Effects of exercise training on Fetuin-a in obese, type 2 diabetes and cardiovascular disease in adults and elderly: A systematic review and Meta-analysis

Background: Elevated levels of fetuin-A are associated with increased risks of metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver disease. This meta-analysis investigated whether exercise interventions can reduce fetuin-A in adults. Methods: We searched clinical trials that objectively assessed fetuin-A and included study arms with exercise intervention. The pre-intervention and post-intervention data were used for meta-analysis. The effect sizes were calculated as standardized mean differences or changes in fetuin-A and expressed as Hedges' g using random-effects models. Results: The overall Hedges' g for fetuin-A in all included interventions was - 0.640 (95%CI - 1.129 to - 0.151; n = 9), but this effect was not observed in obese (g = - 0.096; 95%CI, - 0.328 to 0.135) and type 2 diabetes/dysglycemia (g = - 0.56; 95%CI, - 1.348 to 0.236) individuals. Additionally, the random-effects meta-regression analysis showed that there was not a greater decrease in fetuin-A in individuals who achieved greater body mass index reductions (regression coefficient = 0.065; 95%CI, - 0.185 to 0.315). Conclusion: Supervised exercise is associated with reductions in fetuin-A levels in adults and elderly. However, the results of the present meta-analysis should be interpreted with caution because of the variety of type of exercises and individual obesity related-disorders involve. Therefore, additional high-quality randomized controlled trials describing the effect of supervised exercise interventions on fetuin-A in adults are still needed. © 2019 The Author(s).

• Fecha de publicación: 2019
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22540
• Acceso en línea: https://doi.org/10.1186/s12944-019-0962-2; https://repository.urosario.edu.co/handle/10336/22540
• Palabra clave: Fetuin A; Fetuin A; Adult; Aged; Body mass; Cardiovascular disease; Clinical assessment; Clinical effectiveness; Clinical evaluation; Clinical protocol; Disease association; Enzyme linked immunosorbent assay; Exercise; Exercise intensity; Human; Meta analysis; Non insulin dependent diabetes mellitus; Obesity; Protein blood level; Protein expression; Review; Risk factor; Systematic review; Metabolism; Middle aged; Non insulin dependent diabetes mellitus; Obesity; Publishing; Randomized controlled trial (topic); Regression analysis; Adult; Aged; Alpha-2-HS-Glycoprotein; Exercise; Humans; Middle Aged; Obesity; Publication Bias; Randomized Controlled Trials as Topic; Regression Analysis; Risk Factors; Cardiovascular disease; Exercise training; Fetuin-a; Meta-analysis; Metabolic syndrome; Obesity; Systematic review; Type 2 diabetes; Type 2; Diabetes Mellitus
• License: Abierto (Texto Completo)