Mutaciones del gen RAD51 en el cáncer familiar de ovario: revisión de la literatura

Background: In the last fifteen years, familiar ovarian carcinoma has been related to BRCA 1 and 2 mutations. However, 25% of new cases of ovarian neoplasm are explained by isolated genes involved in the mechanism of homologous recombination. Patients with family history of ovarian and breast carcin...

Full description

Autores:
Madariaga L., Alexandra
Sanabria S., Daniel E.
Gutiérrez C., Luz Dary
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
Repositorio:
Repositorio Digital Institucional ReDi
Idioma:
eng
spa
OAI Identifier:
oai:repositorio.fucsalud.edu.co:001/1502
Acceso en línea:
https://repositorio.fucsalud.edu.co/handle/001/1502
Palabra clave:
RAD51
cáncer de ovario
Neoplasia ovárica
Cáncer familiar de ovario
Neoplasias ováricas
Recombinasa Rad51
Rights
openAccess
License
Atribución-NoComercial 4.0 Internacional (CC BY-NC 4.0)
Description
Summary:Background: In the last fifteen years, familiar ovarian carcinoma has been related to BRCA 1 and 2 mutations. However, 25% of new cases of ovarian neoplasm are explained by isolated genes involved in the mechanism of homologous recombination. Patients with family history of ovarian and breast carcinoma, negative for BRCA mutations and at least with one case of invasive ovarian carcinoma have been identify with monoallelic mutations in RAD51. Objective: To describe mutations on RAD51 complex, in order to identify its role in familiar ovarian cancer. Methodology: A systematic review of the literature of the last ten years involving the main data bases and using the following MeSH terms: “RAD51”, “ovarian cancer”, “ovarian neoplasm”, “family ovarian cancer”. Results: Prevalence reported for RAD51 mutation is between 0.2 and 2.5%, associated with the ethnicity of the population involved. Also is considered a cause for high grade serous ovarian carcinoma in women between 57 and 60 years old. RAD51C and RAD51D germ line mutations are related to ovarian-breast hereditary syndrome, in negative population for BRCA 1 and 2 mutations. Conclusion: Patients with RAD51 mutations, negative for BRCA mutation are associated with ovarian-breast cancer syndrome increasing the risk just for ovarian cancer.