A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis

iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO pr...

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Autores:
Tipo de recurso:
Fecha de publicación:
2007
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23399
Acceso en línea:
https://doi.org/10.1016/j.tube.2007.03.002
https://repository.urosario.edu.co/handle/10336/23399
Palabra clave:
Amino acid
Inducible nitric oxide synthase
Tuberculin
Adult
Allele
Article
Controlled study
Endemic disease
Female
Gene location
Genetic association
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genetic trait
Human
Immunopathogenesis
Infection risk
Long terminal repeat
Lung tuberculosis
Major clinical study
Male
Priority journal
Sample size
Short tandem repeat
Skin test
Adult
Colombia
Female
Gene frequency
Genetic predisposition to disease
Humans
Male
Middle aged
Nitric oxide synthase type ii
Seroepidemiologic studies
Tandem repeat sequences
Genetics
Nitric oxide synthases
Tuberculosis
pulmonary
Tuberculosis
Rights
License
Abierto (Texto Completo)
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oai_identifier_str oai:repository.urosario.edu.co:10336/23399
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repository_id_str
dc.title.spa.fl_str_mv A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
title A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
spellingShingle A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
Amino acid
Inducible nitric oxide synthase
Tuberculin
Adult
Allele
Article
Controlled study
Endemic disease
Female
Gene location
Genetic association
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genetic trait
Human
Immunopathogenesis
Infection risk
Long terminal repeat
Lung tuberculosis
Major clinical study
Male
Priority journal
Sample size
Short tandem repeat
Skin test
Adult
Colombia
Female
Gene frequency
Genetic predisposition to disease
Humans
Male
Middle aged
Nitric oxide synthase type ii
Seroepidemiologic studies
Tandem repeat sequences
Genetics
Nitric oxide synthases
Tuberculosis
pulmonary
Tuberculosis
title_short A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
title_full A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
title_fullStr A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
title_full_unstemmed A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
title_sort A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
dc.subject.keyword.spa.fl_str_mv Amino acid
Inducible nitric oxide synthase
Tuberculin
Adult
Allele
Article
Controlled study
Endemic disease
Female
Gene location
Genetic association
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genetic trait
Human
Immunopathogenesis
Infection risk
Long terminal repeat
Lung tuberculosis
Major clinical study
Male
Priority journal
Sample size
Short tandem repeat
Skin test
Adult
Colombia
Female
Gene frequency
Genetic predisposition to disease
Humans
Male
Middle aged
Nitric oxide synthase type ii
Seroepidemiologic studies
Tandem repeat sequences
Genetics
Nitric oxide synthases
Tuberculosis
topic Amino acid
Inducible nitric oxide synthase
Tuberculin
Adult
Allele
Article
Controlled study
Endemic disease
Female
Gene location
Genetic association
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genetic trait
Human
Immunopathogenesis
Infection risk
Long terminal repeat
Lung tuberculosis
Major clinical study
Male
Priority journal
Sample size
Short tandem repeat
Skin test
Adult
Colombia
Female
Gene frequency
Genetic predisposition to disease
Humans
Male
Middle aged
Nitric oxide synthase type ii
Seroepidemiologic studies
Tandem repeat sequences
Genetics
Nitric oxide synthases
Tuberculosis
pulmonary
Tuberculosis
dc.subject.keyword.eng.fl_str_mv pulmonary
Tuberculosis
description iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.
publishDate 2007
dc.date.created.spa.fl_str_mv 2007
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:01:43Z
dc.date.available.none.fl_str_mv 2020-05-26T00:01:43Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.tube.2007.03.002
dc.identifier.issn.none.fl_str_mv 14729792
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23399
url https://doi.org/10.1016/j.tube.2007.03.002
https://repository.urosario.edu.co/handle/10336/23399
identifier_str_mv 14729792
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 294
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 288
dc.relation.citationTitle.none.fl_str_mv Tuberculosis
dc.relation.citationVolume.none.fl_str_mv Vol. 87
dc.relation.ispartof.spa.fl_str_mv Tuberculosis, ISSN:14729792, Vol.87, No.4 (2007); pp. 288-294
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spelling c5e15d68-2e79-46cc-994c-608ea4c1dc231947477860087f86574-8127-41ca-84bf-d4ad2a844f92585274c5-42d7-4c99-8347-aa1cce3602b3e6a8728d-6fdb-4c54-b9f1-1a39b0ff522f2b38fea9-0054-4c78-8df7-5465664256428adcb1d5-c2d7-4eab-99f8-0bd4ba85c1365ebc8bdf-3749-49a6-8ce5-6110616079fe2020-05-26T00:01:43Z2020-05-26T00:01:43Z2007iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.application/pdfhttps://doi.org/10.1016/j.tube.2007.03.00214729792https://repository.urosario.edu.co/handle/10336/23399eng294No. 4288TuberculosisVol. 87Tuberculosis, ISSN:14729792, Vol.87, No.4 (2007); pp. 288-294https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250656205&doi=10.1016%2fj.tube.2007.03.002&partnerID=40&md5=22d286ccdd393e39aa3dca54851a700bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAmino acidInducible nitric oxide synthaseTuberculinAdultAlleleArticleControlled studyEndemic diseaseFemaleGene locationGenetic associationGenetic polymorphismGenetic riskGenetic susceptibilityGenetic traitHumanImmunopathogenesisInfection riskLong terminal repeatLung tuberculosisMajor clinical studyMalePriority journalSample sizeShort tandem repeatSkin testAdultColombiaFemaleGene frequencyGenetic predisposition to diseaseHumansMaleMiddle agedNitric oxide synthase type iiSeroepidemiologic studiesTandem repeat sequencesGeneticsNitric oxide synthasesTuberculosispulmonaryTuberculosisA polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gómez, Luis MiguelAnaya, Juan-ManuelVilchez, José RamónCadena, JoseHinojosa, RosaVélez, LucianoLopez-Nevot, Miguel AngelMartín, JavierORIGINALA_polymorphism_in_the_inducible_nitric_o.pdfapplication/pdf2170001https://repository.urosario.edu.co/bitstreams/1e7f7f56-eba1-4228-ba52-015d1b5c3218/download4765a8063499caa9a229000c919c37acMD51TEXTA_polymorphism_in_the_inducible_nitric_o.pdf.txtA_polymorphism_in_the_inducible_nitric_o.pdf.txtExtracted texttext/plain32108https://repository.urosario.edu.co/bitstreams/c31db1bd-e5e8-4026-ab76-a90cfc0752d4/download2e83d70b9fefd7225b2f900af45ddb06MD52THUMBNAILA_polymorphism_in_the_inducible_nitric_o.pdf.jpgA_polymorphism_in_the_inducible_nitric_o.pdf.jpgGenerated Thumbnailimage/jpeg5110https://repository.urosario.edu.co/bitstreams/bd2e173c-4cbe-40a1-8f63-920774c2bf04/downloada97ef90009f76a0417257b6b1dd02bc6MD5310336/23399oai:repository.urosario.edu.co:10336/233992022-05-02 07:37:13.515664https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co