A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis
iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO pr...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2007
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23399
- Acceso en línea:
- https://doi.org/10.1016/j.tube.2007.03.002
https://repository.urosario.edu.co/handle/10336/23399
- Palabra clave:
- Amino acid
Inducible nitric oxide synthase
Tuberculin
Adult
Allele
Article
Controlled study
Endemic disease
Female
Gene location
Genetic association
Genetic polymorphism
Genetic risk
Genetic susceptibility
Genetic trait
Human
Immunopathogenesis
Infection risk
Long terminal repeat
Lung tuberculosis
Major clinical study
Male
Priority journal
Sample size
Short tandem repeat
Skin test
Adult
Colombia
Female
Gene frequency
Genetic predisposition to disease
Humans
Male
Middle aged
Nitric oxide synthase type ii
Seroepidemiologic studies
Tandem repeat sequences
Genetics
Nitric oxide synthases
Tuberculosis
pulmonary
Tuberculosis
- Rights
- License
- Abierto (Texto Completo)
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dc.title.spa.fl_str_mv |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
title |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
spellingShingle |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis pulmonary Tuberculosis |
title_short |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
title_full |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
title_fullStr |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
title_full_unstemmed |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
title_sort |
A polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosis |
dc.subject.keyword.spa.fl_str_mv |
Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis |
topic |
Amino acid Inducible nitric oxide synthase Tuberculin Adult Allele Article Controlled study Endemic disease Female Gene location Genetic association Genetic polymorphism Genetic risk Genetic susceptibility Genetic trait Human Immunopathogenesis Infection risk Long terminal repeat Lung tuberculosis Major clinical study Male Priority journal Sample size Short tandem repeat Skin test Adult Colombia Female Gene frequency Genetic predisposition to disease Humans Male Middle aged Nitric oxide synthase type ii Seroepidemiologic studies Tandem repeat sequences Genetics Nitric oxide synthases Tuberculosis pulmonary Tuberculosis |
dc.subject.keyword.eng.fl_str_mv |
pulmonary Tuberculosis |
description |
iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved. |
publishDate |
2007 |
dc.date.created.spa.fl_str_mv |
2007 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:01:43Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:01:43Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.tube.2007.03.002 |
dc.identifier.issn.none.fl_str_mv |
14729792 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23399 |
url |
https://doi.org/10.1016/j.tube.2007.03.002 https://repository.urosario.edu.co/handle/10336/23399 |
identifier_str_mv |
14729792 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
294 |
dc.relation.citationIssue.none.fl_str_mv |
No. 4 |
dc.relation.citationStartPage.none.fl_str_mv |
288 |
dc.relation.citationTitle.none.fl_str_mv |
Tuberculosis |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 87 |
dc.relation.ispartof.spa.fl_str_mv |
Tuberculosis, ISSN:14729792, Vol.87, No.4 (2007); pp. 288-294 |
dc.relation.uri.spa.fl_str_mv |
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dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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application/pdf |
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Universidad del Rosario |
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reponame:Repositorio Institucional EdocUR |
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c5e15d68-2e79-46cc-994c-608ea4c1dc231947477860087f86574-8127-41ca-84bf-d4ad2a844f92585274c5-42d7-4c99-8347-aa1cce3602b3e6a8728d-6fdb-4c54-b9f1-1a39b0ff522f2b38fea9-0054-4c78-8df7-5465664256428adcb1d5-c2d7-4eab-99f8-0bd4ba85c1365ebc8bdf-3749-49a6-8ce5-6110616079fe2020-05-26T00:01:43Z2020-05-26T00:01:43Z2007iNOS or NOS2 is a molecule that plays a key role in the immunological control of a broad spectrum of infectious agents. Investigation is hampered by difficulty in estimating in vivo production of nitric oxide (NO), but genetic studies provide a potential means of examining the relation between NO production and disease outcome. To better characterize the host genetic factors determining the susceptibility to TB, we evaluated the influence of two polymorphisms in the NOS2A gene on the risk of developing pulmonary TB in a Northwestern Colombian population, which is a moderately-high endemic area. One hundred and fourteen patients with TB and negative for human immunodeficiency virus, plus 304 healthy controls were examined for NOS2A CCTTT and TAAA polymorphisms. A total of 160 healthy controls mentioned before, underwent tuberculin skin test (TST). Analysis disclosed significant differences between patients and controls with NOS2A CCTTT polymorphism (P=0.0001, Pc=0.001, OR=0.4, and 95%CI=0.3-0.7) independent of TST status. When the NOS2A alleles were stratified into short (8-11) and long (12-16) repeats, significant differences with short repeats were observed between TB patients and all controls (P=0.005, OR=0.63, 95%CI=0.46-0.86). No individual association with NOS2A TAAA was detected. These results indicate that a polymorphism in the NOS2A gene influences the susceptibility to TB and suggest a role for NOS2A in the pathogenesis of mycobacterial infection. © 2007 Elsevier Ltd. All rights reserved.application/pdfhttps://doi.org/10.1016/j.tube.2007.03.00214729792https://repository.urosario.edu.co/handle/10336/23399eng294No. 4288TuberculosisVol. 87Tuberculosis, ISSN:14729792, Vol.87, No.4 (2007); pp. 288-294https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250656205&doi=10.1016%2fj.tube.2007.03.002&partnerID=40&md5=22d286ccdd393e39aa3dca54851a700bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAmino acidInducible nitric oxide synthaseTuberculinAdultAlleleArticleControlled studyEndemic diseaseFemaleGene locationGenetic associationGenetic polymorphismGenetic riskGenetic susceptibilityGenetic traitHumanImmunopathogenesisInfection riskLong terminal repeatLung tuberculosisMajor clinical studyMalePriority journalSample sizeShort tandem repeatSkin testAdultColombiaFemaleGene frequencyGenetic predisposition to diseaseHumansMaleMiddle agedNitric oxide synthase type iiSeroepidemiologic studiesTandem repeat sequencesGeneticsNitric oxide synthasesTuberculosispulmonaryTuberculosisA polymorphism in the inducible nitric oxide synthase gene is associated with tuberculosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Gómez, Luis MiguelAnaya, Juan-ManuelVilchez, José RamónCadena, JoseHinojosa, RosaVélez, LucianoLopez-Nevot, Miguel AngelMartín, JavierORIGINALA_polymorphism_in_the_inducible_nitric_o.pdfapplication/pdf2170001https://repository.urosario.edu.co/bitstreams/1e7f7f56-eba1-4228-ba52-015d1b5c3218/download4765a8063499caa9a229000c919c37acMD51TEXTA_polymorphism_in_the_inducible_nitric_o.pdf.txtA_polymorphism_in_the_inducible_nitric_o.pdf.txtExtracted texttext/plain32108https://repository.urosario.edu.co/bitstreams/c31db1bd-e5e8-4026-ab76-a90cfc0752d4/download2e83d70b9fefd7225b2f900af45ddb06MD52THUMBNAILA_polymorphism_in_the_inducible_nitric_o.pdf.jpgA_polymorphism_in_the_inducible_nitric_o.pdf.jpgGenerated Thumbnailimage/jpeg5110https://repository.urosario.edu.co/bitstreams/bd2e173c-4cbe-40a1-8f63-920774c2bf04/downloada97ef90009f76a0417257b6b1dd02bc6MD5310336/23399oai:repository.urosario.edu.co:10336/233992022-05-02 07:37:13.515664https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |