Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?

Since the first studies in immunology, there has been a clear need to understand how, under normal conditions, the immune system tolerates its own antigens and attacks some foreign antigens that it perceives as potentially dangerous and how, in certain circumstances, the loss of tolerance triggers a...

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Autores:
Tipo de recurso:
Fecha de publicación:
2013
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23073
Acceso en línea:
https://doi.org/10.1016/S0121-8123(13)70138-5
https://repository.urosario.edu.co/handle/10336/23073
Palabra clave:
Chronic graft rejection
Dendritic cell
Human
Immune system
Immunological tolerance
Immunosuppressive treatment
Measurement accuracy
Regulatory t lymphocyte
Review
Tissue transplantation
Autoimmunity
Dendritic cells
T regulatory cells
Tolerance
anergy
Autoreactivity
Rights
License
Abierto (Texto Completo)
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spelling 9759b2fd-9c09-4f25-a5c5-3e12413524ae-13912b992-d728-4eaa-9dc5-ee3007f708d2-10863db14-9994-4939-85f2-b3a79054eee6-12020-05-25T23:59:36Z2020-05-25T23:59:36Z2013Since the first studies in immunology, there has been a clear need to understand how, under normal conditions, the immune system tolerates its own antigens and attacks some foreign antigens that it perceives as potentially dangerous and how, in certain circumstances, the loss of tolerance triggers autoimmune diseases. It has been over half a century since Billingham, Brent and Medawar demonstrated, in an experimental model, the mechanisms involved in the development of immunological tolerance. Since then transplant immunologists have intensively investigated the mechanisms involved in maintaining tolerance, in the hope of avoiding the complications of non-specific immunosuppression, as well as the prevention of chronic rejection. An important characteristic was observed by Medawar, who argued that during transplantation an individual's immune system is tolerant to transplanted tissue, maintaining the response to other antigens. Recent studies have shown that loss of tolerance to transplantation is associated with a hyper-response to antigens of the transplanted tissue; a problem that has plagued clinical immunologists, who have focused their efforts on developing accurate measurement systems to enable them to measure how an individual could be tolerant to transplant. Attempts to induce tolerance in the individual are based on understanding the basic mechanisms of tolerance, in which there has been significant progress. This growth in knowledge has been in parallel with a better appreciation of the complexity of immune tolerance. In particular, progress has been made in understanding the essential role of tolerogenic dendritic cells (CDS) and the maintenance of tolerance by regulatory T cells. © 2013 Asociación Colombiana de Reumatología. Published by Elsevier España, S.L. All rights reserved.application/pdfhttps://doi.org/10.1016/S0121-8123(13)70138-50121812320279000https://repository.urosario.edu.co/handle/10336/23073engAsociacion Colombiana de Reumatologia249No. 4237Revista Colombiana de ReumatologiaVol. 20Revista Colombiana de Reumatologia, ISSN:01218123, 20279000, Vol.20, No.4 (2013); pp. 237-249https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026339979&doi=10.1016%2fS0121-8123%2813%2970138-5&partnerID=40&md5=e9c53efa93789f6c43d9a12f754f999eAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURChronic graft rejectionDendritic cellHumanImmune systemImmunological toleranceImmunosuppressive treatmentMeasurement accuracyRegulatory t lymphocyteReviewTissue transplantationAutoimmunityDendritic cellsT regulatory cellsToleranceanergyAutoreactivityImmune tolerance, a walk through time: How does the immune system differentiate between self and foreign?Tolerancia inmunológica, un recorrido en el tiempo: ¿Cómo discriminar entre lo propio y lo extraño?articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Heber, Siachoque M.Valero, OscarAntonio, Iglesias G.ORIGINALv20n4a08.pdfapplication/pdf1351198https://repository.urosario.edu.co/bitstreams/24852885-ca6b-4c81-8333-2ca2ff6293a9/download8b9508b7977e4c92d7620a0fc675ef12MD51TEXTv20n4a08.pdf.txtv20n4a08.pdf.txtExtracted texttext/plain70658https://repository.urosario.edu.co/bitstreams/c25cbec2-f6d8-4388-b056-4d5329c156a2/download0768a9df86ff5af6215c67476eaecebfMD52THUMBNAILv20n4a08.pdf.jpgv20n4a08.pdf.jpgGenerated Thumbnailimage/jpeg4165https://repository.urosario.edu.co/bitstreams/36040077-3f3f-4a33-8ddf-5ce3175e4712/downloadf243612e8e7a43b01ea9d60707940304MD5310336/23073oai:repository.urosario.edu.co:10336/230732022-05-02 07:37:20.445228https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
dc.title.TranslatedTitle.spa.fl_str_mv Tolerancia inmunológica, un recorrido en el tiempo: ¿Cómo discriminar entre lo propio y lo extraño?
title Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
spellingShingle Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
Chronic graft rejection
Dendritic cell
Human
Immune system
Immunological tolerance
Immunosuppressive treatment
Measurement accuracy
Regulatory t lymphocyte
Review
Tissue transplantation
Autoimmunity
Dendritic cells
T regulatory cells
Tolerance
anergy
Autoreactivity
title_short Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
title_full Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
title_fullStr Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
title_full_unstemmed Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
title_sort Immune tolerance, a walk through time: How does the immune system differentiate between self and foreign?
dc.subject.keyword.spa.fl_str_mv Chronic graft rejection
Dendritic cell
Human
Immune system
Immunological tolerance
Immunosuppressive treatment
Measurement accuracy
Regulatory t lymphocyte
Review
Tissue transplantation
Autoimmunity
Dendritic cells
T regulatory cells
Tolerance
topic Chronic graft rejection
Dendritic cell
Human
Immune system
Immunological tolerance
Immunosuppressive treatment
Measurement accuracy
Regulatory t lymphocyte
Review
Tissue transplantation
Autoimmunity
Dendritic cells
T regulatory cells
Tolerance
anergy
Autoreactivity
dc.subject.keyword.eng.fl_str_mv anergy
Autoreactivity
description Since the first studies in immunology, there has been a clear need to understand how, under normal conditions, the immune system tolerates its own antigens and attacks some foreign antigens that it perceives as potentially dangerous and how, in certain circumstances, the loss of tolerance triggers autoimmune diseases. It has been over half a century since Billingham, Brent and Medawar demonstrated, in an experimental model, the mechanisms involved in the development of immunological tolerance. Since then transplant immunologists have intensively investigated the mechanisms involved in maintaining tolerance, in the hope of avoiding the complications of non-specific immunosuppression, as well as the prevention of chronic rejection. An important characteristic was observed by Medawar, who argued that during transplantation an individual's immune system is tolerant to transplanted tissue, maintaining the response to other antigens. Recent studies have shown that loss of tolerance to transplantation is associated with a hyper-response to antigens of the transplanted tissue; a problem that has plagued clinical immunologists, who have focused their efforts on developing accurate measurement systems to enable them to measure how an individual could be tolerant to transplant. Attempts to induce tolerance in the individual are based on understanding the basic mechanisms of tolerance, in which there has been significant progress. This growth in knowledge has been in parallel with a better appreciation of the complexity of immune tolerance. In particular, progress has been made in understanding the essential role of tolerogenic dendritic cells (CDS) and the maintenance of tolerance by regulatory T cells. © 2013 Asociación Colombiana de Reumatología. Published by Elsevier España, S.L. All rights reserved.
publishDate 2013
dc.date.created.spa.fl_str_mv 2013
dc.date.accessioned.none.fl_str_mv 2020-05-25T23:59:36Z
dc.date.available.none.fl_str_mv 2020-05-25T23:59:36Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
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dc.identifier.issn.none.fl_str_mv 01218123
20279000
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https://repository.urosario.edu.co/handle/10336/23073
identifier_str_mv 01218123
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dc.relation.citationEndPage.none.fl_str_mv 249
dc.relation.citationIssue.none.fl_str_mv No. 4
dc.relation.citationStartPage.none.fl_str_mv 237
dc.relation.citationTitle.none.fl_str_mv Revista Colombiana de Reumatologia
dc.relation.citationVolume.none.fl_str_mv Vol. 20
dc.relation.ispartof.spa.fl_str_mv Revista Colombiana de Reumatologia, ISSN:01218123, 20279000, Vol.20, No.4 (2013); pp. 237-249
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