Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis
The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and cl...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 2009
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/23694
- Acceso en línea:
- https://doi.org/10.1007/s10067-009-1145-8
https://repository.urosario.edu.co/handle/10336/23694
- Palabra clave:
- Cyclic citrullinated peptide antibody
Disease modifying antirheumatic drug
Hla antigen
Rheumatoid factor
Steroid
Tumor necrosis factor
Adult
Age
Anemia
Antibody titer
Article
Cardiovascular disease
Cardiovascular risk
Cigarette smoking
Clinical feature
Colombia
Comorbidity
Controlled study
Demography
Disease activity
Disease association
Disease duration
Dna polymorphism
Extra articular rheumatoid arthritis
Family history
Female
Gene frequency
Genetic risk
Genetic variability
Human
Hypertension
Lung disease
Major clinical study
Male
Priority journal
Rheumatoid arthritis
Rheumatoid nodule
Sjoegren syndrome
Thrombosis
Autoantibodies
Cardiovascular diseases
Colombia
Cross-sectional studies
European continental ancestry group
Female
Genotype
Histocompatibility testing
Hla-dq antigens
Hla-dr antigens
Humans
Male
Middle aged
Risk factors
Time factors
Cardiovascular disease
Extra-articular manifestations
Hla
Latin america
Rheumatoid arthritis
Smoking
south american
rheumatoid
cyclic
Arthritis
Indians
Peptides
- Rights
- License
- Abierto (Texto Completo)
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514bd3fb-953b-450b-830d-69277be4c312f7fc84f7-ce45-4016-9200-7fc16ae72b68a43c61fc-994f-4bf6-80c3-3ab3990003ef52249701194747786002020-05-26T00:04:33Z2020-05-26T00:04:33Z2009The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA 'shared epitope' (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009.application/pdfhttps://doi.org/10.1007/s10067-009-1145-87703198https://repository.urosario.edu.co/handle/10336/23694eng775No. 7767Clinical RheumatologyVol. 28Clinical Rheumatology, ISSN:7703198, Vol.28, No.7 (2009); pp. 767-775https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349175002&doi=10.1007%2fs10067-009-1145-8&partnerID=40&md5=bc155402acc7aec78242175967db994bAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCyclic citrullinated peptide antibodyDisease modifying antirheumatic drugHla antigenRheumatoid factorSteroidTumor necrosis factorAdultAgeAnemiaAntibody titerArticleCardiovascular diseaseCardiovascular riskCigarette smokingClinical featureColombiaComorbidityControlled studyDemographyDisease activityDisease associationDisease durationDna polymorphismExtra articular rheumatoid arthritisFamily historyFemaleGene frequencyGenetic riskGenetic variabilityHumanHypertensionLung diseaseMajor clinical studyMalePriority journalRheumatoid arthritisRheumatoid noduleSjoegren syndromeThrombosisAutoantibodiesCardiovascular diseasesColombiaCross-sectional studiesEuropean continental ancestry groupFemaleGenotypeHistocompatibility testingHla-dq antigensHla-dr antigensHumansMaleMiddle agedRisk factorsTime factorsCardiovascular diseaseExtra-articular manifestationsHlaLatin americaRheumatoid arthritisSmokingsouth americanrheumatoidcyclicArthritisIndiansPeptidesCardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritisarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ortega-Hernandez, Oscar-DaniloPineda-Tamayo, RicardoPardo, Aryce L.Rojas-Villarraga, AdrianaAnaya, Juan-Manuel10336/23694oai:repository.urosario.edu.co:10336/236942022-05-02 07:37:13.554604https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
title |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
spellingShingle |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis Cyclic citrullinated peptide antibody Disease modifying antirheumatic drug Hla antigen Rheumatoid factor Steroid Tumor necrosis factor Adult Age Anemia Antibody titer Article Cardiovascular disease Cardiovascular risk Cigarette smoking Clinical feature Colombia Comorbidity Controlled study Demography Disease activity Disease association Disease duration Dna polymorphism Extra articular rheumatoid arthritis Family history Female Gene frequency Genetic risk Genetic variability Human Hypertension Lung disease Major clinical study Male Priority journal Rheumatoid arthritis Rheumatoid nodule Sjoegren syndrome Thrombosis Autoantibodies Cardiovascular diseases Colombia Cross-sectional studies European continental ancestry group Female Genotype Histocompatibility testing Hla-dq antigens Hla-dr antigens Humans Male Middle aged Risk factors Time factors Cardiovascular disease Extra-articular manifestations Hla Latin america Rheumatoid arthritis Smoking south american rheumatoid cyclic Arthritis Indians Peptides |
title_short |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
title_full |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
title_fullStr |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
title_full_unstemmed |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
title_sort |
Cardiovascular disease is associated with extra-articular manifestations in patients with rheumatoid arthritis |
dc.subject.keyword.spa.fl_str_mv |
Cyclic citrullinated peptide antibody Disease modifying antirheumatic drug Hla antigen Rheumatoid factor Steroid Tumor necrosis factor Adult Age Anemia Antibody titer Article Cardiovascular disease Cardiovascular risk Cigarette smoking Clinical feature Colombia Comorbidity Controlled study Demography Disease activity Disease association Disease duration Dna polymorphism Extra articular rheumatoid arthritis Family history Female Gene frequency Genetic risk Genetic variability Human Hypertension Lung disease Major clinical study Male Priority journal Rheumatoid arthritis Rheumatoid nodule Sjoegren syndrome Thrombosis Autoantibodies Cardiovascular diseases Colombia Cross-sectional studies European continental ancestry group Female Genotype Histocompatibility testing Hla-dq antigens Hla-dr antigens Humans Male Middle aged Risk factors Time factors Cardiovascular disease Extra-articular manifestations Hla Latin america Rheumatoid arthritis Smoking |
topic |
Cyclic citrullinated peptide antibody Disease modifying antirheumatic drug Hla antigen Rheumatoid factor Steroid Tumor necrosis factor Adult Age Anemia Antibody titer Article Cardiovascular disease Cardiovascular risk Cigarette smoking Clinical feature Colombia Comorbidity Controlled study Demography Disease activity Disease association Disease duration Dna polymorphism Extra articular rheumatoid arthritis Family history Female Gene frequency Genetic risk Genetic variability Human Hypertension Lung disease Major clinical study Male Priority journal Rheumatoid arthritis Rheumatoid nodule Sjoegren syndrome Thrombosis Autoantibodies Cardiovascular diseases Colombia Cross-sectional studies European continental ancestry group Female Genotype Histocompatibility testing Hla-dq antigens Hla-dr antigens Humans Male Middle aged Risk factors Time factors Cardiovascular disease Extra-articular manifestations Hla Latin america Rheumatoid arthritis Smoking south american rheumatoid cyclic Arthritis Indians Peptides |
dc.subject.keyword.eng.fl_str_mv |
south american rheumatoid cyclic Arthritis Indians Peptides |
description |
The objective of this study was to examine the clinical and genetic variables associated with extra-articular rheumatoid arthritis (ExRA). This was a cross-sectional study in which 538 Northwestern Colombian patients with rheumatoid arthritis (RA) were included. Information about demographics and clinical characteristics including disease activity, inflammatory markers, co-morbidities, cardiovascular (CV) risk factors, history of familial autoimmunity and therapy was recorded. The presence of HLA 'shared epitope' (SE) alleles and TNF gene polymorphism was assessed. A multivariate statistical analysis was performed. ExRA was found in 32% of the patients, of which nodulosis, Sjögren's syndrome, and lung involvement were registered in 21%, 9%, and 4% of patients, respectively. Patients with ExRA were older than patients without it and they presented longer disease duration as well. Thus, an association between disease duration and ExRA manifestations was also observed. Patients with ExRA presented significant higher titers of anti-CCP antibodies as compared to patients without ExRA. Hypertension and thrombosis were significantly associated with ExRA. Never having smoked constituted a protective factor against ExRA onset. Associations between ExRA and the presence of traditional CV risk factors were also found. Our results show that duration of RA, CV disease and high titers of anti-CCP antibodies are associated with ExRA in Colombian patients with RA, and highlight the importance of preventing smoking in those who are prone to develop autoimmune diseases including RA. © Clinical Rheumatology 2009. |
publishDate |
2009 |
dc.date.created.spa.fl_str_mv |
2009 |
dc.date.accessioned.none.fl_str_mv |
2020-05-26T00:04:33Z |
dc.date.available.none.fl_str_mv |
2020-05-26T00:04:33Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1007/s10067-009-1145-8 |
dc.identifier.issn.none.fl_str_mv |
7703198 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/23694 |
url |
https://doi.org/10.1007/s10067-009-1145-8 https://repository.urosario.edu.co/handle/10336/23694 |
identifier_str_mv |
7703198 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
775 |
dc.relation.citationIssue.none.fl_str_mv |
No. 7 |
dc.relation.citationStartPage.none.fl_str_mv |
767 |
dc.relation.citationTitle.none.fl_str_mv |
Clinical Rheumatology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 28 |
dc.relation.ispartof.spa.fl_str_mv |
Clinical Rheumatology, ISSN:7703198, Vol.28, No.7 (2009); pp. 767-775 |
dc.relation.uri.spa.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-67349175002&doi=10.1007%2fs10067-009-1145-8&partnerID=40&md5=bc155402acc7aec78242175967db994b |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.rights.acceso.spa.fl_str_mv |
Abierto (Texto Completo) |
rights_invalid_str_mv |
Abierto (Texto Completo) http://purl.org/coar/access_right/c_abf2 |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
institution |
Universidad del Rosario |
dc.source.instname.spa.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.spa.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167434812194816 |