Exposure to pesticide mixtures and DNA damage among rice field workers

This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the...

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Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/22766
Acceso en línea:
https://doi.org/10.1080/19338244.2014.910489
https://repository.urosario.edu.co/handle/10336/22766
Palabra clave:
2 imidazolidinethione
Carbamic acid derivative
Chlorinated hydrocarbon
Organophosphorus compound
Pesticide
Adolescent
Adult
Adverse effects
Aged
Agriculture
Analysis
Blood
Colombia
Comet assay
Cross-sectional study
Dna damage
Drug effects
Female
Human
Male
Middle aged
Occupational exposure
Oryza
Very elderly
Young adult
Adolescent
Adult
Aged
Aged, 80 and over
Agriculture
Carbamates
Colombia
Comet assay
Cross-sectional studies
Dna damage
Ethylenethiourea
Female
Humans
Male
Middle aged
Occupational exposure
Organophosphorus compounds
Oryza
Pesticides
Young adult
Agriculture
Chemical mixtures
Colombia
Genotoxicity
Pesticides
chlorinated
Hydrocarbons
Rights
License
Abierto (Texto Completo)
Description
Summary:This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-?-benzene hexachloride (?-BHC), hexachlorobenzene (HCB), and ?-BHC (?: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (?: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers. © 2016 Taylor and Francis.