A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults

MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with diffe...

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Autores:
Tipo de recurso:
Fecha de publicación:
2016
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27464
Acceso en línea:
https://doi.org/10.1016/j.psychres.2016.01.006
https://repository.urosario.edu.co/handle/10336/27464
Palabra clave:
Executive function
Endophenotypes
MicroRNAs
Rights
License
Restringido (Acceso a grupos específicos)
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oai_identifier_str oai:repository.urosario.edu.co:10336/27464
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 81776c52-6c0d-4c8e-bd5c-e306e67e8a65-17994277260077096774-12020-08-19T14:42:18Z2020-08-19T14:42:18Z2016-02-28MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.application/pdfhttps://doi.org/10.1016/j.psychres.2016.01.006ISSN: 0165-1781EISSN: 1872-7123https://repository.urosario.edu.co/handle/10336/27464engElsevier205202Psychiatry ResearchVol. 236Psychiatry Research, ISSN: 0165-1781;EISSN: 1872-7123, Vol.236 (2016); pp. 202-205 https://www.sciencedirect.com/science/article/abs/pii/S0165178115303498Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecPsychiatry Researchinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURExecutive functionEndophenotypesMicroRNAsA functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adultsUna variante funcional en MIR137, un gen candidato para la esquizofrenia, afecta el rendimiento de la prueba de Stroop en adultos jóvenesarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501González-Giraldo, YeimyGonzález Reyes, Rodrigo EstebanGarzon-Forero, Diego A10336/27464oai:repository.urosario.edu.co:10336/274642021-06-03 00:50:13.528https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
dc.title.TranslatedTitle.spa.fl_str_mv Una variante funcional en MIR137, un gen candidato para la esquizofrenia, afecta el rendimiento de la prueba de Stroop en adultos jóvenes
title A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
spellingShingle A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
Executive function
Endophenotypes
MicroRNAs
title_short A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
title_full A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
title_fullStr A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
title_full_unstemmed A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
title_sort A functional variant in MIR137, a candidate gene for schizophrenia, affects Stroop test performance in young adults
dc.subject.keyword.spa.fl_str_mv Executive function
Endophenotypes
MicroRNAs
topic Executive function
Endophenotypes
MicroRNAs
description MIR137, a brain expressed miRNA, has been identified as a top novel susceptibility gene for schizophrenia (SZ). 230 healthy participants completed the Stroop test and were genotyped for a functional Variable Number Tandem Repeat (VNTR) in MIR137 gene. MIR137 VNTR genotypes were associated with differences in Stroop facilitation and accuracies in congruent trials and for the total number of errors. This is the first study of the functional VNTR in MIR137 gene and Stroop test performance in healthy subjects. Our results could have important implications for the identification of genetic candidates for endophenotypes for SZ.
publishDate 2016
dc.date.created.spa.fl_str_mv 2016-02-28
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:42:18Z
dc.date.available.none.fl_str_mv 2020-08-19T14:42:18Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.psychres.2016.01.006
dc.identifier.issn.none.fl_str_mv ISSN: 0165-1781
EISSN: 1872-7123
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27464
url https://doi.org/10.1016/j.psychres.2016.01.006
https://repository.urosario.edu.co/handle/10336/27464
identifier_str_mv ISSN: 0165-1781
EISSN: 1872-7123
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 205
dc.relation.citationStartPage.none.fl_str_mv 202
dc.relation.citationTitle.none.fl_str_mv Psychiatry Research
dc.relation.citationVolume.none.fl_str_mv Vol. 236
dc.relation.ispartof.spa.fl_str_mv Psychiatry Research, ISSN: 0165-1781;EISSN: 1872-7123, Vol.236 (2016); pp. 202-205
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/abs/pii/S0165178115303498
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Elsevier
dc.source.spa.fl_str_mv Psychiatry Research
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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