Accidentalidad vial por consumo de drogas y alcohol: estado actual

Autores:
Uribe Granja, Camilo
Saavedra, Miguel Ángel
Almarales Navarro, José Rafael
Cabezas Pulido, Lorenzo Eduardo
Soto Bohórquez, Pedro Vicente
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
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Repositorio Digital Institucional ReDi
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spa
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oai:repositorio.fucsalud.edu.co:001/2822
Acceso en línea:
https://repositorio.fucsalud.edu.co/handle/001/2822
https://doi.org/10.31260/RepertMedCir.v21.n2.2012.800
Palabra clave:
drogas ilícitas
drogas diseñadas
etanol
accidentes de tránsito
lesiones
illegal drugs
designed drugs
ethanol
car accidents
injuries
Rights
openAccess
License
https://creativecommons.org/licenses/by-nc-sa/4.0/
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oai_identifier_str oai:repositorio.fucsalud.edu.co:001/2822
network_acronym_str FUCS2
network_name_str Repositorio Digital Institucional ReDi
repository_id_str
dc.title.spa.fl_str_mv Accidentalidad vial por consumo de drogas y alcohol: estado actual
dc.title.translated.eng.fl_str_mv Road traffic accidents related to drugs and alcohol: current situation
title Accidentalidad vial por consumo de drogas y alcohol: estado actual
spellingShingle Accidentalidad vial por consumo de drogas y alcohol: estado actual
drogas ilícitas
drogas diseñadas
etanol
accidentes de tránsito
lesiones
illegal drugs
designed drugs
ethanol
car accidents
injuries
title_short Accidentalidad vial por consumo de drogas y alcohol: estado actual
title_full Accidentalidad vial por consumo de drogas y alcohol: estado actual
title_fullStr Accidentalidad vial por consumo de drogas y alcohol: estado actual
title_full_unstemmed Accidentalidad vial por consumo de drogas y alcohol: estado actual
title_sort Accidentalidad vial por consumo de drogas y alcohol: estado actual
dc.creator.fl_str_mv Uribe Granja, Camilo
Saavedra, Miguel Ángel
Almarales Navarro, José Rafael
Cabezas Pulido, Lorenzo Eduardo
Soto Bohórquez, Pedro Vicente
dc.contributor.author.spa.fl_str_mv Uribe Granja, Camilo
Saavedra, Miguel Ángel
Almarales Navarro, José Rafael
Cabezas Pulido, Lorenzo Eduardo
Soto Bohórquez, Pedro Vicente
dc.subject.spa.fl_str_mv drogas ilícitas
drogas diseñadas
etanol
accidentes de tránsito
lesiones
topic drogas ilícitas
drogas diseñadas
etanol
accidentes de tránsito
lesiones
illegal drugs
designed drugs
ethanol
car accidents
injuries
dc.subject.eng.fl_str_mv illegal drugs
designed drugs
ethanol
car accidents
injuries
publishDate 2012
dc.date.accessioned.none.fl_str_mv 2012-06-01 00:00:00
2022-06-29T19:36:50Z
dc.date.issued.none.fl_str_mv 2012-06-01
dc.date.available.none.fl_str_mv 2012-06-01 00:00:00
2022-06-29T19:36:50Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.eng.fl_str_mv Journal article
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dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
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dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.content.spa.fl_str_mv Text
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dc.identifier.doi.none.fl_str_mv 10.31260/RepertMedCir.v21.n2.2012.800
dc.identifier.issn.none.fl_str_mv 0121-7372
dc.identifier.uri.none.fl_str_mv https://repositorio.fucsalud.edu.co/handle/001/2822
dc.identifier.eissn.none.fl_str_mv 2462-991X
dc.identifier.url.none.fl_str_mv https://doi.org/10.31260/RepertMedCir.v21.n2.2012.800
identifier_str_mv 10.31260/RepertMedCir.v21.n2.2012.800
0121-7372
2462-991X
url https://repositorio.fucsalud.edu.co/handle/001/2822
https://doi.org/10.31260/RepertMedCir.v21.n2.2012.800
dc.language.iso.spa.fl_str_mv spa
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dc.relation.references.spa.fl_str_mv Pecten M., editor. Informe mundial sobre prevención de los traumatismos cau­ sados por el transito[monografía en Intemet].Ginebra: OMS; 2004 [citado 23 Mar 2012]. Disponible en: http://www.paho.org/spanish/dd/pub/resumen_infor­ me_mundial_traumatismos.pdf 2. Clasificación de países [monografía en lntemet].Washington: Banco Mundial; 2010. [citado 23 Mar 2012]. Disponible en: http://datos.bancomundial.org/quie­ nes-somos/clasificacion-paises 3. Informe sobre la situacion mundial de la seguridad vial: es hora de pasar a la accion. Ginebra : OMS; 2009. 4 Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H. Alcohol consumption before sleep is associated with severity of sleep-disordered breathing arnong professio­ nal Japanese truck drivers. Alcohol ClinExp Res. 2007 Dec;31(12):2053-8. 5 Pastor R, Aragon CM. The role of opioid receptor subtypes in the develop­ ment of behavioral sensitization to ethanol. Neuropsychopharmacology. 2006 Jul;31(7): 1489-99. 6 Job MO, Tang A, Hall FS, Sora I, Uhl GR, Bergeson SE, et al. Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry 2007 Sep 15;62(6):627-34. 7 Voronin K, Randall P, Myrick H, Anton R. Aripiprazole effects on alcohol con­ sumption and subjective reports in a clinical laboratory paradigm--possible in­ fluence of self-control. Alcohol ClinExp Res. 2008 Nov;32(1 l ):1954-6 l. 8. Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nat Neurosci. 2009 Aug;12(8):988-95. 9 Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, et al. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.Cell. 2003 Dec 12;115(6):655-66. 10 Dopico AM, Chu B, Lemos JR, Treistrnan SN. Alcohol modulation of calcium­ activated potassium channels.Neurochem Int. 1999 Aug;35(2):103-6. 11 Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively de­ creases ethanol consumption and seeking. ProcNatlAcadSci U S A. 2007 Jul 24;104(30):12518-23. 12 Schuckit M. Ethaool and Methanol. In: Brunton L, editor. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill; 201o. p. 629-48. 13 Stephens R, Ling J, Heffeman TM, Heather N, Janes K. A review of the lite­ rature on the cognitive effects of alcohol hangover. Alcohol Alcohol 2008 Mar;43(2): 163-70. 14 Oslin D, Atkinson RM, Srnith DM, Hendrie H. Alcohol related dementia: propo­ sed clinical criteria. lnt J Geriatr Psychiatry. 1998 Apr;13(4):203-l 2. 15 Pfefferbaum A, Sullivan EV, Rosenbloom MJ, Mathalon DH, Lim KO. A contro­ lled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval.Arch Gen Psychiatry. 1998 Oct;55(10):905-12. 16 Kril JJ, Halliday GM. Brain shrinkage in alcoholics: a decade on and what have we learned?.ProgNeurobiol. 1999 Jul;58(4):381-7. 17 Alexander-Kaufman K, Harper C, Wilce P, Matsumoto l. Cerebellar ver­ mis proteome of chronic alcoholic individuals. Alcohol ClinExp Res. 2007 Aug;31(8):1286-96. 18 Volkow ND, Wang GJ, Hitzemann R, Fowler JS, Overall JE, Burr G, et al. Reco­ very of braio glucosemetabolism in detoxifiedalcoholics. Am JPsychiatry. 1994 Feb;l 51(2):178-83. 19 Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscieoce 1999;91(2):429-38. 20 Bartsch AJ, Homola G, Biller A, Smith SM, Weijers HG, Wiesbeck GA, et al. Manifestations of early brain recovery associated with abstinence from alcoho­ lism. Brain. 2007 Jan;l30(Pt 1):36-47. 21 Yip L. Ethanol. In: Nelson L, Lewin N, Howland MA, Hoffman R, Goldfrank L, Flomenbaum N, editors. Goldfrank'sToxicologic Emergencies. 9thed. New York: McGraw Hill; 2011. 22 OPS. Beber y Conducir: manual de seguridad vial para decisores y profesionales. Washington: OPS; 2010. 23 OPS. Defunciones por accidentes de transito en países seleccionados de las ame­ ricas 1985-2001. Bol. Epidemial. 2004 Mar;25(1):2-5. 24 Filip M, Alenina N, Bader M, Przegalinski E. Behavioral evidence for the signifi­ cance of serotoninergic (5-HT) receptors in cocaine addiction. Addict Biol. 2010 Jul;15(3):227-49. 25 Phillips K, Luk A, Soor GS, Abraham JR, Leong S, Butany J. Cocaine cardio­ toxicity: a review of the pathophysiology, pathology, and treatment options. Am J CardiovascDrugs. 2009;9(3):177-96. 26 Bravo P, Bravo S. Prevalencia de sustancias psicoactivas asociadas con muertes violentas en Cali. ColombMed. 2005 Ju] 1;36(3):146-52. 27 Demaria S Jr, Weinkauf JL. Cocaine and the club drugs. IntAnesthesiolClin. 2011;49(1):79-101. 28 Goldstein RA, DesLauriers C, Burda AM. Cocaine: history, social implications, and toxicity--a review. Dis Mon 2009 Jan;55(1):6-38. 29 Dietrich JB. Alteration of blood-brain barrier function by methamphetamine and cocaine. Cell Tissue Res. 2009 Jun;336(3):385-92. 30 Prosser JM, Hoffman R. Cocaine. In: Nelson L, Lewin N, Howland MA, Hoff man R, Goldfrank L, Flomenbaum N, editors. Goldfrank'sToxicologic Emergen­ cies. 9thed. New York: McGraw Hill; 2010. 31 Seger D. Cocaine, metamfetamine, and MDMA abuse: the role and clinical im­ portance of neuroadaptation. ClinToxicol (Phila). 201O Aug;48(7):695-708. 32 McGuigan M. Cannabinoids. In: Nelson L, Lewin N, Howland MA, Hoffman R, Goldfrank L, Flomenbaum N, editors. Goldfrank'sToxicologic Emergencies. 9thed. New York: McGraw Hill; 2010. 33 Copeland J, Swift W. Cannabis use disorder: epidemiology and management. Int Rev Psychiatry. 2009 Apr;21(2):96-103. 34 Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the tran­ sition to drug dependence. Am J Psychiatry. 2007 Aug;I64(8):I 149-59. 35 DeLisi LE. The effect of cannabis on the brain: can it cause brain anomalies that lead to increased risk for schizophrenia?.CurrOpin Psychiatry. 2008 Mar;2I(2):140-50. 36 Schuckit MA. Comorbidity between substance use disorders and psychiatric con­ ditions. Addiction 2006 Sep;IOI Suppl I:76-88. 37 Sewell RA, Poling J, Sofuoglu M. Toe effect of cannabis compared with alcohol on driving. Am J Addict. 2009 May;l8(3):185-93. 38 Perra S, Pillolla G, Luchicchi A, Pistis M. Alcohol inhibits spontaneous activity of basolateral amygdala projection neurons in the rat: involvement of the endo­ cannabinoid system. Alcohol ClinExp Res. 2008 Mar;32(3):443-9. 39 Kuhns JB, Wilson DB, Maguire ER, Ainsworth SA, Clodfelter TA. A meta­ analysis of marijuana, cocaine and opiate toxicology study findings among ho­ micide victims. Addiction. 2009 Jul; J 04(7):1122-31. 40. Chiang WK. Amphetamines. In: Nelson L, Lewin N, Howland MA, Hoffman R, Goldfrank L, Flomenbaum N, editors. Goldfrank'sToxicologic Emergencies. 9thed. New York: McGraw Hill; 2010. 41 Song BJ, Moon KH, Upreti VV, Eddington ND, Lee !J. Mechanisms of MOMA (ecstasy)-induced oxidative stress, mitochondrial dysfunction, and organ dama­ ge. Curr Pharm Biotechnol. 2010 Aug;l 1(5):434-43. 42 Fiaschi Al, Cerretani D. Causes and effects of cellular oxidative stress as a result of MOMA abuse. CurrPharmBiotechnol. 2010 Aug; l 1(5):444-52. 43 Moreno S. Lesiones de accidentes de transito Colombia 2010. Forensis. 2011;12(1):254-94. 44 Fondo de Prevencion vial. Que el alcohol no afecta la conducción?. Bogotá: Fon­ do de Prevencion Vial; 2011. 45 Heng K, Hargarten S, Layde P, Craven A, Zhu S. Moderate alcohol intake and motor vehicle crashes: the conflict between health advantage and at-risk use. Al­ cohol Alcohol. 2006 Jul;41(4):45!-4. 46 Mockus A. Cultura ciudadana, programa contra la violencia en Santa Fe de Bo­ gota, Colombia 1995 - 1997:estudio técnico. Washington: BID; 2001. 47. Colombia. Senado.Resolución 000414 de 2002. CódigoNacional de Transito Te­ rrestre 48 Odero W,ZwiAB. Alcohol-related traffic injuries and fatalities in developing coutries: A critica! review of literature[monografía en Internet]. London: London School of Hygiene and Tropical Medicine. Departrnent of Public Health.Health Policy Unit; 1995 [citado 23 Mar 2012].Disponible en: http://www.druglibrary. org/schaffer/misc/driving/s26pl.htrn 49. Odero W, Gamer P, Zwi A. Road traffic injuries in developing countries: a comprehensive review of epidemiological studies. Trop Med lnt Health. 1997 May;2(5):445-60. 50 Garg N, Hyder AA. Exploring the relationship between development and road traffic injuries: a case study from India. Eur J Public Health. 2006 Oct;l6(5):487- 9I. 51 Hasin OS, Stinson FS, Ogbum E, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Condi­ tions. Arch Gen Psychiatry. 2007 Jul;64(7):830-42. 52 Harwood HJ, Fountain D, Fountain G. Economic cost of alcohol and drug abuse in the United States, 1992: a report. Addiction. 1999 May;94(5):631-5. 53 Rehm J, Gnam W, Popova S, Baliunas D, Brochu S, Fischer B, et al. The costs of alcohol, illegal drugs, and tobacco in Canada, 2002. J Stud Alcohol Drugs. 2007 Nov;68(6):886-95. 54 Walsh JM, Flegel R, Cangianelli LA, Atkins R, Soderstrom CA, Kems TJ. Epi­ demiology of alcohol and other drug use among motor vehicle crash victims ad­ mitted to a trauma center. Traffic Inj Prev. 2004 Sep;5(3):254-60. 55 National Highway Traffic Safety Administration. Drug Involvement of Fatally Injured Drivers[monografía en Intemet].Washington: NHTSA; 2010.[citado 23 Mar 2012]. Disponible en: http://www-nrd.nhtsa.dot.gov/Pubs/81 l 4 l 5.pdf 56 Goulle JP, Verstraete A, Boulu R, Costentin J, Foucher JP, Raes E, et al. [Illicit drugs, medications and traffic accidents]. Ann Pharm Fr. 2008 Aug;66(4):196- 205. 57 Cimbura G, Lucas DM, Bennett RC, Warren RA, Simpson HM. Incidence and toxicological aspects of drugs detected in 484 fatally injured drivers and pedes­ trians in Ontario. J Forensic Sci. 1982 Oct;27(4):855-67. 58 Mercer GW, Jeffery WK. Alcohol, drugs, and impairrnent in fatal traffic acci­ dents in British Columbia. Accid Anal Prev. 1995 Jun;27(3):335-43. 59 Logan BK, Schwilke EW. Drug and alcohol use in fatally injured drivers in Washington State. J Forensic Sci. 1996 May;41(3):505-10. 60 Mason AP, McBay AJ. Ethanol, marijuana, and other drug use in 600 drivers killed in single-vehicle crashes in North Carolina, 1978-1981. J Forensic Sci. 1984 Oct;29(4):987-1026. 61 Soderstrom CA, Trifi!Jis AL, Shankar BS, Clark WE, Cowley RA. Marijuana and alcohol use among 1023 trauma patients. A prospective study. Arch Surg. 1988 Jun;123(6):733-7. 62 Gerchow J. ["Other intoxicating drugs" in traffic law]. Blutalkohol. I987 Jul;24(4):233-42. 63 Daldrup T, Reudenbach G, Kimm K. [Cannabis and alcohol in traffic]. Blutalko­ hol. 1987 Mar;24(2):144-56. 64 Drummer OH, Gerostamoulos J, Batziris H, Chu M, Caplehom JR, Robertson MO, et al. The incidence of drugs in drivers killed in Australian road traffic cras­ hes. Forensic Scilnt 2003 Jul 8;134(2-3):154-62. 65 McLean S, Parsons RS, Chesterman RB, Dineen R, Johnson MG, Davies NW. Drugs, alcohol and road accidents in Tasmania. Med J Aust 1987 Jul 6;147(1):6- 11. 66 Ramaekers JG, Berghaus G, van LM, Drummer OH. Dose related risk of motor vehicle crashes after cannabis use. Drug Alcohol Depend. 2004 Feb 7;73(2):I09- 19. 67 Oladehinde MK, Adegbehingbe 80, Adeoye AO, Onakoya AO. Central nervous system stimulants: effect on visual functions and occurrence of road traffic acci­ dents. Ann ItalChir. 2009 Jan;80(1):43-8. 68 Carmen del RM, AJvarez FJ. Presence of illegal drugs in drivers involved in fatal road traffic accidents in Spain. Drug Alcohol Depend. 2000 Jan 1;57(3):177-82. 69 Reis AD, Figlie NB, Laranjeira R. Prevalence of substance use among trau­ ma patients treated in a Brazilian emergency room. RevBrasPsiquiatr. 2006 Sep;28(3):191-5. 70 Rodríguez J, Acosta N, Peñaloza R. Carga de enfermedad Colombia 2005: Resul­ tados alcanzados. Documento técnico. Bogotá: Pontificia Universidad Javeriana, Cendex; 2008. 71 Constantin A. Reglamento técnico forense para la determinación del estado de embriaguez aguda. Bogotá: Instituto Nacional de Medicina Legal y Ciencias Fo­ renses; 2005.
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spelling Uribe Granja, Camilod4c481a933b6474794f8aa9aafad1b5a500Saavedra, Miguel Ángelb16d4eee77987ff3ecc216b815f49638500Almarales Navarro, José Rafael58763c4b7a3e8dbf9602c572dd64a8f5500Cabezas Pulido, Lorenzo Eduardob7a21f6b831fea12fd1509707b9f015b300Soto Bohórquez, Pedro Vicente008fbf4d08913ef0463762897c9a92aa3002012-06-01 00:00:002022-06-29T19:36:50Z2012-06-012012-06-01 00:00:002022-06-29T19:36:50ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Saludhttps://revistas.fucsalud.edu.co/index.php/repertorio/article/view/800drogas ilícitasdrogas diseñadasetanolaccidentes de tránsitolesionesillegal drugsdesigned drugsethanolcar accidentsinjuriesAccidentalidad vial por consumo de drogas y alcohol: estado actualRoad traffic accidents related to drugs and alcohol: current situationapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a8510.31260/RepertMedCir.v21.n2.2012.8000121-7372https://repositorio.fucsalud.edu.co/handle/001/28222462-991Xhttps://doi.org/10.31260/RepertMedCir.v21.n2.2012.800spaPecten M., editor. Informe mundial sobre prevención de los traumatismos cau­ sados por el transito[monografía en Intemet].Ginebra: OMS; 2004 [citado 23 Mar 2012]. Disponible en: http://www.paho.org/spanish/dd/pub/resumen_infor­ me_mundial_traumatismos.pdf 2. Clasificación de países [monografía en lntemet].Washington: Banco Mundial; 2010. [citado 23 Mar 2012]. Disponible en: http://datos.bancomundial.org/quie­ nes-somos/clasificacion-paises 3. Informe sobre la situacion mundial de la seguridad vial: es hora de pasar a la accion. Ginebra : OMS; 2009. 4 Sakurai S, Cui R, Tanigawa T, Yamagishi K, Iso H. Alcohol consumption before sleep is associated with severity of sleep-disordered breathing arnong professio­ nal Japanese truck drivers. Alcohol ClinExp Res. 2007 Dec;31(12):2053-8. 5 Pastor R, Aragon CM. The role of opioid receptor subtypes in the develop­ ment of behavioral sensitization to ethanol. Neuropsychopharmacology. 2006 Jul;31(7): 1489-99. 6 Job MO, Tang A, Hall FS, Sora I, Uhl GR, Bergeson SE, et al. Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis. Biol Psychiatry 2007 Sep 15;62(6):627-34. 7 Voronin K, Randall P, Myrick H, Anton R. Aripiprazole effects on alcohol con­ sumption and subjective reports in a clinical laboratory paradigm--possible in­ fluence of self-control. Alcohol ClinExp Res. 2008 Nov;32(1 l ):1954-6 l. 8. Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nat Neurosci. 2009 Aug;12(8):988-95. 9 Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, et al. A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans.Cell. 2003 Dec 12;115(6):655-66. 10 Dopico AM, Chu B, Lemos JR, Treistrnan SN. Alcohol modulation of calcium­ activated potassium channels.Neurochem Int. 1999 Aug;35(2):103-6. 11 Steensland P, Simms JA, Holgate J, Richards JK, Bartlett SE. Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist, selectively de­ creases ethanol consumption and seeking. ProcNatlAcadSci U S A. 2007 Jul 24;104(30):12518-23. 12 Schuckit M. Ethaool and Methanol. In: Brunton L, editor. Goodman & Gilman's The Pharmacological Basis of Therapeutics. 12th ed. New York: McGraw-Hill; 201o. p. 629-48. 13 Stephens R, Ling J, Heffeman TM, Heather N, Janes K. A review of the lite­ rature on the cognitive effects of alcohol hangover. Alcohol Alcohol 2008 Mar;43(2): 163-70. 14 Oslin D, Atkinson RM, Srnith DM, Hendrie H. Alcohol related dementia: propo­ sed clinical criteria. lnt J Geriatr Psychiatry. 1998 Apr;13(4):203-l 2. 15 Pfefferbaum A, Sullivan EV, Rosenbloom MJ, Mathalon DH, Lim KO. A contro­ lled study of cortical gray matter and ventricular changes in alcoholic men over a 5-year interval.Arch Gen Psychiatry. 1998 Oct;55(10):905-12. 16 Kril JJ, Halliday GM. Brain shrinkage in alcoholics: a decade on and what have we learned?.ProgNeurobiol. 1999 Jul;58(4):381-7. 17 Alexander-Kaufman K, Harper C, Wilce P, Matsumoto l. Cerebellar ver­ mis proteome of chronic alcoholic individuals. Alcohol ClinExp Res. 2007 Aug;31(8):1286-96. 18 Volkow ND, Wang GJ, Hitzemann R, Fowler JS, Overall JE, Burr G, et al. Reco­ very of braio glucosemetabolism in detoxifiedalcoholics. Am JPsychiatry. 1994 Feb;l 51(2):178-83. 19 Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. Neuronal loss in functional zones of the cerebellum of chronic alcoholics with and without Wernicke's encephalopathy. Neuroscieoce 1999;91(2):429-38. 20 Bartsch AJ, Homola G, Biller A, Smith SM, Weijers HG, Wiesbeck GA, et al. Manifestations of early brain recovery associated with abstinence from alcoho­ lism. Brain. 2007 Jan;l30(Pt 1):36-47. 21 Yip L. Ethanol. In: Nelson L, Lewin N, Howland MA, Hoffman R, Goldfrank L, Flomenbaum N, editors. Goldfrank'sToxicologic Emergencies. 9thed. New York: McGraw Hill; 2011. 22 OPS. Beber y Conducir: manual de seguridad vial para decisores y profesionales. Washington: OPS; 2010. 23 OPS. Defunciones por accidentes de transito en países seleccionados de las ame­ ricas 1985-2001. Bol. Epidemial. 2004 Mar;25(1):2-5. 24 Filip M, Alenina N, Bader M, Przegalinski E. Behavioral evidence for the signifi­ cance of serotoninergic (5-HT) receptors in cocaine addiction. Addict Biol. 2010 Jul;15(3):227-49. 25 Phillips K, Luk A, Soor GS, Abraham JR, Leong S, Butany J. Cocaine cardio­ toxicity: a review of the pathophysiology, pathology, and treatment options. Am J CardiovascDrugs. 2009;9(3):177-96. 26 Bravo P, Bravo S. Prevalencia de sustancias psicoactivas asociadas con muertes violentas en Cali. ColombMed. 2005 Ju] 1;36(3):146-52. 27 Demaria S Jr, Weinkauf JL. 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