Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?

We tested the influence of blood pressure variability on the reproducibility of dynamic cerebral autoregulation (DCA) estimates. Data were analyzed from the 2nd CARNet bootstrap initiative, where mean arterial blood pressure (MABP), cerebral blood flow velocity (CBFV) and end tidal CO2 were measured...

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Autores:
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22837
Acceso en línea:
https://doi.org/10.1371/JOURNAL.PONE.0227651
https://repository.urosario.edu.co/handle/10336/22837
Palabra clave:
Adult
Article
Autoregulation
Blood flow velocity
Blood pressure variability
Bootstrapping
Brain blood flow
Controlled study
End tidal carbon dioxide tension
Female
Human
Human experiment
Intermethod comparison
Major clinical study
Male
Mean arterial pressure
Prediction
Reproducibility
Spectroscopy
Aged
Arterial pressure
Blood pressure
Blood pressure measurement
Brain circulation
Clinical trial
Homeostasis
Middle aged
Middle cerebral artery
Multicenter study
Normal human
Pathophysiology
Physiology
Procedures
Reproducibility
Adult
Aged
Arterial pressure
Blood flow velocity
Blood pressure
Blood pressure determination
Cerebrovascular circulation
Female
Healthy volunteers
Homeostasis
Humans
Male
Middle aged
Middle cerebral artery
Reproducibility of results
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License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
title Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
spellingShingle Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
Adult
Article
Autoregulation
Blood flow velocity
Blood pressure variability
Bootstrapping
Brain blood flow
Controlled study
End tidal carbon dioxide tension
Female
Human
Human experiment
Intermethod comparison
Major clinical study
Male
Mean arterial pressure
Prediction
Reproducibility
Spectroscopy
Aged
Arterial pressure
Blood pressure
Blood pressure measurement
Brain circulation
Clinical trial
Homeostasis
Middle aged
Middle cerebral artery
Multicenter study
Normal human
Pathophysiology
Physiology
Procedures
Reproducibility
Adult
Aged
Arterial pressure
Blood flow velocity
Blood pressure
Blood pressure determination
Cerebrovascular circulation
Female
Healthy volunteers
Homeostasis
Humans
Male
Middle aged
Middle cerebral artery
Reproducibility of results
title_short Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
title_full Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
title_fullStr Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
title_full_unstemmed Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
title_sort Assessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?
dc.subject.keyword.spa.fl_str_mv Adult
Article
Autoregulation
Blood flow velocity
Blood pressure variability
Bootstrapping
Brain blood flow
Controlled study
End tidal carbon dioxide tension
Female
Human
Human experiment
Intermethod comparison
Major clinical study
Male
Mean arterial pressure
Prediction
Reproducibility
Spectroscopy
Aged
Arterial pressure
Blood pressure
Blood pressure measurement
Brain circulation
Clinical trial
Homeostasis
Middle aged
Middle cerebral artery
Multicenter study
Normal human
Pathophysiology
Physiology
Procedures
Reproducibility
Adult
Aged
Arterial pressure
Blood flow velocity
Blood pressure
Blood pressure determination
Cerebrovascular circulation
Female
Healthy volunteers
Homeostasis
Humans
Male
Middle aged
Middle cerebral artery
Reproducibility of results
topic Adult
Article
Autoregulation
Blood flow velocity
Blood pressure variability
Bootstrapping
Brain blood flow
Controlled study
End tidal carbon dioxide tension
Female
Human
Human experiment
Intermethod comparison
Major clinical study
Male
Mean arterial pressure
Prediction
Reproducibility
Spectroscopy
Aged
Arterial pressure
Blood pressure
Blood pressure measurement
Brain circulation
Clinical trial
Homeostasis
Middle aged
Middle cerebral artery
Multicenter study
Normal human
Pathophysiology
Physiology
Procedures
Reproducibility
Adult
Aged
Arterial pressure
Blood flow velocity
Blood pressure
Blood pressure determination
Cerebrovascular circulation
Female
Healthy volunteers
Homeostasis
Humans
Male
Middle aged
Middle cerebral artery
Reproducibility of results
description We tested the influence of blood pressure variability on the reproducibility of dynamic cerebral autoregulation (DCA) estimates. Data were analyzed from the 2nd CARNet bootstrap initiative, where mean arterial blood pressure (MABP), cerebral blood flow velocity (CBFV) and end tidal CO2 were measured twice in 75 healthy subjects. DCA was analyzed by 14 different centers with a variety of different analysis methods. Intraclass Correlation (ICC) values increased significantly when subjects with low power spectral density MABP (PSD-MABP) values were removed from the analysis for all gain, phase and autoregulation index (ARI) parameters. Gain in the low frequency band (LF) had the highest ICC, followed by phase LF and gain in the very low frequency band. No significant differences were found between analysis methods for gain parameters, but for phase and ARI parameters, significant differences between the analysis methods were found. Alternatively, the Spearman-Brown prediction formula indicated that prolongation of the measurement duration up to 35 minutes may be needed to achieve good reproducibility for some DCA parameters. We conclude that poor DCA reproducibility (ICC and lt;0.4) can improve to good (ICC and gt; 0.6) values when cases with low PSD-MABP are removed, and probably also when measurement duration is increased. © 2020 Elting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:58:18Z
dc.date.available.none.fl_str_mv 2020-05-25T23:58:18Z
dc.date.created.spa.fl_str_mv 2020
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1371/JOURNAL.PONE.0227651
dc.identifier.issn.none.fl_str_mv 19326203
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/22837
url https://doi.org/10.1371/JOURNAL.PONE.0227651
https://repository.urosario.edu.co/handle/10336/22837
identifier_str_mv 19326203
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationTitle.none.fl_str_mv PLoS ONE
dc.relation.citationVolume.none.fl_str_mv Vol. 15
dc.relation.ispartof.spa.fl_str_mv PLoS ONE, ISSN:19326203, Vol.15, No.1 (2020)
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rights_invalid_str_mv Abierto (Texto Completo)
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spelling 53218a4c-5b0d-4d51-aa8d-7884e100b65f-1b314b022-697b-4cf1-8b03-29db8c58a344-17deb38d9-faad-445a-a5a9-641788d4c146-1f593337d-e3a2-439e-b8b3-577bb80d9aa4-1b1f691a3-d4b5-433f-94f3-c696f4dd0533-10544c289-4862-4319-933c-8e691c699821-1b3c2f764-4d8c-461a-860d-80e9b73bea3d-1373c77e3-5093-43fd-831b-0db88cefa50d-149a968e6-d80d-47ce-9bba-3cd250d057bb-169e741c2-cd04-4adb-b90d-fdf2cf766228-189b40cc2-d14b-46ec-8713-52e3efbfacd6-1233ca51b-f900-4069-afca-ca9051010305-1c2ae2e6b-90bc-4db6-b3f8-38a4b37eeffb-10c198e71-86b9-4997-acdb-c2f3e2ebf040-146f4b5fe-f184-470c-b6ca-69b49a7782ee-1a9264f66-9269-43e5-bb9c-74a7e3ea134e-151854686-d4e6-4a53-a5d9-ebfe43825ba9-139745285-1693-4fe1-a4b3-4a6a0fce5791-1470df8ca-a06f-4eb5-94c7-df3f2f0adb3f-15611b762-e643-4cb5-9e09-58279ac2f6a2-184d4ddad-4b4f-4197-8e1a-b41ed5384618-149fa26b3-f365-445e-9e61-4456bf863863-1684a1903-b316-46de-85d5-3efc4843a670-1f3d4383d-3167-4320-bbd7-7b5fbc8d6e0f-1141395126002020-05-25T23:58:18Z2020-05-25T23:58:18Z2020We tested the influence of blood pressure variability on the reproducibility of dynamic cerebral autoregulation (DCA) estimates. Data were analyzed from the 2nd CARNet bootstrap initiative, where mean arterial blood pressure (MABP), cerebral blood flow velocity (CBFV) and end tidal CO2 were measured twice in 75 healthy subjects. DCA was analyzed by 14 different centers with a variety of different analysis methods. Intraclass Correlation (ICC) values increased significantly when subjects with low power spectral density MABP (PSD-MABP) values were removed from the analysis for all gain, phase and autoregulation index (ARI) parameters. Gain in the low frequency band (LF) had the highest ICC, followed by phase LF and gain in the very low frequency band. No significant differences were found between analysis methods for gain parameters, but for phase and ARI parameters, significant differences between the analysis methods were found. Alternatively, the Spearman-Brown prediction formula indicated that prolongation of the measurement duration up to 35 minutes may be needed to achieve good reproducibility for some DCA parameters. We conclude that poor DCA reproducibility (ICC and lt;0.4) can improve to good (ICC and gt; 0.6) values when cases with low PSD-MABP are removed, and probably also when measurement duration is increased. © 2020 Elting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.application/pdfhttps://doi.org/10.1371/JOURNAL.PONE.022765119326203https://repository.urosario.edu.co/handle/10336/22837engPublic Library of ScienceNo. 1PLoS ONEVol. 15PLoS ONE, ISSN:19326203, Vol.15, No.1 (2020)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077765738&doi=10.1371%2fJOURNAL.PONE.0227651&partnerID=40&md5=c8a84e0a8f3fc7206b6fbac25278a68eAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURAdultArticleAutoregulationBlood flow velocityBlood pressure variabilityBootstrappingBrain blood flowControlled studyEnd tidal carbon dioxide tensionFemaleHumanHuman experimentIntermethod comparisonMajor clinical studyMaleMean arterial pressurePredictionReproducibilitySpectroscopyAgedArterial pressureBlood pressureBlood pressure measurementBrain circulationClinical trialHomeostasisMiddle agedMiddle cerebral arteryMulticenter studyNormal humanPathophysiologyPhysiologyProceduresReproducibilityAdultAgedArterial pressureBlood flow velocityBlood pressureBlood pressure determinationCerebrovascular circulationFemaleHealthy volunteersHomeostasisHumansMaleMiddle agedMiddle cerebral arteryReproducibility of resultsAssessment of dynamic cerebral autoregulation in humans: Is reproducibility dependent on blood pressure variability?articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Elting, Jan WillemSanders, Marit L.Panerai, Ronney B.Aries, MarcelBor-Seng-Shu, EdsonChacon, MaxGommer, Erik D.Van Huffel, SabineJara, José L.Kostoglou, KyriakiMahdi, AdamMarmarelis, Vasilis Z.Mitsis, Georgios D.Müller, MartinNikolic, DraganaNogueira, Ricardo C.Payne, Stephen J.Puppo, CorinaShin, Dae C.Simpson, David M.Tarumi, TakashiYelicich, BernardoZhang, RongClaassen, Jurgen A. H. R.Caicedo Dorado, AlexanderORIGINALjournal-pone-0227651.pdfapplication/pdf2223407https://repository.urosario.edu.co/bitstreams/b5473fbf-934a-403c-a427-0d3f807ada01/download1ce8ab8777a1d1b07f289d3a602f8bd5MD51TEXTjournal-pone-0227651.pdf.txtjournal-pone-0227651.pdf.txtExtracted texttext/plain51801https://repository.urosario.edu.co/bitstreams/ffdb560b-06eb-4b9a-a162-fe8eebfc1d64/download6a5843b19d069466c7344c21b40f5e39MD52THUMBNAILjournal-pone-0227651.pdf.jpgjournal-pone-0227651.pdf.jpgGenerated Thumbnailimage/jpeg4577https://repository.urosario.edu.co/bitstreams/138ed5f8-e73a-4c6b-bbea-d104fead9406/downloadede718c52925105c8b99e705c80c7405MD5310336/22837oai:repository.urosario.edu.co:10336/228372022-05-02 07:37:14.388221https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co