Ocular cytokinome is linked to clinical characteristics in ocular toxoplasmosis

Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-conf...

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Autores:
Tipo de recurso:
Fecha de publicación:
2014
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23832
Acceso en línea:
https://doi.org/10.1016/j.cyto.2014.03.005
https://repository.urosario.edu.co/handle/10336/23832
Palabra clave:
Cytokine
Cytokinome
Eotaxin
Fibroblast growth factor
Gamma interferon
Gamma interferon inducible protein 10
Interleukin 10
Interleukin 13
Interleukin 15
Interleukin 17
Interleukin 4
Interleukin 5
Interleukin 9
Macrophage inflammatory protein 1alpha
Macrophage inflammatory protein 1beta
Monocyte chemotactic protein 1
Platelet derived growth factor bb
Platelet derived growth factor beta receptor
Rantes
Unclassified drug
Vasculotropin
Cytokine
Signal peptide
Adult
Aged
Antibody production
Aqueous humor
Article
Cataract extraction
Clinical article
Colombian
Controlled study
Disease severity
Ethnicity
Female
Human
Inflammation
Male
Polymerase chain reaction
Priority journal
Protein expression
Recurrent disease
Regulatory t lymphocyte
Serotype
Symptomatology
Th1 cell
Th17 cell
Th2 cell
Toxoplasma gondii
Toxoplasmosis
Uveitis
Very elderly
Case control study
Eye
Metabolism
Prospective study
Toxoplasmosis
Adult
Aged
Aged, 80 and over
Aqueous humor
Case-control studies
Cytokines
Eye
Female
Humans
Intercellular signaling peptides and proteins
Male
Prospective studies
Colombia
Intraocular cytokines
Th2
Toxoplasma gondii
Uveitis
ocular
Toxoplasmosis
Rights
License
Abierto (Texto Completo)
Description
Summary:Purpose: To determine the cytokine levels in aqueous humor (AH) of Colombian patients with active ocular toxoplasmosis (OT), and to correlate them with their clinical characteristics. Methods: 27 Cytokines/chemokines were assayed in 15 AH samples (nine patients with diagnosis of OT biologically-confirmed and six controls that underwent cataract surgery). Correlations were assessed between cytokine/chemokine levels, type of inflammatory response (Th1, Th2, Th17, Treg), and clinical characteristics. Results: Th2 predominant response was related to more severe clinical features. The presence of VEGF and IL-5 was related to higher number of recurrences. Growth factors (VEGF, FGF, PDGF-?), were related to higher number of lesions. Patients infected by type-I/III strains had a particular intraocular cytokine-pattern. Conclusions: Th2 response was related to more severe clinical characteristics in patients infected by Type I/III strains. IL-5 and VEGF were associated with recurrences. We correlate for the first time, specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain. © 2014 Elsevier Ltd.