https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279
institution Fundación Universitaria de Ciencias de la Salud - FUCS
bitstream.url.fl_str_mv https://repositorio.fucsalud.edu.co/bitstreams/034b4c91-8d55-455d-bcb7-bf68d02ef542/download
bitstream.checksum.fl_str_mv af1d93828565b4ddc27c39cf590226b1
bitstream.checksumAlgorithm.fl_str_mv MD5
repository.name.fl_str_mv Repositorio Digital de la Fundación Universitaria de Ciencias de la Salud
repository.mail.fl_str_mv redi@fucsalud.edu.co
_version_ 1814355541916385280
spelling Reyna Villasmil, Eduardo3b512367dfc5517e0abaabf4232b69c22020-04-06 16:33:032022-06-29T19:39:36Z2020-04-062020-04-06 16:33:032022-06-29T19:39:36ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la SaludRevista Repertorio de Medicina y Cirugía - 2020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279OncologíaMedicina de precisiónPrevenciónDiagnósticoTratamiento.MedicinaMedicina de precisiónOncologyPrecision medicinePreventionDiagnosisTreatmentUtilidad en la prevención, tratamiento y pronóstico de la medicina de precisión en oncologíaUsefulness of precision medicine in improving prevention, treatment and prognosis in oncologyapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a850121-7372https://repositorio.fucsalud.edu.co/handle/001/30832462-991Xhttps://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1279spaSantos-Cortez RLP, Bhutta MF, Earl JP, Hafrén L, Jennings M, Mell JC, Pichichero ME, Ryan AF, Tateossian H, Ehrlich GD. Panel 3: Genomics, precision medicine and targeted therapies. Int J Pediatr Otorhinolaryngol. 2020;130 Suppl 1(Suppl 1):109835. doi: 10.1016/j.ijporl.2019.109835. 2. Amekyeh H, Tarlochan F, Billa N. Practicality of 3D printed personalized medicines in therapeutics. Front Pharmacol. 2021;12:646836. doi: 10.3389/fphar.2021.646836. 3. Hebar A, Valent P, Selzer E. The impact of molecular targets in cancer drug development: major hurdles and future strategies. Expert Rev Clin Pharmacol. 2013;6(1):23-34. doi: 10.1586/ecp.12.71. 4. Yu Z, Song M, Chouchane L, Ma X. Functional genomic analysis of breast cancer metastasis: implications for diagnosis and therapy. Cancers (Basel). 2021;13(13):3276. doi: 10.3390/cancers13133276. 5. Huebner T, Scholl C, Steffens M. Cytogenetic and biochemical genetic techniques for personalized drug therapy in Europe. Diagnostics (Basel). 2021;11(7):1169. doi: 10.3390/diagnostics11071169. 6. Norrie JL, Nityanandam A, Lai K, Chen X, Wilson M, Stewart E, Griffiths L, Jin H, Wu G, Orr B, Tran Q, Allen S, Reilly C, Zhou X, Zhang J, Newman K, Johnson D, Brennan R, Dyer MA. Retinoblastoma from human stem cell-derived retinal organoids. Nat Commun. 2021;12(1):4535. doi: 10.1038/s41467-021-24781-7. 7. Heck JE, Huang X, Calkins KL, Sun Y, Olsen J, Ritz B, Hansen J. Phototherapy and childhood cancer: Shared risk factors. Int J Cancer. 2020;146(7):2059-2062. doi: 10.1002/ijc.32701. 8. Houlston R. Identification of low-penetrance alleles associated with colon cancer risk. Med Sci (Paris). 2009;25 Spec No 1:39-41. doi: 10.1051/medsci/2009251s39. 9. Capellini A, Williams M, Onel K, Huang KL. The functional hallmarks of cancer predisposition genes. Cancer Manag Res. 2021;13:4351-4357. doi: 10.2147/CMAR.S311548. 10. Bharucha PP, Chiu KE, François FM, Scott JL, Khorjekar GR, Tirada NP. Genetic testing and screening recommendations for patients with hereditary breast cancer. Radiographics. 2020;40(4):913-936. doi: 10.1148/rg.2020190181. 11. Howard TP, Vazquez F, Tsherniak A, Hong AL, Rinne M, Aguirre AJ, Boehm JS, Hahn WC. Functional genomic characterization of cancer genomes. Cold Spring Harb Symp Quant Biol. 2016;81:237-246. doi: 10.1101/sqb.2016.81.031070. 12. Kutkowska J, Strzadala L, Rapak A. Synergistic activity of sorafenib and betulinic acid against clonogenic activity of non-small cell lung cancer cells. Cancer Sci. 2017;108(11):2265-2272. doi: 10.1111/cas.13386. 13. Chen L, Liu S, Tao Y. Regulating tumor suppressor genes: post-translational modifications. Signal Transduct Target Ther. 2020;5(1):90. doi: 10.1038/s41392-020-0196-9. 14. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144(5):646-74. doi: 10.1016/j.cell.2011.02.013. 15. Gisselsson D, Egnell R. Cancer - An insurgency of clones. Trends Cancer. 2017;3(2):73-75. doi: 10.1016/j.trecan.2016.11.010. 16. Soltanian S, Matin MM. Cancer stem cells and cancer therapy. Tumour Biol. 2011;32(3):425-40. doi: 10.1007/s13277-011-0155-8. 17. Beijnen JH, Schellens JH. Personalized medicine in oncology: a personal view with myths and facts. Curr Clin Pharmacol. 2010;5(3):141-7. doi: 10.2174/157488410791498789. 18. Vishwakarma R, McManus KJ. Chromosome instability; Implications in cancer development, progression, and clinical outcomes. Cancers (Basel). 2020;12(4):824. doi: 10.3390/cancers12040824. 19. Mainor CB, Isaacs C. Risk Management for BRCA1/BRCA2 mutation carriers without and with breast cancer. Curr Breast Cancer Rep. 2020;12(2):66-74. doi: 10.1007/s12609-019-00350-2. 20. Lewis KM. Identifying hereditary cancer: genetic counseling and cancer risk assessment. Curr Probl Cancer. 2014;38(6):216-25. doi: 10.1016/j.currproblcancer.2014.10.002. 21. McClellan J, King MC. Genetic heterogeneity in human disease. Cell. 2010;141(2):210-7. doi: 10.1016/j.cell.2010.03.032. 22. Tian H, Gao Z, Li H, Zhang B, Wang G, Zhang Q, Pei D, Zheng J. DNA damage response--a double-edged sword in cancer prevention and cancer therapy. Cancer Lett. 2015;358(1):8-16. doi: 10.1016/j.canlet.2014.12.038. 23. Szczerba E, Kamińska K, Mierzwa T, Misiek M, Kowalewski J, Lewandowska MA. BRCA1/2 mutation detection in the tumor tissue from selected polish patients with breast cancer using Next Generation Sequencing. Genes (Basel). 2021;12(4):519. doi: 10.3390/genes12040519. 24. Landrum MJ, Chitipiralla S, Brown GR, Chen C, Gu B, Hart J, Hoffman D, Jang W, Kaur K, Liu C, Lyoshin V, Maddipatla Z, Maiti R, Mitchell J, O'Leary N, Riley GR, Shi W, Zhou G, Schneider V, Maglott D, Holmes JB, Kattman BL. ClinVar: improvements to accessing data. Nucleic Acids Res. 2020;48(D1):D835-D844. doi: 10.1093/nar/gkz972. 25. Dumbrava EI, Meric-Bernstam F. Personalized cancer therapy-leveraging a knowledge base for clinical decision-making. Cold Spring Harb Mol Case Stud. 2018;4(2):a001578. doi: 10.1101/mcs.a001578. 26. Hughes E, Tshiaba P, Wagner S, Judkins T, Rosenthal E, Roa B, Gallagher S, Meek S, Dalton K, Hedegard W, Adami CA, Grear DF, Domchek SM, Garber J, Lancaster JM, Weitzel JN, Kurian AW, Lanchbury JS, Gutin A, Robson ME. Integrating clinical and polygenic factors to predict breast cancer risk in women undergoing genetic testing. JCO Precis Oncol. 2021;5:PO.20.00246. doi: 10.1200/PO.20.00246. 27. Qiu J, Xu J, Zhang K, Gu W, Nie L, Wang G, Luo Y. Refining cancer management using integrated liquid biopsy. Theranostics. 2020;10(5):2374-2384. doi: 10.7150/thno.40677. 28. Kristensen BW, Priesterbach-Ackley LP, Petersen JK, Wesseling P. Molecular pathology of tumors of the central nervous system. Ann Oncol. 2019;30(8):1265-1278. doi: 10.1093/annonc/mdz164. 29. Elkamhawy A, Lu Q, Nada H, Woo J, Quan G, Lee K. The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer. Int J Mol Sci. 2021;22(12):6535. doi: 10.3390/ijms22126535. 30. Krzyszczyk P, Acevedo A, Davidoff EJ, Timmins LM, Marrero-Berrios I, Patel M, White C, Lowe C, Sherba JJ, Hartmanshenn C, O'Neill KM, Balter ML, Fritz ZR, Androulakis IP, Schloss RS, Yarmush ML. The growing role of precision and personalized medicine for cancer treatment. Technology (Singap World Sci). 2018;6(3-4):79-100. doi: 10.1142/S2339547818300020. 31. Helgadottir H, Rocha Trocoli Drakensjö I, Girnita A. Personalized medicine in malignant melanoma: Towards patient tailored treatment. Front Oncol. 2018;8:202. doi: 10.3389/fonc.2018.00202. 32. Afrăsânie VA, Marinca MV, Alexa-Stratulat T, Gafton B, Păduraru M, Adavidoaiei AM, Miron L, Rusu C. KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician. Radiol Oncol. 2019;53(3):265-274. doi: 10.2478/raon-2019-0033. 33. von Manstein V, Yang CM, Richter D, Delis N, Vafaizadeh V, Groner B. Resistance of cancer cells to targeted therapies through the activation of compensating signaling loops. Curr Signal Transduct Ther. 2013;8(3):193-202. doi: 10.2174/1574362409666140206221931. 34. Vieira AF, Schmitt F. An update on breast cancer multigene prognostic tests-emergent clinical biomarkers. Front Med (Lausanne). 2018;5:248. doi: 10.3389/fmed.2018.00248. 35. Schildgen V, Warm M, Brockmann M, Schildgen O. Oncotype DX Breast Cancer recurrence score resists inter-assay reproducibility with RT2-Profiler Multiplex RT-PCR. Sci Rep. 2019;9(1):20266. doi: 10.1038/s41598-019-56910-0.https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1279/1861: Pre-PrintRevista Repertorio de Medicina y CirugíaPublicationOREORE.xmltext/xml2681https://repositorio.fucsalud.edu.co/bitstreams/034b4c91-8d55-455d-bcb7-bf68d02ef542/downloadaf1d93828565b4ddc27c39cf590226b1MD51001/3083oai:repositorio.fucsalud.edu.co:001/30832024-02-02 13:07:14.938https://creativecommons.org/licenses/by-nc-sa/4.0/Revista Repertorio de Medicina y Cirugía - 2020metadata.onlyhttps://repositorio.fucsalud.edu.coRepositorio Digital de la Fundación Universitaria de Ciencias de la Saludredi@fucsalud.edu.co