Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi

Dimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and...

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Fecha de publicación:
2018
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/20070
Acceso en línea:
http://repository.urosario.edu.co/handle/10336/20070
Palabra clave:
Fungal Pathogens
Nonpathogenic Specie
Basal Branching
Branching Nonpathogenic
Enfermedades
Hongos patógenos
Especie no patógeno
Ramificación basal
Ramificación no patógenas
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dc.title.spa.fl_str_mv Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
spellingShingle Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
Fungal Pathogens
Nonpathogenic Specie
Basal Branching
Branching Nonpathogenic
Enfermedades
Hongos patógenos
Especie no patógeno
Ramificación basal
Ramificación no patógenas
title_short Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_full Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_fullStr Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_full_unstemmed Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
title_sort Genome analysis reveals evolutionary mechanisms of adaptation in systemic dimorphic fungi
dc.subject.spa.fl_str_mv Fungal Pathogens
Nonpathogenic Specie
Basal Branching
Branching Nonpathogenic
topic Fungal Pathogens
Nonpathogenic Specie
Basal Branching
Branching Nonpathogenic
Enfermedades
Hongos patógenos
Especie no patógeno
Ramificación basal
Ramificación no patógenas
dc.subject.ddc.spa.fl_str_mv Enfermedades
dc.subject.lemb.spa.fl_str_mv Hongos patógenos
Especie no patógeno
Ramificación basal
Ramificación no patógenas
description Dimorphic fungal pathogens cause a significant human disease burden and unlike most fungal pathogens affect immunocompetent hosts. To examine the origin of virulence of these fungal pathogens, we compared genomes of classic systemic, opportunistic, and non-pathogenic species, including Emmonsia and two basal branching, non-pathogenic species in the Ajellomycetaceae, Helicocarpus griseus and Polytolypa hystricis. We found that gene families related to plant degradation, secondary metabolites synthesis, and amino acid and lipid metabolism are retained in H. griseus and P. hystricis. While genes involved in the virulence of dimorphic pathogenic fungi are conserved in saprophytes, changes in the copy number of proteases, kinases and transcription factors in systemic dimorphic relative to non-dimorphic species may have aided the evolution of specialized gene regulatory programs to rapidly adapt to higher temperatures and new nutritional environments. Notably, both of the basal branching, non-pathogenic species appear homothallic, with both mating type locus idiomorphs fused at a single locus, whereas all related pathogenic species are heterothallic. These differences revealed that independent changes in nutrient acquisition capacity have occurred in the Onygenaceae and Ajellomycetaceae, and underlie how the dimorphic pathogens have adapted to the human host and decreased their capacity for growth in environmental niches. © 2018 The Author(s).
publishDate 2018
dc.date.created.none.fl_str_mv 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2019-08-08T14:53:34Z
dc.date.available.none.fl_str_mv 2019-08-08T14:53:34Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv 10.1038/s41598-018-22816-6
dc.identifier.issn.none.fl_str_mv 2045-2322
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/20070
identifier_str_mv 10.1038/s41598-018-22816-6
2045-2322
url http://repository.urosario.edu.co/handle/10336/20070
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationTitle.none.fl_str_mv Scientific Reports
dc.relation.citationVolume.none.fl_str_mv Vol. 8
dc.relation.ispartof.spa.fl_str_mv Scientific Reports, ISSN:2045-2322, Vol. 8 (2018)
dc.relation.uri.spa.fl_str_mv https://www.nature.com/articles/s41598-018-22816-6
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.bibliographicCitation.spa.fl_str_mv Klein, B.S., Tebbets, B., Dimorphism and virulence in fungi (2007) Curr Opin Microbiol, 10, pp. 314-319
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
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