Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations

Bovine leukocyte antigens (BoLA) have been used as disease markers and immunological traits in cattle due to their primary role in pathogen recognition by the immune system. A higher MHC allele diversity in a population will allow presenting a broader peptide repertoire. However, loss of overall div...

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Autores:
Tipo de recurso:
Fecha de publicación:
2020
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/24084
Acceso en línea:
https://doi.org/10.3389/fgene.2019.01293
https://repository.urosario.edu.co/handle/10336/24084
Palabra clave:
Major histocompatibility antigen class 2
Allele
Article
Bola drb3 gene
Cattle breed
Colombian normande cattle
Controlled study
Gene
Gene frequency
Gene locus
Gene sequence
Genetic distance
Genetic parameters
Genetic variability
Hardy weinberg equilibrium
Heterozygosity
Nonhuman
Population distribution
Population structure
Spanish morucha cattle
Taurine cattle
Zebu
Bola-drb3
Cattle
Genetic diversity
Genetic resistance
Mhc
Peptide-binding region
Rights
License
Abierto (Texto Completo)
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dc.title.spa.fl_str_mv Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
title Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
spellingShingle Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
Major histocompatibility antigen class 2
Allele
Article
Bola drb3 gene
Cattle breed
Colombian normande cattle
Controlled study
Gene
Gene frequency
Gene locus
Gene sequence
Genetic distance
Genetic parameters
Genetic variability
Hardy weinberg equilibrium
Heterozygosity
Nonhuman
Population distribution
Population structure
Spanish morucha cattle
Taurine cattle
Zebu
Bola-drb3
Cattle
Genetic diversity
Genetic resistance
Mhc
Peptide-binding region
title_short Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
title_full Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
title_fullStr Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
title_full_unstemmed Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
title_sort Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations
dc.subject.keyword.spa.fl_str_mv Major histocompatibility antigen class 2
Allele
Article
Bola drb3 gene
Cattle breed
Colombian normande cattle
Controlled study
Gene
Gene frequency
Gene locus
Gene sequence
Genetic distance
Genetic parameters
Genetic variability
Hardy weinberg equilibrium
Heterozygosity
Nonhuman
Population distribution
Population structure
Spanish morucha cattle
Taurine cattle
Zebu
Bola-drb3
Cattle
Genetic diversity
Genetic resistance
Mhc
Peptide-binding region
topic Major histocompatibility antigen class 2
Allele
Article
Bola drb3 gene
Cattle breed
Colombian normande cattle
Controlled study
Gene
Gene frequency
Gene locus
Gene sequence
Genetic distance
Genetic parameters
Genetic variability
Hardy weinberg equilibrium
Heterozygosity
Nonhuman
Population distribution
Population structure
Spanish morucha cattle
Taurine cattle
Zebu
Bola-drb3
Cattle
Genetic diversity
Genetic resistance
Mhc
Peptide-binding region
description Bovine leukocyte antigens (BoLA) have been used as disease markers and immunological traits in cattle due to their primary role in pathogen recognition by the immune system. A higher MHC allele diversity in a population will allow presenting a broader peptide repertoire. However, loss of overall diversity due to domestication process can decrease a population’s peptide repertoire. Within the context of zebu and taurine cattle populations, BoLA-DRB3 genetic diversity in Spanish Morucha and Colombian Normande cattle was analyzed and an approach to estimate functional diversity was performed. Sequence-based typing was used for identifying 29, 23, 27, and 28 alleles in Spanish Morucha, Nariño-, Boyacá-, and Cundinamarca-Normande cattle, respectively. These breeds had remarkably low heterozygosity levels and the Hardy-Weinberg principle revealed significant heterozygote deficiency. FST and DA genetic distance showed that Colombian Normande populations had greater variability than other phenotypically homogeneous breeds, such as Holstein. It was also found that Spanish Morucha cattle were strongly differentiated from other cattle breeds. Spanish Morucha had greater divergence in the peptide-binding region regarding other cattle breeds. However, peptide-binding region covariation indicated that the potential peptide repertoire seemed equivalent among cattle breeds. Despite the genetic divergence observed, the extent of the potential peptide repertoire in the cattle populations studied appears to be similar and thus their pathogen recognition potential should be equivalent, suggesting that functional diversity might persist in the face of bottlenecks imposed by domestication and breeding. © Copyright © 2020 Bohórquez, Ordoñez, Suárez, Vicente, Vieira, López-Abán, Muro, Ordóñez and Patarroyo.
publishDate 2020
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:08:26Z
dc.date.available.none.fl_str_mv 2020-05-26T00:08:26Z
dc.date.created.spa.fl_str_mv 2020
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3389/fgene.2019.01293
dc.identifier.issn.none.fl_str_mv 16648021
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/24084
url https://doi.org/10.3389/fgene.2019.01293
https://repository.urosario.edu.co/handle/10336/24084
identifier_str_mv 16648021
dc.language.iso.spa.fl_str_mv eng
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dc.relation.citationTitle.none.fl_str_mv Frontiers in Genetics
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spelling 6e89741c-41a1-4521-9bb6-4ffe66560c24-1bef0e283-b79d-4c95-8f32-8e35d3334e4b-15e6f806d-b29d-4ce2-a7b8-f8c430646216-1868887e4-7ab6-4d09-9988-7082d1c34dfa-17b6a9581-29ca-4406-9c84-84eb2eb4c7e8-15be4f0c6-d404-42a1-a0ab-b1779f6bbd3c-1c11c8586-67c6-45e0-9457-3cb1c9496cd4-179613230600796530656002020-05-26T00:08:26Z2020-05-26T00:08:26Z2020Bovine leukocyte antigens (BoLA) have been used as disease markers and immunological traits in cattle due to their primary role in pathogen recognition by the immune system. A higher MHC allele diversity in a population will allow presenting a broader peptide repertoire. However, loss of overall diversity due to domestication process can decrease a population’s peptide repertoire. Within the context of zebu and taurine cattle populations, BoLA-DRB3 genetic diversity in Spanish Morucha and Colombian Normande cattle was analyzed and an approach to estimate functional diversity was performed. Sequence-based typing was used for identifying 29, 23, 27, and 28 alleles in Spanish Morucha, Nariño-, Boyacá-, and Cundinamarca-Normande cattle, respectively. These breeds had remarkably low heterozygosity levels and the Hardy-Weinberg principle revealed significant heterozygote deficiency. FST and DA genetic distance showed that Colombian Normande populations had greater variability than other phenotypically homogeneous breeds, such as Holstein. It was also found that Spanish Morucha cattle were strongly differentiated from other cattle breeds. Spanish Morucha had greater divergence in the peptide-binding region regarding other cattle breeds. However, peptide-binding region covariation indicated that the potential peptide repertoire seemed equivalent among cattle breeds. Despite the genetic divergence observed, the extent of the potential peptide repertoire in the cattle populations studied appears to be similar and thus their pathogen recognition potential should be equivalent, suggesting that functional diversity might persist in the face of bottlenecks imposed by domestication and breeding. © Copyright © 2020 Bohórquez, Ordoñez, Suárez, Vicente, Vieira, López-Abán, Muro, Ordóñez and Patarroyo.application/pdfhttps://doi.org/10.3389/fgene.2019.0129316648021https://repository.urosario.edu.co/handle/10336/24084engFrontiers Media S.A.Frontiers in GeneticsVol. 10Frontiers in Genetics, ISSN:16648021, Vol.10,(2020)https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078107738&doi=10.3389%2ffgene.2019.01293&partnerID=40&md5=b0fd1a0ba99f31158872c7c9304f1f17Abierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURMajor histocompatibility antigen class 2AlleleArticleBola drb3 geneCattle breedColombian normande cattleControlled studyGeneGene frequencyGene locusGene sequenceGenetic distanceGenetic parametersGenetic variabilityHardy weinberg equilibriumHeterozygosityNonhumanPopulation distributionPopulation structureSpanish morucha cattleTaurine cattleZebuBola-drb3CattleGenetic diversityGenetic resistanceMhcPeptide-binding regionMajor Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu PopulationsarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Bohórquez, Michel DavidOrdoñez, DiegoVicente, BelénVieira, CarmenLópez-Abán, JulioMuro, AntonioOrdóñez, IvánSuarez Martinez, Carlos FernandoPatarroyo, Manuel A.ORIGINALfgene-10-01293.pdfapplication/pdf2574844https://repository.urosario.edu.co/bitstreams/f2cc4d23-2980-4934-859c-92af717cf585/downloadd19b38b875f639b7ff60c9fb23a531c1MD51TEXTfgene-10-01293.pdf.txtfgene-10-01293.pdf.txtExtracted texttext/plain74273https://repository.urosario.edu.co/bitstreams/b0533cd7-556a-4b0b-a5a1-28a8952e31b8/download9a9990e60f36242165c9f1b7673ca752MD52THUMBNAILfgene-10-01293.pdf.jpgfgene-10-01293.pdf.jpgGenerated Thumbnailimage/jpeg4474https://repository.urosario.edu.co/bitstreams/a6eb1c34-b631-4d08-9d14-ed48947c51da/download84b8e69d5b894e60f1a87cfeaec2bde1MD5310336/24084oai:repository.urosario.edu.co:10336/240842022-05-02 07:37:14.912733https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co