Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

Introduction: Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the...

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Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22816
Acceso en línea:
https://doi.org/10.1007/s11102-016-0725-2
https://repository.urosario.edu.co/handle/10336/22816
Palabra clave:
Growth hormone
Somatomedin c
Acromegaly
Arthropathy
Cardiovascular disease
Comorbidity
Craniofacial development
Endocrine disease
Hormone synthesis
Human
Lung disease
Malignant neoplastic disease
Mental disease
Metabolic disorder
Morbidity
Mortality
Neurologic disease
Priority journal
Quality of life
Retrospective study
Review
Rheumatic disease
Adenoma
Cardiovascular diseases
Carpal tunnel syndrome
Comorbidity
Complication
Diabetes mellitus
Disease management
Growth hormone-secreting pituitary adenoma
Headache
Heart failure
Hypertension
Macroglossia
Osteoarthritis
Prognosis
Sleep apnea syndromes
Vision disorders
Adenoma
Cardiovascular diseases
Carpal tunnel syndrome
Comorbidity
Diabetes mellitus
Disease management
Growth hormone-secreting pituitary adenoma
Headache
Heart failure
Humans
Hypertension
Macroglossia
Osteoarthritis
Prognosis
Sleep apnea syndromes
Vision disorders
Acromegaly comorbidities
Acromegaly diagnosis
Latin america
left ventricular
left ventricular
Hypertrophy
Hypertrophy
Rights
License
Abierto (Texto Completo)
Description
Summary:Introduction: Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life. Methods: We conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment. Findings and conclusions: Successful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management. © 2016, The Author(s).