Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a met...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2012
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/26395
- Acceso en línea:
- https://doi.org/10.1155/2012/569728
https://repository.urosario.edu.co/handle/10336/26395
- Palabra clave:
- autoimmune diseases
latitudinal gradient
systemic lupus erythematosus
- Rights
- License
- Abierto (Texto Completo)
id |
EDOCUR2_fa933357718e745929859857555dd975 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/26395 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
8e1a98cb-2d78-4910-a36d-9d4982bf6ab6b4fedd40-bdff-4c0a-a81c-f58bf142177c52249701fdbf96f1-6f7f-4f65-a28b-bd393c81201b84302927-4b9b-4b6b-a181-aa36df070efb194747786002020-08-06T16:21:33Z2020-08-06T16:21:33Z2012The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95%CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.application/pdfhttps://doi.org/10.1155/2012/569728ISSN: 20900422EISSN: 2090-0430https://repository.urosario.edu.co/handle/10336/26395engHindawi Publishing Corporation728569Autoimmune diseasesVol. 2012Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.569-728http://downloads.hindawi.com/journals/ad/2012/569728.pdfAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Autoimmune diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURautoimmune diseaseslatitudinal gradientsystemic lupus erythematosusShared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.HLA compartida clase II en seis enfermedades autoinmunes en América Latina: un metanálisis.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cruz-Tapias, PaolaPerez-Fernandez, Oscar MRojas-Villarraga, AdrianaRodriguez-Rodriguez, AlbertoArango, Maria-TeresaAnaya, Juan-ManuelORIGINAL569728.pdfapplication/pdf1490929https://repository.urosario.edu.co/bitstreams/2d81b222-7c8a-45d6-86e7-d08ed4da764b/download431ca02d52c01fc480373c583f183b3eMD51TEXT569728.pdf.txt569728.pdf.txtExtracted texttext/plain45661https://repository.urosario.edu.co/bitstreams/73a879d1-9bbf-4000-9559-50852f03e1b5/downloadd7b082d2fa0e3877cd86c5ebdcb60e09MD52THUMBNAIL569728.pdf.jpg569728.pdf.jpgGenerated Thumbnailimage/jpeg4186https://repository.urosario.edu.co/bitstreams/c7070bca-5461-4c82-95a1-5100fd6b942d/download87f9d2f20732a008d5a15c9ec07fac72MD5310336/26395oai:repository.urosario.edu.co:10336/263952022-05-02 07:37:13.768016https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
dc.title.TranslatedTitle.spa.fl_str_mv |
HLA compartida clase II en seis enfermedades autoinmunes en América Latina: un metanálisis. |
title |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
spellingShingle |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. autoimmune diseases latitudinal gradient systemic lupus erythematosus |
title_short |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
title_full |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
title_fullStr |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
title_full_unstemmed |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
title_sort |
Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis. |
dc.subject.keyword.spa.fl_str_mv |
autoimmune diseases latitudinal gradient systemic lupus erythematosus |
topic |
autoimmune diseases latitudinal gradient systemic lupus erythematosus |
description |
The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95%CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics. |
publishDate |
2012 |
dc.date.created.spa.fl_str_mv |
2012 |
dc.date.accessioned.none.fl_str_mv |
2020-08-06T16:21:33Z |
dc.date.available.none.fl_str_mv |
2020-08-06T16:21:33Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1155/2012/569728 |
dc.identifier.issn.none.fl_str_mv |
ISSN: 20900422 EISSN: 2090-0430 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/26395 |
url |
https://doi.org/10.1155/2012/569728 https://repository.urosario.edu.co/handle/10336/26395 |
identifier_str_mv |
ISSN: 20900422 EISSN: 2090-0430 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
728 |
dc.relation.citationStartPage.none.fl_str_mv |
569 |
dc.relation.citationTitle.none.fl_str_mv |
Autoimmune diseases |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 2012 |
dc.relation.ispartof.spa.fl_str_mv |
Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.569-728 |
dc.relation.uri.spa.fl_str_mv |
http://downloads.hindawi.com/journals/ad/2012/569728.pdf |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Hindawi Publishing Corporation |
dc.source.spa.fl_str_mv |
Autoimmune diseases |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/2d81b222-7c8a-45d6-86e7-d08ed4da764b/download https://repository.urosario.edu.co/bitstreams/73a879d1-9bbf-4000-9559-50852f03e1b5/download https://repository.urosario.edu.co/bitstreams/c7070bca-5461-4c82-95a1-5100fd6b942d/download |
bitstream.checksum.fl_str_mv |
431ca02d52c01fc480373c583f183b3e d7b082d2fa0e3877cd86c5ebdcb60e09 87f9d2f20732a008d5a15c9ec07fac72 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167657971187712 |