Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática

Objetivos: Evaluar la efectividad y seguridad del uso de ácido tranexámico administrado por vía endovenosa para el control del sangrado en pacientes sometidos a cirugía electiva y de urgencias en contextos no ortopédicos. Metodología: Revisión sistemática de la literatura realizada de acuerdo a la m...

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Tipo de recurso:
Fecha de publicación:
2019
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/19840
Acceso en línea:
https://doi.org/10.48713/10336_19840
http://repository.urosario.edu.co/handle/10336/19840
Palabra clave:
Enfermedades
Tranexamic acid
Surgery
Bleeding
Adverse effects
Ácido tranexámico
Cirugía
Sangrado
Efectos adversos
Rights
License
Atribución-NoComercial-SinDerivadas 2.5 Colombia
id EDOCUR2_e77f7c19effe37cb250e948aff334155
oai_identifier_str oai:repository.urosario.edu.co:10336/19840
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
title Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
spellingShingle Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
Enfermedades
Tranexamic acid
Surgery
Bleeding
Adverse effects
Ácido tranexámico
Cirugía
Sangrado
Efectos adversos
title_short Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
title_full Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
title_fullStr Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
title_full_unstemmed Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
title_sort Efectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. Revisión sistemática
dc.contributor.advisor.none.fl_str_mv Pinzón, Carlos
dc.subject.ddc.spa.fl_str_mv Enfermedades
topic Enfermedades
Tranexamic acid
Surgery
Bleeding
Adverse effects
Ácido tranexámico
Cirugía
Sangrado
Efectos adversos
dc.subject.keyword.spa.fl_str_mv Tranexamic acid
Surgery
Bleeding
Adverse effects
dc.subject.lemb.spa.fl_str_mv Ácido tranexámico
Cirugía
Sangrado
Efectos adversos
description Objetivos: Evaluar la efectividad y seguridad del uso de ácido tranexámico administrado por vía endovenosa para el control del sangrado en pacientes sometidos a cirugía electiva y de urgencias en contextos no ortopédicos. Metodología: Revisión sistemática de la literatura realizada de acuerdo a la metodología de la Colaboración Cochrane y las recomendaciones de la declaración PRISMA. Se seleccionaron artículos entre el año 2011 y 2018 de las bases de datos Medline, Embase, Central, Web of Science, Lilacs, mRCT y Who International Trials Registry Plataform en idioma español, inglés, portugués y francés. Resultados: Se eligieron 35 estudios clínicos aleatorizados. El uso de ácido tranexámico se relacionó con disminución de sangrado en los contextos de cesárea programada en 225.52cc IC 95% (216,04 - 235,01) y revascularización miocárdica en 170.51 cc IC 95% (138,4 - 202,62), sin embargo, había heterogeneidad estadística entre los estudios. Las otras intervenciones donde se encontró disminución del sangrado incluían otorrinolaringología, maxilofacial, ginecología y urología. En los procedimientos oncológicos no se encontró beneficio por el uso del medicamento, lo cual puede ser explicado por la comorbilidad. Los efectos adversos relacionados con el uso del ácido tranexámico se reportaron en los estudios de forma descriptiva en la mayoría de los estudios. Lo mismo ocurrió con el desenlace de mortalidad o no fue tenido en cuenta. Conclusiones: El uso de ácido tranexámico endovenoso en cirugías no ortopédicas disminuye el volumen de sangrado intraoperatorio. La seguridad medicamento aún no está claro, falta mayor información en los resultados de los estudios.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2019-06-05T16:41:02Z
dc.date.available.none.fl_str_mv 2019-06-05T16:41:02Z
dc.date.created.none.fl_str_mv 2019-06-06
dc.date.issued.none.fl_str_mv 2019
dc.type.eng.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.spa.fl_str_mv Revisión sistemática
dc.type.spa.spa.fl_str_mv Trabajo de grado
dc.identifier.doi.none.fl_str_mv https://doi.org/10.48713/10336_19840
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/19840
url https://doi.org/10.48713/10336_19840
http://repository.urosario.edu.co/handle/10336/19840
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.spa.fl_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 2.5 Colombia
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Universidad del Rosario
dc.publisher.department.spa.fl_str_mv Facultad de medicina
institution Universidad del Rosario
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spelling Pinzón, Carlosee8de85c-2800-4628-94c7-161b1e612903600Carrillo Ávila, Diego LeonardoRamos Hernández, AnamaríaEspecialista en Epidemiología (en Convenio con el CES)Part timea9335e06-ac1c-4bdc-830b-95cba8626d20600baddf5b8-e48d-44b5-941f-d50419d2e1966002019-06-05T16:41:02Z2019-06-05T16:41:02Z2019-06-062019Objetivos: Evaluar la efectividad y seguridad del uso de ácido tranexámico administrado por vía endovenosa para el control del sangrado en pacientes sometidos a cirugía electiva y de urgencias en contextos no ortopédicos. Metodología: Revisión sistemática de la literatura realizada de acuerdo a la metodología de la Colaboración Cochrane y las recomendaciones de la declaración PRISMA. Se seleccionaron artículos entre el año 2011 y 2018 de las bases de datos Medline, Embase, Central, Web of Science, Lilacs, mRCT y Who International Trials Registry Plataform en idioma español, inglés, portugués y francés. Resultados: Se eligieron 35 estudios clínicos aleatorizados. El uso de ácido tranexámico se relacionó con disminución de sangrado en los contextos de cesárea programada en 225.52cc IC 95% (216,04 - 235,01) y revascularización miocárdica en 170.51 cc IC 95% (138,4 - 202,62), sin embargo, había heterogeneidad estadística entre los estudios. Las otras intervenciones donde se encontró disminución del sangrado incluían otorrinolaringología, maxilofacial, ginecología y urología. En los procedimientos oncológicos no se encontró beneficio por el uso del medicamento, lo cual puede ser explicado por la comorbilidad. Los efectos adversos relacionados con el uso del ácido tranexámico se reportaron en los estudios de forma descriptiva en la mayoría de los estudios. Lo mismo ocurrió con el desenlace de mortalidad o no fue tenido en cuenta. Conclusiones: El uso de ácido tranexámico endovenoso en cirugías no ortopédicas disminuye el volumen de sangrado intraoperatorio. La seguridad medicamento aún no está claro, falta mayor información en los resultados de los estudios.Objectives: To evaluate the effectiveness and safety of the use of tranexamic acid administered intravenously for the control of bleeding in patients undergoing elective and emergency surgery in non-orthopedic contexts. Methodology: Systematic review of the literature according to the methodology of the Cochrane Collaboration and the recommendations of the PRISMA statement. Articles between 2011 and 2018 were included from the Medline, Embase, Central, Web of Science, Lilacs, mRCT and Who International Trials Registry Platforms databases in Spanish, English, Portuguese and French. Results: 35 randomized trials were included. The use of tranexamic acid was related to the decrease of bleeding in the elective cesarean sections in 225.52cc 95% CI (216.04 - 235.01) and in myocardial revascularization in 170.51 cc 95% CI (138.4 - 202.62), however, there was statistical heterogeneity between the studies. The other reported interventions where decreased bleeding was found included otorhinolaryngology, maxillofacial, gynecology and urology surgeries. In the oncological procedures no benefit was found, which can be explained by the comorbidity. Adverse effects related to the use of tranexamic acid were reported in the studies descriptively in most of the studies. The same happened with the outcome of mortality or was not considered. Conclusions: The use of intravenous tranexamic acid in non-orthopedic surgeries decreases the volume of intraoperative bleeding. The safety of the use of the medication is not yet clear, there is a lack of information in the results of studies where tranexamic acid is used as an intervention.2021-06-06 01:01:01: Script de automatizacion de embargos. info:eu-repo/date/embargoEnd/2021-06-05application/pdfhttps://doi.org/10.48713/10336_19840 http://repository.urosario.edu.co/handle/10336/19840spaUniversidad del RosarioFacultad de medicinaAtribución-NoComercial-SinDerivadas 2.5 ColombiaAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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Effect of topical tranexamic acid on bleeding and quality of surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple blind randomized clinical trial. PLoS One. 2014;9(8):e104477.89. Jendoubi A, Malouch A, Bouzouita A, Riahi Y, Necib H, Ghedira S, et al. [Safety and efficacy of intravenous tranexamic acid in endoscopic transurethral resections in urology: Prospective randomized trial]2017 2017-1-1. 1036-42 p.90. Kumar S, Randhawa MS, Ganesamoni R, Singh SK. Tranexamic acid reduces blood loss during percutaneous nephrolithotomy: a prospective randomized controlled study2013 2013-1-1. 1757-61 p.91. Santosh UP, Prashanth KB, Abhilash S. A comparative study to verify the efficacy of preoperative intravenous tranexamic acid in control of tonsillectomy bleeding. Otorhinolaryngol Clin. 2016;8(1):22-5.92. Ali Shah MU, Asghar MI, Siddiqi R, Chaudhri MS, Janjua AM, Iqbal A. Topical application of tranexamic acid reduces postoperative bleeding in open-heart surgery: myth or fact? J Coll Physicians Surg Pak. 2015;25(3):161-5.93. Siddiq A, Khalid S, Mithani H, Anis S, Sharif I, Shaikh J. Preventing Excessive Blood Loss During Percutaneous Nephrolithotomy by Using Tranexamic Acid: A Double Blinded Prospective Randomized Controlled Trial. Journal Of Urological Surgery. 2017;4(4):195-201.94. Taksaudom N, Siwachat S, Tantraworasin A. Additional effects of topical tranexamic acid in on-pump cardiac surgery. Asian Cardiovasc Thorac Ann. 2017;25(1):24-30.instname:Universidad del Rosarioreponame:Repositorio Institucional EdocUREnfermedades616600Tranexamic acidSurgeryBleedingAdverse effectsÁcido tranexámicoCirugíaSangradoEfectos adversosEfectividad y seguridad de ácido tranexámico en pacientes quirúrgicos no ortopédicos. 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