Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana

Introducción: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune compleja con comportamiento heterogéneo. Actualmente, no existen herramientas clínicas suficientes para su diagnóstico, solo hay criterios clasificatorios asociados al desarrollo de la enfermedad, pero ninguno patognomón...

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2024
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Universidad del Rosario
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Palabra clave:
Lupus eritematoso sistémico
Enfermedades autoinmunes
Criterios de clasificación
Validación de escalas
Systemic lupus erythematosus
Autoimmune diseases
Classification criteria
Validation of scales
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id EDOCUR2_d225d458530756f18beda9871f6d8045
oai_identifier_str oai:repository.urosario.edu.co:10336/43014
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
dc.title.TranslatedTitle.none.fl_str_mv Performance of the systemic lupus erythematosus risk probability index (slerpi) in a Colombian population sample
title Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
spellingShingle Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana

Lupus eritematoso sistémico
Enfermedades autoinmunes
Criterios de clasificación
Validación de escalas
Systemic lupus erythematosus
Autoimmune diseases
Classification criteria
Validation of scales
title_short Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
title_full Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
title_fullStr Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
title_full_unstemmed Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
title_sort Desempeño del índice de probabilidad de riesgo de lupus eritematoso sistémico (slerpi) en una muestra de población colombiana
dc.creator.none.fl_str_mv
author
author_facet
author_role author
dc.contributor.advisor.none.fl_str_mv Rojas Quintana, Manuel Eduardo
Rodríguez Jiménez, Mónica María del Pilar
Ramírez Santana, Heily Carolina
dc.contributor.gruplac.none.fl_str_mv Centro de Estudio de Enfermedades Autoinmunes - CREA
dc.subject.none.fl_str_mv Lupus eritematoso sistémico
Enfermedades autoinmunes
Criterios de clasificación
Validación de escalas
topic Lupus eritematoso sistémico
Enfermedades autoinmunes
Criterios de clasificación
Validación de escalas
Systemic lupus erythematosus
Autoimmune diseases
Classification criteria
Validation of scales
dc.subject.keyword.none.fl_str_mv Systemic lupus erythematosus
Autoimmune diseases
Classification criteria
Validation of scales
description Introducción: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune compleja con comportamiento heterogéneo. Actualmente, no existen herramientas clínicas suficientes para su diagnóstico, solo hay criterios clasificatorios asociados al desarrollo de la enfermedad, pero ninguno patognomónico. Objetivos: Evaluar el desempeño diagnóstico y clasificatorio del índice de probabilidad de riesgo de lupus eritematoso sistémico (SLERPI) en una muestra de población colombiana. Metodología: Se incluyeron 435 pacientes con LES y 430 controles. Un SLERPI >7 indicó LES, comparándose con criterios ACR-1997, SLICC-2012 y EULAR/ACR-2019 mediante la estimación de sensibilidad (SN) y especificidad (ES). Se evaluó el impacto de la poliautoinmunidad (PolyA) en los puntajes de SLERPI y la contribución de sus componentes mediante regresión multivariada. Resultados: Los pacientes con LES tuvieron puntajes de SLERPI más altos en comparación con el grupo control (P < 0,0001), clasificando con diagnóstico "definitivo" cercano a un 90% de los pacientes. Los principales factores relacionados con los puntajes de SLERPI en la población incluyeron trastorno inmunológico, erupción malar/maculopapular y anticuerpos antinucleares. La enfermedad pulmonar intersticial y el lupus cutáneo subagudo/discoide carecieron de significancia (P > 0,0500). SLERPI tuvo alta SN en PolyA y no PolyA (95,4% y 94,6%), con menor ES (92,8% y 93,7%) y niveles de precisión comparables. Además, destacó en LES temprano, nefritis y LES hematológico (SN >96%), pero en LES neuropsiquiátrico tuvo un menor rendimiento (SN 92%). Conclusión: SLERPI identificó eficazmente el LES en una cohorte colombiana con alta SN pero menor ES, teniendo un excelente rendimiento en la detección de LES temprano y en ciertos subfenotipos, pero requiere precaución en LES neuropsiquiátrico.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-07-15T16:04:24Z
dc.date.available.none.fl_str_mv 2024-07-15T16:04:24Z
dc.date.created.none.fl_str_mv 2024-06-16
dc.type.none.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.none.fl_str_mv Trabajo de grado
dc.type.spa.none.fl_str_mv Trabajo de grado
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/43014
url https://repository.urosario.edu.co/handle/10336/43014
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.none.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nc-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.none.fl_str_mv 101 pp
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
dc.publisher.department.none.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Especialización en Epidemiología
publisher.none.fl_str_mv Universidad del Rosario
Universidad CES. Facultad de Medicina
institution Universidad del Rosario
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Albrecht, J; Berlin, J A; Braverman, I M; Callen, J P; Costner, M I; Dutz, J; Fivenson, D; Franks, A G; Jorizzo, J L; Lee, L A; McCauliffe, D P; Sontheimer, R D; Werth, V P (2004) Dermatology position paper on the revision of the 1982 ACR criteria for systemic lupus erythematosus. En: Lupus. Vol. 13; No. 11; pp. 839 - 849; Disponible en: 10.1191/0961203304lu2020oa.
Petri, Michelle; Orbai, Ana-Maria; Alarcón, Graciela S.; Gordon, Caroline; Merrill, Joan T.; Fortin, Paul R.; Bruce, Ian N.; Isenberg, David; Wallace, Daniel J.; Nived, Ola; Sturfelt, Gunnar; Ramsey-Goldman, Rosalind; Bae, Sang-Cheol; Hanly, John G.; Sánchez-Guerrero, Jorge; Clarke, Ann; Aranow, Cynthia; Manzi, Susan; Urowitz, Murray; Gladman, Dafna; Kalunian, Kenneth; Costner, Melissa; Werth, Victoria P.; Zoma, Asad; Bernatsky, Sasha; Ruiz-Irastorza, Guillermo; Khamashta, Munther A.; Jacobsen, Soren; Buyon, Jill P.; Maddison, Peter; Dooley, Mary Anne; van Vollenhoven, Ronald F.; Ginzler, Ellen; Stoll, Thomas; Peschken, Christine; Jorizzo, Joseph L.; Callen, Jeffrey P.; Lim, S. Sam; Fessler, Barri J.; Inanc, Murat; Kamen, Diane L.; Rahman, Anisur; Steinsson, Kristjan; Franks, Andrew G.; Sigler, Lisa; Hameed, Suhail; Fang, Hong; Pham, Ngoc; Brey, Robin; Weisman, Michael H.; McGwin, Gerald; Magder, Laurence S. (2012) Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. En: Arthritis & Rheumatism. Vol. 64; No. 8; pp. 2677 - 2686; Disponible en: 10.1002/art.34473.
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Aringer, Martin; Costenbader, Karen; Daikh, David; Brinks, Ralph; Mosca, Marta; Ramsey‐Goldman, Rosalind; Smolen, Josef S.; Wofsy, David; Boumpas, Dimitrios T.; Kamen, Diane L.; Jayne, David; Cervera, Ricard; Costedoat‐Chalumeau, Nathalie; Diamond, Betty; Gladman, Dafna D.; Hahn, Bevra; Hiepe, Falk; Jacobsen, Søren; Khanna, Dinesh; Lerstrøm, Kirsten; Massarotti, Elena; McCune, Joseph; Ruiz‐Irastorza, Guillermo; Sanchez‐Guerrero, Jorge; Schneider, Matthias; Urowitz, Murray; Bertsias, George; Hoyer, Bimba F.; Leuchten, Nicolai; Tani, Chiara; Tedeschi, Sara K.; Touma, Zahi; Schmajuk, Gabriela; Anic, Branimir; Assan, Florence; Chan, Tak Mao; Clarke, Ann Elaine; Crow, Mary K.; Czirják, László; Doria, Andrea; Graninger, Winfried; Halda‐Kiss, Bernadett; Hasni, Sarfaraz; Izmirly, Peter M.; Jung, Michelle; Kumánovics, Gábor; Mariette, Xavier; Padjen, Ivan; Pego‐Reigosa, José M.; Romero‐Diaz, Juanita; Rúa‐Figueroa Fernández, Íñigo; Seror, Raphaèle; Stummvoll, Georg H.; Tanaka, Yoshiya; Tektonidou, Maria G.; Vasconcelos, Carlos; Vital, Edward M.; Wallace, Daniel J.; Yavuz, Sule; Meroni, Pier Luigi; Fritzler, Marvin J.; Naden, Ray; Dörner, Thomas; Johnson, Sindhu R. (2019) 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus. En: Arthritis & Rheumatology. Vol. 71; No. 9; pp. 1400 - 1412; Disponible en: 10.1002/art.40930.
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Buyon, Jill P.; Petri, Michelle A.; Kim, Mimi Y.; Kalunian, Kenneth C.; Grossman, Jennifer; Hahn, Bevra H.; Merrill, Joan T.; Sammaritano, Lisa; Lockshin, Michael; Alarcón, Graciela S.; Manzi, Susan; Belmont, H. Michael; Askanase, Anca D.; Sigler, Lisa; Dooley, Mary Anne; Von Feldt, Joan; McCune, W. Joseph; Friedman, Alan; Wachs, Jane; Cronin, Mary; Hearth-Holmes, Michelene; Tan, Mark; Licciardi, Frederick (2005) The Effect of Combined Estrogen and Progesterone Hormone Replacement Therapy on Disease Activity in Systemic Lupus Erythematosus: A Randomized Trial. En: Annals of Internal Medicine. Vol. 142; No. 12_Part_1; pp. 953 - 953; Disponible en: 10.7326/0003-4819-142-12_Part_1-200506210-00004.
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spelling Rojas Quintana, Manuel Eduardo1110541485600Rodríguez Jiménez, Mónica María del Pilar0cbf3e9a-3150-4aaf-a5f1-a799bbc1e414-1Ramírez Santana, Heily Carolina52483526600Centro de Estudio de Enfermedades Autoinmunes - CREAEspecialista en Epidemiología (en Convenio con el CES)EspecializaciónFull time436ac941-3556-4336-9999-a311e0febd7f6002024-07-15T16:04:24Z2024-07-15T16:04:24Z2024-06-16Introducción: El lupus eritematoso sistémico (LES) es una enfermedad autoinmune compleja con comportamiento heterogéneo. Actualmente, no existen herramientas clínicas suficientes para su diagnóstico, solo hay criterios clasificatorios asociados al desarrollo de la enfermedad, pero ninguno patognomónico. Objetivos: Evaluar el desempeño diagnóstico y clasificatorio del índice de probabilidad de riesgo de lupus eritematoso sistémico (SLERPI) en una muestra de población colombiana. Metodología: Se incluyeron 435 pacientes con LES y 430 controles. Un SLERPI >7 indicó LES, comparándose con criterios ACR-1997, SLICC-2012 y EULAR/ACR-2019 mediante la estimación de sensibilidad (SN) y especificidad (ES). Se evaluó el impacto de la poliautoinmunidad (PolyA) en los puntajes de SLERPI y la contribución de sus componentes mediante regresión multivariada. Resultados: Los pacientes con LES tuvieron puntajes de SLERPI más altos en comparación con el grupo control (P < 0,0001), clasificando con diagnóstico "definitivo" cercano a un 90% de los pacientes. Los principales factores relacionados con los puntajes de SLERPI en la población incluyeron trastorno inmunológico, erupción malar/maculopapular y anticuerpos antinucleares. La enfermedad pulmonar intersticial y el lupus cutáneo subagudo/discoide carecieron de significancia (P > 0,0500). SLERPI tuvo alta SN en PolyA y no PolyA (95,4% y 94,6%), con menor ES (92,8% y 93,7%) y niveles de precisión comparables. Además, destacó en LES temprano, nefritis y LES hematológico (SN >96%), pero en LES neuropsiquiátrico tuvo un menor rendimiento (SN 92%). Conclusión: SLERPI identificó eficazmente el LES en una cohorte colombiana con alta SN pero menor ES, teniendo un excelente rendimiento en la detección de LES temprano y en ciertos subfenotipos, pero requiere precaución en LES neuropsiquiátrico.Introduction: Systemic lupus erythematosus (SLE) is a complex autoimmune disease with heterogeneous behavior. Currently, there are no sufficient clinical tools for its diagnosis, there are only classifying criteria associated with the development of the disease, but no pathognomonic. Objectives: To evaluate the diagnostic and classifying performance of the systemic lupus erythematosus risk probability index (SLERPI) in a sample of the Colombian population. Methodology: 435 patients with SLE and 430 controls were included. SLERPI >7 indicated SLE, compared with ACR-1997, SLICC-2012 and EULAR/ACR-2019 criteria by estimating sensitivity (SN) and specificity (ES). The impact of polyautoimmunity (PolyA) on SLERPI scores and the contribution of its components was evaluated using multivariate regression. Results: Patients with SLE had higher SLERPI scores compared to the SLE control group (P < 0.0001), classifying close to 90% of patients with a "definitive" diagnosis. The main factors associated to SLERPI scores in the population included immunological disorder, malar/maculopapular rash, and antinuclear antibodies. Interstitial lung disease and subacute cutaneous/discoid lupus were non-significant (P > 0.0500). SLERPI had high SN in PolyA and non-PolyA (95.4% and 94.6%), with lower ES (92.8% and 93.7%) and comparable precision levels. Furthermore, it stood out in early SLE, nephritis and hematological SLE (SN >96%), but it had a lower performance in neuropsychiatric SLE (SN 92%). Conclusion: SLERPI identified efficiently SLE disease in a Colombian cohort with high SN but lower ES. It had excellent performance in detecting early SLE and in certain sub phenotypes but requires caution in neuropsychiatric SLE.101 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/43014spaUniversidad del RosarioUniversidad CES. Facultad de MedicinaEscuela de Medicina y Ciencias de la SaludEspecialización en EpidemiologíaAttribution-NonCommercial-NoDerivatives 4.0 InternationalAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2Adamichou, Christina; Genitsaridi, Irini; Nikolopoulos, Dionysis; Nikoloudaki, Myrto; Repa, Argyro; Bortoluzzi, Alessandra; Fanouriakis, Antonis; Sidiropoulos, Prodromos; Boumpas, Dimitrios T; Bertsias, George K (2021) Lupus or not? SLE Risk Probability Index (SLERPI): a simple, clinician-friendly machine learning-based model to assist the diagnosis of systemic lupus erythematosus. En: Annals of the Rheumatic Diseases. Vol. 80; No. 6; pp. 758 - 766; Disponible en: 10.1136/annrheumdis-2020-219069.Doria, Andrea; Zen, Margherita; Canova, Mariagrazia; Bettio, Silvano; Bassi, Nicola; Nalotto, Linda; Rampudda, Mariaelisa; Ghirardello, Anna; Iaccarino, Luca (2010) SLE diagnosis and treatment: When early is early. En: Autoimmunity Reviews. Vol. 10; No. 1; pp. 55 - 60; Disponible en: 10.1016/j.autrev.2010.08.014.Morgan, C; Bland, A R; Maker, C; Dunnage, J; Bruce, I N (2018) Individuals living with lupus: findings from the LUPUS UK Members Survey 2014. En: Lupus. Vol. 27; No. 4; pp. 681 - 687; Disponible en: 10.1177/0961203317749746.Oglesby, Alan; Korves, Caroline; Laliberté, François; Dennis, Gregory; Rao, Sapna; Suthoff, Ellison Dial; Wei, Robert; Duh, Mei Sheng (2014) Impact of Early Versus Late Systemic Lupus Erythematosus Diagnosis on Clinical and Economic Outcomes. En: Applied Health Economics and Health Policy. Vol. 12; No. 2; pp. 179 - 190; Disponible en: 10.1007/s40258-014-0085-x.Rahman, Anisur; Isenberg, David A. (2008) Systemic Lupus Erythematosus. En: New England Journal of Medicine. Vol. 358; No. 9; pp. 929 - 939; Disponible en: 10.1056/NEJMra071297.Gergianaki, Irini; Bertsias, George (2018) Systemic Lupus Erythematosus in Primary Care: An Update and Practical Messages for the General Practitioner. En: Frontiers in Medicine. Vol. 5; Disponible en: 10.3389/fmed.2018.00161.Johnson, A.E; Gordon, C; Bacon, P.A; Hobbs, F.D.R (1996) Undiagnosed systemic lupus erythematosus in the community. En: The Lancet. Vol. 347; No. 8998; pp. 367 - 369; Disponible en: 10.1016/S0140-6736(96)90539-5.Aringer, Martin; Costenbader, Karen; Daikh, David; Brinks, Ralph; Mosca, Marta; Ramsey‐Goldman, Rosalind; Smolen, Josef S.; Wofsy, David; Boumpas, Dimitrios T.; Kamen, Diane L.; Jayne, David; Cervera, Ricard; Costedoat‐Chalumeau, Nathalie; Diamond, Betty; Gladman, Dafna D.; Hahn, Bevra; Hiepe, Falk; Jacobsen, Søren; Khanna, Dinesh; Lerstrøm, Kirsten; Massarotti, Elena; McCune, Joseph; Ruiz‐Irastorza, Guillermo; Sanchez‐Guerrero, Jorge; Schneider, Matthias; Urowitz, Murray; Bertsias, George; Hoyer, Bimba F.; Leuchten, Nicolai; Tani, Chiara; Tedeschi, Sara K.; Touma, Zahi; Schmajuk, Gabriela; Anic, Branimir; Assan, Florence; Chan, Tak Mao; Clarke, Ann Elaine; Crow, Mary K.; Czirják, László; Doria, Andrea; Graninger, Winfried; Halda‐Kiss, Bernadett; Hasni, Sarfaraz; Izmirly, Peter M.; Jung, Michelle; Kumánovics, Gábor; Mariette, Xavier; Padjen, Ivan; Pego‐Reigosa, José M.; Romero‐Diaz, Juanita; Rúa‐Figueroa Fernández, Íñigo; Seror, Raphaèle; Stummvoll, Georg H.; Tanaka, Yoshiya; Tektonidou, Maria G.; Vasconcelos, Carlos; Vital, Edward M.; Wallace, Daniel J.; Yavuz, Sule; Meroni, Pier Luigi; Fritzler, Marvin J.; Naden, Ray; Dörner, Thomas; Johnson, Sindhu R. 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