Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica

Plasmodium vivax, es un endoparásito de origen Asiático que se dispersó alrededor del mundo y, actualmente, es predominante en las regiones tropicales y subtropicales del planeta que se encuentran entre los 15 y 16 °C. P. vivax, presenta una importancia biomédica dado que es el segundo agente respon...

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Fecha de publicación:
2019
Institución:
Universidad del Rosario
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Repositorio EdocUR - U. Rosario
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spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/19876
Acceso en línea:
https://doi.org/10.48713/10336_19876
http://repository.urosario.edu.co/handle/10336/19876
Palabra clave:
Plasmodium vivax
Malaria
Vacuna
Diversidad genética
Antígenos conservados
Selección natural
Promisorios candidatos vacunales
Selección negativa
Incidencia & prevención de la enfermedad
Malaria
Plasmodium vivax
Malaria
Antimalarial vaccine
Genetic diversity
Vaccine candidates
Vatural selection
Conserved regions
Negatively selected regions
Medicina
Epidemiología
Vacunas
Rights
License
Atribución-NoComercial-SinDerivadas 2.5 Colombia
id EDOCUR2_e7caaa4e159f2c401168ff11b15010c3
oai_identifier_str oai:repository.urosario.edu.co:10336/19876
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
dc.title.alternative.spa.fl_str_mv Selección natural en genes de Plasmodium vivax y su potencial uso en una vacuna antimalárica
title Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
spellingShingle Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
Plasmodium vivax
Malaria
Vacuna
Diversidad genética
Antígenos conservados
Selección natural
Promisorios candidatos vacunales
Selección negativa
Incidencia & prevención de la enfermedad
Malaria
Plasmodium vivax
Malaria
Antimalarial vaccine
Genetic diversity
Vaccine candidates
Vatural selection
Conserved regions
Negatively selected regions
Medicina
Epidemiología
Vacunas
title_short Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
title_full Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
title_fullStr Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
title_full_unstemmed Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
title_sort Identificación de señales de selección natural en genes de Plasmodium vivax que codifican proteínas involucradas en el proceso de invasión para determinar su potencial uso en una vacuna antimalárica
dc.contributor.advisor.none.fl_str_mv Patarroyo, Manuel A.
dc.subject.spa.fl_str_mv Plasmodium vivax
Malaria
Vacuna
Diversidad genética
Antígenos conservados
Selección natural
Promisorios candidatos vacunales
Selección negativa
topic Plasmodium vivax
Malaria
Vacuna
Diversidad genética
Antígenos conservados
Selección natural
Promisorios candidatos vacunales
Selección negativa
Incidencia & prevención de la enfermedad
Malaria
Plasmodium vivax
Malaria
Antimalarial vaccine
Genetic diversity
Vaccine candidates
Vatural selection
Conserved regions
Negatively selected regions
Medicina
Epidemiología
Vacunas
dc.subject.ddc.spa.fl_str_mv Incidencia & prevención de la enfermedad
dc.subject.decs.spa.fl_str_mv Malaria
dc.subject.keyword.spa.fl_str_mv Plasmodium vivax
Malaria
Antimalarial vaccine
Genetic diversity
Vaccine candidates
Vatural selection
Conserved regions
Negatively selected regions
dc.subject.lemb.spa.fl_str_mv Medicina
Epidemiología
Vacunas
description Plasmodium vivax, es un endoparásito de origen Asiático que se dispersó alrededor del mundo y, actualmente, es predominante en las regiones tropicales y subtropicales del planeta que se encuentran entre los 15 y 16 °C. P. vivax, presenta una importancia biomédica dado que es el segundo agente responsable de malaria en humanos. Aunque numerosos esfuerzos se han realizado para disminuir el impacto de esta enfermedad, las condiciones sociales y económicas de los lugares más afectados, sumado a los conflictos sociales y políticos en varias áreas endémicas, hacen del control y eliminación de este parásito una tarea nada fácil. Como si esto no fuera suficiente, la aparición de resistencia a los insecticidas por parte del vector trasmisor, así como de parásitos resistentes a los antimaláricos, podría provocar una recurrencia de esta enfermedad. Teniendo en cuenta lo anterior, nuevas estrategias que permitan disminuir la incidencia de malaria por P. vivax se hacen prioritarias. Una de las alternativas que podría ayudar al control de la malaria es el desarrollo de una vacuna contra los patógenos que la causan. Sin embargo, la elevada diversidad genética que P. vivax presenta, ha generado uno de los retos a afrontar para el diseño de una vacuna completamente efectiva. Actualmente, se han descrito varios antígenos potenciales candidatos a vacuna contra P. vivax. No obstante, la diversidad genética de un reducido número de estos antígenos ha sido evaluada, debido a los requerimientos de tiempo y recursos económicos. Adicionalmente, poco se sabe acerca del rol real de estos antígenos durante el proceso de invasión de este parasito a las células hospederas. Es por esto, que nuevos enfoques, que permitan en un menor tiempo y a bajo costo identificar las regiones de estos antígenos conservadas por selección natural (usualmente asociadas con regiones funcionales) se hacen necesarios. Estos nuevos enfoques podrían entonces servir como punto de partida para la identificación o priorización de nuevos y promisorios candidatos vacunales. Este trabajo presenta los resultados un enfoque alternativo que permite hacer un acercamiento a la diversidad genética de antígenos de P. vivax, determinando regiones bajo selección negativa, para ser consideradas durante el diseño de una vacuna completamente efectiva. Aunque este enfoque se utilizó para P. vivax, este podría también ser aplicado en otros organismos.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-06-18T20:54:59Z
dc.date.available.none.fl_str_mv 2019-06-18T20:54:59Z
dc.date.created.none.fl_str_mv 2019-01-31
dc.date.issued.none.fl_str_mv 2019
dc.type.eng.fl_str_mv doctoralThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_db06
dc.type.document.spa.fl_str_mv Tesis
dc.type.spa.spa.fl_str_mv Tesis de doctorado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_19876
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/19876
url https://doi.org/10.48713/10336_19876
http://repository.urosario.edu.co/handle/10336/19876
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de Ciencias Naturales y Matemáticas
dc.publisher.program.spa.fl_str_mv Doctorado en Ciencias Biomédicas y Biológicas
institution Universidad del Rosario
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spelling Patarroyo, Manuel A.79653065600Garzón-Ospina, Diego EdisonDoctor en Ciencias Biomédicas y BiológicasFull time7cfc6d0c-bf47-46fe-b46e-613c85cc8ed26002019-06-18T20:54:59Z2019-06-18T20:54:59Z2019-01-312019Plasmodium vivax, es un endoparásito de origen Asiático que se dispersó alrededor del mundo y, actualmente, es predominante en las regiones tropicales y subtropicales del planeta que se encuentran entre los 15 y 16 °C. P. vivax, presenta una importancia biomédica dado que es el segundo agente responsable de malaria en humanos. Aunque numerosos esfuerzos se han realizado para disminuir el impacto de esta enfermedad, las condiciones sociales y económicas de los lugares más afectados, sumado a los conflictos sociales y políticos en varias áreas endémicas, hacen del control y eliminación de este parásito una tarea nada fácil. Como si esto no fuera suficiente, la aparición de resistencia a los insecticidas por parte del vector trasmisor, así como de parásitos resistentes a los antimaláricos, podría provocar una recurrencia de esta enfermedad. Teniendo en cuenta lo anterior, nuevas estrategias que permitan disminuir la incidencia de malaria por P. vivax se hacen prioritarias. Una de las alternativas que podría ayudar al control de la malaria es el desarrollo de una vacuna contra los patógenos que la causan. Sin embargo, la elevada diversidad genética que P. vivax presenta, ha generado uno de los retos a afrontar para el diseño de una vacuna completamente efectiva. Actualmente, se han descrito varios antígenos potenciales candidatos a vacuna contra P. vivax. No obstante, la diversidad genética de un reducido número de estos antígenos ha sido evaluada, debido a los requerimientos de tiempo y recursos económicos. Adicionalmente, poco se sabe acerca del rol real de estos antígenos durante el proceso de invasión de este parasito a las células hospederas. Es por esto, que nuevos enfoques, que permitan en un menor tiempo y a bajo costo identificar las regiones de estos antígenos conservadas por selección natural (usualmente asociadas con regiones funcionales) se hacen necesarios. Estos nuevos enfoques podrían entonces servir como punto de partida para la identificación o priorización de nuevos y promisorios candidatos vacunales. Este trabajo presenta los resultados un enfoque alternativo que permite hacer un acercamiento a la diversidad genética de antígenos de P. vivax, determinando regiones bajo selección negativa, para ser consideradas durante el diseño de una vacuna completamente efectiva. Aunque este enfoque se utilizó para P. vivax, este podría también ser aplicado en otros organismos.Plasmodium vivax, an endoparasite that arose in Asia and spread around the world, has biomedical importance given that it is the second most important human-malaria parasite. Although efforts have been made to reduce the impact of this disease, the social and economic conditions of the most affected places, together with social and political conflicts in several endemic areas, make the parasite control and elimination a laborious task. The emergence of insecticide resistance by the transmitting vector as well as antimalarialresistant parasites worsen the problem. Therefore, new alternatives to allow reducing the incidence of the disease have become a priority. An antimalarial vaccine development against the causal pathogens has been proposed as a cost-effective intervention which would help in controlling malaria. However, the high P. vivax genetic diversity remains as one of the challenges to overcome for the design of afully effective vaccine. Currently, several potential P. vivax vaccine candidates have been described. Nevertheless, the genetic diversity of a small number of them has been assessed, due to the high amount of time and economic resources required. Additionally, there is a modest knowledge about the real role of these antigens during the invasion process of target cells since maintaining an in vitro culture of this parasite species is particularly difficult. Therefore, new approaches that allow identifying conserved regions by natural selection which are frequently associated with functional importance, might be used as a starting point for the identification or prioritization of new potential vaccine candidates. This work presents a new approach to assess the genetic diversity of potential candidate antigens, determining negatively selected regions that can then be considered for designing a fully effective vaccine. 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