Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación

Autores:
Miño Bernal , Jorge Fernando
López Morales , Edna
Sandino , Nelly Jazmín
Molano Franco, Daniel
Tipo de recurso:
Article of journal
Fecha de publicación:
2020
Institución:
Fundación Universitaria de Ciencias de la Salud - FUCS
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Repositorio Digital Institucional ReDi
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https://repositorio.fucsalud.edu.co/handle/001/2981
https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1052
Palabra clave:
Cirrosis
Falla Hepática Crónica Agudizada
Falla Orgánica Múltiple
Puntaje CLIFF SOFA
Cuidado Intensivo
Medicina Critica
Hepatologia
Gastroenterollogia
Cirrosis
cirrhosis
acute-on-chronic liver failure
multiple organ failure
CLIFF SOFA score
critical care medicine
Intensive Care Unit
Hepatology
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openAccess
License
Revista Repertorio de Medicina y Cirugía - 2020
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dc.title.spa.fl_str_mv Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
dc.title.translated.eng.fl_str_mv Cirrhosis or acute-on-chronic liver failure: definition and classification
title Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
spellingShingle Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
Cirrosis
Falla Hepática Crónica Agudizada
Falla Orgánica Múltiple
Puntaje CLIFF SOFA
Cuidado Intensivo
Medicina Critica
Hepatologia
Gastroenterollogia
Cirrosis
cirrhosis
acute-on-chronic liver failure
multiple organ failure
CLIFF SOFA score
critical care medicine
Intensive Care Unit
Hepatology
title_short Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
title_full Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
title_fullStr Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
title_full_unstemmed Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
title_sort Cirrosis hepática o falla hepática crónica agudizada: definición y clasificación
dc.creator.fl_str_mv Miño Bernal , Jorge Fernando
López Morales , Edna
Sandino , Nelly Jazmín
Molano Franco, Daniel
dc.contributor.author.spa.fl_str_mv Miño Bernal , Jorge Fernando
López Morales , Edna
Sandino , Nelly Jazmín
Molano Franco, Daniel
dc.subject.spa.fl_str_mv Cirrosis
Falla Hepática Crónica Agudizada
Falla Orgánica Múltiple
Puntaje CLIFF SOFA
Cuidado Intensivo
Medicina Critica
Hepatologia
Gastroenterollogia
Cirrosis
topic Cirrosis
Falla Hepática Crónica Agudizada
Falla Orgánica Múltiple
Puntaje CLIFF SOFA
Cuidado Intensivo
Medicina Critica
Hepatologia
Gastroenterollogia
Cirrosis
cirrhosis
acute-on-chronic liver failure
multiple organ failure
CLIFF SOFA score
critical care medicine
Intensive Care Unit
Hepatology
dc.subject.eng.fl_str_mv cirrhosis
acute-on-chronic liver failure
multiple organ failure
CLIFF SOFA score
critical care medicine
Intensive Care Unit
Hepatology
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-04-06 16:33:03
2022-06-29T19:38:32Z
dc.date.issued.none.fl_str_mv 2020-04-06
dc.date.available.none.fl_str_mv 2020-04-06 16:33:03
2022-06-29T19:38:32Z
dc.type.spa.fl_str_mv Artículo de revista
dc.type.eng.fl_str_mv Journal article
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dc.relation.references.spa.fl_str_mv Lefton H, Rosa A, Cohen M. Diagnosis and Epidemiology of Cirrhosis. Med Clin N Am. 2009;93(4):787-99, vii. doi: 10.1016/j.mcna.2009.03.002 2. Tsochatzis EA, Bosch J, Burroughs JK. Liver cirrhosis. Lancet. 2014;383(9930):1749-61. doi: 10.1016/S0140-6736(14)60121-5 3. Fleming K, Aithal G, Solaymani-Dodaran M, Card T, West J. Incidence and prevalence of cirrhosis in the United Kingdom, 1992–2001: A general population-based study. J Hepatol. 2008;49(5):732-8. doi: 10.1016/j.jhep.2008.05.023 4. Kamath P, Shah V. Overview of Cirrhosis In: Feldman V, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11 ed. Philadelphia: Elsevier; 2016. p. 1254-60.e1 5. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med. 2009;360(26):2758-69. doi: 10.1056/NEJMra0805786 6. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9(3):349-51. doi: 10.1002/hep.1840090302 7. Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol. 2012;56(1):255-66. doi: 10.1016/j.jhep.2011.06.010. 8. Stravitz RT, Lefkowitch JH, Fontana RJ, Gershwin ME, Leung PS, Sterling RK, et al. Autoimmune acute liver failure: proposed clinical and histological criteria. Hepatology. 2011;53(2):517-26. doi: 10.1002/hep.24080 9. Páramo Hernández D, Otero Regino W, Pineda Ovalle L. Fibrogénesis hepática. Rev Col Gastroenterol. 2010;25(2):187– 97 10. Pinzani M, Rosselli M, Zuckermann M, Liver Cirrhosis. Best Pract Res Clin Gastroenterol. 2011;25(2):281-290. doi: 10.1016/j.bpg.2011.02.009 11. Bosch J, Garcia-Pagrin JC. Complications of cirrhosis. I. Portal hypertension. J Hepatol. 2000;32(1 Suppl):141-56. doi: 10.1016/s0168-8278(00)80422- 12. Rockey D. Hepatic Fibrosis and Cirrhosis. In: McManus LM, Mitchell RN, editors. Pathobiology of Human Disease: a dynamic encyclopedia of disease mechanisms Elsevier; 2014. p. 1809–16. 13. Bird TG, Ramachandran P, Thomson E. Decompensated liver cirrhosis. Anaesthesia and Intensive Care Medicine. 2015;16(4):180–185. https://doi.org/10.1016/j.mpaic.2015.01.012 14. Soublett, J, Páez M, Aldana L. Cirrosis Hepática: características de la peritonitis bacteriana espontánea. Gen. 2017;71(2):68-73. 15. A Arroyo V, Jimenez W. Complications of cirrhosis. II. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem. J Hepatol. 2000;32(1 Suppl):157-70. doi: 10.1016/s0168-8278(00)80423-7 16. Villanueva Bendek, I. (2004). Síndrome hepatorrenal: Revisión de la literatura y análisis crítico de los criterios diagnósticos. Rev Col Gastroenterol. 2004;19(3):195-204. 17. Erly B, Carey WD, Kapoor B, McKinney JM, Tam M, Wang W. Hepatorenal syndrome: a review of pathophysiology and current treatment options. Semin Intervent Radiol. 2015;32(4):445-54. doi: 10.1055/s-0035-1564794 18. Venkat D, Venkat KK. Hepatorenal syndrome. South Med J. 2010;103(7):654-661. doi: 10.1097/SMJ.0b013e3181e07751 19. Belcher JM, Parikh CR, Garcia–Tsao G. Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013;11(12):1550-8. doi: 10.1016/j.cgh.2013.03.018 20. McCormick PA, Donnelly C. Management of hepatorenal syndrome. Pharmacol Ther. 2008;119(1):1-6. doi: 10.1016/j.pharmthera.2008.02.012 21. Márquez-Aguirre AL, Canales-Aguirre AA, Gómez-Pinedo U, Gálvez-Gastélum FJ. Aspectos moleculares de la encefalopatía hepática. Neurología. 20102;5(4): 239-247. doi: 10.1016/j.nrl.2009.12.001 22. Butterworth R. Complications of cirrhosis III. Hepatic encephalopathy. J Hepatol. 2000;32(1 Suppl):171-80. doi: 10.1016/s0168-8278(00)80424-9 23. Butterworth R Hepatic encephalopathy in alcoholic cirrhosis. Handb Clin Neurol. 2014;125:589-602. doi: 10.1016/B978-0-444-62619-6.00034-3 24. Aguilar Reina J. Encefalopatía hepática. Medicine. 2022;11(11):652-659. doi: 10.1016/S0304-5412(12)70362-1 25. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002;35(3):716-21. doi: 10.1053/jhep.2002.31250 26. Fallon MB, Abrams GA. Pulmonary dysfunction in chronic liver disease. Hepatology. 2000;32(4 Pt 1):859-65. doi: 10.1053/jhep.2000.7519 27. Hernaez R, Solà E, Moreau R, Ginès P. Acute-on-chronic liver failure: an update. Gut. 2017;66(3):541-553. doi: 10.1136/gutjnl-2016-312670 28. Figueiredo A, Romero-Bermejo F, Perdigoto R, Marcelino P. The end-organ impairment in liver cirrhosis: appointments for critical care. Crit Care Res Pract. 2012;2012:539412. doi: 10.1155/2012/539412 29. Pudil R, Pelouch R, Praus R., Vašatová M, Hůlek P. Heart failure in patients with liver cirrhosis. Cor et Vasa. 2013;55(4):e391-e396. https://doi.org/10.1016/j.crvasa.2013.06.002 30. Gaduputi V, Abdulsamad M, Sakam S, Abbas N, Tariq N, Ihimoyan A. Systemic vascular resistance in cirrhosis: a predictor of severity?. Hepat Med. 2014;6:95-101. doi: 10.2147/HMER.S67036 31. Poordad FF. Presentation and complications associated with cirrhosis of the liver. Curr Med Res Opin. 2015;31(5):925-37. doi: 10.1185/03007995.2015.1021905 32. Garcia‐Tsao G, Parikh CR, Viola A.. Acute kidney injury in cirrhosis. Hepatology. 2008;48(6):2064-2077. doi: 10.1002/hep.22605 33. Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, Davies NA, Jalan R. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology, 2007;6(3):831-840. doi: 10.1002/hep.21737 34. Arroyo V, Garcia-Martinez R, Salvatella X. Human serum albumin, systemic inflammation, and cirrhosis. J Hepatol. 2014;61(2):396-407. doi: 10.1016/j.jhep.2014.04.012 35. Abdel-Khalek E, El-Fakhry A, Helaly M, Hamed M, Elbaz O. Systemic inflammatory response syndrome in patients with liver cirrhosis. Arab J Gastroenterol. 2011;12(4):173-177. doi: 10.1016/j.ajg.2011.11.006 36. Ferreira FL, Bota DP, Bross A, Melot C. Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA. 2001;286(14):1754-8. doi: 10.1001/jama.286.14.1754 37. Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Gerbes A. Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis. Gastroenterology. 2013;144(7):1426-1437. doi: 10.1053/j.gastro.2013.02.042 38. Durand, F, Valla D. Assessment of the prognosis of cirrhosis: Child–Pugh versus MELD. J Hepatol. 2005;42 Suppl(1):S100-7. doi: 10.1016/j.jhep.2004.11.01 39. Onaca NN, Levy MF, Sanchez EQ, Chinnakotla S, Fasola CG, Thomas MJ, et al. A correlation between the pretransplantation MELD score and mortality in the first two years after liver transplantation. Liver Transpl. 2003;9(2):117-23. doi: 10.1053/jlts.2003.50027 40. Duan BW, Lu SC, Wang ML, Liu JN, Chi P, Lai W, et al. Liver transplantation in acute-on-chronic liver failure patients with high model for end-stage liver disease (MELD) scores: a single center experience of 100 consecutive cases. J Surg Res. 2013;183(2):936-943. doi: 10.1016/j.jss.2013.03.008 41. Ravindra BS, Surude R, Srinivas MG, Deviprasad S, Samarth A, Sawant, P. Comparison of CHILD, MELD and MELD-Na in Predicting Survival in Patients with Cirrhosis of Liver. Journal of Clinical and Experimental Hepatology. 2011:1(1):17. doi: 10.1016/S0973-6883(11)60037-6 42. Cooper GS, Bellamy P. Dawson NV, Desbiens N, Jr Fulkerson WJ, Goldman L, Landefeld CS. A prognostic model for patients with end-stage liver disease. Gastroenterology. 1997;113(4):1278-88. doi: 10.1053/gast.1997.v113.pm9322523 43. Jalan R, Saliba F, Pavesi M, Amoros A, Moreau R, Ginès P, Hopf C. Development and validation of a prognostic score to predict mortality in patients with acute-on-chronic liver failure. J Hepatol. 2014;61(5):1038-47. doi: 10.1016/j.jhep.2014.06.012 44. Stravitz RT. Acute-on-chronic liver failure—no longer an entity without definition. Nat. Rev. Gastroenterol. Hepatol. 2014;11:580–581. https://doi.org/10.1038/nrgastro.2014.161 45. Barosa R, Roque-Ramos L, Patita M, Nunes G, Fonseca J. CLIF-C ACLF score is a better mortality predictor than MELD, MELD-Na and CTP in patients with Acute on chronic liver failure admitted to the ward. Rev. Esp. Enferm. Dig. 2017;109(6): 399-405. https://dx.doi.org/10.17235/reed.2017.4701/2016 46. Cavallazzi R, Awe O, Vasu T, Hirani A, Vaid U, Leiby B, Kraft W , Kane G Model for End-Stage Liver Disease score for predicting outcome in critically ill medical patients with liver cirrhosis. Crit Care. 2012;27(4):424.e1-6. doi: 10.1016/j.jcrc.2011.11.014 47. Morimoto N, Okada K, Okita Y. The Model for End-Stage Liver Disease (MELD) Predicts Early and Late Outcomes of Cardiovascular Operations in Patients With Liver Cirrhosis. Ann Thorac Surg. 2013;96(5):1672–8. doi: 10.1016/j.athoracsur.2013.06.007 48. Lucidi V, Gusto T, Moreno C, Donckier V. Liver transplantation in the context of organ shortage: toward extension and restriction of indications considering recent clinical data and ethical framework. Curr Opin Crit Care. 2015;21(2):163–170. doi: 10.1097/MCC.0000000000000186 49. Jalan R, Pavesi M, Saliba F, Amorós A, Fernandez J, Holland-Fischer P, et al. The CLIF Consortium Acute Decompensation score (CLIF-C ADs) for prognosis of hospitalised cirrhotic patients without acute-on-chronic liver failure. J Hepatol. 2015;62(4):831-40. doi: 10.1016/j.jhep.2014.11.012
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spelling Miño Bernal , Jorge Fernandoe0043c69f22cd022f574a3d8bec838e4300López Morales , Ednafc26a5f43f1a13885c878d47175d2301300Sandino , Nelly Jazmín2300bb98e7dd8d32add45ea8af343917300Molano Franco, Daniel43ccbaa8f9b368cd7ca4202c0299755d5002020-04-06 16:33:032022-06-29T19:38:32Z2020-04-062020-04-06 16:33:032022-06-29T19:38:32ZSociedad de Cirugía de Bogotá, Hospital de San José y Fundación Universitaria de Ciencias de la SaludRevista Repertorio de Medicina y Cirugía - 2020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2https://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1052CirrosisFalla Hepática Crónica AgudizadaFalla Orgánica MúltiplePuntaje CLIFF SOFACuidado IntensivoMedicina CriticaHepatologiaGastroenterollogiaCirrosiscirrhosisacute-on-chronic liver failuremultiple organ failureCLIFF SOFA scorecritical care medicineIntensive Care UnitHepatologyCirrosis hepática o falla hepática crónica agudizada: definición y clasificaciónCirrhosis or acute-on-chronic liver failure: definition and classificationapplication/pdfArtículo de revistaJournal articlehttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_dcae04bchttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionTexthttp://purl.org/redcol/resource_type/ARTREVhttp://purl.org/coar/version/c_970fb48d4fbd8a850121-7372https://repositorio.fucsalud.edu.co/handle/001/29812462-991Xhttps://revistas.fucsalud.edu.co/index.php/repertorio/article/view/1052spaLefton H, Rosa A, Cohen M. Diagnosis and Epidemiology of Cirrhosis. Med Clin N Am. 2009;93(4):787-99, vii. doi: 10.1016/j.mcna.2009.03.002 2. Tsochatzis EA, Bosch J, Burroughs JK. Liver cirrhosis. Lancet. 2014;383(9930):1749-61. doi: 10.1016/S0140-6736(14)60121-5 3. Fleming K, Aithal G, Solaymani-Dodaran M, Card T, West J. Incidence and prevalence of cirrhosis in the United Kingdom, 1992–2001: A general population-based study. J Hepatol. 2008;49(5):732-8. doi: 10.1016/j.jhep.2008.05.023 4. Kamath P, Shah V. Overview of Cirrhosis In: Feldman V, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11 ed. Philadelphia: Elsevier; 2016. p. 1254-60.e1 5. Lucey MR, Mathurin P, Morgan TR. Alcoholic hepatitis. N Engl J Med. 2009;360(26):2758-69. doi: 10.1056/NEJMra0805786 6. McClain CJ, Cohen DA. Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology. 1989;9(3):349-51. doi: 10.1002/hep.1840090302 7. Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. J Hepatol. 2012;56(1):255-66. doi: 10.1016/j.jhep.2011.06.010. 8. Stravitz RT, Lefkowitch JH, Fontana RJ, Gershwin ME, Leung PS, Sterling RK, et al. Autoimmune acute liver failure: proposed clinical and histological criteria. Hepatology. 2011;53(2):517-26. doi: 10.1002/hep.24080 9. Páramo Hernández D, Otero Regino W, Pineda Ovalle L. Fibrogénesis hepática. Rev Col Gastroenterol. 2010;25(2):187– 97 10. Pinzani M, Rosselli M, Zuckermann M, Liver Cirrhosis. Best Pract Res Clin Gastroenterol. 2011;25(2):281-290. doi: 10.1016/j.bpg.2011.02.009 11. Bosch J, Garcia-Pagrin JC. Complications of cirrhosis. I. Portal hypertension. J Hepatol. 2000;32(1 Suppl):141-56. doi: 10.1016/s0168-8278(00)80422- 12. Rockey D. Hepatic Fibrosis and Cirrhosis. In: McManus LM, Mitchell RN, editors. Pathobiology of Human Disease: a dynamic encyclopedia of disease mechanisms Elsevier; 2014. p. 1809–16. 13. Bird TG, Ramachandran P, Thomson E. Decompensated liver cirrhosis. Anaesthesia and Intensive Care Medicine. 2015;16(4):180–185. https://doi.org/10.1016/j.mpaic.2015.01.012 14. Soublett, J, Páez M, Aldana L. Cirrosis Hepática: características de la peritonitis bacteriana espontánea. Gen. 2017;71(2):68-73. 15. A Arroyo V, Jimenez W. Complications of cirrhosis. II. Renal and circulatory dysfunction. Lights and shadows in an important clinical problem. J Hepatol. 2000;32(1 Suppl):157-70. doi: 10.1016/s0168-8278(00)80423-7 16. Villanueva Bendek, I. (2004). Síndrome hepatorrenal: Revisión de la literatura y análisis crítico de los criterios diagnósticos. Rev Col Gastroenterol. 2004;19(3):195-204. 17. Erly B, Carey WD, Kapoor B, McKinney JM, Tam M, Wang W. Hepatorenal syndrome: a review of pathophysiology and current treatment options. Semin Intervent Radiol. 2015;32(4):445-54. doi: 10.1055/s-0035-1564794 18. Venkat D, Venkat KK. Hepatorenal syndrome. South Med J. 2010;103(7):654-661. doi: 10.1097/SMJ.0b013e3181e07751 19. Belcher JM, Parikh CR, Garcia–Tsao G. Acute kidney injury in patients with cirrhosis: perils and promise. Clin Gastroenterol Hepatol. 2013;11(12):1550-8. doi: 10.1016/j.cgh.2013.03.018 20. McCormick PA, Donnelly C. Management of hepatorenal syndrome. Pharmacol Ther. 2008;119(1):1-6. doi: 10.1016/j.pharmthera.2008.02.012 21. Márquez-Aguirre AL, Canales-Aguirre AA, Gómez-Pinedo U, Gálvez-Gastélum FJ. Aspectos moleculares de la encefalopatía hepática. Neurología. 20102;5(4): 239-247. doi: 10.1016/j.nrl.2009.12.001 22. Butterworth R. Complications of cirrhosis III. Hepatic encephalopathy. J Hepatol. 2000;32(1 Suppl):171-80. doi: 10.1016/s0168-8278(00)80424-9 23. Butterworth R Hepatic encephalopathy in alcoholic cirrhosis. Handb Clin Neurol. 2014;125:589-602. doi: 10.1016/B978-0-444-62619-6.00034-3 24. Aguilar Reina J. Encefalopatía hepática. Medicine. 2022;11(11):652-659. doi: 10.1016/S0304-5412(12)70362-1 25. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy—definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology. 2002;35(3):716-21. doi: 10.1053/jhep.2002.31250 26. Fallon MB, Abrams GA. Pulmonary dysfunction in chronic liver disease. Hepatology. 2000;32(4 Pt 1):859-65. doi: 10.1053/jhep.2000.7519 27. Hernaez R, Solà E, Moreau R, Ginès P. Acute-on-chronic liver failure: an update. Gut. 2017;66(3):541-553. doi: 10.1136/gutjnl-2016-312670 28. Figueiredo A, Romero-Bermejo F, Perdigoto R, Marcelino P. The end-organ impairment in liver cirrhosis: appointments for critical care. Crit Care Res Pract. 2012;2012:539412. doi: 10.1155/2012/539412 29. Pudil R, Pelouch R, Praus R., Vašatová M, Hůlek P. 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J Hepatol. 2015;62(4):831-40. doi: 10.1016/j.jhep.2014.11.012https://revistas.fucsalud.edu.co/index.php/repertorio/article/download/1052/1856: Pre-PrintRevista Repertorio de Medicina y CirugíaPublicationOREORE.xmltext/xml2829https://repositorio.fucsalud.edu.co/bitstreams/970d889f-6d4b-4e3f-a5ca-e4317026b08f/downloadec8f615a9bdbe9a9498f3c227036a647MD51001/2981oai:repositorio.fucsalud.edu.co:001/29812024-02-02 13:10:57.665https://creativecommons.org/licenses/by-nc-sa/4.0/Revista Repertorio de Medicina y Cirugía - 2020metadata.onlyhttps://repositorio.fucsalud.edu.coRepositorio Digital de la Fundación Universitaria de Ciencias de la Saludredi@fucsalud.edu.co