Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017

Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorit...

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Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23477
Acceso en línea:
https://doi.org/10.3390/v12030268
https://repository.urosario.edu.co/handle/10336/23477
Palabra clave:
HIV drug resistance mutations
Migrants
Molecular epidemiology
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spelling ce22075d-9669-4fd9-abc8-2e6826bf7dbd-1fccbef2a-d710-4b64-a586-8aec0da2ef1b-118a0223e-2550-44e9-b3ce-626f4bb25ccd-1ca037ef1-a213-4b6a-9c7b-0050ab75385b-1708393ee-e090-4f67-af62-1a79055d6db7-1a66051ea-8580-4ec7-a813-61696171fb48-19b02898b-c882-467c-81df-625db337b206-122ccc596-fd94-4bac-b23f-1102a1fe0d9c-11a8eed71-6557-4370-bf6c-0851a044ab1f-1b9880e41-89ca-4b4a-ad30-285d033141d8-105c3f457-35b5-47d8-841a-9b3f18d18031-12146fa94-5cd4-4a82-99e3-b67f55feb975-1a033810b-23ba-47e2-895b-e666ffb6a285-12020-05-26T00:02:22Z2020-05-26T00:02:22Z2020Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) andNucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur. © 2020 by the authors.application/pdfhttps://doi.org/10.3390/v1203026819994915https://repository.urosario.edu.co/handle/10336/23477engMDPI AGNo. 3VirusesVol. 12Viruses, ISSN:19994915, Vol.12, No.3 (2020)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080989468&doi=10.3390%2fv12030268&partnerID=40&md5=0512709d5623dfc048fc07877205b6ddAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHIV drug resistance mutationsMigrantsMolecular epidemiologyMolecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Pimentel, VictorPingarilho, MartaAlves, DanielaDiogo, IsabelFernandes, SandraMiranda, MafaldaPineda-Peña, Andrea-ClemenciaLibin, PieterMartins, M. Rosário O.Vandamme, Anne-MiekeCamacho, Ricardo J.Gomes, PerpétuaAbecasis, AnaORIGINALviruses-12-00268-v2.pdfapplication/pdf4639092https://repository.urosario.edu.co/bitstreams/416eb9e0-ad1c-4ffc-935a-b4de3dfb0449/download07cd6bdb3d00526ca490e7f68ba5f82aMD51TEXTviruses-12-00268-v2.pdf.txtviruses-12-00268-v2.pdf.txtExtracted texttext/plain62740https://repository.urosario.edu.co/bitstreams/57dd67a8-0e3f-475a-bb70-732f3c9196e1/downloadba7668d64ebad102fc3ce6443e690c87MD52THUMBNAILviruses-12-00268-v2.pdf.jpgviruses-12-00268-v2.pdf.jpgGenerated Thumbnailimage/jpeg5007https://repository.urosario.edu.co/bitstreams/653aa6fd-4209-4304-9bdd-b8e7a491b950/download3730f23d9b693deb8688af1a5d406e1aMD5310336/23477oai:repository.urosario.edu.co:10336/234772022-05-02 07:37:14.540012https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
title Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
spellingShingle Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
HIV drug resistance mutations
Migrants
Molecular epidemiology
title_short Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
title_full Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
title_fullStr Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
title_full_unstemmed Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
title_sort Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
dc.subject.keyword.spa.fl_str_mv HIV drug resistance mutations
Migrants
Molecular epidemiology
topic HIV drug resistance mutations
Migrants
Molecular epidemiology
description Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) andNucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur. © 2020 by the authors.
publishDate 2020
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https://repository.urosario.edu.co/handle/10336/23477
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dc.language.iso.spa.fl_str_mv eng
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dc.relation.citationIssue.none.fl_str_mv No. 3
dc.relation.citationTitle.none.fl_str_mv Viruses
dc.relation.citationVolume.none.fl_str_mv Vol. 12
dc.relation.ispartof.spa.fl_str_mv Viruses, ISSN:19994915, Vol.12, No.3 (2020)
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