Facts and challenges for the autoimmunologist. Lessons from the second Colombian autoimmune symposium

The first Colombian Autoimmune Symposium took place in Medellin in February 2005 [1]. Since then, much progress has been made. Among others, two facts have marked the recent history of the field of autoimmunity. The first one consists of the demonstration of a common origin for autoimmune diseases (ADs) [2–11] and, the second one, corresponds to the introduction of the autoimmunologist as the specialist devoted to diagnosis and therapy of ADs [12–15]. The fact that ADs share several clinical signs and symptoms, physiopathological mechanisms and genetic factors has been called autoimmune tautology and indicates that they have a common origin [9]. This concept had its origins in the clinical observations describing a possible shift of one disease to another or the fact that more than one AD may coexist in a single patient (i.e. polyautoimmunity) or in the same family (i.e. familial autoimmunity or autoimmune aggregation). The term “kaleidoscope of autoimmunity” [16–19] was coined as a result of the observations while the term “mosaic of autoimmunity” was introduced to explain the multifactorial origin and diversity of ADs expression [20,21]. In fact, different combinations of the many factors involved in autoimmunity as complex diseases produce varying and unique clinical pictures that represent the wide spectrum of ADs [20,21].

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/25911
• Acceso en línea: https://doi.org/10.1016/j.autrev.2011.10.001; https://repository.urosario.edu.co/handle/10336/25911
• Palabra clave: Heat shock protein; Antibody detection; Autoimmune disease; B lymphocyte; Colombia; Cytomegalovirus; Editorial; Epstein barr virus; Health care; Heredity; Human; Medical specialist; Physician; Risk factor; Sjoegren syndrome; Symposium; Systemic lupus erythematosus; Systemic sclerosis; Antibodies; antiphospholipid; Antigens; cd11b; Autoimmune diseases; Colombia; Cytomegalovirus infections; Epigenesis; genetic; Gene-environment interaction; Genetic predisposition to disease; Hla antigens; Humans; Neoplasms; Polymorphism; genetic
• License: Restringido (Acceso a grupos específicos)