Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants

Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and r...

Full description

Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/28873
Acceso en línea:
https://doi.org/10.1007/978-1-4614-7411-1_15
https://repository.urosario.edu.co/handle/10336/28873
Palabra clave:
Pulse Pressure
Mean Arterial Blood Pressure
Cerebral Autoregulation
Cerebral Blood Flow Velocity
Transfer Function Analysis
Rights
License
Restringido (Acceso a grupos específicos)
id EDOCUR2_db678db75da601a7027a5d45d78af2b8
oai_identifier_str oai:repository.urosario.edu.co:10336/28873
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 14139512600fa5269e9-e8e3-4541-8566-008e9ef870ca-155320cda-97a5-498e-9555-cec06026ceda-196a23ae0-f7bb-46ab-afe4-4ff142ad6509-11d162d95-7736-4068-ab14-cba2d36b67a2-1373c77e3-5093-43fd-831b-0db88cefa50d-12020-08-28T15:49:58Z2020-08-28T15:49:58Z2013-06-04Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.application/pdfhttps://doi.org/10.1007/978-1-4614-7411-1_15ISBN: 978-1-4614-7256-8https://repository.urosario.edu.co/handle/10336/28873engSpringer Nature111105Advances in Experimental Medicine and BiologyVol. 789Advances in Experimental Medicine and Biology, ISBN: 978-1-4614-7256-8, Vol.789 (2013); pp. 105-111https://link.springer.com/chapter/10.1007/978-1-4614-7411-1_15Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecAdvances in Experimental Medicine and Biologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPulse PressureMean Arterial Blood PressureCerebral AutoregulationCerebral Blood Flow VelocityTransfer Function AnalysisEffect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature InfantsEfecto del uso materno de labetalol sobre la autorregulación cerebral en lactantes prematurosbookPartParte de librohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_3248Caicedo Dorado, AlexanderAlderliesten, ThomasNaulaers, GunnarLemmers, PetraVan Bel, FrankVan Huffel, Sabine10336/28873oai:repository.urosario.edu.co:10336/288732021-06-03 00:49:42.477https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
dc.title.TranslatedTitle.spa.fl_str_mv Efecto del uso materno de labetalol sobre la autorregulación cerebral en lactantes prematuros
title Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
spellingShingle Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
Pulse Pressure
Mean Arterial Blood Pressure
Cerebral Autoregulation
Cerebral Blood Flow Velocity
Transfer Function Analysis
title_short Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
title_full Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
title_fullStr Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
title_full_unstemmed Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
title_sort Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
dc.subject.keyword.spa.fl_str_mv Pulse Pressure
Mean Arterial Blood Pressure
Cerebral Autoregulation
Cerebral Blood Flow Velocity
Transfer Function Analysis
topic Pulse Pressure
Mean Arterial Blood Pressure
Cerebral Autoregulation
Cerebral Blood Flow Velocity
Transfer Function Analysis
description Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.
publishDate 2013
dc.date.created.spa.fl_str_mv 2013-06-04
dc.date.accessioned.none.fl_str_mv 2020-08-28T15:49:58Z
dc.date.available.none.fl_str_mv 2020-08-28T15:49:58Z
dc.type.eng.fl_str_mv bookPart
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_3248
dc.type.spa.spa.fl_str_mv Parte de libro
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/978-1-4614-7411-1_15
dc.identifier.issn.none.fl_str_mv ISBN: 978-1-4614-7256-8
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/28873
url https://doi.org/10.1007/978-1-4614-7411-1_15
https://repository.urosario.edu.co/handle/10336/28873
identifier_str_mv ISBN: 978-1-4614-7256-8
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 111
dc.relation.citationStartPage.none.fl_str_mv 105
dc.relation.citationTitle.none.fl_str_mv Advances in Experimental Medicine and Biology
dc.relation.citationVolume.none.fl_str_mv Vol. 789
dc.relation.ispartof.spa.fl_str_mv Advances in Experimental Medicine and Biology, ISBN: 978-1-4614-7256-8, Vol.789 (2013); pp. 105-111
dc.relation.uri.spa.fl_str_mv https://link.springer.com/chapter/10.1007/978-1-4614-7411-1_15
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Springer Nature
dc.source.spa.fl_str_mv Advances in Experimental Medicine and Biology
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167444064829440