Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017
Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorit...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2020
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23477
- Acceso en línea:
- https://doi.org/10.3390/v12030268
https://repository.urosario.edu.co/handle/10336/23477
- Palabra clave:
- HIV drug resistance mutations
Migrants
Molecular epidemiology
- Rights
- License
- Abierto (Texto Completo)
id |
EDOCUR2_f28fd72ee931cbbed54cad5e3beec89e |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/23477 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
spelling |
ce22075d-9669-4fd9-abc8-2e6826bf7dbd-1fccbef2a-d710-4b64-a586-8aec0da2ef1b-118a0223e-2550-44e9-b3ce-626f4bb25ccd-1ca037ef1-a213-4b6a-9c7b-0050ab75385b-1708393ee-e090-4f67-af62-1a79055d6db7-1a66051ea-8580-4ec7-a813-61696171fb48-19b02898b-c882-467c-81df-625db337b206-122ccc596-fd94-4bac-b23f-1102a1fe0d9c-11a8eed71-6557-4370-bf6c-0851a044ab1f-1b9880e41-89ca-4b4a-ad30-285d033141d8-105c3f457-35b5-47d8-841a-9b3f18d18031-12146fa94-5cd4-4a82-99e3-b67f55feb975-1a033810b-23ba-47e2-895b-e666ffb6a285-12020-05-26T00:02:22Z2020-05-26T00:02:22Z2020Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) andNucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur. © 2020 by the authors.application/pdfhttps://doi.org/10.3390/v1203026819994915https://repository.urosario.edu.co/handle/10336/23477engMDPI AGNo. 3VirusesVol. 12Viruses, ISSN:19994915, Vol.12, No.3 (2020)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080989468&doi=10.3390%2fv12030268&partnerID=40&md5=0512709d5623dfc048fc07877205b6ddAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURHIV drug resistance mutationsMigrantsMolecular epidemiologyMolecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Pimentel, VictorPingarilho, MartaAlves, DanielaDiogo, IsabelFernandes, SandraMiranda, MafaldaPineda-Peña, Andrea-ClemenciaLibin, PieterMartins, M. Rosário O.Vandamme, Anne-MiekeCamacho, Ricardo J.Gomes, PerpétuaAbecasis, AnaORIGINALviruses-12-00268-v2.pdfapplication/pdf4639092https://repository.urosario.edu.co/bitstreams/416eb9e0-ad1c-4ffc-935a-b4de3dfb0449/download07cd6bdb3d00526ca490e7f68ba5f82aMD51TEXTviruses-12-00268-v2.pdf.txtviruses-12-00268-v2.pdf.txtExtracted texttext/plain62740https://repository.urosario.edu.co/bitstreams/57dd67a8-0e3f-475a-bb70-732f3c9196e1/downloadba7668d64ebad102fc3ce6443e690c87MD52THUMBNAILviruses-12-00268-v2.pdf.jpgviruses-12-00268-v2.pdf.jpgGenerated Thumbnailimage/jpeg5007https://repository.urosario.edu.co/bitstreams/653aa6fd-4209-4304-9bdd-b8e7a491b950/download3730f23d9b693deb8688af1a5d406e1aMD5310336/23477oai:repository.urosario.edu.co:10336/234772022-05-02 07:37:14.540012https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
title |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
spellingShingle |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 HIV drug resistance mutations Migrants Molecular epidemiology |
title_short |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
title_full |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
title_fullStr |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
title_full_unstemmed |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
title_sort |
Molecular epidemiology of hiv-1 infected migrants followed up in Portugal: Trends between 2001-2017 |
dc.subject.keyword.spa.fl_str_mv |
HIV drug resistance mutations Migrants Molecular epidemiology |
topic |
HIV drug resistance mutations Migrants Molecular epidemiology |
description |
Migration is associated with HIV-1 vulnerability. Objectives: To identify long-term trends in HIV-1 molecular epidemiology and antiretroviral drug resistance (ARV) among migrants followed up in Portugal Methods: 5177 patients were included between 2001 and 2017. Rega, Scuel, Comet, and jPHMM algorithms were used for subtyping. Transmitted drug resistance (TDR) and Acquired drug resistance (ADR) were defined as the presence of surveillance drug resistance mutations (SDRMs) and as mutations of the IAS-USA 2015 algorithm, respectively. Statistical analyses were performed. Results: HIV-1 subtypes infecting migrants were consistent with the ones prevailing in their countries of origin. Over time, overall TDR significantly increased and specifically for Non-nucleoside reverse transcriptase inhibitor (NNRTIs) andNucleoside reverse transcriptase inhibitor (NRTIs). TDR was higher in patients from Mozambique. Country of origin Mozambique and subtype B were independently associated with TDR. Overall, ADR significantly decreased over time and specifically for NRTIs and Protease Inhibitors (PIs). Age, subtype B, and viral load were independently associated with ADR. Conclusions: HIV-1 molecular epidemiology in migrants suggests high levels of connectivity with their country of origin. The increasing levels of TDR in migrants could indicate an increase also in their countries of origin, where more efficient surveillance should occur. © 2020 by the authors. |
publishDate |
2020 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:02:22Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:02:22Z |
dc.date.created.spa.fl_str_mv |
2020 |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.3390/v12030268 |
dc.identifier.issn.none.fl_str_mv |
19994915 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23477 |
url |
https://doi.org/10.3390/v12030268 https://repository.urosario.edu.co/handle/10336/23477 |
identifier_str_mv |
19994915 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 3 |
dc.relation.citationTitle.none.fl_str_mv |
Viruses |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 12 |
dc.relation.ispartof.spa.fl_str_mv |
Viruses, ISSN:19994915, Vol.12, No.3 (2020) |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080989468&doi=10.3390%2fv12030268&partnerID=40&md5=0512709d5623dfc048fc07877205b6dd |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
MDPI AG |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/416eb9e0-ad1c-4ffc-935a-b4de3dfb0449/download https://repository.urosario.edu.co/bitstreams/57dd67a8-0e3f-475a-bb70-732f3c9196e1/download https://repository.urosario.edu.co/bitstreams/653aa6fd-4209-4304-9bdd-b8e7a491b950/download |
bitstream.checksum.fl_str_mv |
07cd6bdb3d00526ca490e7f68ba5f82a ba7668d64ebad102fc3ce6443e690c87 3730f23d9b693deb8688af1a5d406e1a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167676576071680 |