Characterisation and comparative analysis of MHC-DPA1 exon 2 in the owl monkey (Aotus nancymaae)

The Aotus nancymaae (owl monkey) is an important animal model in biomedical research, particularly for the preclinical evaluation of vaccine candidates against Plasmodium falciparum and Plasmodium vivax, which require a precisely typed major histocompatibility complex. The exon 2 from A. nancymaae MHC-DPA1 gene was characterised in order to infer its allelic diversity and evolutionary history. Aona-DPA1 shows no polymorphism and is related to other primate DPA alleles (including Catarrhini and Platyrrhini), constituting an ancient trans-specific and strongly supported lineage with different variability and selective patterns when compared to other primate-MHC-DPA1 lineages. A. nancymaae monkeys have thus a smaller MHC-DP polymorphism than MHC-DQ or MHC-DR. © 2010 Elsevier B.V.

• Fecha de publicación: 2011
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/24128
• Acceso en línea: https://doi.org/10.1016/j.gene.2010.09.006; https://repository.urosario.edu.co/handle/10336/24128
• Palabra clave: Major histocompatibility antigen class 2; Animal experiment; Aotus; Article; Catarrhini; Controlled study; Exon; Female; Gene; Genetic polymorphism; Male; Mhc dpa1 gene; Molecular cloning; Molecular evolution; Natural selection; Nonhuman; Nucleotide sequence; Phylogeny; Platyrrhini; Priority journal; Sequence analysis; Unindexed sequence; Amino acid sequence; Animals; Aotidae; Exons; Female; Histocompatibility antigens class ii; Humans; Major histocompatibility complex; Male; Molecular sequence data; Animalia; Aotus nancymaae; Aotus trivirgatus; Catarrhini; Plasmodium falciparum; Plasmodium vivax; Platyrrhini; Primates; Animal model; Mhc class ii molecule; Molecular evolution; New world monkeys; Platyrrhini; genetic; molecular; Models; Selection
• License: Abierto (Texto Completo)