The multisystemic functions of FOXD1 in development and disease

Transcription factors (TFs) participate in a wide range of cellular processes due to their inherent function as essential regulatory proteins. Their dysfunction has been linked to numerous human diseases. The forkhead box (FOX) family of TFs belongs to the “winged helix” superfamily, consisting of proteins sharing a related winged helix-turn-helix DNA-binding motif. FOX genes have been extensively present during vertebrates and invertebrates’ evolution, participating in numerous molecular cascades and biological functions, such as embryonic development and organogenesis, cell cycle regulation, metabolism control, stem cell niche maintenance, signal transduction, and many others. FOXD1, a forkhead TF, has been related to different key biological processes such as kidney and retina development and embryo implantation. FOXD1 dysfunction has been linked to different pathologies, thereby constituting a diagnostic biomarker and a promising target for future therapies. This paper aims to present, for the first time, a comprehensive review of FOXD1’s role in mouse development and human disease. Molecular, structural, and functional aspects of FOXD1 are presented in light of physiological and pathogenic conditions, including its role in human disease aetiology, such as cancer and recurrent pregnancy loss. Taken together, the information given here should enable a better understanding of FOXD1 function for basic science researchers and clinicians. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.

• Fecha de publicación: 2018
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22405
• Acceso en línea: https://doi.org/10.1007/s00109-018-1665-2; https://repository.urosario.edu.co/handle/10336/22405
• Palabra clave: Forkhead box D1 protein; Forkhead transcription factor; Transcription factor; Unclassified drug; Forkhead transcription factor; Body patterning; Cell proliferation; Central nervous system; Gene expression; Human; Immunohistochemistry; Implantation; Kidney development; Malignant neoplasm; Microarray analysis; Molecular biology; Nonhuman; Organogenesis; Pathogenesis; Physician; Protein function; Protein protein interaction; Protein structure; Recurrent abortion; Reproductive success; Retina development; Retina ganglion cell; Review; Risk factor; Scientist; Animal; Antibody specificity; Disease predisposition; Embryo development; Female; Gene expression regulation; Genetics; Metabolism; Pregnancy; Signal transduction; Animals; Disease Susceptibility; Embryonic Development; Female; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Organ Specificity; Organogenesis; Pregnancy; Signal Transduction; Cancer aetiology; FOXD1; Kidney morphogenesis; Recurrent pregnancy loss; Retina development; Transcription factor; human; FOXD1 protein
• License: Abierto (Texto Completo)