Prevalence of classic and non-classic antiphospholipid antibodies in multiple sclerosis

Background: The association between antiphospholipid antibodies (aPL) and multiple sclerosis (MS) has been suggested previously, but prior studies provided contradicting findings. Objectives: To characterize the expression profile of eight classic and non-classic aPL in patients diagnosed with MS. Methods: Using the BioPlex™ 2200 immunoassay, we measured the levels of serum immunoglobulin (Ig)M and IgG isotypes of three classic aPL and five non-classic aPL in 98 subjects with MS and 237 healthy controls. Results: Three non-classic aPL were significantly more prevalent among MS patients in comparison to the control group. These antibodies included IgM and IgG against phosphatidylserine- ?2GPI (PS-B2), IgG prothrombin complex (PT-PT) and IgM prothrombin (PT). The positive results according to Bonferroni correction are PS-B2 IgG and PT-PT IgG. The remaining aPL profiles did not differ significantly between the two groups. Conclusions: An association between certain non-classic aPL and MS has been established. The specific role of these autoantibodies in the pathogenesis of the condition remains uncertain. © 2015, Israel Medical Association. All rights reserved.

• Fecha de publicación: 2015
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22196
• Acceso en línea: https://repository.urosario.edu.co/handle/10336/22196
• Palabra clave: Beta2 glycoprotein 1; Cardiolipin antibody; Immunoglobulin g; Immunoglobulin m; Phosphatidylethanolamine; Phosphatidylserine; Phospholipid antibody; Prothrombin; Prothrombin complex; Immunoglobulin g; Immunoglobulin m; Phospholipid antibody; Adult; Antibody titer; Article; Controlled study; Disease duration; Female; Flow cytometry; Fluorescence analysis; Human; Immunoassay; Major clinical study; Male; Middle aged; Multiple sclerosis; Protein expression; Blood; Case control study; Cross-sectional study; Immunology; Multiple sclerosis; Prevalence; Adult; Case-control studies; Cross-sectional studies; Female; Humans; Immunoglobulin g; Immunoglobulin m; Male; Middle aged; Multiple sclerosis; Prevalence; Antiphospholipid syndrome (aps); Autoantibodies; Autoimmunity; Beta 2-glycoprotein 1 (?2gpi); Cardiolipin; Immunoglobulin (ig); Multiple sclerosis (ms); antiphospholipid; Antibodies
• License: Abierto (Texto Completo)