Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases

Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the pre...

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Autores:
Tipo de recurso:
Fecha de publicación:
2010
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23249
Acceso en línea:
https://doi.org/10.1093/rheumatology/kep470
https://repository.urosario.edu.co/handle/10336/23249
Palabra clave:
Cd226 protein
Chromosome protein
Unclassified drug
Argentina
Article
Autoimmune disease
Autoimmunity
Caucasian
Celiac disease
China
Colombia
Controlled study
Ethnic difference
Female
Gene frequency
Genetic association
Genetic susceptibility
Genetic variability
Genotype
Geographic distribution
Human
Insulin dependent diabetes mellitus
Japan
Major clinical study
Male
Phenotype
Population research
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
Argentina
Asian continental ancestry group
Autoimmune diseases
Case-control studies
Colombia
European continental ancestry group
Gene frequency
Genetic predisposition to disease
Genotype
Humans
Statistics as topic
Asia
Autoimmunity
Cd226
Latin-america
differentiation
t-lymphocyte
Antigens
Rights
License
Abierto (Texto Completo)
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network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
spellingShingle Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
Cd226 protein
Chromosome protein
Unclassified drug
Argentina
Article
Autoimmune disease
Autoimmunity
Caucasian
Celiac disease
China
Colombia
Controlled study
Ethnic difference
Female
Gene frequency
Genetic association
Genetic susceptibility
Genetic variability
Genotype
Geographic distribution
Human
Insulin dependent diabetes mellitus
Japan
Major clinical study
Male
Phenotype
Population research
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
Argentina
Asian continental ancestry group
Autoimmune diseases
Case-control studies
Colombia
European continental ancestry group
Gene frequency
Genetic predisposition to disease
Genotype
Humans
Statistics as topic
Asia
Autoimmunity
Cd226
Latin-america
differentiation
t-lymphocyte
Antigens
title_short Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_full Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_fullStr Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_full_unstemmed Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
title_sort Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases
dc.subject.keyword.spa.fl_str_mv Cd226 protein
Chromosome protein
Unclassified drug
Argentina
Article
Autoimmune disease
Autoimmunity
Caucasian
Celiac disease
China
Colombia
Controlled study
Ethnic difference
Female
Gene frequency
Genetic association
Genetic susceptibility
Genetic variability
Genotype
Geographic distribution
Human
Insulin dependent diabetes mellitus
Japan
Major clinical study
Male
Phenotype
Population research
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
Argentina
Asian continental ancestry group
Autoimmune diseases
Case-control studies
Colombia
European continental ancestry group
Gene frequency
Genetic predisposition to disease
Genotype
Humans
Statistics as topic
Asia
Autoimmunity
Cd226
Latin-america
topic Cd226 protein
Chromosome protein
Unclassified drug
Argentina
Article
Autoimmune disease
Autoimmunity
Caucasian
Celiac disease
China
Colombia
Controlled study
Ethnic difference
Female
Gene frequency
Genetic association
Genetic susceptibility
Genetic variability
Genotype
Geographic distribution
Human
Insulin dependent diabetes mellitus
Japan
Major clinical study
Male
Phenotype
Population research
Priority journal
Rheumatoid arthritis
Single nucleotide polymorphism
Sjoegren syndrome
Systemic lupus erythematosus
Argentina
Asian continental ancestry group
Autoimmune diseases
Case-control studies
Colombia
European continental ancestry group
Gene frequency
Genetic predisposition to disease
Genotype
Humans
Statistics as topic
Asia
Autoimmunity
Cd226
Latin-america
differentiation
t-lymphocyte
Antigens
dc.subject.keyword.eng.fl_str_mv differentiation
t-lymphocyte
Antigens
description Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using ?2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.
publishDate 2010
dc.date.created.spa.fl_str_mv 2010
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:00:37Z
dc.date.available.none.fl_str_mv 2020-05-26T00:00:37Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1093/rheumatology/kep470
dc.identifier.issn.none.fl_str_mv 14620324
14620332
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23249
url https://doi.org/10.1093/rheumatology/kep470
https://repository.urosario.edu.co/handle/10336/23249
identifier_str_mv 14620324
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dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1244
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 1239
dc.relation.citationTitle.none.fl_str_mv Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 49
dc.relation.ispartof.spa.fl_str_mv Rheumatology, ISSN:14620324, 14620332, Vol.49, No.7 (2010); pp. 1239-1244
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institution Universidad del Rosario
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spelling 1a95d51e-198e-46c6-83d2-25b513e2615d5a1d2b19-ce5a-49e8-bd50-6bd90a8463c6fc2efb80-a632-4403-96f5-093344652168be43f647-836d-4991-b77e-6520e14c9b5bd90ea1fb-511c-4f43-8ae6-97078c334f75522497015cb26dc6-4ad2-4faf-b7f8-9ec601b6d3ffc919c968-8439-4d2c-917d-c5c70d8cb3e6261beea8-903d-47ec-b5c6-53b77cdbd6e8a2a840f2-1bd0-4d31-a198-4523d887d96c9f7f48b7-804c-4a28-aa04-943135e42ffe58190483-9699-4dc6-b01e-24a0e570ee6a1947477860041f8164b-3ecf-4dc5-ad77-a3580104bd352020-05-26T00:00:37Z2020-05-26T00:00:37Z2010Objectives. Recently, a non-synonymous (Gly307Ser) variant, rs763361, in the CD226 gene was shown to be associated with multiple autoimmune diseases (ADs) in European Caucasian populations. However, shared autoimmunity with CD226 has not been evaluated in non-European populations. The aim of the present study is to assess the association of this single nucleotide polymorphism (SNP) with ADs in non-European populations. Methods. To replicate this association in non-European populations, we evaluated case-control association between rs763361 and coeliac disease (CED) samples from Argentina; SLE, RA, type-1 diabetes (T1D) and primary SS (pSS) from Colombia; and SLE samples from China and Japan. We genotyped rs763361 and evaluated its genetic association with multiple ADs, using ?2-test. For each association, odds ratio (OR) and 95% CI were calculated. Results. We show that rs763361 is significantly associated with Argentinean CED (P = 0.0009, OR= 1.60). We also observed a trend of possible association with Chinese SLE (P = 0.01, OR= 1.19), RA (P = 0.047, OR= 1.25), SLE (P = 0.0899, OR= 1.24) and pSS (P = 0.09, OR= 1.33) in Colombians. Meta-analyses for SLE (using our three populations) and T1D (our population and three published populations) yielded significant association with rs763361, P = 0.009 (OR = 1.16) and P = 1.1.46×10-9 (OR = 1.14), respectively. Conclusions. Our results demonstrate that the coding variant rs763361 in CD226 gene is associated with multiple ADs in non-European populations. © The Author 2010. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org.application/pdfhttps://doi.org/10.1093/rheumatology/kep4701462032414620332https://repository.urosario.edu.co/handle/10336/23249eng1244No. 71239RheumatologyVol. 49Rheumatology, ISSN:14620324, 14620332, Vol.49, No.7 (2010); pp. 1239-1244https://www.scopus.com/inward/record.uri?eid=2-s2.0-77954208061&doi=10.1093%2frheumatology%2fkep470&partnerID=40&md5=5cd799a98204949dfedaeedbc289287dAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCd226 proteinChromosome proteinUnclassified drugArgentinaArticleAutoimmune diseaseAutoimmunityCaucasianCeliac diseaseChinaColombiaControlled studyEthnic differenceFemaleGene frequencyGenetic associationGenetic susceptibilityGenetic variabilityGenotypeGeographic distributionHumanInsulin dependent diabetes mellitusJapanMajor clinical studyMalePhenotypePopulation researchPriority journalRheumatoid arthritisSingle nucleotide polymorphismSjoegren syndromeSystemic lupus erythematosusArgentinaAsian continental ancestry groupAutoimmune diseasesCase-control studiesColombiaEuropean continental ancestry groupGene frequencyGenetic predisposition to diseaseGenotypeHumansStatistics as topicAsiaAutoimmunityCd226Latin-americadifferentiationt-lymphocyteAntigensNon-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseasesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Maiti, Amit K.Kim-Howard, XanaViswanathan, ParvathiGuillén, LauraQian, XiaoxiaRojas-Villarraga, AdrianaSun, CeliCañas, CarlosTobón, Gabriel J.Matsuda, KoichiShen, NanCherñavsky, Alejandra C.Anaya, Juan-ManuelNath, Swapan K.ORIGINALkep470.pdfapplication/pdf99471https://repository.urosario.edu.co/bitstreams/9af1f2a3-d21a-4676-ac65-797b8080cdb3/downloada64b30c83f3235ebc2c4822b8f04efd4MD51TEXTkep470.pdf.txtkep470.pdf.txtExtracted texttext/plain30335https://repository.urosario.edu.co/bitstreams/2e939a68-b61a-46fc-97ad-eaa6e25b27d9/download207ac66cc15ae11b901e9106334d5acfMD52THUMBNAILkep470.pdf.jpgkep470.pdf.jpgGenerated Thumbnailimage/jpeg4693https://repository.urosario.edu.co/bitstreams/e33b0368-1209-4632-9ff0-0cba350d90a9/download1081f1da86ac4a208a817bb5f59e711cMD5310336/23249oai:repository.urosario.edu.co:10336/232492022-05-02 07:37:13.721985https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co