Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases

One hundred and ninety-one patients with severe rheumatoid arthritis (RA) were included in a prospective open longterm study of the safety, efficacy and maintenance of methotrexate (MTX) treatment. The mean duration of MTX treatment was 19 +/- 13.2 (3-58) months; the mean weekly dose of MTX was 10.2...

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Fecha de publicación:
1991
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/27135
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/27135
Palabra clave:
Safety
Efficacy
Maintenance
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oai_identifier_str oai:repository.urosario.edu.co:10336/27135
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling 19474778600e8938956-af14-46bd-9749-62565a90def1daee595c-77a5-458b-beb8-527c52db67c6363a398e-e9c8-42e8-bf3b-ad30173847266029d3dc-05de-488a-bd99-05891264bfec2020-08-19T14:41:06Z2020-08-19T14:41:06Z1991One hundred and ninety-one patients with severe rheumatoid arthritis (RA) were included in a prospective open longterm study of the safety, efficacy and maintenance of methotrexate (MTX) treatment. The mean duration of MTX treatment was 19 +/- 13.2 (3-58) months; the mean weekly dose of MTX was 10.2 +/- 0.2 mg. Analysis of the 191 patients in an intent-to-treat manner showed a significant improvement of all the clinical variables and a decrease of erythrocyte sedimentation rate with a steroid sparing effect. The probability of continuing MTX therapy for up to 2 years was 65% and for up to 5 years was 46%. Adverse effects of MTX occurred in 37.1% of the patients, but only 15.7% discontinued MTX permanently.application/pdfISSN: 0315-162XEISSN: 1499-2752https://repository.urosario.edu.co/handle/10336/27135engEurope PMC1327No. 91323Journal of RheumatologyVol. 18Journal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.18, No.9 (31 Agosto 1991); pp.1323-1327https://europepmc.org/article/med/1757932Bloqueado (Texto referencial)http://purl.org/coar/access_right/c_14cbJournal of Rheumatologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSafetyEfficacyMaintenanceTreatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 casesTratamiento de la artritis reumatoide con metotrexato: un estudio prospectivo abierto a largo plazo de 191 casosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelSany, J.Couret, M.Combe, B.Daures JP.10336/27135oai:repository.urosario.edu.co:10336/271352022-05-02 07:37:13.450353https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
dc.title.TranslatedTitle.spa.fl_str_mv Tratamiento de la artritis reumatoide con metotrexato: un estudio prospectivo abierto a largo plazo de 191 casos
title Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
spellingShingle Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
Safety
Efficacy
Maintenance
title_short Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
title_full Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
title_fullStr Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
title_full_unstemmed Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
title_sort Treatment of rheumatoid arthritis with methotrexate: A prospective open longterm study of 191 cases
dc.subject.keyword.spa.fl_str_mv Safety
Efficacy
Maintenance
topic Safety
Efficacy
Maintenance
description One hundred and ninety-one patients with severe rheumatoid arthritis (RA) were included in a prospective open longterm study of the safety, efficacy and maintenance of methotrexate (MTX) treatment. The mean duration of MTX treatment was 19 +/- 13.2 (3-58) months; the mean weekly dose of MTX was 10.2 +/- 0.2 mg. Analysis of the 191 patients in an intent-to-treat manner showed a significant improvement of all the clinical variables and a decrease of erythrocyte sedimentation rate with a steroid sparing effect. The probability of continuing MTX therapy for up to 2 years was 65% and for up to 5 years was 46%. Adverse effects of MTX occurred in 37.1% of the patients, but only 15.7% discontinued MTX permanently.
publishDate 1991
dc.date.created.spa.fl_str_mv 1991
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:41:06Z
dc.date.available.none.fl_str_mv 2020-08-19T14:41:06Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.issn.none.fl_str_mv ISSN: 0315-162X
EISSN: 1499-2752
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/27135
identifier_str_mv ISSN: 0315-162X
EISSN: 1499-2752
url https://repository.urosario.edu.co/handle/10336/27135
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1327
dc.relation.citationIssue.none.fl_str_mv No. 9
dc.relation.citationStartPage.none.fl_str_mv 1323
dc.relation.citationTitle.none.fl_str_mv Journal of Rheumatology
dc.relation.citationVolume.none.fl_str_mv Vol. 18
dc.relation.ispartof.spa.fl_str_mv Journal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.18, No.9 (31 Agosto 1991); pp.1323-1327
dc.relation.uri.spa.fl_str_mv https://europepmc.org/article/med/1757932
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_14cb
dc.rights.acceso.spa.fl_str_mv Bloqueado (Texto referencial)
rights_invalid_str_mv Bloqueado (Texto referencial)
http://purl.org/coar/access_right/c_14cb
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv Europe PMC
dc.source.spa.fl_str_mv Journal of Rheumatology
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
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