New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis

Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North...

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Autores:
Tipo de recurso:
Fecha de publicación:
2014
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24331
Acceso en línea:
https://doi.org/10.1016/j.ijpara.2013.09.007
https://repository.urosario.edu.co/handle/10336/24331
Palabra clave:
Disease
Gene
Genetic marker
Parasite
Parasite transmission
Protein
Protozoan
Virulence
Europe
Genetic marker
Genetic variability
Geographic distribution
Host parasite interaction
Host susceptibility
Human
Immune response
Immunogenetics
Nonhuman
North america
Parasite incidence
Parasite load
Parasite prevalence
Parasite virulence
Pathophysiology
Review
South america
Toxoplasmosis
South america
Protozoa
Toxoplasma gondii
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
Americas
Animals
Europe
Eye diseases
Humans
Toxoplasmosis
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
title New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
spellingShingle New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
Disease
Gene
Genetic marker
Parasite
Parasite transmission
Protein
Protozoan
Virulence
Europe
Genetic marker
Genetic variability
Geographic distribution
Host parasite interaction
Host susceptibility
Human
Immune response
Immunogenetics
Nonhuman
North america
Parasite incidence
Parasite load
Parasite prevalence
Parasite virulence
Pathophysiology
Review
South america
Toxoplasmosis
South america
Protozoa
Toxoplasma gondii
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
Americas
Animals
Europe
Eye diseases
Humans
Toxoplasmosis
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
title_short New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
title_full New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
title_fullStr New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
title_full_unstemmed New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
title_sort New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis
dc.subject.keyword.spa.fl_str_mv Disease
Gene
Genetic marker
Parasite
Parasite transmission
Protein
Protozoan
Virulence
Europe
Genetic marker
Genetic variability
Geographic distribution
Host parasite interaction
Host susceptibility
Human
Immune response
Immunogenetics
Nonhuman
North america
Parasite incidence
Parasite load
Parasite prevalence
Parasite virulence
Pathophysiology
Review
South america
Toxoplasmosis
South america
Protozoa
Toxoplasma gondii
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
Americas
Animals
Europe
Eye diseases
Humans
Toxoplasmosis
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
topic Disease
Gene
Genetic marker
Parasite
Parasite transmission
Protein
Protozoan
Virulence
Europe
Genetic marker
Genetic variability
Geographic distribution
Host parasite interaction
Host susceptibility
Human
Immune response
Immunogenetics
Nonhuman
North america
Parasite incidence
Parasite load
Parasite prevalence
Parasite virulence
Pathophysiology
Review
South america
Toxoplasmosis
South america
Protozoa
Toxoplasma gondii
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
Americas
Animals
Europe
Eye diseases
Humans
Toxoplasmosis
Human studies
Inflammation
Mouse models
Ocular toxoplasmosis
Parasite strains
South america
Toxoplasma gondii
description Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America. © 2013 Australian Society for Parasitology Inc.
publishDate 2014
dc.date.created.spa.fl_str_mv 2014
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:11:46Z
dc.date.available.none.fl_str_mv 2020-05-26T00:11:46Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.ijpara.2013.09.007
dc.identifier.issn.none.fl_str_mv 207519
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24331
url https://doi.org/10.1016/j.ijpara.2013.09.007
https://repository.urosario.edu.co/handle/10336/24331
identifier_str_mv 207519
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dc.relation.citationIssue.none.fl_str_mv No. 2
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dc.relation.citationTitle.none.fl_str_mv International Journal for Parasitology
dc.relation.citationVolume.none.fl_str_mv Vol. 44
dc.relation.ispartof.spa.fl_str_mv International Journal for Parasitology, ISSN:207519, Vol.44, No.2 (2014); pp. 99-107
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spelling 6462e55c-0f3a-4b80-854d-c52159637cf8517013556002e182d6e-1605-40b2-8736-a765b76875a749baebc5-daf7-4e05-a740-32cef8f32b88bd33ed81-156a-4453-8d7b-f059816cc71214ac8f34-bbe7-4d61-9562-ef8f781391c28185629e-f0c8-4412-80e4-2aea46c87592a52a0519-55ce-4e5d-9adc-a00d2ec3588e03b8c52d-1599-41ad-9106-a559058a88312020-05-26T00:11:46Z2020-05-26T00:11:46Z2014Retinal lesions or other ocular manifestations are serious consequences of infection with the protozoan parasite Toxoplasma gondii. Whilst classically considered a consequence of congenital transmission, recent screening studies estimated that 2% of T. gondii seropositive persons in Europe and North America have retinal lesions, most of them persisting unnoticed. The situation is more dramatic in South America, probably due to the predominance of virulent strains. Some of these strains seem to exhibit ocular or neuronal tropism and are responsible for severe ocular lesions. Despite the medical importance, the physiopathological mechanisms have only recently begun to be elucidated. The particular immune-privileged situation in the eye has to be considered. Studies on French patients showed low or undetectable ocular parasite loads, but a clear Th1/Th17 type immune reaction. Suitable mouse models have appeared in the last few years. Using such a model, IL-17A proved to impair parasite control and induce pathology. In contrast, in South American patients, the parasite seems to be much less efficiently controlled through a Th2 type or suppressive immune response that favors parasite replication. Finally, several host genetic markers controlling immune response factors have been associated with ocular involvement of T. gondii infection, mainly in South America. © 2013 Australian Society for Parasitology Inc.application/pdfhttps://doi.org/10.1016/j.ijpara.2013.09.007207519https://repository.urosario.edu.co/handle/10336/24331eng107No. 299International Journal for ParasitologyVol. 44International Journal for Parasitology, ISSN:207519, Vol.44, No.2 (2014); pp. 99-107https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892499165&doi=10.1016%2fj.ijpara.2013.09.007&partnerID=40&md5=decb55eb699face4834934e1aa1c3b82Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURDiseaseGeneGenetic markerParasiteParasite transmissionProteinProtozoanVirulenceEuropeGenetic markerGenetic variabilityGeographic distributionHost parasite interactionHost susceptibilityHumanImmune responseImmunogeneticsNonhumanNorth americaParasite incidenceParasite loadParasite prevalenceParasite virulencePathophysiologyReviewSouth americaToxoplasmosisSouth americaProtozoaToxoplasma gondiiHuman studiesInflammationMouse modelsOcular toxoplasmosisParasite strainsSouth americaToxoplasma gondiiAmericasAnimalsEuropeEye diseasesHumansToxoplasmosisHuman studiesInflammationMouse modelsOcular toxoplasmosisParasite strainsSouth americaToxoplasma gondiiNew clinical and experimental insights into Old World and neotropical ocular toxoplasmosisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Pfaff, Alexander W.de-la-Torre, AlejandraRochet, EliseBrunet, JulieSabou, MarcelaSauer, ArnaudBourcier, TristanGomez-Marin, Jorge E.Candolfi, ErmannoORIGINALNew_clinical_and_experimental_insights_i.pdfapplication/pdf14833204https://repository.urosario.edu.co/bitstreams/7e4a28fc-639a-4f3c-823c-640223871ef4/downloadd6288676b4ff1325ee1c9851077b77b8MD51TEXTNew_clinical_and_experimental_insights_i.pdf.txtNew_clinical_and_experimental_insights_i.pdf.txtExtracted texttext/plain67910https://repository.urosario.edu.co/bitstreams/fa74b4da-998a-40d6-b20d-4b987282c64f/download6a498c837da7a4cbd9e68b92ccef5a79MD52THUMBNAILNew_clinical_and_experimental_insights_i.pdf.jpgNew_clinical_and_experimental_insights_i.pdf.jpgGenerated Thumbnailimage/jpeg4917https://repository.urosario.edu.co/bitstreams/3b9eded0-cd46-44db-9175-8fb686a9d7bd/download10ca5c4ea5bc70f49f86e80f6a87b82cMD5310336/24331oai:repository.urosario.edu.co:10336/243312022-05-02 07:37:15.973123https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co