The Long Pentraxin 3 and Its Role in Autoimmunity

Objectives: To review the physiological and physiopathological roles of pentraxin 3 (PTX3), focusing on autoimmunity and vascular pathology. Methods: A systematic literature review using the keywords 'pentraxin 3,' 'innate immunity,' 'apoptosis,' 'autoimmunity,...

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Autores:
Tipo de recurso:
Fecha de publicación:
2009
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23294
Acceso en línea:
https://doi.org/10.1016/j.semarthrit.2008.03.006
https://repository.urosario.edu.co/handle/10336/23294
Palabra clave:
Cytokine
Pentraxin 3
Amino terminal sequence
Antigen antibody reaction
Antigen presentation
Apoptosis
Article
Atherosclerosis
Autoimmune disease
Autoimmunity
Carboxy terminal sequence
Cardiovascular inflammation
Central nervous system
Disease activity
Disease association
Disease course
Disease exacerbation
Disease predisposition
Dna polymorphism
Endothelial dysfunction
Fertility
Gene function
Human
Immune response
Immunological tolerance
Immunopathogenesis
Immunoregulation
Inflammation
Innate immunity
Molecular biology
Molecular weight
Nonhuman
Pregnancy
Priority journal
Promoter region
Protein deficiency
Protein domain
Protein function
Protein modification
Protein secretion
Protein stability
Protein structure
Rna sequence
Single nucleotide polymorphism
Systematic review
Vascular disease
Vascular endothelium
Autoimmunity
C-reactive protein
Humans
Serum amyloid p-component
Vascular diseases
Apoptosis
Autoimmunity
Endothelial dysfunction
Genetics
Innate immunity
Pentraxin 3
innate
vascular
Endothelium
Immunity
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Abierto (Texto Completo)
Description
Summary:Objectives: To review the physiological and physiopathological roles of pentraxin 3 (PTX3), focusing on autoimmunity and vascular pathology. Methods: A systematic literature review using the keywords 'pentraxin 3,' 'innate immunity,' 'apoptosis,' 'autoimmunity,' and 'endothelial dysfunction' from 1990 to 2007 was performed. All relevant articles and pertinent secondary references in English were reviewed. Results: PTX3 has a large number of multiple functions in different contexts. PTX3 plays an important role in innate immunity, inflammation, vascular integrity, fertility, pregnancy, and also in the central nervous system. In innate immunity, its normal function is to increase the immune response to selected pathogens while also exerting control over potential autoimmune reactions. It maintains a tightly homeostatic equilibrium in the local immune microenvironment by avoiding an exaggerated immune response and controlling peripheral tolerance to self-antigens. In contrast, in some autoimmune diseases, PTX3 appears to be involved in the development of autoimmune phenomena. A possible explanation for these apparent paradoxical functions may be related to the highly polymorphic PTX3 gene. Conclusion: PTX3 is physiologically a protective molecule. However, in several autoimmune diseases PTX3 appears to facilitate the development of autoimmunity. The PTX3 gene could influence the development of autoimmune reactions and vascular involvement in human pathology. © 2008 Elsevier Inc. All rights reserved.