Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children

Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely...

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Fecha de publicación:
2008
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
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oai:repository.urosario.edu.co:10336/18424
Acceso en línea:
http://repository.urosario.edu.co/handle/10336/18424
Palabra clave:
Sensitivity and specificity
Glomerular filtration rate
Creatinine
Cystatins
Insuficiencia Renal Crónica
Tasa de Filtración Glomerular
Creatinina
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License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
title Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
spellingShingle Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
Sensitivity and specificity
Glomerular filtration rate
Creatinine
Cystatins
Insuficiencia Renal Crónica
Tasa de Filtración Glomerular
Creatinina
title_short Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
title_full Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
title_fullStr Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
title_full_unstemmed Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
title_sort Cystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in children
dc.contributor.gruplac.spa.fl_str_mv Bio-Bio
dc.subject.keyword.spa.fl_str_mv Sensitivity and specificity
Glomerular filtration rate
Creatinine
Cystatins
topic Sensitivity and specificity
Glomerular filtration rate
Creatinine
Cystatins
Insuficiencia Renal Crónica
Tasa de Filtración Glomerular
Creatinina
dc.subject.lemb.spa.fl_str_mv Insuficiencia Renal Crónica
Tasa de Filtración Glomerular
Creatinina
description Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (ClTc) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD. Methods: Data were collected from 109 Colombian outpatients aged less than 18 years referred for determination of GFR because of suspected or definite renal insufficiency. The cost of each test was determined in Bogotá, Colombia, and in Madrid, Spain. Results: Using a GFR of 90 mL/min as a cut-off value, we found: CysC sensitivity 75%, specificity 84%, and area under ROC curve (AUC) 0.84. SCr sensitivity 46%, specificity 100%, and AUC 0.72. Using a GFR of 70 mL/min as a cut-off value, we found: CysC sensitivity 100%, specificity 48%, and AUC 0.94. SCr sensitivity 77%, specificity 91%, and AUC 0.81. In all calculations predictive values behave correspondingly and ranges were narrow at CI 95%. In AUC, p = 0.0001. Cost per enzymatic test in Bogotá: CysC U$ 27; SCr U$ 2. Cost per enzymatic test in Madrid: CysC U$ 3; SCr U$ 0.08. Conclusion: CysC is a very interesting option, and could be a replacement to serum creatinine for diagnosing and possibly for monitoring kidney function in children.
publishDate 2008
dc.date.created.none.fl_str_mv 2008
dc.date.issued.none.fl_str_mv 2008
dc.date.accessioned.none.fl_str_mv 2018-08-30T15:50:53Z
dc.date.available.none.fl_str_mv 2018-08-30T15:50:53Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv 0009-9120
dc.identifier.uri.none.fl_str_mv http://repository.urosario.edu.co/handle/10336/18424
identifier_str_mv 0009-9120
url http://repository.urosario.edu.co/handle/10336/18424
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 503
dc.relation.citationIssue.none.fl_str_mv No. 41
dc.relation.citationStartPage.none.fl_str_mv 498
dc.relation.citationTitle.none.fl_str_mv Clinical Biochemistry
dc.relation.ispartof.spa.fl_str_mv Clinical Biochemistry, ISSN 0009-9120, No. 41, (2008); pp. 498–503
dc.relation.uri.spa.fl_str_mv https://www.elsevier.com/journals/clinical-biochemistry/0009-9120/open-access-options
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institution Universidad del Rosario
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spelling Bio-BioNarvaez-Sanchez, RaulGonzalez, LuzSalamanca-Matta, Alba LucíaSilva, MyriamRios-Chaparro, Dora-InesArevalo, SinayGastelbondo Amaya, RicardoSanchez, JavierLuz Stella Gonzalez, Myriam Silva, Dora Rios, Sinay Arevalo, Ricardo Gastelbondo, Alba Lucía Salamanca Matta, Narvaez Sanchez-Sanchez, RaulRios Chaparro, Dora InesArevalo Leal, SinayNarvaez, RaulGastelbondo Amaya, Ricardoc6cedfde-75c8-4a91-a151-c782dbcb91ab60091478b54-7dab-4af4-b4c8-5b7ab8ed1381600c1e9a0af-4310-4cb2-a267-b93c087c940f6008578e035-5b0f-4ead-a2ce-733264b97ecb6003344983360084085a89-f024-400b-95b8-705c132b30a86009da6018f-a707-4c73-a8ef-785b118cbfbd6000527460c-d19a-43bf-b39a-a8a5ff6028026002018-08-30T15:50:53Z2018-08-30T15:50:53Z20082008Background: Chronic kidney disease (CKD) is a worldwide public health problem. Glomerular filtration rate (GFR) is accepted as the best way to diagnose and monitor kidney function. Plasma Cystatin C (CysC) has been proposed as a better marker of GFR than serum creatinine (SCr), but it is not widely used because of some drawbacks with CysC assays. Our purpose is to determine the diagnostic accuracy of CysC and SCr for GFR estimation in children, using 99Tc-DTPA clearance (ClTc) as the reference standard. We also discuss some of the economic implications of these tests, in order to guide clinicians when to use CysC or SCr for the diagnosis or monitoring of CKD. Methods: Data were collected from 109 Colombian outpatients aged less than 18 years referred for determination of GFR because of suspected or definite renal insufficiency. The cost of each test was determined in Bogotá, Colombia, and in Madrid, Spain. Results: Using a GFR of 90 mL/min as a cut-off value, we found: CysC sensitivity 75%, specificity 84%, and area under ROC curve (AUC) 0.84. SCr sensitivity 46%, specificity 100%, and AUC 0.72. Using a GFR of 70 mL/min as a cut-off value, we found: CysC sensitivity 100%, specificity 48%, and AUC 0.94. SCr sensitivity 77%, specificity 91%, and AUC 0.81. In all calculations predictive values behave correspondingly and ranges were narrow at CI 95%. In AUC, p = 0.0001. Cost per enzymatic test in Bogotá: CysC U$ 27; SCr U$ 2. Cost per enzymatic test in Madrid: CysC U$ 3; SCr U$ 0.08. Conclusion: CysC is a very interesting option, and could be a replacement to serum creatinine for diagnosing and possibly for monitoring kidney function in children.application/pdf0009-9120http://repository.urosario.edu.co/handle/10336/18424eng503No. 41498Clinical BiochemistryClinical Biochemistry, ISSN 0009-9120, No. 41, (2008); pp. 498–503https://www.elsevier.com/journals/clinical-biochemistry/0009-9120/open-access-optionsAbierto (Texto Completo)https://ac.els-cdn.com/S0009912008000519/1-s2.0-S0009912008000519-main.pdf?_tid=5c154ea4-ba61-11e7-8cc7-00000aacb362&acdnat=1509031478_89757a5d0c4937671de2768438e29747http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSensitivity and specificityGlomerular filtration rateCreatinineCystatinsInsuficiencia Renal CrónicaTasa de Filtración GlomerularCreatininaCystatin C could be a replacement to serum creatinine for diagnosing and monitoring kidney function in childrenarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501ORIGINAL5.pdfapplication/pdf262179https://repository.urosario.edu.co/bitstreams/27a1d6ad-fb1d-4f9c-859b-e88dfdc057ce/download4e3fc7051203a34ef3497c474603e25fMD51TEXT5.pdf.txt5.pdf.txtExtracted texttext/plain29932https://repository.urosario.edu.co/bitstreams/972718b4-803c-4e06-b917-5ee3744fae52/download7c306465e9a8352474e2d4e20c726373MD52THUMBNAIL5.pdf.jpg5.pdf.jpgGenerated Thumbnailimage/jpeg4475https://repository.urosario.edu.co/bitstreams/523ce35e-9cd3-4071-9a25-9bfd199a301e/download4f23e6b865a3d499be0814db26a420d7MD5310336/18424oai:repository.urosario.edu.co:10336/184242019-09-19 07:38:03.190837https://ac.els-cdn.com/S0009912008000519/1-s2.0-S0009912008000519-main.pdf?_tid=5c154ea4-ba61-11e7-8cc7-00000aacb362&acdnat=1509031478_89757a5d0c4937671de2768438e29747https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co