Cytokine imbalance in patients with systemic sclerosis and resilience: the key role of interleukin-6

OBJECTIVES: Resilience, the ability to respond positively to adverse events, may be influenced by long-term stressors and autoimmune/inflammatory conditions such as systemic sclerosis (SSc). Since the immune system plays a role in the development of resilience, we aimed to evaluate the relationship between a panel of cytokines and resilience in patients with SSc. METHODS: Thirty-five consecutive women with established SSc were involved in this exploratory study. Clinical characteristics, including severity of symptoms and resilience, a panel of 15 serum cytokines and 17 autoantibodies were assessed simultaneously. Multivariate methods were used to analyse the data. RESULTS: Interleukin-6 (IL-6) levels were associated with severity of symptoms (?=1.8395, p=0.04), and low resilience scores (?= -0.581120, p=0.02). Furthermore, resilience was not associated with clinical manifestations nor polyautoimmunity. Cytokine levels did not significantly differ between groups based on regular physical activity. CONCLUSIONS: The results highlight the importance of IL-6 as a key mediator in the altered cytokine network of SSc.

• Fecha de publicación: 2019
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23673
• Acceso en línea: https://repository.urosario.edu.co/handle/10336/23673
• Palabra clave: Autoantibody; Cytokine; Interleukin 6; Blood; Female; Human; Immunology; Physiology; Severity of illness index; Systemic sclerosis; Autoantibodies; Cytokines; Female; Humans; Interleukin-6; Severity of illness index; systemic; Scleroderma
• License: Abierto (Texto Completo)