Sjögren's syndrome at the crossroad of polyautoimmunity

The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjögren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases. © 2012 Elsevier Ltd.

• Fecha de publicación: 2012
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22253
• Acceso en línea: https://doi.org/10.1016/j.jaut.2012.05.008; https://repository.urosario.edu.co/handle/10336/22253
• Palabra clave: Adult; Antiphospholipid syndrome; Article; Autoimmune disease; Autoimmune hepatitis; Autoimmune thyroiditis; Cigarette smoking; Comorbidity; Cross-sectional study; Disease duration; Enteritis; Female; Human; Major clinical study; Male; Multiple sclerosis; Pernicious anemia; Prevalence; Priority journal; Psoriasis; Rheumatoid arthritis; Risk factor; Sjoegren syndrome; Spontaneous abortion; Systemic lupus erythematosus; Systemic sclerosis; Vasculitis; Vitiligo; Adult; Autoantibodies; Cross-sectional studies; Female; Humans; Inflammatory bowel diseases; Male; Middle aged; Pregnancy; Regression analysis; Risk factors; Sjogren's syndrome; Smoking; Abortion; Autoimmune disease; Multiple autoimmune syndrome; Polyautoimmunity; Sjögren's syndrome; Smoking; autoimmune; rheumatoid; spontaneous; systemic; Abortion; Arthritis; Lupus erythematosus; Thyroiditis
• License: Abierto (Texto Completo)