Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje

Autores:
Campo, Piedad
Bonilla, Luis Jairo
Calderón, Adriana
Tipo de recurso:
Article of journal
Fecha de publicación:
2012
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
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Repositorio Digital Institucional ReDi
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spa
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https://doi.org/10.31260/RepertMedCir.v21.n3.2012.811
Palabra clave:
atipia escamosa de significado indeterminado (ASCOS)
virus del papiloma humano
citología en base líquida
reacción en cadena de la polimerasa
alto riesgo
neoplasia intraepitelial cervical
Atypical Squamous Cells of Undetermined Significance (ASCUS)
human papillomavirus
liquid-based cytology
polymerase chain reaction
high risk
cervical intraepithelial neoplasia
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dc.title.spa.fl_str_mv Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
dc.title.translated.eng.fl_str_mv Cervical cancer: liquid-based, conventional cytology and other screening tests
title Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
spellingShingle Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
atipia escamosa de significado indeterminado (ASCOS)
virus del papiloma humano
citología en base líquida
reacción en cadena de la polimerasa
alto riesgo
neoplasia intraepitelial cervical
Atypical Squamous Cells of Undetermined Significance (ASCUS)
human papillomavirus
liquid-based cytology
polymerase chain reaction
high risk
cervical intraepithelial neoplasia
title_short Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
title_full Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
title_fullStr Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
title_full_unstemmed Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
title_sort Cáncer cervical: citología en base líquida, convencional y otras pruebas de tamizaje
dc.creator.fl_str_mv Campo, Piedad
Bonilla, Luis Jairo
Calderón, Adriana
dc.contributor.author.spa.fl_str_mv Campo, Piedad
Bonilla, Luis Jairo
Calderón, Adriana
dc.subject.spa.fl_str_mv atipia escamosa de significado indeterminado (ASCOS)
virus del papiloma humano
citología en base líquida
reacción en cadena de la polimerasa
alto riesgo
neoplasia intraepitelial cervical
topic atipia escamosa de significado indeterminado (ASCOS)
virus del papiloma humano
citología en base líquida
reacción en cadena de la polimerasa
alto riesgo
neoplasia intraepitelial cervical
Atypical Squamous Cells of Undetermined Significance (ASCUS)
human papillomavirus
liquid-based cytology
polymerase chain reaction
high risk
cervical intraepithelial neoplasia
dc.subject.eng.fl_str_mv Atypical Squamous Cells of Undetermined Significance (ASCUS)
human papillomavirus
liquid-based cytology
polymerase chain reaction
high risk
cervical intraepithelial neoplasia
publishDate 2012
dc.date.accessioned.none.fl_str_mv 2012-09-01 00:00:00
2022-06-29T19:36:56Z
dc.date.issued.none.fl_str_mv 2012-09-01
dc.date.available.none.fl_str_mv 2012-09-01 00:00:00
2022-06-29T19:36:56Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.eng.fl_str_mv Journal article
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dc.relation.references.spa.fl_str_mv David Oddó B. MD. George Nicholas Papanicolaou. Vida y Obra de uno de los médicos más conocidos del siglo XX (1 y II partes). http://www.sld.cu/galerias/ pdf/sitios/histologia/georgenicholaspapanicolaou.pdf Consultado24/02/2012 7:57 am. 2. Recomendaciones para la tamización de neoplasias del cuello uterino en muje­ res sin antecedentes de patología cervical (preinvasora o invasora) en Colom­ bia. ISBN_978-958-98496-4-4 Guías de práctica clínica (No. 3) Ministerio de la protección social, Instituto Nacional de Cancerología . Disponible http://www.cancer.gov.co/documentos/RecomendacionesyGuias/GuiaN3.pdf Febrero 18-2012 6:54p.m. 3. GLOBOCAN 2008, International Agency for Research on Cancer. 4. Cuzick J, et al. Overview of the Europan and North American studies on HPV testing in primary cervical screening. lnt J Cancer 2006; 119(5):1905-1 lO. 5. Maribel Almonte, PhD, Raúl Murillo, MD, Gloria Inés Sánchez, PhD. Nuevos paradigmas y desafíos en la prevención y control del cáncer de cuello uterino en América Latina. Salud Pública de México / vol. 52, no. 6, noviembre-diciembre de 2010. 6. Ricardo Cendales, Marion Piñeros, Carolina Wiesner, Raúl Murillo, Sandra To­ var. Cobertura de la citología cérvico-uterina y factores relacionados en cuatro departamentos de Colombia. Rev Colomb Cancerol 2008; 12(3):119-125. 7. Libro Blanco de la Anatomía Patológica en España. Sociedad Española de Ana­ tomía Patológica. Citopatología pág. 57. 8. Paolo Ricci A., Ernesto Perucca P., Josip Koljanin V., Eduardo Baeriswyl T. Citología de base líquida: Revisión de la historia y los estudios al respecto. Rev Chil Obstet Ginecol 2004; 69 (3): 256-262. 9. Hutchinson ML, Zahniser DJ, Sherman ME, Herrero R, Alfaro M, Bratti MC, Hildesheim A, Lorincz AT, Greenberg MD, Morales J, Schiffman M. Utility of liquid-based cytology for cervical carcinomas screening: results of a population­ based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma. Cancer 1999; 87(2): 48-55. 10. New Options for Cervical Cancer Screening and Treatment in Low-Resource Settings. Cervical Cancer Action CoaJition / New options for cervical cancer screening and treatment. Disponible http://www.rho.org/files/CCA_cervical_ cancer_screening_treatment.pdf 11. Taoka Hideki MD. Comparasion of convencional and liquid-based cytology, and human papillomavirus testing using SurePath preparation in Japan. Human Cell 2010; 23:126-133. 12. Arbyn Marc, MD, Bergeron Christine, MD, PhD. Liquid compared with conven­ tional cervical cytology. Obstet Gynecol 2008; 111:167-77. 13. Sherrnan ME, Lorinez AT, DR. Baseline cytology,human papillomavirus tes­ ting and risk for cervical neoplasia:al 0-year cohort analysis. Jnatl Cancer Inst 2003;95:46 52. 14. Naucler P, TornbergS, etal. Human papillomavirus and Papanicolaou tests to screen for cervical cancer. N Engl J Med 2007;357:1589 97. 15. Bulkmans NW, BerkhofJ, RozendaalL, etal. Human papilloma virus DNA testing for the detection of cervical intraepitelial neoplasia grade 3 and cancer:5-year follow- upofa randomised controlled implementation trial.Lancet 2007;37:1764-72. 16. CuzickJ, ClavelC, PetryKU, etal. Overview of the European and North American studies on HPV testing in primary cervical cancer screening. Int J Cancer 2006; 119: 1095 -101. 17. Controversias en Ginecología y Obstetricia 2008; 20 (114); 3861-71. 18. Goldie Sj, Gaffikin L et al. Cost-effectiveness of cervical-cáncer screening in five developing countries. N Eng J Med 2005;353(20):2158-68. 19. Abulafia O, Pezzullo JC, Sherer DM: Performance of ThinPrcpliquid-based cer­ vical cytology in comparison with conventionally prepared Papanicolaou smears: A quantitative survey. Gynecol Oncol 2003; 90:137-144. 20. Baker J: Conventional and liquid-based cervicovaginal cytology: A comparison study with clinical and histologic follow-up. Diagn Cytopathol 2002; 27:185- 188.Bavikatty NR, Michael CW. Cytologic features of small-cell carcinoma on ThinPrep®. Diagn Cytopathol 2003; 29:8-12. 21. Bernstein SJ, Sanchez-Ramos L, Ndubisi B.: Liquid-based cervical Cytologic smear study and conventional Papanicolaou smears: A metaanalysis of prospec­ tive studies comparing Cytologic diagnosis and sample adequacy. Am J Obstet Gynecol 2001; 185:308-317. 22. Austin RM, Ramzy l. lncreased detection of epithelial cell abnormalities by liquid-based gynecologic cytology preparations. A review of accumulated data. Acta Cytol 1998; 42:178-184. 23. Merea E, Le Gales C, Cochand-Priollet B, Cartier !, de Cremoux P. Vacher­ Levenu MC, Vielh P, Coste J. Cost of screening for cancerous and precancerous lesions of the cervix. Diagn Cytopathol 2002; 27:251-257. 24. Selvaggi SM: Cytologic features of high-grade squamous intraepithelial lesions involving endocervical glands on ThinPrep cytology. DiagnCytopathol 2002;26:181-185. 25. Salud femenina. Citología en Base Liquida Disponible: www.mujersaludable. blogspot.com. Fecha de acceso 09-10-2001. 26. Gilbert Bigras, MD, FRCPC, PhD, 1 Malgorzata Anna Ricder, CT, 1 Jean-marc Lambercy, MD, 2 Bernard Kunz, MD, 2 Jean-Paul Chatelain, MD, 2 Olivier Reymond, MD, 2 and Daniel Cornaz, MD2. Keeping Collecting Device in Liquid Medium Is Mandatory to Ensure Optirnized Liquid-Based Cervical Cytologic Sampling. Rev Journal of Lower Genital Tract Disease, Volumen 7, Number 3, 2003, 168-174. 27. Maurice Fremont-Smith, M.D.I James Marino, B.S., CMIACI Bryan Griffin, M.D.2 Lynn Spencer, David Bolick, M.O., MIAC. Comparison of the Sure­ PathT" Liquid-Based Papanicolaou Smear with the Conventional Papanicolaou Smear in a Multisite Direct-to-Vial Study. Rev Cancer Cytopathology published online 31 August 2004 in Wiley InterScience. 28. Brenda J. Sweeney, C.T. 1 Zafarul Haq, M.T., C.T. I James F. Happel, D.L.M. I Barbará Weinstein, M.D.2 Douglas Schneider, M.D.l .Comparison of the Effecliveness of Two Liquid-Based Papanicolaou Systems in the Handling of Adverse Limiting Factors, such as Excessive Blood. Rev Cancer Cytopathology published online 21 November 2005 in Wiley InterScience. 29. Colgan TJ, McLachlin CM, Cotterchio M, Howlett R, Seidenfeld AM, Mai VM. Cancer Cylopathology. 2004; 102(6):362-367. 30. Keith V. Nance, M.O. Evolution of Pap Testing al a Community Hospital- A Ten Year Experence. Diagnostic Cytopathology 2007, Vol. 35, Issue 3,148-153. 31. Hazem T. Jafer, Mathilde E. Boon and Elizabeth Ouwerkerk-Noordam Leiden Cytology and Pathology Laboratory, Leiden, The Netherlands. Catching properties of brushes used in ThinPred-liquid-based cytology. Disponible http://www. k.linicyte.nl/26/SurePath®-LBC-in-Nederland.html. Consultado Marzo 11-2012. 32. Ronco Guglielmo, Cruzick Jack. Accuracy of liquid based versus conventional cytology: overall results of new technologies for cancer cervical screening: randomized controlled trial. Bmj.com 4 august 2008. 33. Fang-Hui Zhao, MD, PhD; Shang-Ying Hu, MD. Comparison of ThinPred and SurePath Liquid-Based Cytology and Subsequent Human Papillomavirus DNA Testing in China. Cancer Cytopathology Month 00, 2011. 34. Wright P.K. Comparison of SurePath and ThinPred liquid-based cervical cytology using positive predictive value, atypical predictive value and total predictive value as performance indicators. Cytopathology 20 I O; 21 :374-378. 35. Bergeron Christine MD., PhD. Accuracy of Thin-Layer cytology in patients undergoing cervical cone biopsy. Acta Citológica 2001; 45 :519-524. 36. Kenyon Shelly, MD. Comparasion of BD SurePath and ThinPred pap systems in the processing of mucus rich specimens. Cancer Cytopathology 20 IO; 25:244- 249. 37. Allen C. Rinas, M.S., C.T. (ASCP), C.M.l.A.C., Benjamín W. Mittman, Jr., B.S., et al. Split - Sample Analysis of Discarded Cells from Liquid - Based Pap smear Sampling Devices. Acta Cytologica 2006-50:55-62. 38. Cheung AN, Szeto EF, Leung BS, Khoo US, Ng AW. Liquid based cytology and convencional cervical smears Cancer 2003; 99(6): 331-5. 39. Vassilakos P, Schwartz D, de Marval F, Yousfi L, Broquel G, Mathez-Loic F, Campana A, Major A. Biopsy-base comparison of liquid-based, thin-layer preparations to conventional Pap smears. J Reprod Med 2000; 45(1): 116. 40. Bogdanich W. Lex Laboratories: The Pap test misses much cervical cancer through labs 'errors. The Wall Street Joumal, November 11, 1987. 41. Guidos BJ, Selvaggi SM. Use of the Thin Prep Pap Test in clinical practice. Diagn Cytopathol 1999; 20(2): 70-3. 164 Repertorio de Medicina y Cirugía.Vol 21 N º 3 • 2012 42. McGoogan E. Liquid-based cytology: the new screening test for cervical cancer control. Joumal of Family Planning and Reproductive Health Care 2004; 30: 123-125. 43. Lewis, MJ. Análisis de la situación del cáncer cervico uterino en América Latina y el Caribe. Washington, DC: Organización Panamericana de la Salud / Organización Mundial de la Salud (OPS/OMS), 2004. 44. World Health Organization. Cytology screening. [Revista en línea] fecha de acceso 24/02/09, Disponible en www.who.int/entity/cancer/detection/cytologyscreen/en/index.html. 45. César La cruz Pelea. Nomenclatura de las lesiones cervicales (de Papanicolaou a Bethesda 2001). Revista Española de Patología. 2003; 36. 46. American College of Obstetricians and Gynecologists. ACOG committee opinion. Recommendations on frequency of Pap test screening. Number 152-March 1995.Committee on Gynecologic Practice.lnt J Gynecol Obste! 1995; 49:210-1. 47. Javier Sáenz de Santamaría, Julio Rodríguez Costa, Domingo de Agustín Vásquez. Cuadernos de Citopatología. 48. Klinkhamer PJ, Meerding WJ, Rosier PF, Hanselaar AG. Liquid based cervical cytology. Cancer.2003; 99:263-271. 49. Nanda K, McCrory DC, Myers ER, et al. Accuracy of the Papanicolaou test in screening for an follow up of cervical cytologic abnorrnalities systematic review. Ann lntem Med. 2000; 132:810-819. 50. Maksem J. A manual method of liquid based cytology: Implementation, testing, col and outcomes. American Society for Clinical Pathology Teleconference Series, 2004. 51. Lee JM, Kelly D, Gravitt PE, Fansier Z, Maksem JA, Clarck DP. Validation of a low cost, liquid based screening method for cervical intraepithelial neoplasia. Am J Obste! Gynecol 2006; I 95:965-70. 52. CelikC, Gezginc K, Toy H, Findik S, Yilmaz O. A comparison of liquid based cytology with conventional cytology. Int J Gynecol Obste! 2008; 100:263-6. 53. Gustafsin KS, Fuerth EE, Heitjan DF, Fansier ZB, Ciare DC. DNA methylation profiling of cervical squamous intraepithelial lesions using Iiquid based cytology specimens. Cancer Cytopathol 2004; I02:259-68. 54. Rosenthal DL, Geddes S, Trimble CL, Carson KA, Alli PM. The PapSpin: A: A reasonable alternative to other, more expensive liquid-based Papanicolaou test. Cancer 2006; 108:137-43. 55. Kavatkar AN, Nagwanshi CA, Dabak SM. Study of a manual method of liquidbased cervical cytology.2008; 51: 190-4.
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spelling Campo, Piedadc089bcfd68e93c5ec5a63be552fdaaefBonilla, Luis Jairo2de919912102dfd4c33cca36bce27275300Calderón, Adriana07a43e6af309b1af64912b1b972536d63002012-09-01 00:00:002022-06-29T19:36:56Z2012-09-012012-09-01 00:00:002022-06-29T19:36:56ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la Saludhttps://revistas.fucsalud.edu.co/index.php/repertorio/article/view/811atipia escamosa de significado indeterminado (ASCOS)virus del papiloma humanocitología en base líquidareacción en cadena de la polimerasaalto riesgoneoplasia intraepitelial cervicalAtypical Squamous Cells of Undetermined Significance (ASCUS)human papillomavirusliquid-based cytologypolymerase chain reactionhigh riskcervical intraepithelial neoplasiaCáncer cervical: citología en base líquida, convencional y otras pruebas de tamizajeCervical cancer: liquid-based, conventional cytology and other screening testsapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a8510.31260/RepertMedCir.v21.n3.2012.8110121-7372https://repositorio.fucsalud.edu.co/handle/001/28322462-991Xhttps://doi.org/10.31260/RepertMedCir.v21.n3.2012.811spaDavid Oddó B. MD. George Nicholas Papanicolaou. Vida y Obra de uno de los médicos más conocidos del siglo XX (1 y II partes). http://www.sld.cu/galerias/ pdf/sitios/histologia/georgenicholaspapanicolaou.pdf Consultado24/02/2012 7:57 am. 2. Recomendaciones para la tamización de neoplasias del cuello uterino en muje­ res sin antecedentes de patología cervical (preinvasora o invasora) en Colom­ bia. ISBN_978-958-98496-4-4 Guías de práctica clínica (No. 3) Ministerio de la protección social, Instituto Nacional de Cancerología . Disponible http://www.cancer.gov.co/documentos/RecomendacionesyGuias/GuiaN3.pdf Febrero 18-2012 6:54p.m. 3. GLOBOCAN 2008, International Agency for Research on Cancer. 4. Cuzick J, et al. Overview of the Europan and North American studies on HPV testing in primary cervical screening. lnt J Cancer 2006; 119(5):1905-1 lO. 5. Maribel Almonte, PhD, Raúl Murillo, MD, Gloria Inés Sánchez, PhD. Nuevos paradigmas y desafíos en la prevención y control del cáncer de cuello uterino en América Latina. Salud Pública de México / vol. 52, no. 6, noviembre-diciembre de 2010. 6. Ricardo Cendales, Marion Piñeros, Carolina Wiesner, Raúl Murillo, Sandra To­ var. Cobertura de la citología cérvico-uterina y factores relacionados en cuatro departamentos de Colombia. Rev Colomb Cancerol 2008; 12(3):119-125. 7. Libro Blanco de la Anatomía Patológica en España. Sociedad Española de Ana­ tomía Patológica. Citopatología pág. 57. 8. Paolo Ricci A., Ernesto Perucca P., Josip Koljanin V., Eduardo Baeriswyl T. Citología de base líquida: Revisión de la historia y los estudios al respecto. Rev Chil Obstet Ginecol 2004; 69 (3): 256-262. 9. Hutchinson ML, Zahniser DJ, Sherman ME, Herrero R, Alfaro M, Bratti MC, Hildesheim A, Lorincz AT, Greenberg MD, Morales J, Schiffman M. Utility of liquid-based cytology for cervical carcinomas screening: results of a population­ based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma. Cancer 1999; 87(2): 48-55. 10. New Options for Cervical Cancer Screening and Treatment in Low-Resource Settings. Cervical Cancer Action CoaJition / New options for cervical cancer screening and treatment. Disponible http://www.rho.org/files/CCA_cervical_ cancer_screening_treatment.pdf 11. Taoka Hideki MD. Comparasion of convencional and liquid-based cytology, and human papillomavirus testing using SurePath preparation in Japan. Human Cell 2010; 23:126-133. 12. Arbyn Marc, MD, Bergeron Christine, MD, PhD. Liquid compared with conven­ tional cervical cytology. Obstet Gynecol 2008; 111:167-77. 13. Sherrnan ME, Lorinez AT, DR. Baseline cytology,human papillomavirus tes­ ting and risk for cervical neoplasia:al 0-year cohort analysis. Jnatl Cancer Inst 2003;95:46 52. 14. Naucler P, TornbergS, etal. Human papillomavirus and Papanicolaou tests to screen for cervical cancer. N Engl J Med 2007;357:1589 97. 15. Bulkmans NW, BerkhofJ, RozendaalL, etal. Human papilloma virus DNA testing for the detection of cervical intraepitelial neoplasia grade 3 and cancer:5-year follow- upofa randomised controlled implementation trial.Lancet 2007;37:1764-72. 16. CuzickJ, ClavelC, PetryKU, etal. Overview of the European and North American studies on HPV testing in primary cervical cancer screening. Int J Cancer 2006; 119: 1095 -101. 17. Controversias en Ginecología y Obstetricia 2008; 20 (114); 3861-71. 18. Goldie Sj, Gaffikin L et al. Cost-effectiveness of cervical-cáncer screening in five developing countries. N Eng J Med 2005;353(20):2158-68. 19. Abulafia O, Pezzullo JC, Sherer DM: Performance of ThinPrcpliquid-based cer­ vical cytology in comparison with conventionally prepared Papanicolaou smears: A quantitative survey. Gynecol Oncol 2003; 90:137-144. 20. Baker J: Conventional and liquid-based cervicovaginal cytology: A comparison study with clinical and histologic follow-up. Diagn Cytopathol 2002; 27:185- 188.Bavikatty NR, Michael CW. Cytologic features of small-cell carcinoma on ThinPrep®. Diagn Cytopathol 2003; 29:8-12. 21. Bernstein SJ, Sanchez-Ramos L, Ndubisi B.: Liquid-based cervical Cytologic smear study and conventional Papanicolaou smears: A metaanalysis of prospec­ tive studies comparing Cytologic diagnosis and sample adequacy. Am J Obstet Gynecol 2001; 185:308-317. 22. Austin RM, Ramzy l. lncreased detection of epithelial cell abnormalities by liquid-based gynecologic cytology preparations. A review of accumulated data. Acta Cytol 1998; 42:178-184. 23. Merea E, Le Gales C, Cochand-Priollet B, Cartier !, de Cremoux P. Vacher­ Levenu MC, Vielh P, Coste J. Cost of screening for cancerous and precancerous lesions of the cervix. Diagn Cytopathol 2002; 27:251-257. 24. Selvaggi SM: Cytologic features of high-grade squamous intraepithelial lesions involving endocervical glands on ThinPrep cytology. DiagnCytopathol 2002;26:181-185. 25. Salud femenina. Citología en Base Liquida Disponible: www.mujersaludable. blogspot.com. Fecha de acceso 09-10-2001. 26. Gilbert Bigras, MD, FRCPC, PhD, 1 Malgorzata Anna Ricder, CT, 1 Jean-marc Lambercy, MD, 2 Bernard Kunz, MD, 2 Jean-Paul Chatelain, MD, 2 Olivier Reymond, MD, 2 and Daniel Cornaz, MD2. Keeping Collecting Device in Liquid Medium Is Mandatory to Ensure Optirnized Liquid-Based Cervical Cytologic Sampling. Rev Journal of Lower Genital Tract Disease, Volumen 7, Number 3, 2003, 168-174. 27. Maurice Fremont-Smith, M.D.I James Marino, B.S., CMIACI Bryan Griffin, M.D.2 Lynn Spencer, David Bolick, M.O., MIAC. Comparison of the Sure­ PathT" Liquid-Based Papanicolaou Smear with the Conventional Papanicolaou Smear in a Multisite Direct-to-Vial Study. 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Study of a manual method of liquidbased cervical cytology.2008; 51: 190-4.https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/811/846Núm. 3 , Año 2012 : Julio – Septiembre164315521Revista Repertorio de Medicina y Cirugíainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2PublicationOREORE.xmltext/xml2730https://repositorio.fucsalud.edu.co/bitstreams/221b5976-6e3d-4741-823b-0e33e2888f81/downloadb7409361ce0c3dcd73cdbc4ad057ab20MD51001/2832oai:repositorio.fucsalud.edu.co:001/28322024-02-02 13:07:26.812https://creativecommons.org/licenses/by-nc-sa/4.0/metadata.onlyhttps://repositorio.fucsalud.edu.coRepositorio Digital de la Fundación Universitaria de Ciencias de la Saludredi@fucsalud.edu.co