Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants
Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and r...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2013
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/28873
- Acceso en línea:
- https://doi.org/10.1007/978-1-4614-7411-1_15
https://repository.urosario.edu.co/handle/10336/28873
- Palabra clave:
- Pulse Pressure
Mean Arterial Blood Pressure
Cerebral Autoregulation
Cerebral Blood Flow Velocity
Transfer Function Analysis
- Rights
- License
- Restringido (Acceso a grupos específicos)
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Repositorio EdocUR - U. Rosario |
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14139512600fa5269e9-e8e3-4541-8566-008e9ef870ca-155320cda-97a5-498e-9555-cec06026ceda-196a23ae0-f7bb-46ab-afe4-4ff142ad6509-11d162d95-7736-4068-ab14-cba2d36b67a2-1373c77e3-5093-43fd-831b-0db88cefa50d-12020-08-28T15:49:58Z2020-08-28T15:49:58Z2013-06-04Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation.application/pdfhttps://doi.org/10.1007/978-1-4614-7411-1_15ISBN: 978-1-4614-7256-8https://repository.urosario.edu.co/handle/10336/28873engSpringer Nature111105Advances in Experimental Medicine and BiologyVol. 789Advances in Experimental Medicine and Biology, ISBN: 978-1-4614-7256-8, Vol.789 (2013); pp. 105-111https://link.springer.com/chapter/10.1007/978-1-4614-7411-1_15Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecAdvances in Experimental Medicine and Biologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPulse PressureMean Arterial Blood PressureCerebral AutoregulationCerebral Blood Flow VelocityTransfer Function AnalysisEffect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature InfantsEfecto del uso materno de labetalol sobre la autorregulación cerebral en lactantes prematurosbookPartParte de librohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_3248Caicedo Dorado, AlexanderAlderliesten, ThomasNaulaers, GunnarLemmers, PetraVan Bel, FrankVan Huffel, Sabine10336/28873oai:repository.urosario.edu.co:10336/288732021-06-03 00:49:42.477https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
dc.title.TranslatedTitle.spa.fl_str_mv |
Efecto del uso materno de labetalol sobre la autorregulación cerebral en lactantes prematuros |
title |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
spellingShingle |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants Pulse Pressure Mean Arterial Blood Pressure Cerebral Autoregulation Cerebral Blood Flow Velocity Transfer Function Analysis |
title_short |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
title_full |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
title_fullStr |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
title_full_unstemmed |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
title_sort |
Effect of Maternal use of Labetalol on the Cerebral Autoregulation in Premature Infants |
dc.subject.keyword.spa.fl_str_mv |
Pulse Pressure Mean Arterial Blood Pressure Cerebral Autoregulation Cerebral Blood Flow Velocity Transfer Function Analysis |
topic |
Pulse Pressure Mean Arterial Blood Pressure Cerebral Autoregulation Cerebral Blood Flow Velocity Transfer Function Analysis |
description |
Hypertensive disorders of pregnancy (HDP) are normally treated to avoid maternal complications. In this study we aimed to investigate if there was an effect of maternal HDP treatment on the cerebral autoregulation of the neonates by analysing measurements of mean arterial blood pressure (MABP) and rScO2 by means of correlation, coherence, and transfer function analysis. We found that these infants presented higher values of transfer function gain, which indicates impaired cerebral autoregulation, with a decreasing trend towards normality. We hypothesised that this trend was due to a vasodilation effect of the maternal use of labetalol due to accumulation, which disappeared by the third day after birth. Therefore, we investigated the values of pulse pressure in order to find evidence for a vasodilatory effect. We found that lower values of pulse pressure were present in these infants when compared with a control population, which, together with increased transfer function gain values, suggests an effect of the drug on the cerebral autoregulation. |
publishDate |
2013 |
dc.date.created.spa.fl_str_mv |
2013-06-04 |
dc.date.accessioned.none.fl_str_mv |
2020-08-28T15:49:58Z |
dc.date.available.none.fl_str_mv |
2020-08-28T15:49:58Z |
dc.type.eng.fl_str_mv |
bookPart |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_3248 |
dc.type.spa.spa.fl_str_mv |
Parte de libro |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/978-1-4614-7411-1_15 |
dc.identifier.issn.none.fl_str_mv |
ISBN: 978-1-4614-7256-8 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/28873 |
url |
https://doi.org/10.1007/978-1-4614-7411-1_15 https://repository.urosario.edu.co/handle/10336/28873 |
identifier_str_mv |
ISBN: 978-1-4614-7256-8 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
111 |
dc.relation.citationStartPage.none.fl_str_mv |
105 |
dc.relation.citationTitle.none.fl_str_mv |
Advances in Experimental Medicine and Biology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 789 |
dc.relation.ispartof.spa.fl_str_mv |
Advances in Experimental Medicine and Biology, ISBN: 978-1-4614-7256-8, Vol.789 (2013); pp. 105-111 |
dc.relation.uri.spa.fl_str_mv |
https://link.springer.com/chapter/10.1007/978-1-4614-7411-1_15 |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
Springer Nature |
dc.source.spa.fl_str_mv |
Advances in Experimental Medicine and Biology |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167444064829440 |