Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes

Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in imm...

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Autores:
Tipo de recurso:
Fecha de publicación:
2004
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26992
Acceso en línea:
https://doi.org/10.1016/j.vaccine.2003.09.029
https://repository.urosario.edu.co/handle/10336/26992
Palabra clave:
Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
Rights
License
Restringido (Acceso a grupos específicos)
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oai_identifier_str oai:repository.urosario.edu.co:10336/26992
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
spelling eba5265c-2b9f-49a4-8c8c-4e3459a41e19c558796b-4d23-4bf9-b8b3-7d818293f92034b82e95-53e0-4ba5-a5c5-d4191164afa12545c992-99b1-4106-8dc9-0a8d111b2438c4dd6f1e-a512-4c2f-87d2-d8ff29ce609682d12a15-58b8-4501-8514-f212b7279e1791225589fa33b517-50cf-4bb5-a980-3773caf84cd884cece1e-359c-45a6-b251-f8e4b62a84eb51890881bc380284-d23e-4afd-ad07-efa220c5bd4bc444cac4-b734-4d95-9f17-d8947506f7fb10ecd4f9-843f-4ef2-bec0-7d39d3381a13518488266002020-08-19T14:40:42Z2020-08-19T14:40:42Z2004-03-12Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.application/pdfhttps://doi.org/10.1016/j.vaccine.2003.09.029ISSN: 0264-410XEISSN: 1873-2518https://repository.urosario.edu.co/handle/10336/26992engThe Japanese Society for VaccinologyElsevier1156No. 9-101150VaccineVol. 22Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.22, No.9-10 (2004); pp. 1150-1156https://www.sciencedirect.com/science/article/pii/S0264410X03006972?via%3DihubRestringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecVaccineinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURPlasmodium falciparumSALSA proteinBinding peptidesCritical residuesHepatocyte binding peptidesSporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytesLos péptidos de plasmodium falciparum del antígeno de la etapa hepática y del esporozoito se unen específicamente a los hepatocitos humanosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Puentes, AlvaroGarcía, JavierVera, RicardoLópez, RamsésSuarez, JorgeRodríguez, LuisCurtidor, HernandoTovar, DianaForero, MarthaBermudez, AdrianaCortes, JimenaUrquiza, MauricioPatarroyo, Manuel E.Ocampo, Marisol10336/26992oai:repository.urosario.edu.co:10336/269922021-06-10 23:36:49.656https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co
dc.title.spa.fl_str_mv Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
dc.title.TranslatedTitle.spa.fl_str_mv Los péptidos de plasmodium falciparum del antígeno de la etapa hepática y del esporozoito se unen específicamente a los hepatocitos humanos
title Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
spellingShingle Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
title_short Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_full Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_fullStr Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_full_unstemmed Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
title_sort Sporozoite and liver stage antigen plasmodium falciparum peptides bind specifically to human hepatocytes
dc.subject.keyword.spa.fl_str_mv Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
topic Plasmodium falciparum
SALSA protein
Binding peptides
Critical residues
Hepatocyte binding peptides
description Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 () and 20611 () peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSKDEKAQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides’ (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes.
publishDate 2004
dc.date.created.spa.fl_str_mv 2004-03-12
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:42Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:42Z
dc.type.eng.fl_str_mv article
dc.type.coarversion.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.vaccine.2003.09.029
dc.identifier.issn.none.fl_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26992
url https://doi.org/10.1016/j.vaccine.2003.09.029
https://repository.urosario.edu.co/handle/10336/26992
identifier_str_mv ISSN: 0264-410X
EISSN: 1873-2518
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 1156
dc.relation.citationIssue.none.fl_str_mv No. 9-10
dc.relation.citationStartPage.none.fl_str_mv 1150
dc.relation.citationTitle.none.fl_str_mv Vaccine
dc.relation.citationVolume.none.fl_str_mv Vol. 22
dc.relation.ispartof.spa.fl_str_mv Vaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.22, No.9-10 (2004); pp. 1150-1156
dc.relation.uri.spa.fl_str_mv https://www.sciencedirect.com/science/article/pii/S0264410X03006972?via%3Dihub
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_16ec
dc.rights.acceso.spa.fl_str_mv Restringido (Acceso a grupos específicos)
rights_invalid_str_mv Restringido (Acceso a grupos específicos)
http://purl.org/coar/access_right/c_16ec
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.spa.fl_str_mv The Japanese Society for Vaccinology
Elsevier
dc.source.spa.fl_str_mv Vaccine
institution Universidad del Rosario
dc.source.instname.none.fl_str_mv instname:Universidad del Rosario
dc.source.reponame.none.fl_str_mv reponame:Repositorio Institucional EdocUR
repository.name.fl_str_mv Repositorio institucional EdocUR
repository.mail.fl_str_mv edocur@urosario.edu.co
_version_ 1814167667391594496

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