Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-?), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.

• Fecha de publicación: 2014
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23832
• Acceso en línea: https://doi.org/10.1016/j.cyto.2014.03.005; https://repository.urosario.edu.co/handle/10336/23832
• Palabra clave: Cytokine; Cytokinome; Eotaxin; Fibroblast growth factor; Gamma interferon; Gamma interferon inducible protein 10; Interleukin 10; Interleukin 13; Interleukin 15; Interleukin 17; Interleukin 4; Interleukin 5; Interleukin 9; Macrophage inflammatory protein 1alpha; Macrophage inflammatory protein 1beta; Monocyte chemotactic protein 1; Platelet derived growth factor bb; Platelet derived growth factor beta receptor; Rantes; Unclassified drug; Vasculotropin; Cytokine; Signal peptide; Adult; Aged; Antibody production; Aqueous humor; Article; Cataract extraction; Clinical article; Colombian; Controlled study; Disease severity; Ethnicity; Female; Human; Inflammation; Male; Polymerase chain reaction; Priority journal; Protein expression; Recurrent disease; Regulatory t lymphocyte; Serotype; Symptomatology; Th1 cell; Th17 cell; Th2 cell; Toxoplasma gondii; Toxoplasmosis; Uveitis; Very elderly; Case control study; Eye; Metabolism; Prospective study; Toxoplasmosis; Adult; Aged; Aged, 80 and over; Aqueous humor; Case-control studies; Cytokines; Eye; Female; Humans; Intercellular signaling peptides and proteins; Male; Prospective studies; Colombia; Intraocular cytokines; Th2; Toxoplasma gondii; Uveitis; ocular; Toxoplasmosis
• License: Abierto (Texto Completo)