Association of HIV status with infection by multiple HPV types

Objectives: To identify the clinical and demographic characteristics of HIV-positive and HIV-negative women infected by multiple HPV types. Methods: 1399 women participated in the study (240 HIV-positive and 1159 HIV-negative women). Samples were provided for Pap tests and for HPV detection and typing by PCR. Data were collected on HPV infection, frequency of multiple infection, and HPV type distribution. Odds ratios were reported from logistic regression models. Results: Compared with HIV-negative women, HIV-positive women had higher frequencies of cervical abnormality (30% vs. 20.8%), higher HPV prevalence (68.3% vs. 51.3%) and were more commonly infected with multiple HPV types (78.7% vs. 44.3%). HPV-16 was the most common type detected in the study population, with other types showing variable associations with HIV status. Positive associations were observed between infection by multiple HPV types and HIV status, cervical abnormality and having had more than three pregnancies. The odds of multiple infection by HPV types were higher in HIV-positive women who used an intrauterine device, who had a history of abortions and who had HIV viral loads and gt;100 000 copies/ml, whilst the odds were lower in women with and gt;500 CD4 cells/mm 3 . Conclusions: HIV immunosuppression favours infection by multiple high-risk HPV types, mainly in women affected by low-grade squamous intraepithelial lesions. Antiretroviral therapy had no effect on infection by multiple HPV types. Risk factors related to progressive damage to the cervix were positively associated with infection by multiple HPV types in women living with HIV. © 2018 John Wiley and Sons Ltd

• Fecha de publicación: 2018
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/23398
• Acceso en línea: https://doi.org/10.1111/tmi.13142; https://repository.urosario.edu.co/handle/10336/23398
• Palabra clave: Anti human immunodeficiency virus agent; Hemoglobin beta chain; Virus dna; Abnormality; Disease prevalence; Disinfection; Epidemiology; Human immunodeficiency virus; Infectious disease; Pregnancy; Risk factor; Womens employment; Womens health; Abortion; Adolescent; Adult; Antiretroviral therapy; Article; Cd4 lymphocyte count; Cross-sectional study; Demography; Disease association; Female; Human; Human immunodeficiency virus; Human immunodeficiency virus infection; Human papillomavirus type 16; Human papillomavirus type 18; Human papillomavirus type 31; Human papillomavirus type 33; Human papillomavirus type 45; Human papillomavirus type 58; Life expectancy; Major clinical study; Middle aged; Mixed infection; Observational study; Papanicolaou test; Papillomavirus infection; Polymerase chain reaction; Pregnancy; Quality of life; Sexual intercourse; Sexuality; Virus load; Young adult; Aged; Colombia; Comorbidity; Comparative study; Human immunodeficiency virus infection; Papillomavirus infection; Pathophysiology; Risk factor; Very elderly; Human immunodeficiency virus; Human papillomavirus; Human papillomavirus type 16; Adult; Aged; Aged, 80 and over; Colombia; Comorbidity; Female; Hiv infections; Humans; Middle aged; Papillomavirus infections; Risk factors; Young adult; Epidemiology; Human immunodeficiency virus; Human papillomavirus; Multiple infection; Risk factor
• License: Abierto (Texto Completo)