Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.

Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple a...

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Fecha de publicación:
2012
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/25976
Acceso en línea:
https://doi.org/10.1155/2012/254319
https://repository.urosario.edu.co/handle/10336/25976
Palabra clave:
pathophysiological mechanisms
Polyautoimmunity
autoimmune disease
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spelling 5224970106d01a9c-7112-4ad7-b82e-5dedc26c7a1ffdbf96f1-6f7f-4f65-a28b-bd393c81201bcb44c18d-c693-4ba5-ba89-8993a5634ee0194747786002020-08-06T16:20:22Z2020-08-06T16:20:22Z2012Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjogren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006-September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.application/pdfhttps://doi.org/10.1155/2012/254319ISSN: 20900422EISSN: 2090-0430https://repository.urosario.edu.co/handle/10336/25976engHindawi Publishing Corporation319254Autoimmune diseasesVol. 2012Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.254-319http://downloads.hindawi.com/journals/ad/2012/254319.pdfAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Autoimmune diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURpathophysiological mechanismsPolyautoimmunityautoimmune diseaseIntroducing polyautoimmunity: Secondary autoimmune diseases no longer exist.Introducción de la poliautoinmunidad: las enfermedades autoinmunes secundarias ya no existen.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Rojas-Villarraga, AdrianaAmaya-Amaya, JennyRodriguez-Rodriguez, AlbertoMantilla, Ruben DAnaya, Juan-ManuelORIGINAL254319.pdfapplication/pdf1366963https://repository.urosario.edu.co/bitstreams/b927f1a0-1f22-4a0f-abf3-427968ae9219/downloaddbff329cd8e47a2ff9f9b1c940ae29b6MD51TEXT254319.pdf.txt254319.pdf.txtExtracted texttext/plain45366https://repository.urosario.edu.co/bitstreams/78fc0abf-b527-4228-88a4-622126a7162c/downloade8e0c315204b4c4a0d49c8b4996a78c3MD52THUMBNAIL254319.pdf.jpg254319.pdf.jpgGenerated Thumbnailimage/jpeg4157https://repository.urosario.edu.co/bitstreams/d1f152ad-62c1-4211-970a-6bba61b9e263/download95300bcb1ec900607a5a47dc548d1720MD5310336/25976oai:repository.urosario.edu.co:10336/259762021-08-13 07:01:08.144https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
dc.title.TranslatedTitle.spa.fl_str_mv Introducción de la poliautoinmunidad: las enfermedades autoinmunes secundarias ya no existen.
title Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
spellingShingle Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
pathophysiological mechanisms
Polyautoimmunity
autoimmune disease
title_short Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
title_full Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
title_fullStr Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
title_full_unstemmed Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
title_sort Introducing polyautoimmunity: Secondary autoimmune diseases no longer exist.
dc.subject.keyword.spa.fl_str_mv pathophysiological mechanisms
Polyautoimmunity
autoimmune disease
topic pathophysiological mechanisms
Polyautoimmunity
autoimmune disease
description Similar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjogren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006-September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.
publishDate 2012
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dc.date.accessioned.none.fl_str_mv 2020-08-06T16:20:22Z
dc.date.available.none.fl_str_mv 2020-08-06T16:20:22Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
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dc.identifier.issn.none.fl_str_mv ISSN: 20900422
EISSN: 2090-0430
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url https://doi.org/10.1155/2012/254319
https://repository.urosario.edu.co/handle/10336/25976
identifier_str_mv ISSN: 20900422
EISSN: 2090-0430
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language eng
dc.relation.citationEndPage.none.fl_str_mv 319
dc.relation.citationStartPage.none.fl_str_mv 254
dc.relation.citationTitle.none.fl_str_mv Autoimmune diseases
dc.relation.citationVolume.none.fl_str_mv Vol. 2012
dc.relation.ispartof.spa.fl_str_mv Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.254-319
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dc.source.spa.fl_str_mv Autoimmune diseases
institution Universidad del Rosario
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