Effects of preterm birth and fetal growth retardation on life-course cardiovascular risk factors among schoolchildren from Colombia: The FUPRECOL study

Background Both fetal growth restriction and prematurity have been associated with cardiometabolic risk in youth and adults, however, data on their combined effects on cardiometabolic health in youth are scarce. Aims This study aimed at assessing the effects of birth weight and gestational age combi...

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Autores:
Tipo de recurso:
Fecha de publicación:
2017
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23872
Acceso en línea:
https://doi.org/10.1016/j.earlhumdev.2017.02.001
https://repository.urosario.edu.co/handle/10336/23872
Palabra clave:
Glucose
Adolescent
Anthropometry
Article
Blood pressure
Body height
Body mass
Cardiovascular risk
Child
Childhood obesity
Colombia
Controlled study
Cross-sectional study
Female
Gestational age
Glucose blood level
Human
Intrauterine growth retardation
Low birth weight
Major clinical study
Male
Metabolic syndrome x
Premature labor
Prematurity
Puberty
Randomized controlled trial
School child
Term birth
Waist circumference
World health organization
Cardiovascular disease
Case control study
Intrauterine growth retardation
Newborn
Adolescent
Cardiovascular diseases
Case-control studies
Child
Colombia
Female
Fetal growth retardation
Humans
Male
Blood pressure
Dyslipidemias
Glucose metabolism
Low birth weight
Metabolic syndrome
Premature birth
premature
development and aging
newborn
Growth
Infant
Infant
Rights
License
Abierto (Texto Completo)
Description
Summary:Background Both fetal growth restriction and prematurity have been associated with cardiometabolic risk in youth and adults, however, data on their combined effects on cardiometabolic health in youth are scarce. Aims This study aimed at assessing the effects of birth weight and gestational age combined on life-course cardiovascular risk factors and obesity among schoolchildren from Colombia. Study design A cross-sectional study. Subjects Participants comprised 2510 Colombian schoolchildren (54.8% girls) aged 9–17.9 years. Outcome measures Four groups were created according to WHO criteria: those born at term with an appropriate birth weight (? 2500 g to ? 4000 g) for gestational age (term AGA); those born preterm ( less than  37 to less than  42 completed weeks) with an appropriate birth weight for gestational age (preterm AGA); those born at term with low birth weight for gestational age (term SGA); and those born preterm with low birth weight for gestational age (preterm SGA). Anthropometric markers (body mass, height, waist circumference, and body mass index), blood pressure, lipids profile, fasting glucose, and pubertal stage were assessed. The prevalence of metabolic syndrome was determined by de Ferranti definition. Results There were differences between the 4 groups for calendar age (p = 0.011), body mass (p = 0.001), height (p = 0.001), and body mass index (p = 0.027). Overall, preterm SGA group had a greater risk for having elevated fasting glucose and metabolic syndrome (total sample and in boys) compared with term AGA group (p  less than  0.05). For other cardiovascular risk factors, no significant relationships were observed based on birth characteristics. Conclusions School-age children and adolescents with combined fetal growth restriction and prematurity exhibited an increased prevalence of glucose risk and metabolic syndrome. © 2017