Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.

The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a met...

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Fecha de publicación:
2012
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26395
Acceso en línea:
https://doi.org/10.1155/2012/569728
https://repository.urosario.edu.co/handle/10336/26395
Palabra clave:
autoimmune diseases
latitudinal gradient
systemic lupus erythematosus
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spelling 8e1a98cb-2d78-4910-a36d-9d4982bf6ab6b4fedd40-bdff-4c0a-a81c-f58bf142177c52249701fdbf96f1-6f7f-4f65-a28b-bd393c81201b84302927-4b9b-4b6b-a181-aa36df070efb194747786002020-08-06T16:21:33Z2020-08-06T16:21:33Z2012The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95%CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.application/pdfhttps://doi.org/10.1155/2012/569728ISSN: 20900422EISSN: 2090-0430https://repository.urosario.edu.co/handle/10336/26395engHindawi Publishing Corporation728569Autoimmune diseasesVol. 2012Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.569-728http://downloads.hindawi.com/journals/ad/2012/569728.pdfAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Autoimmune diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURautoimmune diseaseslatitudinal gradientsystemic lupus erythematosusShared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.HLA compartida clase II en seis enfermedades autoinmunes en América Latina: un metanálisis.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Cruz-Tapias, PaolaPerez-Fernandez, Oscar MRojas-Villarraga, AdrianaRodriguez-Rodriguez, AlbertoArango, Maria-TeresaAnaya, Juan-ManuelORIGINAL569728.pdfapplication/pdf1490929https://repository.urosario.edu.co/bitstreams/2d81b222-7c8a-45d6-86e7-d08ed4da764b/download431ca02d52c01fc480373c583f183b3eMD51TEXT569728.pdf.txt569728.pdf.txtExtracted texttext/plain45661https://repository.urosario.edu.co/bitstreams/73a879d1-9bbf-4000-9559-50852f03e1b5/downloadd7b082d2fa0e3877cd86c5ebdcb60e09MD52THUMBNAIL569728.pdf.jpg569728.pdf.jpgGenerated Thumbnailimage/jpeg4186https://repository.urosario.edu.co/bitstreams/c7070bca-5461-4c82-95a1-5100fd6b942d/download87f9d2f20732a008d5a15c9ec07fac72MD5310336/26395oai:repository.urosario.edu.co:10336/263952022-05-02 07:37:13.768016https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
dc.title.TranslatedTitle.spa.fl_str_mv HLA compartida clase II en seis enfermedades autoinmunes en América Latina: un metanálisis.
title Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
spellingShingle Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
autoimmune diseases
latitudinal gradient
systemic lupus erythematosus
title_short Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
title_full Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
title_fullStr Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
title_full_unstemmed Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
title_sort Shared HLA class II in six autoimmune diseases in Latin America: A meta-analysis.
dc.subject.keyword.spa.fl_str_mv autoimmune diseases
latitudinal gradient
systemic lupus erythematosus
topic autoimmune diseases
latitudinal gradient
systemic lupus erythematosus
description The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary depending on latitudinal gradient and ethnicity. The aims of this study were to identify common human leukocyte antigen (HLA) class II alleles that contribute to susceptibility to six ADs in Latin Americans through a meta-analysis and to review additional clinical, immunological, and genetic characteristics of those ADs sharing HLA alleles. DRB1()03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), and type 1 diabetes mellitus (T1D). DRB1()04:05 (OR: 4.64; 95%CI: 2.14-10.05) influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; DRB1()04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. DQB1()06:02 and DRB1()15 alleles were risk factors for MS but protective factors for T1D. Likewise, DQB1()06:03 allele was a risk factor for AIH but a protective one for T1D. Several common autoantibodies and clinical associations as well as additional shared genes have been reported in these ADs, which are reviewed herein. These results indicate that in Latin Americans ADs share major loci and immune characteristics.
publishDate 2012
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dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
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dc.identifier.issn.none.fl_str_mv ISSN: 20900422
EISSN: 2090-0430
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url https://doi.org/10.1155/2012/569728
https://repository.urosario.edu.co/handle/10336/26395
identifier_str_mv ISSN: 20900422
EISSN: 2090-0430
dc.language.iso.spa.fl_str_mv eng
language eng
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dc.relation.citationStartPage.none.fl_str_mv 569
dc.relation.citationTitle.none.fl_str_mv Autoimmune diseases
dc.relation.citationVolume.none.fl_str_mv Vol. 2012
dc.relation.ispartof.spa.fl_str_mv Autoimmune diseases, ISSN: 20900422 ; EISSN: 2090-0430, Vol.2012 (2012); pp.569-728
dc.relation.uri.spa.fl_str_mv http://downloads.hindawi.com/journals/ad/2012/569728.pdf
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dc.publisher.spa.fl_str_mv Hindawi Publishing Corporation
dc.source.spa.fl_str_mv Autoimmune diseases
institution Universidad del Rosario
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dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
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