Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology

Primary agammaglobulinemia is a rare disorder which is associated with articular symptoms in 11% of patients. Septic arthritis may occur, but often patients complain of chronic oligoarthritis and have a clinical presentation similar to rheumatoid arthritis. We report 2 cases of primary agammaglobuli...

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Fecha de publicación:
1992
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27247
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/27247
Palabra clave:
Primary agammaglobulinemia
Septic arthritis
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id EDOCUR2_eac7ae9885ef569b215aab4641f0cb95
oai_identifier_str oai:repository.urosario.edu.co:10336/27247
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling e8938956-af14-46bd-9749-62565a90def17162c578-7dfa-426b-94cb-147dc0164f74194747786006fdc324f-d229-4e2c-8776-e4dbea7e7b642a4f949e-804f-4f12-946a-92fce519775d2101dab4-c36e-42d2-bb84-413ee663d195f05bcf06-469b-442c-a19d-2146dc53db912020-08-19T14:41:29Z2020-08-19T14:41:29Z1992Primary agammaglobulinemia is a rare disorder which is associated with articular symptoms in 11% of patients. Septic arthritis may occur, but often patients complain of chronic oligoarthritis and have a clinical presentation similar to rheumatoid arthritis. We report 2 cases of primary agammaglobulinemia in adults, associated with non-erosive chronic arthritis. Peripheral blood lymphocyte phenotyping showed a predominance of CD8 lymphocytes with a CD4/CD8 ratio < 1. We did not find any abnormalities in cellular immunity. A histological study of the synovium showed chronic synovitis with perivascular CD8 lymphocyte infiltrates. Intravenous infusion of immunoglobulins resulted in a dramatic improvement in the arthritis in both cases. In one patient we noticed a decrease in CD8 lymphocytosis. These results suggest that CD8 lymphocytes are involved in the pathogenesis of the arthritis associated with agammaglobulinemia.application/pdfISSN: 0392-856XEISSN: 1593-098Xhttps://repository.urosario.edu.co/handle/10336/27247engEurope PMC69No. 165Clinical and Experimental RheumatologyVol. 11Clinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X , Vol.11, No.1 (1992); pp. 65-69https://europepmc.org/article/med/8453802Bloqueado (Texto referencial)http://purl.org/coar/access_right/c_14cbClinical and Experimental Rheumatologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPrimary agammaglobulinemiaSeptic arthritisArthritis associated with primary agammaglobulinemia: New clues to its immunopathologyArtritis asociada a agammaglobulinemia primaria: nuevas pistas sobre su inmunopatologíaarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Sany, J.Jorgensen, CH.Anaya, Juan-ManuelDidry, CAndary, M.Serre, I.Baldet, P.10336/27247oai:repository.urosario.edu.co:10336/272472021-08-06 11:44:31.872https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
dc.title.TranslatedTitle.spa.fl_str_mv Artritis asociada a agammaglobulinemia primaria: nuevas pistas sobre su inmunopatología
title Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
spellingShingle Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
Primary agammaglobulinemia
Septic arthritis
title_short Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
title_full Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
title_fullStr Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
title_full_unstemmed Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
title_sort Arthritis associated with primary agammaglobulinemia: New clues to its immunopathology
dc.subject.keyword.spa.fl_str_mv Primary agammaglobulinemia
Septic arthritis
topic Primary agammaglobulinemia
Septic arthritis
description Primary agammaglobulinemia is a rare disorder which is associated with articular symptoms in 11% of patients. Septic arthritis may occur, but often patients complain of chronic oligoarthritis and have a clinical presentation similar to rheumatoid arthritis. We report 2 cases of primary agammaglobulinemia in adults, associated with non-erosive chronic arthritis. Peripheral blood lymphocyte phenotyping showed a predominance of CD8 lymphocytes with a CD4/CD8 ratio < 1. We did not find any abnormalities in cellular immunity. A histological study of the synovium showed chronic synovitis with perivascular CD8 lymphocyte infiltrates. Intravenous infusion of immunoglobulins resulted in a dramatic improvement in the arthritis in both cases. In one patient we noticed a decrease in CD8 lymphocytosis. These results suggest that CD8 lymphocytes are involved in the pathogenesis of the arthritis associated with agammaglobulinemia.
publishDate 1992
dc.date.created.spa.fl_str_mv 1992
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:41:29Z
dc.date.available.none.fl_str_mv 2020-08-19T14:41:29Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN: 0392-856X
EISSN: 1593-098X
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27247
identifier_str_mv ISSN: 0392-856X
EISSN: 1593-098X
url https://repository.urosario.edu.co/handle/10336/27247
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 69
dc.relation.citationIssue.none.fl_str_mv No. 1
dc.relation.citationStartPage.none.fl_str_mv 65
dc.relation.citationTitle.none.fl_str_mv Clinical and Experimental Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 11
dc.relation.ispartof.spa.fl_str_mv Clinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X , Vol.11, No.1 (1992); pp. 65-69
dc.relation.uri.spa.fl_str_mv https://europepmc.org/article/med/8453802
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.acceso.spa.fl_str_mv Bloqueado (Texto referencial)
rights_invalid_str_mv Bloqueado (Texto referencial)
http://purl.org/coar/access_right/c_14cb
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Europe PMC
dc.source.spa.fl_str_mv Clinical and Experimental Rheumatology
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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