Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the pre...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2010
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23249
- Acceso en línea:
- https://doi.org/10.1093/rheumatology/kep470
https://repository.urosario.edu.co/handle/10336/23249
- Palabra clave:
- Cd226 protein
Chromosome protein
Unclassified drug
Argentina
Article
Autoimmune disease
Autoimmunity
Caucasian
Celiac disease
China
Colombia
Controlled study
Ethnic difference
Female
Gene frequency
Genetic association
Genetic susceptibility
Genetic variability
Genotype
Geographic distribution
Human
Insulin dependent diabetes mellitus
Japan
Major clinical study
Male
Phenotype
Population research
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
Argentina
Asian continental ancestry group
Autoimmune diseases
Case-control studies
Colombia
European continental ancestry group
Gene frequency
Genetic predisposition to disease
Genotype
Humans
Statistics as topic
Asia
Autoimmunity
Cd226
Latin-america
differentiation
t-lymphocyte
Antigens
- Rights
- License
- Abierto (Texto Completo)
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dc.title.spa.fl_str_mv |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
spellingShingle |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases Cd226 protein Chromosome protein Unclassified drug Argentina Article Autoimmune disease Autoimmunity Caucasian Celiac disease China Colombia Controlled study Ethnic difference Female Gene frequency Genetic association Genetic susceptibility Genetic variability Genotype Geographic distribution Human Insulin dependent diabetes mellitus Japan Major clinical study Male Phenotype Population research Priority journal Rheumatoid arthritis Single nucleotide polymorphism Sjoegren syndrome Systemic lupus erythematosus Argentina Asian continental ancestry group Autoimmune diseases Case-control studies Colombia European continental ancestry group Gene frequency Genetic predisposition to disease Genotype Humans Statistics as topic Asia Autoimmunity Cd226 Latin-america differentiation t-lymphocyte Antigens |
title_short |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_full |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_fullStr |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_full_unstemmed |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
title_sort |
Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases |
dc.subject.keyword.spa.fl_str_mv |
Cd226 protein Chromosome protein Unclassified drug Argentina Article Autoimmune disease Autoimmunity Caucasian Celiac disease China Colombia Controlled study Ethnic difference Female Gene frequency Genetic association Genetic susceptibility Genetic variability Genotype Geographic distribution Human Insulin dependent diabetes mellitus Japan Major clinical study Male Phenotype Population research Priority journal Rheumatoid arthritis Single nucleotide polymorphism Sjoegren syndrome Systemic lupus erythematosus Argentina Asian continental ancestry group Autoimmune diseases Case-control studies Colombia European continental ancestry group Gene frequency Genetic predisposition to disease Genotype Humans Statistics as topic Asia Autoimmunity Cd226 Latin-america |
topic |
Cd226 protein Chromosome protein Unclassified drug Argentina Article Autoimmune disease Autoimmunity Caucasian Celiac disease China Colombia Controlled study Ethnic difference Female Gene frequency Genetic association Genetic susceptibility Genetic variability Genotype Geographic distribution Human Insulin dependent diabetes mellitus Japan Major clinical study Male Phenotype Population research Priority journal Rheumatoid arthritis Single nucleotide polymorphism Sjoegren syndrome Systemic lupus erythematosus Argentina Asian continental ancestry group Autoimmune diseases Case-control studies Colombia European continental ancestry group Gene frequency Genetic predisposition to disease Genotype Humans Statistics as topic Asia Autoimmunity Cd226 Latin-america differentiation t-lymphocyte Antigens |
dc.subject.keyword.eng.fl_str_mv |
differentiation t-lymphocyte Antigens |
description |
Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using ?2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org. |
publishDate |
2010 |
dc.date.created.spa.fl_str_mv |
2010 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:00:37Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:00:37Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1093/rheumatology/kep470 |
dc.identifier.issn.none.fl_str_mv |
14620324 14620332 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23249 |
url |
https://doi.org/10.1093/rheumatology/kep470 https://repository.urosario.edu.co/handle/10336/23249 |
identifier_str_mv |
14620324 14620332 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
1244 |
dc.relation.citationIssue.none.fl_str_mv |
No. 7 |
dc.relation.citationStartPage.none.fl_str_mv |
1239 |
dc.relation.citationTitle.none.fl_str_mv |
Rheumatology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 49 |
dc.relation.ispartof.spa.fl_str_mv |
Rheumatology, ISSN:14620324, 14620332, Vol.49, No.7 (2010); pp. 1239-1244 |
dc.relation.uri.spa.fl_str_mv |
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dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
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Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
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reponame:Repositorio Institucional EdocUR |
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1a95d51e-198e-46c6-83d2-25b513e2615d5a1d2b19-ce5a-49e8-bd50-6bd90a8463c6fc2efb80-a632-4403-96f5-093344652168be43f647-836d-4991-b77e-6520e14c9b5bd90ea1fb-511c-4f43-8ae6-97078c334f75522497015cb26dc6-4ad2-4faf-b7f8-9ec601b6d3ffc919c968-8439-4d2c-917d-c5c70d8cb3e6261beea8-903d-47ec-b5c6-53b77cdbd6e8a2a840f2-1bd0-4d31-a198-4523d887d96c9f7f48b7-804c-4a28-aa04-943135e42ffe58190483-9699-4dc6-b01e-24a0e570ee6a1947477860041f8164b-3ecf-4dc5-ad77-a3580104bd352020-05-26T00:00:37Z2020-05-26T00:00:37Z2010Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using ?2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.application/pdfhttps://doi.org/10.1093/rheumatology/kep4701462032414620332https://repository.urosario.edu.co/handle/10336/23249eng1244No. 71239RheumatologyVol. 49Rheumatology, ISSN:14620324, 14620332, Vol.49, No.7 (2010); pp. 1239-1244https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954208061&doi=10.1093%2frheumatology%2fkep470&partnerID=40&md5=5cd799a98204949dfedaeedbc289287dAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCd226 proteinChromosome proteinUnclassified drugArgentinaArticleAutoimmune diseaseAutoimmunityCaucasianCeliac diseaseChinaColombiaControlled studyEthnic differenceFemaleGene frequencyGenetic associationGenetic susceptibilityGenetic variabilityGenotypeGeographic distributionHumanInsulin dependent diabetes mellitusJapanMajor clinical studyMalePhenotypePopulation researchPriority journalRheumatoid arthritisSingle nucleotide polymorphismSjoegren syndromeSystemic lupus erythematosusArgentinaAsian continental ancestry groupAutoimmune diseasesCase-control studiesColombiaEuropean continental ancestry groupGene frequencyGenetic predisposition to diseaseGenotypeHumansStatistics as topicAsiaAutoimmunityCd226Latin-americadifferentiationt-lymphocyteAntigensNon-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseasesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Maiti, Amit K.Kim-Howard, XanaViswanathan, ParvathiGuillén, LauraQian, XiaoxiaRojas-Villarraga, AdrianaSun, CeliCañas, CarlosTobón, Gabriel J.Matsuda, KoichiShen, NanCherñavsky, Alejandra C.Anaya, Juan-ManuelNath, Swapan K.ORIGINALkep470.pdfapplication/pdf99471https://repository.urosario.edu.co/bitstreams/9af1f2a3-d21a-4676-ac65-797b8080cdb3/downloada64b30c83f3235ebc2c4822b8f04efd4MD51TEXTkep470.pdf.txtkep470.pdf.txtExtracted texttext/plain30335https://repository.urosario.edu.co/bitstreams/2e939a68-b61a-46fc-97ad-eaa6e25b27d9/download207ac66cc15ae11b901e9106334d5acfMD52THUMBNAILkep470.pdf.jpgkep470.pdf.jpgGenerated Thumbnailimage/jpeg4693https://repository.urosario.edu.co/bitstreams/e33b0368-1209-4632-9ff0-0cba350d90a9/download1081f1da86ac4a208a817bb5f59e711cMD5310336/23249oai:repository.urosario.edu.co:10336/232492022-05-02 07:37:13.721985https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |