Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura

Autores:
Romero, Héctor
García, Carlos Artemo
Galindo, Jack Paul
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
Repositorio:
Repositorio Digital Institucional ReDi
Idioma:
spa
OAI Identifier:
oai:repositorio.fucsalud.edu.co:001/2504
Acceso en línea:
https://repositorio.fucsalud.edu.co/handle/001/2504
https://doi.org/10.31260/RepertMedCir.v24.n3.2015.614
Palabra clave:
unidades de cuidado intensivo neonatal
dolor
manejo del dolor
recién nacido
prematuro
escala
neonatal intensive care units
pain
pain management
newborn
premature
scale
Rights
openAccess
License
Fundación Universitaria de Ciencias de la Salud FUCS - 0
id FUCS2_44440a91a86cb1bf9766cb980537875f
oai_identifier_str oai:repositorio.fucsalud.edu.co:001/2504
network_acronym_str FUCS2
network_name_str Repositorio Digital Institucional ReDi
repository_id_str
dc.title.spa.fl_str_mv Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
dc.title.translated.eng.fl_str_mv Pain management in hospitalized neonates: Extended literature review
title Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
spellingShingle Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
unidades de cuidado intensivo neonatal
dolor
manejo del dolor
recién nacido
prematuro
escala
neonatal intensive care units
pain
pain management
newborn
premature
scale
title_short Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
title_full Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
title_fullStr Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
title_full_unstemmed Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
title_sort Manejo de dolor en neonatos hospitalizados: Revisión ampliada de la literatura
dc.creator.fl_str_mv Romero, Héctor
García, Carlos Artemo
Galindo, Jack Paul
dc.contributor.author.spa.fl_str_mv Romero, Héctor
García, Carlos Artemo
Galindo, Jack Paul
dc.subject.spa.fl_str_mv unidades de cuidado intensivo neonatal
dolor
manejo del dolor
recién nacido
prematuro
escala
topic unidades de cuidado intensivo neonatal
dolor
manejo del dolor
recién nacido
prematuro
escala
neonatal intensive care units
pain
pain management
newborn
premature
scale
dc.subject.eng.fl_str_mv neonatal intensive care units
pain
pain management
newborn
premature
scale
publishDate 2015
dc.date.accessioned.none.fl_str_mv 2015-09-01 00:00:00
2022-02-21T20:38:10Z
dc.date.issued.none.fl_str_mv 2015-09-01
dc.date.available.none.fl_str_mv 2015-09-01 00:00:00
2022-02-21T20:38:10Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.eng.fl_str_mv Journal article
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.spa.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.driver.spa.fl_str_mv info:eu-repo/semantics/article
dc.type.version.spa.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.content.spa.fl_str_mv Text
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dc.identifier.doi.none.fl_str_mv 10.31260/RepertMedCir.v24.n3.2015.614
dc.identifier.issn.none.fl_str_mv 0121-7372
dc.identifier.uri.none.fl_str_mv https://repositorio.fucsalud.edu.co/handle/001/2504
dc.identifier.eissn.none.fl_str_mv 2462-991X
dc.identifier.url.none.fl_str_mv https://doi.org/10.31260/RepertMedCir.v24.n3.2015.614
identifier_str_mv 10.31260/RepertMedCir.v24.n3.2015.614
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url https://repositorio.fucsalud.edu.co/handle/001/2504
https://doi.org/10.31260/RepertMedCir.v24.n3.2015.614
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dc.relation.references.spa.fl_str_mv Razmus I, Wilson D. Current trends in the development of sedation analgesia scales for the pediatric critical care patient. Pediatr Nurs. 2006;32(5):435-41.
Maxwell LG, Malavolta CP, Fraga MV. Assessment of pain in the neonate. Clin Perinatol. 2013;40(3):457-69.
Lago P, Garetti E, Merazzi D, Pieragostini L, Ancora G, Pirelli A, Bellieni CV. Guidelines for procedural pain in the newborn. Acta Paediatr. 2009;98(6):932-9.
Martínez-Tellería A, Delgado JA, Cano ME, Núñez J, Gálvez R. Analgesia postoperatoria en el neonato. Rev Soc Esp Dolor. 2002; 9:317-27.
Lago P, Garetti E, Boccuzzo G, Merazzi D, Pirelli A, Pieragostini L, et al. Procedural pain in neonates: the state of the art in the implementation of national guidelines in Italy. Pediatr Anesth. 2013; 23(5):407-14.
Guedj R, Danan C, Daoud P, Zupan V, Renolleau S, Zana E, et al. Does neonatal pain management in intensive care units differ between night and day? An observational study. BMJ open. 2014;4(2):e004086.
Ranger M, Grunau RE. Early repetitive pain in preterm infants in relation to the developing brain. Pain Manag. 2014;4(1): 57-67.
Grunau RE. Neonatal pain in very preterm infants: long-term effects on brain, neurodevelopment and pain Reactivity. Rambam Maimonides Med J. 2013 Oct 29;4(4):e0025.
Rodrigues AC, Guinsburg R. Pain evaluation after a non-nociceptive stimulus in preterm infants during the first 28days of life. Early Hum Dev. 2013;89(2):75-9.
Walker SM. Biological and neurodevelopmental implications of neonatal pain. Clin Perinatol. 2013; 40(3):471-91.
Vinall J, Miller SP, Chau V, Brummelte S, Synnes AR, Grunau RE. Neonatal pain in relation to postnatal growth in infants born very preterm. Pain. 2012;153(7):1374-81.
Consideraciones generales sobre dolor. En: Sociedad Venezolana de Puericultura y Pediatría. Dolor en pediatría. Caracas: Médica Panamericana; 2010. p. 16.
Mayock DE, Gleason CA. Pain and sedation in the NICU. NeoReviews. 2013;14(1): e22-31.
Holsti L, Grunau RE, Oberlander TF, Osiovich H. Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scale. Clin J Pain. 2008 Jan;24(1):83-8.
Narbona López E, Contreras Chova F, García Iglesias F, Miras Baldo MJ. Manejo del dolor en el recién nacido. En: Asociación Española de Pediatría. Protocolos diagnósticos terapeúticos de la AEP: neonatología [monografía en Internet]. Madrid, España: AEP; 2008. [citado 15 Jul 2015]. Disponible en: http://www.aeped.es/sites/default/files/documentos/49.pdf. 36. Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101(2):E1. 37.
Taylor BJ, Robbins JM, Gold JI, Logsdon TR, Bird T, Anand K. Assessing postoperative pain in neonates: a multicenter observational study. Pediatrics. 2006;118(4):e992-e1000.
Codipietro L, Bailo E, Nangeroni M, Ponzone A, Grazia G. Analgesic techniques in minor painful procedures in neonatal units: a survey in northern Italy. Pain Prac. 2011;11(2):154-9.
an Dijk M, Peters JW, van Deventer P, Tibboel D. The COMFORT Behavior Scale: a tool for assessing pain and sedation in infants. Am J Nurs. 2005 Jan; 105(1):33-6.
Ozawa M, Yokoo K. Pain management of neonatal intensive care units in Japan. Acta Paediatr. 2013;102(4):366-72.
Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. The Cochrane database of systematic reviews. 2001(2):CD001452.
Franck LS, Oulton K, Nderitu S, Lim M, Fang S, Kaiser A. Parent involvement in pain management for NICU infants: a randomized controlled trial. Pediatrics. 2011 Sep; 128(3):510-8.
Allegaert K, Tibboel D. Shouldn’t we reconsider procedural techniques to prevent neonatal pain?. Eur J Pain. 2007;11(8):910-2.
American Academic of Pediatrics. Committee on Fetus Newborn. Section on Surgery, Canadian Paediatric Society. Fetus Newborn Committee. Prevention and management of pain in the neonate: an update. Pediatrics. 2006. 118(5): 2231-41.
Kumar P, Denson SE, Mancuso TJ. Premedication for nonemergency endotracheal intubation in the neonate. Pediatrics. 2010 Mar;125(3):608-15.
Harrison D, Beggs S, Stevens B. Sucrose for procedural pain management in infants. Pediatrics. 2012;130(5): 918-25.
Batton DG, Barrington KJ, Wallman C. Prevention and management of pain in the neonate: an update. Pediatrics. 2006 Nov; 118(5): 2231-41.
Campbell-Yeo M, Johnston C, Benoit B, Latimer M, Vincer M, Walker D, Streiner D, Inglis D, Caddell K. Trial of repeated analgesia with Kangaroo Mother Care. BMC pediatrics. 2013;13(1):182.
Scottish Intercollegiate Guidelines Network. SIGN 50: a guideline developer’s handbook [monograph on the Internet]. Edinburgh: SIGN; 2014. [cited 2014 Nov 14]. Available in: http://www.sign.ac.uk/pdf/sign50.pdf
Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #23: Non-pharmacologic management of procedure-related pain in the breastfeeding infant. Breastfeed Med. 2010 Dec; 5(6):315-9.
Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. Cochrane Database Syst Rev. 2007 Oct 17; (4):CD001452.
Barker D, Willetts B, Cappendijk V, Rutter N. Capillary blood sampling: should the heel be warmed?. Arch Dis Child Fetal Neonatal Ed.1996;74(2):F139-40.
Johnston C, Campbell-Yeo M, Rich B, Whitley J, Filion F, Cogan J, et al. Therapeutic touch is not therapeutic for procedural pain in very preterm neonates: a randomized trial. Clin J Pain. 2013; 29(9):824-9.
Johnston C, Campbell-Yeo M, Fernandes A, Inglis D, Streiner D, Zee R. Skinto-skin care for procedural pain in neonates. Cochrane Database Syst Rev. 2014; (1): CD008435.
O’Brien L, Taddio A, Lyszkiewicz DA, Koren G. A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain. Pediatr Drugs. 2005;7(1):41-54.
Bonetto G, Salvatico E, Várela N, Cometto C, Gómez PF, Calvo B. Prevención del dolor en recién nacidos de término: estudio aleatorizado sobre tres métodos. Rev Soc Bol Ped. 2010; 49(2):108-13.
Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101(2):E1.
Kluger N, Raison Peyron N, Michot C, Guillot B, Bessis D. Acute bullous irritant contact dermatitis caused by EMLA® cream. Contact Dermatitis. 2011;65(3):181-2.
Spence K, Henderson Smart D, New K, Evans C, Whitelaw J, Woolnough R. Evidenced based clinical practice guideline for management of newborn pain. J Paediatr Child Health. 2010;46(4):184-92.
Taddio A, Soin HK, Schuh S, Koren G, Scolnik D. Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: a randomized controlled trial. CMAJ. 2005;172(13):1691-5.
Taddio A, Shah V, Stephens D, Parvez E, Hogan M-E, Kikuta A, Koren G, Katz J. Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newborns. Pediatrics. 2011;127(4):e940-7.
Niño A, Cristo J. Abordaje del dolor en el recién nacido. Guía de práctica clínica [monografía en Internet]. Bogotá: Universidad Militar Nueva Granada; 2014. [citado 17 Jul 2015]. Disponible en: http://repository.unimilitar.edu.co/bitstream/10654/10763/3/Ni%C3%B1oAdaVirginia2013.pdf
Yamada J, Stinson J, Lamba J, Dickson A, McGrath PJ, Stevens B. A review of systematic reviews on pain interventions in hospitalized infants. Pain Res Manag. 2008 Sep-Oct;13(5):413-20.
Walker S. Neonatal Pain. Paediatr Anaesth. 2014 Jan; 24(1): 39-48.
Ng E, Taddio A, Ohlsson A. Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit. Cochrane Database Syst Rev. 2012 Jun 13; 6: CD002052.
Harrison D, Beggs S, Stevens B. Sucrose for procedural pain management in infants. Pediatrics. 2012 Nov; 130(5): 918-25.
Wong C, Lau E, Palozzi L, Campbell F. Pain management in children: Part 1—Pain assessment tools and a brief review of nonpharmacological and pharmacological treatment options. Can Pharm J (Ott). 2012;145(5):222-5.
Anand K, McIntosh N, Lagercrantz H, Pelausa E, Young TE, Vasa R. Analgesia and sedation in preterm neonates who require ventilatory support: results from the NOPAIN trial. Arch Pediatr Adolesc Med. 1999;153(4):331-8.
Attarian S, Tran LC, Moore A, Stanton G, Meyer E, Moore RP. The neurodevelopmental impact of neonatal morphine administration. Brain Sci. 2014; 4(2): 321-34.
Storch De Gracia Calvo P, De La Torre Espí M, Martín Díaz M, García Ruiz S, Domínguez Ortega G, Novoa Carballal R, editors. ¿Se realiza correctamente la punción lumbar en pediatría?. Revisión de las recomendaciones actuales y análisis de la realidad. An Pediatr (Barc). 2012; 77(2): 115-23.
Lago P, Garetti E, Merazzi D, Pieragostini L, Ancora G, Pirelli A, Bellieni CV. Guidelines for procedural pain in the newborn. Acta Paediatr. 2009 Jun; 98(6): 932-9.
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spelling Romero, Héctor1a91312a6d700c9f5736a8e9c3617bbf500García, Carlos Artemo0aea70ddd447b592c9e4a2daac2c0839300Galindo, Jack Paulbf9a02571e6a933ed3ece1f6ecd95c093002015-09-01 00:00:002022-02-21T20:38:10Z2015-09-012015-09-01 00:00:002022-02-21T20:38:10ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la SaludFundación Universitaria de Ciencias de la Salud FUCS - 0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/614unidades de cuidado intensivo neonataldolormanejo del dolorrecién nacidoprematuroescalaneonatal intensive care unitspainpain managementnewbornprematurescaleManejo de dolor en neonatos hospitalizados: Revisión ampliada de la literaturaPain management in hospitalized neonates: Extended literature reviewapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/coar/version/c_970fb48d4fbd8a8510.31260/RepertMedCir.v24.n3.2015.6140121-7372https://repositorio.fucsalud.edu.co/handle/001/25042462-991Xhttps://doi.org/10.31260/RepertMedCir.v24.n3.2015.614spaRazmus I, Wilson D. Current trends in the development of sedation analgesia scales for the pediatric critical care patient. Pediatr Nurs. 2006;32(5):435-41.Maxwell LG, Malavolta CP, Fraga MV. Assessment of pain in the neonate. Clin Perinatol. 2013;40(3):457-69.Lago P, Garetti E, Merazzi D, Pieragostini L, Ancora G, Pirelli A, Bellieni CV. Guidelines for procedural pain in the newborn. Acta Paediatr. 2009;98(6):932-9.Martínez-Tellería A, Delgado JA, Cano ME, Núñez J, Gálvez R. Analgesia postoperatoria en el neonato. Rev Soc Esp Dolor. 2002; 9:317-27.Lago P, Garetti E, Boccuzzo G, Merazzi D, Pirelli A, Pieragostini L, et al. Procedural pain in neonates: the state of the art in the implementation of national guidelines in Italy. Pediatr Anesth. 2013; 23(5):407-14.Guedj R, Danan C, Daoud P, Zupan V, Renolleau S, Zana E, et al. Does neonatal pain management in intensive care units differ between night and day? An observational study. BMJ open. 2014;4(2):e004086.Ranger M, Grunau RE. Early repetitive pain in preterm infants in relation to the developing brain. Pain Manag. 2014;4(1): 57-67.Grunau RE. Neonatal pain in very preterm infants: long-term effects on brain, neurodevelopment and pain Reactivity. Rambam Maimonides Med J. 2013 Oct 29;4(4):e0025.Rodrigues AC, Guinsburg R. Pain evaluation after a non-nociceptive stimulus in preterm infants during the first 28days of life. Early Hum Dev. 2013;89(2):75-9.Walker SM. Biological and neurodevelopmental implications of neonatal pain. Clin Perinatol. 2013; 40(3):471-91.Vinall J, Miller SP, Chau V, Brummelte S, Synnes AR, Grunau RE. Neonatal pain in relation to postnatal growth in infants born very preterm. Pain. 2012;153(7):1374-81.Consideraciones generales sobre dolor. En: Sociedad Venezolana de Puericultura y Pediatría. Dolor en pediatría. Caracas: Médica Panamericana; 2010. p. 16.Mayock DE, Gleason CA. Pain and sedation in the NICU. NeoReviews. 2013;14(1): e22-31.Holsti L, Grunau RE, Oberlander TF, Osiovich H. Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scale. Clin J Pain. 2008 Jan;24(1):83-8.Narbona López E, Contreras Chova F, García Iglesias F, Miras Baldo MJ. Manejo del dolor en el recién nacido. En: Asociación Española de Pediatría. Protocolos diagnósticos terapeúticos de la AEP: neonatología [monografía en Internet]. Madrid, España: AEP; 2008. [citado 15 Jul 2015]. Disponible en: http://www.aeped.es/sites/default/files/documentos/49.pdf. 36. Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101(2):E1. 37.Taylor BJ, Robbins JM, Gold JI, Logsdon TR, Bird T, Anand K. Assessing postoperative pain in neonates: a multicenter observational study. Pediatrics. 2006;118(4):e992-e1000.Codipietro L, Bailo E, Nangeroni M, Ponzone A, Grazia G. Analgesic techniques in minor painful procedures in neonatal units: a survey in northern Italy. Pain Prac. 2011;11(2):154-9.an Dijk M, Peters JW, van Deventer P, Tibboel D. The COMFORT Behavior Scale: a tool for assessing pain and sedation in infants. Am J Nurs. 2005 Jan; 105(1):33-6.Ozawa M, Yokoo K. Pain management of neonatal intensive care units in Japan. Acta Paediatr. 2013;102(4):366-72.Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. The Cochrane database of systematic reviews. 2001(2):CD001452.Franck LS, Oulton K, Nderitu S, Lim M, Fang S, Kaiser A. Parent involvement in pain management for NICU infants: a randomized controlled trial. Pediatrics. 2011 Sep; 128(3):510-8.Allegaert K, Tibboel D. Shouldn’t we reconsider procedural techniques to prevent neonatal pain?. Eur J Pain. 2007;11(8):910-2.American Academic of Pediatrics. Committee on Fetus Newborn. Section on Surgery, Canadian Paediatric Society. Fetus Newborn Committee. Prevention and management of pain in the neonate: an update. Pediatrics. 2006. 118(5): 2231-41.Kumar P, Denson SE, Mancuso TJ. Premedication for nonemergency endotracheal intubation in the neonate. Pediatrics. 2010 Mar;125(3):608-15.Harrison D, Beggs S, Stevens B. Sucrose for procedural pain management in infants. Pediatrics. 2012;130(5): 918-25.Batton DG, Barrington KJ, Wallman C. Prevention and management of pain in the neonate: an update. Pediatrics. 2006 Nov; 118(5): 2231-41.Campbell-Yeo M, Johnston C, Benoit B, Latimer M, Vincer M, Walker D, Streiner D, Inglis D, Caddell K. Trial of repeated analgesia with Kangaroo Mother Care. BMC pediatrics. 2013;13(1):182.Scottish Intercollegiate Guidelines Network. SIGN 50: a guideline developer’s handbook [monograph on the Internet]. Edinburgh: SIGN; 2014. [cited 2014 Nov 14]. Available in: http://www.sign.ac.uk/pdf/sign50.pdfAcademy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #23: Non-pharmacologic management of procedure-related pain in the breastfeeding infant. Breastfeed Med. 2010 Dec; 5(6):315-9.Shah V, Ohlsson A. Venepuncture versus heel lance for blood sampling in term neonates. Cochrane Database Syst Rev. 2007 Oct 17; (4):CD001452.Barker D, Willetts B, Cappendijk V, Rutter N. Capillary blood sampling: should the heel be warmed?. Arch Dis Child Fetal Neonatal Ed.1996;74(2):F139-40.Johnston C, Campbell-Yeo M, Rich B, Whitley J, Filion F, Cogan J, et al. Therapeutic touch is not therapeutic for procedural pain in very preterm neonates: a randomized trial. Clin J Pain. 2013; 29(9):824-9.Johnston C, Campbell-Yeo M, Fernandes A, Inglis D, Streiner D, Zee R. Skinto-skin care for procedural pain in neonates. Cochrane Database Syst Rev. 2014; (1): CD008435.O’Brien L, Taddio A, Lyszkiewicz DA, Koren G. A critical review of the topical local anesthetic amethocaine (Ametop) for pediatric pain. Pediatr Drugs. 2005;7(1):41-54.Bonetto G, Salvatico E, Várela N, Cometto C, Gómez PF, Calvo B. Prevención del dolor en recién nacidos de término: estudio aleatorizado sobre tres métodos. Rev Soc Bol Ped. 2010; 49(2):108-13.Taddio A, Ohlsson A, Einarson TR, Stevens B, Koren G. A systematic review of lidocaine-prilocaine cream (EMLA) in the treatment of acute pain in neonates. Pediatrics. 1998;101(2):E1.Kluger N, Raison Peyron N, Michot C, Guillot B, Bessis D. Acute bullous irritant contact dermatitis caused by EMLA® cream. Contact Dermatitis. 2011;65(3):181-2.Spence K, Henderson Smart D, New K, Evans C, Whitelaw J, Woolnough R. Evidenced based clinical practice guideline for management of newborn pain. J Paediatr Child Health. 2010;46(4):184-92.Taddio A, Soin HK, Schuh S, Koren G, Scolnik D. Liposomal lidocaine to improve procedural success rates and reduce procedural pain among children: a randomized controlled trial. CMAJ. 2005;172(13):1691-5.Taddio A, Shah V, Stephens D, Parvez E, Hogan M-E, Kikuta A, Koren G, Katz J. Effect of liposomal lidocaine and sucrose alone and in combination for venipuncture pain in newborns. Pediatrics. 2011;127(4):e940-7.Niño A, Cristo J. Abordaje del dolor en el recién nacido. Guía de práctica clínica [monografía en Internet]. Bogotá: Universidad Militar Nueva Granada; 2014. [citado 17 Jul 2015]. Disponible en: http://repository.unimilitar.edu.co/bitstream/10654/10763/3/Ni%C3%B1oAdaVirginia2013.pdfYamada J, Stinson J, Lamba J, Dickson A, McGrath PJ, Stevens B. A review of systematic reviews on pain interventions in hospitalized infants. Pain Res Manag. 2008 Sep-Oct;13(5):413-20.Walker S. Neonatal Pain. Paediatr Anaesth. 2014 Jan; 24(1): 39-48.Ng E, Taddio A, Ohlsson A. Intravenous midazolam infusion for sedation of infants in the neonatal intensive care unit. Cochrane Database Syst Rev. 2012 Jun 13; 6: CD002052.Harrison D, Beggs S, Stevens B. 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