Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis

Antecedentes: La Artritis Reumatoide (AR) es una enfermedad autoinmune, caracterizada por un daño articular progresivo que limita la calidad de vida y años laborales de los pacientes, y un alto costo para los sistemas de salud. Aún se desconoce completamente su fisiopatología, sin embargo, se han re...

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2024
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Universidad del Rosario
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Repositorio EdocUR - U. Rosario
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spa
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oai:repository.urosario.edu.co:10336/42989
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https://repository.urosario.edu.co/handle/10336/42989
Palabra clave:
Artritis reumatoide
Artritis reumatoide sistémica juvenil
Artritis Idiopática juvenil
Survivina
Biomarcadores
Rheumatoid arthritis
Juvenile Systemic Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
Survivin
Biomarkers
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Attribution-NonCommercial-NoDerivatives 4.0 International
id EDOCUR2_df03497be6ec27b87f1561136040c657
oai_identifier_str oai:repository.urosario.edu.co:10336/42989
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
dc.title.TranslatedTitle.none.fl_str_mv Survivin levels and its clinical utility in rheumatoid arthritis/juvenile idiopathic arthritis: systematic review of the literature and meta-analysis
title Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
spellingShingle Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
Artritis reumatoide
Artritis reumatoide sistémica juvenil
Artritis Idiopática juvenil
Survivina
Biomarcadores
Rheumatoid arthritis
Juvenile Systemic Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
Survivin
Biomarkers
title_short Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
title_full Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
title_fullStr Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
title_full_unstemmed Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
title_sort Niveles de survivina y su utilidad clínica en la artritis reumatoide/artritis idiopática juvenil: revisión sistemática de la literatura y meta-análisis
dc.contributor.advisor.none.fl_str_mv Rojas Quintana, Manuel Eduardo
Acosta Ampudia, Yeny Yasbleidy
dc.contributor.gruplac.none.fl_str_mv Centro de Estudio de Enfermedades Autoinmunes - CREA
dc.subject.none.fl_str_mv Artritis reumatoide
Artritis reumatoide sistémica juvenil
Artritis Idiopática juvenil
Survivina
Biomarcadores
topic Artritis reumatoide
Artritis reumatoide sistémica juvenil
Artritis Idiopática juvenil
Survivina
Biomarcadores
Rheumatoid arthritis
Juvenile Systemic Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
Survivin
Biomarkers
dc.subject.keyword.none.fl_str_mv Rheumatoid arthritis
Juvenile Systemic Rheumatoid Arthritis
Juvenile Idiopathic Arthritis
Survivin
Biomarkers
description Antecedentes: La Artritis Reumatoide (AR) es una enfermedad autoinmune, caracterizada por un daño articular progresivo que limita la calidad de vida y años laborales de los pacientes, y un alto costo para los sistemas de salud. Aún se desconoce completamente su fisiopatología, sin embargo, se han realizado estudios en busca de nuevos biomarcadores para su diagnóstico. La Survivina aparentemente está implicada en la fisiopatología de la enfermedad y es un potencial biomarcador en esta condición. Objetivos: Integrar la evidencia del papel de la proteína Survivina y su asociación con la AR y Artritis Idiopática Juvenil (AIJ), a través de una revisión sistemática de la literatura. Métodos de búsqueda: Se hicieron búsquedas en las siguientes bases de datos hasta abril de 2023: PubMed, EMBASE, y CINAHL. Criterios de selección: Se incluyeron todos los estudios observacionales analíticos y ensayos clínicos que incluían pacientes con AR o AIJ, y controles sanos, que evaluaran la presencia de Survivina en suero, plasma o líquido sinovial detectado por medio de ELISA o qPCR. Obtención y análisis de los datos: Dos investigadores revisaron y evaluaron de forma independiente la literatura para inclusión y riesgo de sesgo, se extrajeron los datos y verificaron su exactitud, se construyó la base de datos con las variables incluidas. Para la positividad de Survivina se usó la estimación de OR usando modelo de efectos aleatorios, y para el caso de los valores cuantitativos usamos la diferencia de medias estandarizadas (DME). Resultados principales: El meta-análisis incluyó siete estudios, 5 estudios incluyeron casos y controles (n: 3 para AR, y n: 2 AIJ) y 2 fueron estudios transversales (AR). Los pacientes con AR/AIJ tuvieron una mayor positividad para Survivina en suero en comparación con los controles (913/1738 [52,5%] frente a 245/2010 [ 12,1%]) con un OR 13,89 [IC 95%, 1,74- 110,89]). El análisis de DME confirmó que los pacientes con AR/AIJ presentan niveles más elevados de Survivina en comparación con los controles (DME = 2,05 [IC del 95 %: 0,55-3,56]). Respecto a líquido sinovial, estudios demostraron niveles elevados de Survivina en líquido sinovial en pacientes con AIJ y AR en comparación con controles, mediante ELISA, inmunohistoquímica, entre otras. Así mismo, diferentes estudios han reportado la correlación entre niveles elevados de Survivina, con tabaquismo y positividad de autoanticuerpos (FR y ACPAs). 12 Conclusiones: La Survivina es un potencial biomarcador para el diagnóstico de AR/AIJ. Estudios que evalúen si el biomarcador de artritis-especifico, así como su importancia en la actividad de la enfermedad y el pronóstico, son necesarios.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-10T14:29:24Z
dc.date.available.none.fl_str_mv 2024-07-10T14:29:24Z
dc.date.created.none.fl_str_mv 2024-06-10
dc.type.none.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.none.fl_str_mv Trabajo de grado
dc.type.spa.none.fl_str_mv Trabajo de grado
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/42989
url https://repository.urosario.edu.co/handle/10336/42989
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.none.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.none.fl_str_mv 70 pp
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
dc.publisher.department.none.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Especialización en Epidemiología
publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
institution Universidad del Rosario
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Chaudhary, Ajay K.; Yadav, Neelu; Bhat, Tariq A.; O’Malley, Jordan; Kumar, Sandeep; Chandra, Dhyan (2016) A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy. En: Drug Discovery Today. Vol. 21; No. 1; pp. 38 - 47; Disponible en: 10.1016/j.drudis.2015.07.014.
Dharmapatni, Anak ASSK; Smith, Malcolm D; Findlay, David M; Holding, Christopher A; Evdokiou, Andreas; Ahern, Michael J; Weedon, Helen; Chen, Paul; Screaton, Gavin; Xu, Xiao N; Haynes, David R (2009) Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synovium. En: Arthritis Research & Therapy. Vol. 11; No. 1; pp. R13 - R13; Disponible en: 10.1186/ar2603.
Ahn, Joong Kyong; Oh, Ji-Min; Lee, Jaejoon; Bae, Eun-Kyung; Ahn, Kwang-Sung; Cha, Hoon-Suk; Koh, Eun-Mi (2010) Increased extracellular survivin in the synovial fluid of rheumatoid arthritis patients: fibroblast-like synoviocytes as a potential source of extracellular survivin. En: Inflammation. Vol. 33; No. 6; pp. 381 - 8; Disponible en: 10.1007/s10753-010-9196-1.
Prahalad, Sampath; Glass, David N (2002) Is juvenile rheumatoid arthritis/juvenile idiopathic arthritis different from rheumatoid arthritis?. En: Arthritis Research. Vol. 4; No. Suppl 3; pp. 303 - 303; Disponible en: 10.1186/ar594.
Chang, Jang-Yang; Cheung, Chun Hei Antonio; Huang, Chien-Chang; Tsai, Fang-Ying; Lee, Jane Ying-Chieh; Cheng, Siao Muk; Chang, Yung-Chieh; Huang, Yi-Chun; Chen, Shang-Hung (2013) Survivin. En: OncoTargets and Therapy. pp. 1453 - 1453; Disponible en: 10.2147/OTT.S33374.
Li, Fengzhi (2003) Survivin study: What is the next wave?. En: Journal of Cellular Physiology. Vol. 197; No. 1; pp. 8 - 29; Disponible en: 10.1002/jcp.10327.
Gravina, G.; Wasén, C.; Garcia-Bonete, M.J.; Turkkila, M.; Erlandsson, M.C.; Töyrä Silfverswärd, S.; Brisslert, M.; Pullerits, R.; Andersson, K.M.; Katona, G.; Bokarewa, M.I. (2017) Survivin in autoimmune diseases. En: Autoimmunity Reviews. Vol. 16; No. 8; pp. 845 - 855; Disponible en: 10.1016/j.autrev.2017.05.016.
Kitagawa, Mayumi; Lee, Sang Hyun (2015) The chromosomal passenger complex (CPC) as a key orchestrator of orderly mitotic exit and cytokinesis. En: Frontiers in Cell and Developmental Biology. Vol. 3; Disponible en: 10.3389/fcell.2015.00014.
Eckelman, Brendan P; Salvesen, Guy S; Scott, Fiona L (2006) Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. En: EMBO reports. Vol. 7; No. 10; pp. 988 - 994; Disponible en: 10.1038/sj.embor.7400795.
Araya, Luam E.; Soni, Ishankumar V.; Hardy, Jeanne A.; Julien, Olivier (2021) Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. En: ACS Chemical Biology. Vol. 16; No. 11; pp. 2280 - 2296; Disponible en: 10.1021/acschembio.1c00456.
Altznauer, Frank; Martinelli, Sibylla; Yousefi, Shida; Thürig, Christine; Schmid, Inès; Conway, Edward M.; Schöni, Martin H.; Vogt, Peter; Mueller, Christoph; Fey, Martin F.; Zangemeister-Wittke, Uwe; Simon, Hans-Uwe (2004) Inflammation-associated Cell Cycle–independent Block of Apoptosis by Survivin in Terminally Differentiated Neutrophils. En: The Journal of Experimental Medicine. Vol. 199; No. 10; pp. 1343 - 1354; Disponible en: 10.1084/jem.20032033.
Xing, Zheng; Conway, Edward M.; Kang, Chulho; Winoto, Astar (2004) Essential Role of Survivin, an Inhibitor of Apoptosis Protein, in T Cell Development, Maturation, and Homeostasis. En: The Journal of Experimental Medicine. Vol. 199; No. 1; pp. 69 - 80; Disponible en: 10.1084/jem.20031588.
Bokarewa, Maria; Brink, Mikael; Erlandsson, Malin; Rantapää Dahlqvist, Solbritt (2014) Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study. En: Arthritis Research & Therapy. Vol. 16; No. 1; pp. R45 - R45; Disponible en: 10.1186/ar4474.
Levitsky, Adrian; Erlandsson, Malin C.; van Vollenhoven, Ronald F.; Bokarewa, Maria I. (2015) Serum survivin predicts responses to treatment in active rheumatoid arthritis: a post hoc analysis from the SWEFOT trial. En: BMC Medicine. Vol. 13; No. 1; pp. 247 - 247; Disponible en: 10.1186/s12916-015-0485-2.
Shi, Rui; Chen, Muzhi; Litifu, Bahaerguli; Zhaorigetu (2018) Serum interleukin-6 and survivin levels predict clinical response to etanercept treatment in patients with established rheumatoid arthritis. En: Modern Rheumatology. Vol. 28; No. 1; pp. 126 - 132; Disponible en: 10.1080/14397595.2017.1317384.
Figus, Fabiana Assunta; Piga, Matteo; Azzolin, Irene; McConnell, Rebecca; Iagnocco, Annamaria (2021) Rheumatoid arthritis: Extra-articular manifestations and comorbidities. En: Autoimmunity Reviews. Vol. 20; No. 4; pp. 102776 - 102776; Disponible en: 10.1016/j.autrev.2021.102776.
Pahlavan, Yasamin; kahroba, Houman; Samadi, Nasser; Karimi, Abbas; Ansarin, Khalil; Khabbazi, Alireza (2019) Survivin modulatory role in autoimmune and autoinflammatory diseases. En: Journal of Cellular Physiology. Vol. 234; No. 11; pp. 19440 - 19450; Disponible en: 10.1002/jcp.28725.
Littlejohn, Emily A.; Monrad, Seetha U. (2018) Early Diagnosis and Treatment of Rheumatoid Arthritis. En: Primary Care: Clinics in Office Practice. Vol. 45; No. 2; pp. 237 - 255; Disponible en: 10.1016/j.pop.2018.02.010.
Smith, M. D.; Weedon, H.; Papangelis, V.; Walker, J.; Roberts-Thomson, P. J.; Ahern, M. J. (2010) Apoptosis in the rheumatoid arthritis synovial membrane: modulation by disease-modifying anti-rheumatic drug treatment. En: Rheumatology. Vol. 49; No. 5; pp. 862 - 875; Disponible en: 10.1093/rheumatology/kep467.
Erlandsson, Malin C.; Forslind, Kristina; Andersson, Sofia E. M.; Lund, Annelie; Bokarewa, Maria I. (2012) Metastasin S100A4 is increased in proportion to radiographic damage in patients with RA. En: Rheumatology. Vol. 51; No. 5; pp. 932 - 940; Disponible en: 10.1093/rheumatology/ker362.
Park, M-C; Chung, S-J; Park, Y-B; Lee, S-K (2008) Relationship of angiogenic factors to disease activity and radiographic damage in rheumatoid arthritis. En: Clinical and experimental rheumatology. Vol. 26; No. 5; pp. 881 - 6;
Wasén, Caroline; Turkkila, Minna; Bossios, Apostolos; Erlandsson, Malin; Andersson, Karin M.; Ekerljung, Linda; Malmhäll, Carina; Brisslert, Mikael; Töyrä Silfverswärd, Sofia; Lundbäck, Bo; Bokarewa, Maria I. (2017) Smoking activates cytotoxic CD8+ T cells and causes survivin release in rheumatoid arthritis. En: Journal of Autoimmunity. Vol. 78; pp. 101 - 110; Disponible en: 10.1016/j.jaut.2016.12.009.
Turkkila, Minna; Andersson, Karin M.E.; Amu, Sylvie; Brisslert, Mikael; Erlandsson, Malin C.; Silfverswärd, Sofia; Bokarewa, Maria I. (2015) Suppressed diversity of survivin splicing in active rheumatoid arthritis. En: Arthritis Research & Therapy. Vol. 17; No. 1; pp. 175 - 175; Disponible en: 10.1186/s13075-015-0689-z.
Andersson, Karin M.E.; Turkkila, Minna; Erlandsson, Malin C.; Bossios, Apostolos; Silfverswärd, Sofia Töyrä; Hu, Dan; Ekerljung, Linda; Malmhäll, Carina; Weiner, Howard L.; Lundbäck, Bo; Bokarewa, Maria I. (2017) Survivin controls biogenesis of microRNA in smokers: A link to pathogenesis of rheumatoid arthritis. En: Biochimica et Biophysica Acta (BBA). Vol. 1863; No. 3; pp. 663 - 673; Disponible en: 10.1016/j.bbadis.2016.11.033.
Erlandsson, Malin C.; Turkkila, Minna; Siljehult, Filip; Pullerits, Rille; Eriksson, Catharina; Rantapää-Dahlqvist, Solbritt; Bokarewa, Maria I. (2018) Survivin improves the early recognition of rheumatoid arthritis among patients with arthralgia: A population-based study within two university cities of Sweden. En: Seminars in Arthritis and Rheumatism. Vol. 47; No. 6; pp. 778 - 785; Disponible en: 10.1016/j.semarthrit.2017.10.020.
Baran, Marcin; Möllers, Linda Nilsson; Andersson, Sofia; Jonsson, Ing‐Marie; Ekwall, Anna‐Karin Hultgård; Bjersing, Jan; Tarkowski, Andrej; Bokarewa, Maria (2009) Survivin is an essential mediator of arthritis interacting with urokinase signalling. En: Journal of Cellular and Molecular Medicine. Vol. 13; No. 9b; pp. 3797 - 3808; Disponible en: 10.1111/j.1582-4934.2009.00721.x.
Jenko, Barbara; Praprotnik, Sonja; Čučnik, Saša; Rotar, Žiga; Tomšič, Matija; Dolžan, Vita (2016) Survivin polymorphism is associated with disease activity in rheumatoid arthritis patients. En: Pharmacogenomics. Vol. 17; No. 1; pp. 45 - 9; Disponible en: 10.2217/pgs.15.147.
Ma, Sha; Wang, Jing; Lin, Jun; Jin, Song; He, Fang; Mei, Jian; Zhang, Hong; Wang, Shuya; Li, Qin (2021) Survivin promotes rheumatoid arthritis fibroblast‐like synoviocyte cell proliferation, and the expression of angiogenesis‐related proteins by activating the NOTCH pathway. En: International Journal of Rheumatic Diseases. Vol. 24; No. 7; pp. 922 - 929; Disponible en: 10.1111/1756-185X.14150.
Ebrahimiyan, Hamidreza; Rezaei, Nima; Vojdanian, Mahdi; Aslani, Saeed; Jamshidi, Ahmadreza; Mahmoudi, Mahdi (2019) microRNA involvement in the regulation of survivin in peripheral blood mononuclear cells from rheumatoid arthritis patients. En: International Journal of Rheumatic Diseases. Vol. 22; No. 6; pp. 1107 - 1114; Disponible en: 10.1111/1756-185X.13520.
Chen, Danna; Liu, Dongdong; Liu, Dan; He, Min; Peng, Anping; Xu, Jiarui; Lin, Li; Luo, Fudong; Chen, Lin; Huang, Xianzhang; Zhuang, Junhua; Xu, Jianhua (2017) Rheumatoid Arthritis Fibroblast-like Synoviocyte Suppression Mediated by PTEN Involves Survivin Gene Silencing. En: Scientific Reports. Vol. 7; No. 1; pp. 367 - 367; Disponible en: 10.1038/s41598-017-00517-w.
YANG, SHUZHONG; YANG, YOUGENG (2015) Downregulation of microRNA-221 decreases migration and invasion in fibroblast-like synoviocytes in rheumatoid arthritis. En: Molecular Medicine Reports. Vol. 12; No. 2; pp. 2395 - 2401; Disponible en: 10.3892/mmr.2015.3642.
Mokuda, Sho; Miyazaki, Tatsuhiko; Ito, Yuki; Yamasaki, Satoshi; Inoue, Hiroko; Guo, Yun; Kong, Weng-Sheng; Kanno, Masamoto; Takasugi, Kiyoshi; Sugiyama, Eiji; Masumoto, Junya (2015) The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. En: Scientific Reports. Vol. 5; No. 1; pp. 9795 - 9795; Disponible en: 10.1038/srep09795.
Mera, Simona; Magnusson, Mattias; Tarkowski, Andrej; Bokarewa, Maria (2008) Extracellular survivin up-regulates adhesion molecules on the surface of leukocytes changing their reactivity pattern. En: Journal of Leukocyte Biology. Vol. 83; No. 1; pp. 149 - 155; Disponible en: 10.1189/jlb.0507287.
Long, Xian Ming (2014) Expression of Survivin in Patients With Refractory Rheumatoid Arthritis in a Chinese Population. En: Archives of Rheumatology. Vol. 29; No. 2; pp. 81 - 87; Disponible en: 10.5606/ArchRheumatol.2014.3841.
Liu, Yun; Aryee, Martin J; Padyukov, Leonid; Fallin, M Daniele; Hesselberg, Espen; Runarsson, Arni; Reinius, Lovisa; Acevedo, Nathalie; Taub, Margaret; Ronninger, Marcus; Shchetynsky, Klementy; Scheynius, Annika; Kere, Juha; Alfredsson, Lars; Klareskog, Lars; Ekström, Tomas J; Feinberg, Andrew P (2013) Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. En: Nature Biotechnology. Vol. 31; No. 2; pp. 142 - 147; Disponible en: 10.1038/nbt.2487.
Klein, Kerstin; Gay, Steffen (2015) Epigenetics in rheumatoid arthritis. En: Current opinion in rheumatology. Vol. 27; No. 1; pp. 76 - 82; Disponible en: 10.1097/BOR.0000000000000128.
Vandeputte, Doris; Kathagen, Gunter; D’hoe, Kevin; Vieira-Silva, Sara; Valles-Colomer, Mireia; Sabino, João; Wang, Jun; Tito, Raul Y.; De Commer, Lindsey; Darzi, Youssef; Vermeire, Séverine; Falony, Gwen; Raes, Jeroen (2017) Quantitative microbiome profiling links gut community variation to microbial load. En: Nature. Vol. 551; No. 7681; pp. 507 - 511; Disponible en: 10.1038/nature24460.
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Pimsen, Apiradee; Kao, Chi-Yin; Hsu, Sheng-Tzu; Shu, Bih-Ching (2022) The Effect of Advance Care Planning Intervention on Hospitalization Among Nursing Home Residents: A Systematic Review and Meta-Analysis. En: Journal of the American Medical Directors Association. Vol. 23; No. 9; pp. 1448 - 1460.e1; Disponible en: 10.1016/j.jamda.2022.07.017.
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spelling Rojas Quintana, Manuel Eduardo1110541485600Acosta Ampudia, Yeny Yasbleidy38361933600Centro de Estudio de Enfermedades Autoinmunes - CREAGuerrero Acosta, NicolásEspecialista en Epidemiología (en Convenio con el CES)EspecializaciónFull timeb41e15f4-5a64-434f-88c3-470b2d86fc112024-07-10T14:29:24Z2024-07-10T14:29:24Z2024-06-10Antecedentes: La Artritis Reumatoide (AR) es una enfermedad autoinmune, caracterizada por un daño articular progresivo que limita la calidad de vida y años laborales de los pacientes, y un alto costo para los sistemas de salud. Aún se desconoce completamente su fisiopatología, sin embargo, se han realizado estudios en busca de nuevos biomarcadores para su diagnóstico. La Survivina aparentemente está implicada en la fisiopatología de la enfermedad y es un potencial biomarcador en esta condición. Objetivos: Integrar la evidencia del papel de la proteína Survivina y su asociación con la AR y Artritis Idiopática Juvenil (AIJ), a través de una revisión sistemática de la literatura. Métodos de búsqueda: Se hicieron búsquedas en las siguientes bases de datos hasta abril de 2023: PubMed, EMBASE, y CINAHL. Criterios de selección: Se incluyeron todos los estudios observacionales analíticos y ensayos clínicos que incluían pacientes con AR o AIJ, y controles sanos, que evaluaran la presencia de Survivina en suero, plasma o líquido sinovial detectado por medio de ELISA o qPCR. Obtención y análisis de los datos: Dos investigadores revisaron y evaluaron de forma independiente la literatura para inclusión y riesgo de sesgo, se extrajeron los datos y verificaron su exactitud, se construyó la base de datos con las variables incluidas. Para la positividad de Survivina se usó la estimación de OR usando modelo de efectos aleatorios, y para el caso de los valores cuantitativos usamos la diferencia de medias estandarizadas (DME). Resultados principales: El meta-análisis incluyó siete estudios, 5 estudios incluyeron casos y controles (n: 3 para AR, y n: 2 AIJ) y 2 fueron estudios transversales (AR). Los pacientes con AR/AIJ tuvieron una mayor positividad para Survivina en suero en comparación con los controles (913/1738 [52,5%] frente a 245/2010 [ 12,1%]) con un OR 13,89 [IC 95%, 1,74- 110,89]). El análisis de DME confirmó que los pacientes con AR/AIJ presentan niveles más elevados de Survivina en comparación con los controles (DME = 2,05 [IC del 95 %: 0,55-3,56]). Respecto a líquido sinovial, estudios demostraron niveles elevados de Survivina en líquido sinovial en pacientes con AIJ y AR en comparación con controles, mediante ELISA, inmunohistoquímica, entre otras. Así mismo, diferentes estudios han reportado la correlación entre niveles elevados de Survivina, con tabaquismo y positividad de autoanticuerpos (FR y ACPAs). 12 Conclusiones: La Survivina es un potencial biomarcador para el diagnóstico de AR/AIJ. Estudios que evalúen si el biomarcador de artritis-especifico, así como su importancia en la actividad de la enfermedad y el pronóstico, son necesarios.Background: Rheumatoid arthritis (RA) is an autoimmune disease characterized by progressive joint damage that limits patients' quality of life and working years, generating high costs for healthcare systems. Its pathophysiology is still completely unknown; however, studies have been conducted in search of new biomarkers for its diagnosis. Survivin is apparently involved in the pathophysiology of the disease and is a potential biomarker in this condition. Objectives: To integrate the evidence on the role of the Survivin protein and its association with RA and Juvenile Idiopathic Arthritis (JIA), through a systematic review of the literature. Search methods: Searches were conducted in the following databases until April 2023: PubMed, EMBASE, and CINAHL. Selection criteria: Were included all analytical observational studies and clinical trials including patients with RA or JIA versus controls, evaluating the presence of Survivin in serum, plasma, or synovial fluid detected by ELISA or qPCR. Data collection and analysis: Two researchers independently reviewed and assessed the literature for inclusion and risk of bias, extracted data and checked their accuracy, and constructed the database with the included variables. For Survivin positivity, the OR was estimated using a random effects model, and for quantitative values we used the standardized mean difference (SMD). Main results: The meta-analysis included seven studies, five studies included case-control studies (n: 3 for RA, and n: 2 JIA) and two were cross-sectional studies (RA). RA/JIA patients had higher serum Survivin positivity compared to controls (913/1738 [52.5%] vs. 245/2010 [12.1%]) with an OR (13.89 [95% CI, 1.74-110.89]). SMD analysis confirmed that RA/JIA patients have higher levels of Survivin compared to controls (SMD = 2.05 [95% CI, 0.55-3.56]). Regarding synovial fluid, studies demonstrated elevated levels of Survivin in synovial fluid in JIA and RA patients compared to controls, as measured by ELISA, immunohistochemistry, among others. Likewise, different studies have reported a correlation between elevated levels of Survivin and both smoking and positivity of autoantibodies (RF and ACPAs). Conclusions: Survivin is a potential biomarker for the diagnosis of RA/JIA. Studies evaluating the suitability of this arthritis-specific biomarker is suitable, as well as its importance in disease activity and prognosis, are needed.70 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/42989spaUniversidad del RosarioUniversidad CES. Facultad de MedicinaEscuela de Medicina y Ciencias de la SaludEspecialización en EpidemiologíaAttribution-NonCommercial-NoDerivatives 4.0 InternationalAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Smolen, Josef S; Aletaha, Daniel; McInnes, Iain B (2016) Rheumatoid arthritis. En: The Lancet. Vol. 388; No. 10055; pp. 2023 - 2038; Disponible en: 10.1016/S0140-6736(16)30173-8.Finckh, Axel; Gilbert, Benoît; Hodkinson, Bridget; Bae, Sang-Cheol; Thomas, Ranjeny; Deane, Kevin D.; Alpizar-Rodriguez, Deshiré; Lauper, Kim (2022) Global epidemiology of rheumatoid arthritis. En: Nature Reviews Rheumatology. Disponible en: 10.1038/s41584-022-00827-y.Birnbaum, Howard; Pike, Crystal; Kaufman, Rebecca; Maynchenko, Maryna; Kidolezi, Yohanne; Cifaldi, Mary (2010) Societal cost of rheumatoid arthritis patients in the US. En: Current Medical Research and Opinion. 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