Bilateral Herpes Simplex Uveitis: Review of the Literature and Own Reports?

Purpose: Herpes simplex-associated uveitis is usually considered a unilateral eye disease, and rarely included in the differential diagnosis whenever there is bilateral involvement. We report three cases of bilateral herpetic anterior uveitis. Methods: We evaluated three patients who presented with clinical manifestations of bilateral uveitis suggestive of viral origin. Results: We found intraocular hypertension, cells in the anterior chamber, paralytic mydriasis, iris atrophy with transillumination defects, and variable anterior vitreous cellularity. According to the clinical findings, supported with herpes-specific antibody titers and aqueous humor PCR results in two of them, they were diagnosed with bilateral anterior herpetic uveitis. Conclusions: Our patients were initially misdiagnosed as having non-infectious uveitis and were treated with immunomodulatory medications, which could have favored the extension of infection bilaterally. Although uncommon, bilateral herpetic uveitis should always be considered in the differential diagnoses, when patients present with hypertensive uveitis in both eyes. © Taylor and Francis Group, LLC.

• Fecha de publicación: 2017
• Institución: Universidad del Rosario
• Repositorio: Repositorio EdocUR - U. Rosario
• Idioma: eng
• OAI Identifier: oai:repository.urosario.edu.co:10336/22715
• Acceso en línea: https://doi.org/10.3109/09273948.2016.1142572; https://repository.urosario.edu.co/handle/10336/22715
• Palabra clave: Acetazolamide; Aciclovir; Antibody; Atropine; Belimumab; Brimonidine; Corticosteroid; Cyclophosphamide; Cyclosporin; Cytomegalovirus antibody; Dorzolamide; Hepatitis b surface antigen; Hydroxychloroquine sulfate; Immunoglobulin g; Methotrexate; Prednisolone acetate; Prednisone; Steroid; Tacrolimus; Valaciclovir; Antivirus agent; Virus antibody; Adult; Anterior eye chamber; Antibody titer; Aqueous humor; Arthralgia; Article; Astigmatism; Best corrected visual acuity; Blurred vision; Case report; Clinical article; Clinical evaluation; Clinical feature; Conjunctival hyperemia; Cornea ulcer; Diagnostic error; Drug dose reduction; Drug substitution; Drug withdrawal; Epiretinal membrane; Eye pain; Female; Genital herpes; Headache; Herpes simplex; Herpes simplex virus; Human; Human alphaherpesvirus 1; Intraocular hypertension; Iridocyclitis; Iris atrophy; Keratectomy; Keratoplasty; Lumbar puncture; Male; Meningitis; Middle aged; Mydriasis; Photophobia; Polymerase chain reaction; Pseudophakia; Rash; Sjoegren syndrome; Slit lamp; Systemic lupus erythematosus; Transillumination defect; Treatment response; Vomiting; Atrophy; Blood; Combination drug therapy; Herpes simplex; Herpes simplex virus 2; Intraocular hypertension; Iridocyclitis; Iris; Isolation and purification; Mydriasis; Pathology; Viral eye infection; Virology; Adult; Anterior chamber; Antiviral agents; Aqueous humor; Atrophy; Female; Herpes simplex; Humans; Iris; Male; Middle aged; Mydriasis; Ocular hypertension; Anterior; Bilateral; Herpes simplex virus (hsv); Herpetic; Uveitis; viral; viral; human; combination; anterior; human; Antibodies; Drug therapy; Eye infections; Herpesvirus 1; Herpesvirus 2; Uveitis
• License: Abierto (Texto Completo)