Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2008
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/18424
- Acceso en línea:
- http://repository.urosario.edu.co/handle/10336/18424
- Palabra clave:
- Sensitivity and specificity
Glomerular filtration rate
Creatinine
Cystatins
Insuficiencia Renal Crónica
Tasa de Filtración Glomerular
Creatinina
- Rights
- License
- Abierto (Texto Completo)
id |
EDOCUR2_d1e61cafdd0f3d5733ddbf0c259c8b52 |
---|---|
oai_identifier_str |
oai:repository.urosario.edu.co:10336/18424 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
|
dc.title.spa.fl_str_mv |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
title |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
spellingShingle |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children Sensitivity and specificity Glomerular filtration rate Creatinine Cystatins Insuficiencia Renal Crónica Tasa de Filtración Glomerular Creatinina |
title_short |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
title_full |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
title_fullStr |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
title_full_unstemmed |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
title_sort |
Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children |
dc.contributor.gruplac.spa.fl_str_mv |
Bio-Bio |
dc.subject.keyword.spa.fl_str_mv |
Sensitivity and specificity Glomerular filtration rate Creatinine Cystatins |
topic |
Sensitivity and specificity Glomerular filtration rate Creatinine Cystatins Insuficiencia Renal Crónica Tasa de Filtración Glomerular Creatinina |
dc.subject.lemb.spa.fl_str_mv |
Insuficiencia Renal Crónica Tasa de Filtración Glomerular Creatinina |
description |
Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (ClTc) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD. Methods: Data were collected from 109 Colombian outpatients aged less than 18 years referred for determination of GFR because of suspected or definite renal insufficiency. The cost of each test was determined in Bogotá, Colombia, and in Madrid, Spain. Results: Using a GFR of 90 mL/min as a cut-off value, we found: CysC sensitivity 75%, specificity 84%, and area under ROC curve (AUC) 0.84. SCr sensitivity 46%, specificity 100%, and AUC 0.72. Using a GFR of 70 mL/min as a cut-off value, we found: CysC sensitivity 100%, specificity 48%, and AUC 0.94. SCr sensitivity 77%, specificity 91%, and AUC 0.81. In all calculations predictive values behave correspondingly and ranges were narrow at CI 95%. In AUC, p = 0.0001. Cost per enzymatic test in Bogotá: CysC U$ 27; SCr U$ 2. Cost per enzymatic test in Madrid: CysC U$ 3; SCr U$ 0.08. Conclusion: CysC is a very interesting option, and could be a replacement to serum creatinine for diagnosing and possibly for monitoring kidney function in children. |
publishDate |
2008 |
dc.date.created.none.fl_str_mv |
2008 |
dc.date.issued.none.fl_str_mv |
2008 |
dc.date.accessioned.none.fl_str_mv |
2018-08-30T15:50:53Z |
dc.date.available.none.fl_str_mv |
2018-08-30T15:50:53Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
0009-9120 |
dc.identifier.uri.none.fl_str_mv |
http://repository.urosario.edu.co/handle/10336/18424 |
identifier_str_mv |
0009-9120 |
url |
http://repository.urosario.edu.co/handle/10336/18424 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
503 |
dc.relation.citationIssue.none.fl_str_mv |
No. 41 |
dc.relation.citationStartPage.none.fl_str_mv |
498 |
dc.relation.citationTitle.none.fl_str_mv |
Clinical Biochemistry |
dc.relation.ispartof.spa.fl_str_mv |
Clinical Biochemistry, ISSN 0009-9120, No. 41, (2008); pp. 498–503 |
dc.relation.uri.spa.fl_str_mv |
https://www.elsevier.com/journals/clinical-biochemistry/0009-9120/open-access-options |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
bitstream.url.fl_str_mv |
https://repository.urosario.edu.co/bitstreams/27a1d6ad-fb1d-4f9c-859b-e88dfdc057ce/download https://repository.urosario.edu.co/bitstreams/972718b4-803c-4e06-b917-5ee3744fae52/download https://repository.urosario.edu.co/bitstreams/523ce35e-9cd3-4071-9a25-9bfd199a301e/download |
bitstream.checksum.fl_str_mv |
4e3fc7051203a34ef3497c474603e25f 7c306465e9a8352474e2d4e20c726373 4f23e6b865a3d499be0814db26a420d7 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167677915103232 |
spelling |
Bio-BioNarvaez-Sanchez, RaulGonzalez, LuzSalamanca-Matta, Alba LucíaSilva, MyriamRios-Chaparro, Dora-InesArevalo, SinayGastelbondo Amaya, RicardoSanchez, JavierLuz Stella Gonzalez, Myriam Silva, Dora Rios, Sinay Arevalo, Ricardo Gastelbondo, Alba Lucía Salamanca Matta, Narvaez Sanchez-Sanchez, RaulRios Chaparro, Dora InesArevalo Leal, SinayNarvaez, RaulGastelbondo Amaya, Ricardoc6cedfde-75c8-4a91-a151-c782dbcb91ab60091478b54-7dab-4af4-b4c8-5b7ab8ed1381600c1e9a0af-4310-4cb2-a267-b93c087c940f6008578e035-5b0f-4ead-a2ce-733264b97ecb6003344983360084085a89-f024-400b-95b8-705c132b30a86009da6018f-a707-4c73-a8ef-785b118cbfbd6000527460c-d19a-43bf-b39a-a8a5ff6028026002018-08-30T15:50:53Z2018-08-30T15:50:53Z20082008Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (ClTc) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD. Methods: Data were collected from 109 Colombian outpatients aged less than 18 years referred for determination of GFR because of suspected or definite renal insufficiency. The cost of each test was determined in Bogotá, Colombia, and in Madrid, Spain. Results: Using a GFR of 90 mL/min as a cut-off value, we found: CysC sensitivity 75%, specificity 84%, and area under ROC curve (AUC) 0.84. SCr sensitivity 46%, specificity 100%, and AUC 0.72. Using a GFR of 70 mL/min as a cut-off value, we found: CysC sensitivity 100%, specificity 48%, and AUC 0.94. SCr sensitivity 77%, specificity 91%, and AUC 0.81. In all calculations predictive values behave correspondingly and ranges were narrow at CI 95%. In AUC, p = 0.0001. Cost per enzymatic test in Bogotá: CysC U$ 27; SCr U$ 2. Cost per enzymatic test in Madrid: CysC U$ 3; SCr U$ 0.08. Conclusion: CysC is a very interesting option, and could be a replacement to serum creatinine for diagnosing and possibly for monitoring kidney function in children.application/pdf0009-9120http://repository.urosario.edu.co/handle/10336/18424eng503No. 41498Clinical BiochemistryClinical Biochemistry, ISSN 0009-9120, No. 41, (2008); pp. 498–503https://www.elsevier.com/journals/clinical-biochemistry/0009-9120/open-access-optionsAbierto (Texto Completo)https://ac.els-cdn.com/S0009912008000519/1-s2.0-S0009912008000519-main.pdf?_tid=5c154ea4-ba61-11e7-8cc7-00000aacb362&acdnat=1509031478_89757a5d0c4937671de2768438e29747http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSensitivity and specificityGlomerular filtration rateCreatinineCystatinsInsuficiencia Renal CrónicaTasa de Filtración GlomerularCreatininaCystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in childrenarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501ORIGINAL5.pdfapplication/pdf262179https://repository.urosario.edu.co/bitstreams/27a1d6ad-fb1d-4f9c-859b-e88dfdc057ce/download4e3fc7051203a34ef3497c474603e25fMD51TEXT5.pdf.txt5.pdf.txtExtracted texttext/plain29932https://repository.urosario.edu.co/bitstreams/972718b4-803c-4e06-b917-5ee3744fae52/download7c306465e9a8352474e2d4e20c726373MD52THUMBNAIL5.pdf.jpg5.pdf.jpgGenerated Thumbnailimage/jpeg4475https://repository.urosario.edu.co/bitstreams/523ce35e-9cd3-4071-9a25-9bfd199a301e/download4f23e6b865a3d499be0814db26a420d7MD5310336/18424oai:repository.urosario.edu.co:10336/184242019-09-19 07:38:03.190837https://ac.els-cdn.com/S0009912008000519/1-s2.0-S0009912008000519-main.pdf?_tid=5c154ea4-ba61-11e7-8cc7-00000aacb362&acdnat=1509031478_89757a5d0c4937671de2768438e29747https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |