Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis

The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and cl...

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Autores:
Tipo de recurso:
Fecha de publicación:
2009
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/23694
Acceso en línea:
https://doi.org/10.1007/s10067-009-1145-8
https://repository.urosario.edu.co/handle/10336/23694
Palabra clave:
Cyclic citrullinated peptide antibody
Disease modifying antirheumatic drug
Hla antigen
Rheumatoid factor
Steroid
Tumor necrosis factor
Adult
Age
Anemia
Antibody titer
Article
Cardiovascular disease
Cardiovascular risk
Cigarette smoking
Clinical feature
Colombia
Comorbidity
Controlled study
Demography
Disease activity
Disease association
Disease duration
Dna polymorphism
Extra articular rheumatoid arthritis
Family history
Female
Gene frequency
Genetic risk
Genetic variability
Human
Hypertension
Lung disease
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Rheumatoid nodule
Sjoegren syndrome
Thrombosis
Autoantibodies
Cardiovascular diseases
Colombia
Cross-sectional studies
European continental ancestry group
Female
Genotype
Histocompatibility testing
Hla-dq antigens
Hla-dr antigens
Humans
Male
Middle aged
Risk factors
Time factors
Cardiovascular disease
Extra-articular manifestations
Hla
Latin america
Rheumatoid arthritis
Smoking
south american
rheumatoid
cyclic
Arthritis
Indians
Peptides
Rights
License
Abierto (Texto Completo)
id EDOCUR2_c94874b70078b4b62ff80744cdff777c
oai_identifier_str oai:repository.urosario.edu.co:10336/23694
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 514bd3fb-953b-450b-830d-69277be4c312f7fc84f7-ce45-4016-9200-7fc16ae72b68a43c61fc-994f-4bf6-80c3-3ab3990003ef52249701194747786002020-05-26T00:04:33Z2020-05-26T00:04:33Z2009The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA 'shared epitope' (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.application/pdfhttps://doi.org/10.1007/s10067-009-1145-87703198https://repository.urosario.edu.co/handle/10336/23694eng775No. 7767Clinical RheumatologyVol. 28Clinical Rheumatology, ISSN:7703198, Vol.28, No.7 (2009); pp. 767-775https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349175002&doi=10.1007%2fs10067-009-1145-8&partnerID=40&md5=bc155402acc7aec78242175967db994bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCyclic citrullinated peptide antibodyDisease modifying antirheumatic drugHla antigenRheumatoid factorSteroidTumor necrosis factorAdultAgeAnemiaAntibody titerArticleCardiovascular diseaseCardiovascular riskCigarette smokingClinical featureColombiaComorbidityControlled studyDemographyDisease activityDisease associationDisease durationDna polymorphismExtra articular rheumatoid arthritisFamily historyFemaleGene frequencyGenetic riskGenetic variabilityHumanHypertensionLung diseaseMajor clinical studyMalePriority journalRheumatoid arthritisRheumatoid noduleSjoegren syndromeThrombosisAutoantibodiesCardiovascular diseasesColombiaCross-sectional studiesEuropean continental ancestry groupFemaleGenotypeHistocompatibility testingHla-dq antigensHla-dr antigensHumansMaleMiddle agedRisk factorsTime factorsCardiovascular diseaseExtra-articular manifestationsHlaLatin americaRheumatoid arthritisSmokingsouth americanrheumatoidcyclicArthritisIndiansPeptidesCardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ortega-Hernandez, Oscar-DaniloPineda-Tamayo, RicardoPardo, Aryce L.Rojas-Villarraga, AdrianaAnaya, Juan-Manuel10336/23694oai:repository.urosario.edu.co:10336/236942022-05-02 07:37:13.554604https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
title Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
spellingShingle Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
Cyclic citrullinated peptide antibody
Disease modifying antirheumatic drug
Hla antigen
Rheumatoid factor
Steroid
Tumor necrosis factor
Adult
Age
Anemia
Antibody titer
Article
Cardiovascular disease
Cardiovascular risk
Cigarette smoking
Clinical feature
Colombia
Comorbidity
Controlled study
Demography
Disease activity
Disease association
Disease duration
Dna polymorphism
Extra articular rheumatoid arthritis
Family history
Female
Gene frequency
Genetic risk
Genetic variability
Human
Hypertension
Lung disease
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Rheumatoid nodule
Sjoegren syndrome
Thrombosis
Autoantibodies
Cardiovascular diseases
Colombia
Cross-sectional studies
European continental ancestry group
Female
Genotype
Histocompatibility testing
Hla-dq antigens
Hla-dr antigens
Humans
Male
Middle aged
Risk factors
Time factors
Cardiovascular disease
Extra-articular manifestations
Hla
Latin america
Rheumatoid arthritis
Smoking
south american
rheumatoid
cyclic
Arthritis
Indians
Peptides
title_short Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
title_full Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
title_fullStr Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
title_full_unstemmed Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
title_sort Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
dc.subject.keyword.spa.fl_str_mv Cyclic citrullinated peptide antibody
Disease modifying antirheumatic drug
Hla antigen
Rheumatoid factor
Steroid
Tumor necrosis factor
Adult
Age
Anemia
Antibody titer
Article
Cardiovascular disease
Cardiovascular risk
Cigarette smoking
Clinical feature
Colombia
Comorbidity
Controlled study
Demography
Disease activity
Disease association
Disease duration
Dna polymorphism
Extra articular rheumatoid arthritis
Family history
Female
Gene frequency
Genetic risk
Genetic variability
Human
Hypertension
Lung disease
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Rheumatoid nodule
Sjoegren syndrome
Thrombosis
Autoantibodies
Cardiovascular diseases
Colombia
Cross-sectional studies
European continental ancestry group
Female
Genotype
Histocompatibility testing
Hla-dq antigens
Hla-dr antigens
Humans
Male
Middle aged
Risk factors
Time factors
Cardiovascular disease
Extra-articular manifestations
Hla
Latin america
Rheumatoid arthritis
Smoking
topic Cyclic citrullinated peptide antibody
Disease modifying antirheumatic drug
Hla antigen
Rheumatoid factor
Steroid
Tumor necrosis factor
Adult
Age
Anemia
Antibody titer
Article
Cardiovascular disease
Cardiovascular risk
Cigarette smoking
Clinical feature
Colombia
Comorbidity
Controlled study
Demography
Disease activity
Disease association
Disease duration
Dna polymorphism
Extra articular rheumatoid arthritis
Family history
Female
Gene frequency
Genetic risk
Genetic variability
Human
Hypertension
Lung disease
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Rheumatoid nodule
Sjoegren syndrome
Thrombosis
Autoantibodies
Cardiovascular diseases
Colombia
Cross-sectional studies
European continental ancestry group
Female
Genotype
Histocompatibility testing
Hla-dq antigens
Hla-dr antigens
Humans
Male
Middle aged
Risk factors
Time factors
Cardiovascular disease
Extra-articular manifestations
Hla
Latin america
Rheumatoid arthritis
Smoking
south american
rheumatoid
cyclic
Arthritis
Indians
Peptides
dc.subject.keyword.eng.fl_str_mv south american
rheumatoid
cyclic
Arthritis
Indians
Peptides
description The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA 'shared epitope' (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.
publishDate 2009
dc.date.created.spa.fl_str_mv 2009
dc.date.accessioned.none.fl_str_mv 2020-05-26T00:04:33Z
dc.date.available.none.fl_str_mv 2020-05-26T00:04:33Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1007/s10067-009-1145-8
dc.identifier.issn.none.fl_str_mv 7703198
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/23694
url https://doi.org/10.1007/s10067-009-1145-8
https://repository.urosario.edu.co/handle/10336/23694
identifier_str_mv 7703198
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 775
dc.relation.citationIssue.none.fl_str_mv No. 7
dc.relation.citationStartPage.none.fl_str_mv 767
dc.relation.citationTitle.none.fl_str_mv Clinical Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 28
dc.relation.ispartof.spa.fl_str_mv Clinical Rheumatology, ISSN:7703198, Vol.28, No.7 (2009); pp. 767-775
dc.relation.uri.spa.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349175002&doi=10.1007%2fs10067-009-1145-8&partnerID=40&md5=bc155402acc7aec78242175967db994b
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.spa.fl_str_mv Abierto (Texto Completo)
rights_invalid_str_mv Abierto (Texto Completo)
http://purl.org/coar/access_right/c_abf2
dc.format.mimetype.none.fl_str_mv application/pdf
institution Universidad del Rosario
dc.source.instname.spa.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.spa.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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