Sjögren's syndrome in childhood.
To describe the clinical characteristics of juvenile Sjögren's syndrome (JSS) and report 5 new primary cases. Patients with SS whose disease began before age 16 were identified from a cohort study on SS. Previous patients with JSS published from 1952 to 1993 were found by literature review. Thi...
- Autores:
- Tipo de recurso:
- Fecha de publicación:
- 1995
- Institución:
- Universidad del Rosario
- Repositorio:
- Repositorio EdocUR - U. Rosario
- Idioma:
- eng
- OAI Identifier:
- oai:repository.urosario.edu.co:10336/28402
- Acceso en línea:
- https://repository.urosario.edu.co/handle/10336/28402
- Palabra clave:
- Sjögren's syndrome
Childhood
- Rights
- License
- Restringido (Acceso a grupos específicos)
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oai:repository.urosario.edu.co:10336/28402 |
network_acronym_str |
EDOCUR2 |
network_name_str |
Repositorio EdocUR - U. Rosario |
repository_id_str |
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194747786006e84280f-9562-41a7-bc79-65a3191228f2-122a3bd8c-89b4-4c98-b36a-7b77243faeff-12020-08-28T15:48:07Z2020-08-28T15:48:07Z1995-06-01To describe the clinical characteristics of juvenile Sjögren's syndrome (JSS) and report 5 new primary cases. Patients with SS whose disease began before age 16 were identified from a cohort study on SS. Previous patients with JSS published from 1952 to 1993 were found by literature review. Thirty-nine adult patients with primary SS were selected as a control group. Five patients with primary JSS were identified and described. Thirty-four published primary JSS were reviewed. Altogether, there were 30 girls (77%). The mean age at onset was 7.8 +/- 4 years. Parotitis was the most common first symptom. An extraglandular manifestation (EGM) was the presenting feature in 9.3% of cases. Rheumatoid factor (RF) was positive in 71% and antinuclear antibodies (ANA) in 67%. During the course of disease, at least one EGM was noted in 20 cases (51%). Leukopenia was the most frequent of these (7/20, 35%). HLA-DR3 was observed in 4 of 6 cases in which HLA typing was done. Compared with adult primary SS, parotitis at onset was more frequent in children (62.5 vs 13%). The frequency of ANA and articular manifestations were higher in adults (67 vs 92%, and 15.4 vs 38.5%, respectively). We reviewed 31 cases of secondary JSS, of which the most common associated autoimmune disease was juvenile rheumatoid arthritis (42%). JSS preceded by years the associated autoimmune disease in nearly 50% of cases. JSS may be a common disease. Parotitis and the presence of RF and ANA are the main features at onset. Characteristics similar to those seen in adults are observed in children. Long-term followup is needed to assess outcome associated factors.application/pdfISSN: 0315-162XEISSN: 1499-2752https://repository.urosario.edu.co/handle/10336/28402engThe Journal of Rheumatology Publishing1158No. 61152Journal of RheumatologyVol. 22Journal of Rheumatology, ISSN: 0315-162X; EISSN: 1499-2752, Vol.22, No.6 (June, 1995); pp. 1152 - 1158https://pubmed.ncbi.nlm.nih.gov/7674246/Restringido (Acceso a grupos específicos)http://purl.org/coar/access_right/c_16ecJournal of Rheumatologyinstname:Universidad del Rosarioreponame:Repositorio Institucional EdocURSjögren's syndromeChildhoodSjögren's syndrome in childhood.Síndrome de Sjögren en la infancia.articleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Anaya, Juan-ManuelOgawa, N.Talal N.10336/28402oai:repository.urosario.edu.co:10336/284022021-06-03 00:49:47.65https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co |
dc.title.spa.fl_str_mv |
Sjögren's syndrome in childhood. |
dc.title.TranslatedTitle.spa.fl_str_mv |
Síndrome de Sjögren en la infancia. |
title |
Sjögren's syndrome in childhood. |
spellingShingle |
Sjögren's syndrome in childhood. Sjögren's syndrome Childhood |
title_short |
Sjögren's syndrome in childhood. |
title_full |
Sjögren's syndrome in childhood. |
title_fullStr |
Sjögren's syndrome in childhood. |
title_full_unstemmed |
Sjögren's syndrome in childhood. |
title_sort |
Sjögren's syndrome in childhood. |
dc.subject.keyword.spa.fl_str_mv |
Sjögren's syndrome Childhood |
topic |
Sjögren's syndrome Childhood |
description |
To describe the clinical characteristics of juvenile Sjögren's syndrome (JSS) and report 5 new primary cases. Patients with SS whose disease began before age 16 were identified from a cohort study on SS. Previous patients with JSS published from 1952 to 1993 were found by literature review. Thirty-nine adult patients with primary SS were selected as a control group. Five patients with primary JSS were identified and described. Thirty-four published primary JSS were reviewed. Altogether, there were 30 girls (77%). The mean age at onset was 7.8 +/- 4 years. Parotitis was the most common first symptom. An extraglandular manifestation (EGM) was the presenting feature in 9.3% of cases. Rheumatoid factor (RF) was positive in 71% and antinuclear antibodies (ANA) in 67%. During the course of disease, at least one EGM was noted in 20 cases (51%). Leukopenia was the most frequent of these (7/20, 35%). HLA-DR3 was observed in 4 of 6 cases in which HLA typing was done. Compared with adult primary SS, parotitis at onset was more frequent in children (62.5 vs 13%). The frequency of ANA and articular manifestations were higher in adults (67 vs 92%, and 15.4 vs 38.5%, respectively). We reviewed 31 cases of secondary JSS, of which the most common associated autoimmune disease was juvenile rheumatoid arthritis (42%). JSS preceded by years the associated autoimmune disease in nearly 50% of cases. JSS may be a common disease. Parotitis and the presence of RF and ANA are the main features at onset. Characteristics similar to those seen in adults are observed in children. Long-term followup is needed to assess outcome associated factors. |
publishDate |
1995 |
dc.date.created.spa.fl_str_mv |
1995-06-01 |
dc.date.accessioned.none.fl_str_mv |
2020-08-28T15:48:07Z |
dc.date.available.none.fl_str_mv |
2020-08-28T15:48:07Z |
dc.type.eng.fl_str_mv |
article |
dc.type.coarversion.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.spa.spa.fl_str_mv |
Artículo |
dc.identifier.issn.none.fl_str_mv |
ISSN: 0315-162X EISSN: 1499-2752 |
dc.identifier.uri.none.fl_str_mv |
https://repository.urosario.edu.co/handle/10336/28402 |
identifier_str_mv |
ISSN: 0315-162X EISSN: 1499-2752 |
url |
https://repository.urosario.edu.co/handle/10336/28402 |
dc.language.iso.spa.fl_str_mv |
eng |
language |
eng |
dc.relation.citationEndPage.none.fl_str_mv |
1158 |
dc.relation.citationIssue.none.fl_str_mv |
No. 6 |
dc.relation.citationStartPage.none.fl_str_mv |
1152 |
dc.relation.citationTitle.none.fl_str_mv |
Journal of Rheumatology |
dc.relation.citationVolume.none.fl_str_mv |
Vol. 22 |
dc.relation.ispartof.spa.fl_str_mv |
Journal of Rheumatology, ISSN: 0315-162X; EISSN: 1499-2752, Vol.22, No.6 (June, 1995); pp. 1152 - 1158 |
dc.relation.uri.spa.fl_str_mv |
https://pubmed.ncbi.nlm.nih.gov/7674246/ |
dc.rights.coar.fl_str_mv |
http://purl.org/coar/access_right/c_16ec |
dc.rights.acceso.spa.fl_str_mv |
Restringido (Acceso a grupos específicos) |
rights_invalid_str_mv |
Restringido (Acceso a grupos específicos) http://purl.org/coar/access_right/c_16ec |
dc.format.mimetype.none.fl_str_mv |
application/pdf |
dc.publisher.spa.fl_str_mv |
The Journal of Rheumatology Publishing |
dc.source.spa.fl_str_mv |
Journal of Rheumatology |
institution |
Universidad del Rosario |
dc.source.instname.none.fl_str_mv |
instname:Universidad del Rosario |
dc.source.reponame.none.fl_str_mv |
reponame:Repositorio Institucional EdocUR |
repository.name.fl_str_mv |
Repositorio institucional EdocUR |
repository.mail.fl_str_mv |
edocur@urosario.edu.co |
_version_ |
1814167657995304960 |