Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases

To define the clinical and immunologic pattern of expression of Sjo¨gren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at lea...

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Tipo de recurso:
Fecha de publicación:
2005
Institución:
Universidad del Rosario
Repositorio:
Repositorio EdocUR - U. Rosario
Idioma:
eng
OAI Identifier:
oai:repository.urosario.edu.co:10336/26957
Acceso en línea:
https://doi.org/10.1097/01.md.0000157397.30055.c9
https://repository.urosario.edu.co/handle/10336/26957
Palabra clave:
Cryoglobulinemia complications
Hepatitis C
chronic immunology
Sjogren's syndrome blood
Vasculitis complications
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network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.spa.fl_str_mv Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
dc.title.TranslatedTitle.spa.fl_str_mv Síndrome de Sjoegren asociado al virus de la hepatitis C: análisis multicéntrico de 137 casos
title Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
spellingShingle Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
Cryoglobulinemia complications
Hepatitis C
chronic immunology
Sjogren's syndrome blood
Vasculitis complications
title_short Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
title_full Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
title_fullStr Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
title_full_unstemmed Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
title_sort Sjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
dc.subject.keyword.spa.fl_str_mv Cryoglobulinemia complications
Hepatitis C
chronic immunology
Sjogren's syndrome blood
Vasculitis complications
topic Cryoglobulinemia complications
Hepatitis C
chronic immunology
Sjogren's syndrome blood
Vasculitis complications
description To define the clinical and immunologic pattern of expression of Sjo¨gren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCVRNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive antiRo/SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS. In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term ‘‘SS secondary to HCV’’ when these patients fulfill the 2002 classification criteria for SS.
publishDate 2005
dc.date.created.spa.fl_str_mv 2005-03
dc.date.accessioned.none.fl_str_mv 2020-08-19T14:40:37Z
dc.date.available.none.fl_str_mv 2020-08-19T14:40:37Z
dc.type.eng.fl_str_mv article
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dc.type.spa.spa.fl_str_mv Artículo
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1097/01.md.0000157397.30055.c9
dc.identifier.issn.none.fl_str_mv ISSN: 0025-7974
EISSN: 1536-5964
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/26957
url https://doi.org/10.1097/01.md.0000157397.30055.c9
https://repository.urosario.edu.co/handle/10336/26957
identifier_str_mv ISSN: 0025-7974
EISSN: 1536-5964
dc.language.iso.spa.fl_str_mv eng
language eng
dc.relation.citationEndPage.none.fl_str_mv 89
dc.relation.citationIssue.none.fl_str_mv No. 2
dc.relation.citationStartPage.none.fl_str_mv 81
dc.relation.citationTitle.none.fl_str_mv Medicine (Baltimore)
dc.relation.citationVolume.none.fl_str_mv Vol. 84
dc.relation.ispartof.spa.fl_str_mv Medicine (Baltimore), ISSN: 0025-7974;EISSN: 1536-5964, Vol.84, No.2 (March 2005); pp. 81-89
dc.relation.uri.spa.fl_str_mv https://journals.lww.com/md-journal/Fulltext/2005/03000/Sj_gren_Syndrome_Associated_With_Hepatitis_C.2.aspx
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dc.publisher.spa.fl_str_mv Williams & Wilkins
Wolters Kluwer Health
dc.source.spa.fl_str_mv Medicine (Baltimore)
institution Universidad del Rosario
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spelling 8e65e67d-e83d-4d5a-a74a-6b78eb76ea47c6b7da78-20b4-4bf2-bf44-f4e8b7ad52659f45fda5-6644-4986-8091-f242d5bd20d555f830b7-1db3-4edf-bd53-e579196f3a0ab7f1df6d-b8dd-43b9-ad1e-b95871421725ce58b111-6956-4aa8-bc86-30d5324b1cdec6461ced-440b-4091-8bfc-8f97a006950a1a959232-e8ef-43fa-b91e-2f71038644631947477860077f2c330-c5b3-4ad5-8cd0-f69d43c8bbcd2020-08-19T14:40:37Z2020-08-19T14:40:37Z2005-03To define the clinical and immunologic pattern of expression of Sjo¨gren syndrome (SS) associated with chronic hepatitis C virus (HCV) infection, we conducted a multicenter study aiming to collect a large number of patients with SS and HCV infection. Inclusion criteria were the fulfillment of at least 4 of the classification criteria for SS proposed by the European Community Study Group and repeated positive HCV serology, confirmed by recombinant immunoblot assay and/or detection of serum HCVRNA by polymerase chain reaction. One hundred thirty-seven patients were included (104 female and 33 male; mean age, 65 yr). Seventy-nine (58%) patients presented a systemic process with diverse extraglandular manifestations, with articular involvement (44%), vasculitis (20%), and neuropathy (16%) being the most frequent features observed. The main immunologic features were antinuclear antibodies (65%), hypocomplementemia (51%), and cryoglobulinemia (50%). Cryoglobulins were associated with a higher frequency of cutaneous vasculitis, rheumatoid factor, and hypocomplementemia. Thirty-two (23%) patients had positive antiRo/SS-A and/or anti-La/SS-B antibodies; these patients were predominantly women and had a higher prevalence of some extraglandular features and a lower frequency of liver involvement. Nineteen (14%) patients developed neoplasia, with hematologic neoplasia (8 cases) and hepatocellular carcinoma (6 cases) being the most frequent types. Eighty-five percent of SS-HCV patients also fulfilled the recently proposed 2002 classification criteria for SS. In conclusion, HCV-associated SS is indistinguishable in most cases from the primary form using the most recent set of classification criteria. Chronic HCV infection should be considered an exclusion criterion for the classification of primary SS, not because it mimics primary SS, but because the virus may be implicated in the development of SS in a specific subset of patients. We propose the term ‘‘SS secondary to HCV’’ when these patients fulfill the 2002 classification criteria for SS.application/pdfhttps://doi.org/10.1097/01.md.0000157397.30055.c9ISSN: 0025-7974EISSN: 1536-5964https://repository.urosario.edu.co/handle/10336/26957engWilliams & WilkinsWolters Kluwer Health89No. 281Medicine (Baltimore)Vol. 84Medicine (Baltimore), ISSN: 0025-7974;EISSN: 1536-5964, Vol.84, No.2 (March 2005); pp. 81-89https://journals.lww.com/md-journal/Fulltext/2005/03000/Sj_gren_Syndrome_Associated_With_Hepatitis_C.2.aspxAbierto (Texto Completo)http://purl.org/coar/access_right/c_abf2Medicine (Baltimore)instname:Universidad del Rosarioreponame:Repositorio Institucional EdocURCryoglobulinemia complicationsHepatitis Cchronic immunologySjogren's syndrome bloodVasculitis complicationsSjoegren syndrome associated with hepatitis C virus: a multicenter analysis of 137 casesSíndrome de Sjoegren asociado al virus de la hepatitis C: análisis multicéntrico de 137 casosarticleArtículohttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_6501Ramos-Casals, ManuelLoustaud-Ratti, VeroniqueDe Vita, SalvatoreZeher, MargitBosch, Jose-AngelToussirot, EricMedina, FranciscoRosas, JoseAnaya, Juan-ManuelFont, JosepORIGINALSj_gren_Syndrome_Associated_With_Hepatitis_C-2.pdfapplication/pdf142580https://repository.urosario.edu.co/bitstreams/19961547-9a21-462e-b9f5-c1cba5bc56cf/downloadf5fa03c52be5fdc57188c6378fb787e0MD51TEXTSj_gren_Syndrome_Associated_With_Hepatitis_C-2.pdf.txtSj_gren_Syndrome_Associated_With_Hepatitis_C-2.pdf.txtExtracted texttext/plain44997https://repository.urosario.edu.co/bitstreams/ee053a68-c905-4e73-8c6b-cfe112292bfd/downloadc89f63835dcda89587cddcaf722312baMD52THUMBNAILSj_gren_Syndrome_Associated_With_Hepatitis_C-2.pdf.jpgSj_gren_Syndrome_Associated_With_Hepatitis_C-2.pdf.jpgGenerated Thumbnailimage/jpeg4712https://repository.urosario.edu.co/bitstreams/62980685-5b54-494f-8b78-a1d37498bd84/download81ee90f61cd2cda0a1c29f3ee6f7e321MD5310336/26957oai:repository.urosario.edu.co:10336/269572022-05-02 07:37:13.772845https://repository.urosario.edu.coRepositorio institucional EdocURedocur@urosario.edu.co