Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study
Background Survival time or time to discontinuation of medication is a surrogate of the long-term impact on the course of disease in real life. It reflects clinical effectiveness in the absence of significant adverse events [1]. Treatment discontinuation can result from loss of efficacy or safety co...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2017
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/28079
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/28079
- Palabra clave:
- Long-term
Survival of subcutaneous
Rheumatoid arthritis
- Rights
- License
- Abierto (Texto Completo)
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3e8ff7f8-f1ed-41bd-acea-4b8a86b1e1c180873475600517994996007ba3a914-410e-48b9-be8f-11061dd324742020-08-19T14:45:38Z2020-08-19T14:45:38Z2017-06-17Background Survival time or time to discontinuation of medication is a surrogate of the long-term impact on the course of disease in real life. It reflects clinical effectiveness in the absence of significant adverse events [1]. Treatment discontinuation can result from loss of efficacy or safety concerns, but prognostic factors for patient retention have not been explored thoroughly despite data for abatacept and other biologics being available from national registries [2]. Objectives To assess drug survival of subcutaneous (SC) abatacept among patients with rheumatoid arthritis (RA) according to treatment background. Methods This was a prospective study in which well-characterized patients with RA (by 1987 ACR criteria) were assessed from April 2014 to December 2016. Each patient was evaluated by a rheumatologist in a single rheumatology outpatient private center in Bogotá, Colombia. Patients were stratified by treatment background: (n=54) biologic-naïve, (n=24) switched from IV to SC abatacept administration, and (n=51) inadequate response to at least 1 biologic disease-modifying antirheumatic drug. The Mantel-Haenszel test was used to test if there were any differences in the survival curves among groups. The test was performed by the survdiff function of the “survival” R package [3]. Results A total of 129 patients were included. Baseline characteristics of patients were as follows: female gender 86%, mean age 52±13 years, median disease duration 10 (IQR 11) years, Rheumatoid Factor positive 94%, Anti-Cyclic Citrullinated Peptide Antibodies 89%, and erosive phenotype 35%. At baseline, mean DAS28 and RAPID3 were 5.4±1.3 and 16.6±6.8, respectively. SC abatacept monotherapy was reported in 27%. Demographics and disease characteristics were similar in all groups, except for baseline DAS28 and RAPID3 in switch group (p<0.0001). According to the Mantel-Haenszel test (Fig.1), there were not significant differences between survival curves (p=0.158). Forty-three patients (33%) discontinued treatment. The most frequent reasons for drug suspension were loss of efficacy in 25%, insurance-related problems (i.e., access to medication/specialist) and adverse drug reactions in 16%. Other causes include lack of efficacy, surgeries (i.e., articular replacement), patient preference, and pregnancy.application/pdfISSN: 0003-4967EISSN: 1468-2060https://repository.urosario.edu.co/handle/10336/28079engEuropean League Against RheumatismBMJ PublishingNo. 2850Annals of the Rheumatic DiseasesVol. 76Annals of the Rheumatic Diseases, ISSN: 0003-4967;EISSN: 1468-2060, Vol.76, Suppl No.2 (2017); pp. 850Scientific Abstracts; pp. SAT0205https://ard.bmj.com/content/annrheumdis/76/Suppl_2/850.2.full.pdfAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Annals of the Rheumatic Diseasesinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURLong-termSurvival of subcutaneousRheumatoid arthritisLong-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort studySupervivencia del fármaco a largo plazo y causas de interrupción del abatacept subcutáneo en la artritis reumatoide: resultados a 32 meses de un estudio de cohorte prospectivoarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Sarmiento-Monroy, JCMolano González, NicolásRodríguez Jiménez, Mónica María del PilarMantilla, RD10336/28079oai:repository.urosario.edu.co:10336/280792021-10-15 06:23:17.618https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
dc.title.TranslatedTitle.spa.fl_str_mv |
Supervivencia del fármaco a largo plazo y causas de interrupción del abatacept subcutáneo en la artritis reumatoide: resultados a 32 meses de un estudio de cohorte prospectivo |
title |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
spellingShingle |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study Long-term Survival of subcutaneous Rheumatoid arthritis |
title_short |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
title_full |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
title_fullStr |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
title_full_unstemmed |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
title_sort |
Long-term drug survival and causes of discontinuation of subcutaneous abatacept in rheumatoid arthritis: 32-month results from a prospective cohort study |
dc.subject.keyword.spa.fl_str_mv |
Long-term Survival of subcutaneous Rheumatoid arthritis |
topic |
Long-term Survival of subcutaneous Rheumatoid arthritis |
description |
Background Survival time or time to discontinuation of medication is a surrogate of the long-term impact on the course of disease in real life. It reflects clinical effectiveness in the absence of significant adverse events [1]. Treatment discontinuation can result from loss of efficacy or safety concerns, but prognostic factors for patient retention have not been explored thoroughly despite data for abatacept and other biologics being available from national registries [2]. Objectives To assess drug survival of subcutaneous (SC) abatacept among patients with rheumatoid arthritis (RA) according to treatment background. Methods This was a prospective study in which well-characterized patients with RA (by 1987 ACR criteria) were assessed from April 2014 to December 2016. Each patient was evaluated by a rheumatologist in a single rheumatology outpatient private center in Bogotá, Colombia. Patients were stratified by treatment background: (n=54) biologic-naïve, (n=24) switched from IV to SC abatacept administration, and (n=51) inadequate response to at least 1 biologic disease-modifying antirheumatic drug. The Mantel-Haenszel test was used to test if there were any differences in the survival curves among groups. The test was performed by the survdiff function of the “survival” R package [3]. Results A total of 129 patients were included. Baseline characteristics of patients were as follows: female gender 86%, mean age 52±13 years, median disease duration 10 (IQR 11) years, Rheumatoid Factor positive 94%, Anti-Cyclic Citrullinated Peptide Antibodies 89%, and erosive phenotype 35%. At baseline, mean DAS28 and RAPID3 were 5.4±1.3 and 16.6±6.8, respectively. SC abatacept monotherapy was reported in 27%. Demographics and disease characteristics were similar in all groups, except for baseline DAS28 and RAPID3 in switch group (p<0.0001). According to the Mantel-Haenszel test (Fig.1), there were not significant differences between survival curves (p=0.158). Forty-three patients (33%) discontinued treatment. The most frequent reasons for drug suspension were loss of efficacy in 25%, insurance-related problems (i.e., access to medication/specialist) and adverse drug reactions in 16%. Other causes include lack of efficacy, surgeries (i.e., articular replacement), patient preference, and pregnancy. |
publishDate |
2017 |
dc.date.created.spa.fl_str_mv |
2017-06-17 |
dc.date.accessioned.none.fl_str_mv |
2020-08-19T14:45:38Z |
dc.date.available.none.fl_str_mv |
2020-08-19T14:45:38Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0003-4967 EISSN: 1468-2060 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/28079 |
identifier_str_mv |
ISSN: 0003-4967 EISSN: 1468-2060 |
url |
https://repository.urosario.edu.co/handle/10336/28079 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationIssue.none.fl_str_mv |
No. 2 |
dc.relation.citationStartPage.none.fl_str_mv |
850 |
dc.relation.citationTitle.none.fl_str_mv |
Annals of the Rheumatic Diseases |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 76 |
dc.relation.ispartof.spa.fl_str_mv |
Annals of the Rheumatic Diseases, ISSN: 0003-4967;EISSN: 1468-2060, Vol.76, Suppl No.2 (2017); pp. 850 Scientific Abstracts; pp. SAT0205 |
dc.relation.uri.spa.fl_str_mv |
https://ard.bmj.com/content/annrheumdis/76/Suppl_2/850.2.full.pdf |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
European League Against Rheumatism BMJ Publishing |
dc.source.spa.fl_str_mv |
Annals of the Rheumatic Diseases |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167435194925056 |