Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica

La cardiopatía Chagásica crónica (CCC) es una antropozoonosis causada por el Trypanosoma cruzi (T. cruzi) y en Colombia se estima una prevalencia entre el 1-2%. La resonancia magnética cardíaca (RMNC) es el estándar de oro para la evaluación de la función y tamaño cardíaco. Métodos: Este es un estud...

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Fecha de publicación:
2023
Institución:
Universidad del Rosario
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Repositorio EdocUR - U. Rosario
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spa
OAI Identifier:
oai:repository.urosario.edu.co:10336/41965
Acceso en línea:
https://repository.urosario.edu.co/handle/10336/41965
Palabra clave:
Enfermedad de chagas
Resonancia cardíaca
Pronóstico
Falla cardíaca
Chagas disease
Cardiac resonance
Prognosis
Heart failure
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License
Attribution-NoDerivatives 4.0 International
id EDOCUR2_bee3aec7068091cad095022910ef8445
oai_identifier_str oai:repository.urosario.edu.co:10336/41965
network_acronym_str EDOCUR2
network_name_str Repositorio EdocUR - U. Rosario
repository_id_str
dc.title.none.fl_str_mv Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
dc.title.TranslatedTitle.none.fl_str_mv Cardiac resonance markers and clinical events in patients with chronic chagasic heart disease in a Latin American center
title Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
spellingShingle Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
Enfermedad de chagas
Resonancia cardíaca
Pronóstico
Falla cardíaca
Chagas disease
Cardiac resonance
Prognosis
Heart failure
title_short Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
title_full Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
title_fullStr Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
title_full_unstemmed Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
title_sort Marcadores de resonancia cardíaca y eventos clínicos en pacientes con cardiopatía chagásica crónica en un centro de latinoamérica
dc.contributor.advisor.none.fl_str_mv Medina Zuluaga, Héctor Manuel
Vaquiro Hererra, Eliana
dc.contributor.gruplac.none.fl_str_mv Grupo de Investigacion en Cardiologia
dc.subject.none.fl_str_mv Enfermedad de chagas
Resonancia cardíaca
Pronóstico
Falla cardíaca
topic Enfermedad de chagas
Resonancia cardíaca
Pronóstico
Falla cardíaca
Chagas disease
Cardiac resonance
Prognosis
Heart failure
dc.subject.keyword.none.fl_str_mv Chagas disease
Cardiac resonance
Prognosis
Heart failure
description La cardiopatía Chagásica crónica (CCC) es una antropozoonosis causada por el Trypanosoma cruzi (T. cruzi) y en Colombia se estima una prevalencia entre el 1-2%. La resonancia magnética cardíaca (RMNC) es el estándar de oro para la evaluación de la función y tamaño cardíaco. Métodos: Este es un estudio observacional, analítico de casos y controles anidado en una cohorte retrospectiva. Se incluyeron todos los pacientes con diagnóstico de CCC que se sometieron a RMNC en la Fundación Cardioinfantil-laCardio entre el 2016 hasta el 2022. Se evaluó un desenlace compuesto (mortalidad por todas las causas, hospitalización por causa cardiovascular, trasplante cardíaco y evento cerebrovascular). Resultados: Se incluyeron un total de 133 pacientes. La mediana de edad de los pacientes fue de 64 años (IQR: 12) con un predominio de mujeres (53,4%). El 97,0% de los pacientes tenían RTG en al menos un segmento miocárdico, siendo de predominio transmural e inferolateral. Durante una mediana de seguimiento de 554 días (IQR: 960) se documentó el evento compuesto en 63 sujetos (47,4%). Se encontró que la FEVI ≤ a 40% tuvo asociación significativa en el análisis multivariado con el primario compuesto (OR: 2,81; p=0,028). Conclusión: Los pacientes de nuestro estudio presentaron una alta incidencia de eventos cardiovasculares y la reducción de la FEVI fue un predictor independiente para su desarrollo.
publishDate 2023
dc.date.created.none.fl_str_mv 2023
dc.date.accessioned.none.fl_str_mv 2024-01-11T19:02:21Z
dc.date.available.none.fl_str_mv 2024-01-11T19:02:21Z
dc.type.none.fl_str_mv bachelorThesis
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_7a1f
dc.type.document.none.fl_str_mv Trabajo de grado
dc.type.spa.none.fl_str_mv Trabajo de grado
dc.identifier.uri.none.fl_str_mv https://repository.urosario.edu.co/handle/10336/41965
url https://repository.urosario.edu.co/handle/10336/41965
dc.language.iso.none.fl_str_mv spa
language spa
dc.rights.*.fl_str_mv Attribution-NoDerivatives 4.0 International
dc.rights.coar.fl_str_mv http://purl.org/coar/access_right/c_abf2
dc.rights.acceso.none.fl_str_mv Abierto (Texto Completo)
dc.rights.uri.*.fl_str_mv http://creativecommons.org/licenses/by-nd/4.0/
rights_invalid_str_mv Attribution-NoDerivatives 4.0 International
Abierto (Texto Completo)
http://creativecommons.org/licenses/by-nd/4.0/
http://purl.org/coar/access_right/c_abf2
dc.format.extent.none.fl_str_mv 62 pp
dc.format.mimetype.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
dc.publisher.department.none.fl_str_mv Escuela de Medicina y Ciencias de la Salud
dc.publisher.program.none.fl_str_mv Especialización en Cardiología
publisher.none.fl_str_mv Universidad del Rosario
institution Universidad del Rosario
dc.source.bibliographicCitation.none.fl_str_mv Bonney KM, Luthringer DJ, Kim SA, Garg NJ, Engman DM. Pathology and Pathogenesis of Chagas Heart Disease. Annu Rev Pathol Mech Dis. 2019;14(1):421–47.
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Nunes MCP, Kreuser LJ, Ribeiro AL, Sousa GR, Costa HS, Botoni FA, et al. Prevalence and Risk Factors of Embolic Cerebrovascular Events Associated with Chagas Heart Disease. Glob Heart. 2015;10(3):151–7
Chadalawada S, Rassi A, Samara O, Monzon A, Gudapati D, Vargas Barahona L, et al. Mortality risk in chronic Chagas cardiomyopathy: a systematic review and meta-analysis. ESC Hear Fail. 2021;8(6).
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Rassi A, Rassi A, Little WC, Xavier SS, Rassi SG, Rassi AG, et al. Development and Validation of a Risk Score for Predicting Death in Chagas’ Heart Disease. N Engl J Med. 2006;355(8):799–808.
Umezawa ES, Bastos SF, Camargo ME, Yamauchi LM, Santos MR, Gonzalez A, et al. Evaluation of recombinant antigens for serodiagnosis of Chagas’ disease in South and Central America. J Clin Microbiol. 1999;37(5):1554–60.
Cançado JR. Criteria of Chagas Disease Cure. Mem Inst Oswaldo Cruz. 1999;94(SUPPL. 1).
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Volpe GJ, Moreira HT, Trad HS, Wu K, Braggion-Santos MF, Santos MK, et al. Presence of scar by late gadolinium enhancement is a strong predictor of events in Chagas Heart Disease. J Cardiovasc Magn Reson. 2014;16(S1).
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Nardi Gemme C, Silva TQAC, Martins LC, da Silva LM, Paim LR, Sposito A, et al. Diffuse Myocardial Fibrosis and Cardiomyocyte Diameter Are Associated With Heart Failure Symptoms in Chagas Cardiomyopathy. Front Cardiovasc Med. 2022;9(June):1–12.
Mello RP de, Szarf G, Schvartzman PR, Nakano EM, Espinosa MM, Szejnfeld D, et al. Delayed enhancement cardiac magnetic resonance imaging can identify the risk for ventricular tachycardia in chronic Chagas’ heart disease. Arq Bras Cardiol. 2012;98(5):421–30
Mansur AP, Pereira-Barretto AC, del Carlo CH, Ianni BM, Avakian SD, Gonçalinho GHF, et al. Sex Differences in Prognosis of Heart Failure Due to Chronic Chagas Cardiomyopathy. JACC Hear Fail. 2023;11(9):1284–6.
Acosta IC, Pérez-Tanoira R, Prieto-Pérez L, Úbeda AC, Álvarez Álvarez B, Antoranz PA, et al. Chagas’ heart disease: Descriptive analysis of 141 patients in a hospital of Madrid, Spain. Travel Med Infect Dis. 2020;37:101690.
Kammerlander AA, Wiesinger M, Duca F, Aschauer S, Binder C, Zotter Tufaro C, et al. Diagnostic and Prognostic Utility of Cardiac Magnetic Resonance Imaging in Aortic Regurgitation. JACC Cardiovasc Imaging. 2019;12(8):1474–83.
Yokota H, Heidary S, Katikireddy CK, Nguyen P, Pauly JM, McConnell M V., et al. Quantitative characterization of myocardial infarction by cardiovascular magnetic resonance predicts future cardiovascular events in patients with ischemic cardiomyopathy. J Cardiovasc Magn Reson. 2008;10(1):17.
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Marin-Neto JA, Simões M V., Ayres-Neto EM, Attab-Santos JL, Gallo Jr. L, Amorim DS, et al. Studies of the coronary circulation in Chagas’ heart disease. Sao Paulo Med J. 1995;113(2):826–34.
Gomes VAM, Alves GF, Hadlich M, Azevedo CF, Pereira IM, Santos CRF, et al. Analysis of Regional Left Ventricular Strain in Patients with Chagas Disease and Normal Left Ventricular Systolic Function. J Am Soc Echocardiogr. 2016;29(7).
Lee-Felker SA, Thomas M, Felker ER, Traina M, Salih M, Hernandez S, et al. Value of cardiac MRI for evaluation of chronic Chagas disease cardiomyopathy. Clin Radiol. 2016;71(6):618.e1-618.e7.
Santos JB de F, Gottlieb I, Tassi EM, Camargo GC, Atié J, Xavier SS, et al. Fibrose Cardíaca e Mudanças Evolutivas na Função Ventricular Esquerda em Pacientes com Cardiopatia Chagásica Crônica. Arq Bras Cardiol. 2021;117(6).
Matta JAM da, Aras R, Macedo CRB de, Cruz CG da, Netto EM. Stroke Correlates in Chagasic and Non-Chagasic Cardiomyopathies. Saks V, editor. PLoS One. 2012;7(4):e35116.
Cerqueira-Silva T, Gonçalves BMM, Pereira CB, Porto LM, Marques MEL, Santos LSB, et al. Chagas disease is an independent predictor of stroke and death in a cohort of heart failure patients. Int J Stroke. 2022;17(2):180–8.
Lage TAR, Tupinambás JT, Pádua LB de, Ferreira M de O, Ferreira AC, Teixeira AL, et al. Stroke in Chagas disease: from pathophysiology to clinical practice. Rev Soc Bras Med Trop. 2022;55.
Moreira HT, Volpe GJ, Mesquita GM, Braggion-Santos MF, Pazin-Filho A, Marin-Neto JA, et al. Association of left ventricular abnormalities with incident cerebrovascular events and sources of thromboembolism in patients with chronic Chagas cardiomyopathy. J Cardiovasc Magn Reson. 2022;24(1)
de Brito ASX, Moll-Bernardes RJ, Pinheiro MVT, Camargo GC, Siqueira FPR, Oliveira RS, et al. Autonomic denervation, myocardial hypoperfusion and fibrosis may predict ventricular arrhythmia in the early stages of Chagas cardiomyopathy. J Nucl Cardiol. 2023 Dec;30(6):2379-2388.
Tassi EM, Continentino MA, Nascimento EM, Pereira Bde B, Pedrosa RC. Relationship between fibrosis and ventricular arrhythmias in Chagas heart disease without ventricular dysfunction. Arq Bras Cardiol. 2014 May;102(5):456-64.
Mello RP de, Szarf G, Schvartzman PR, Nakano EM, Espinosa MM, Szejnfeld D, et al. Realce Tardio miocárdico por Ressonância Magnética Cardíaca pode identificar risco para Taquicardia Ventricular na Cardiopatia Chagásica Crônica. Arq Bras Cardiol. 2012;98(5):421–30.
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spelling Medina Zuluaga, Héctor Manuel0a733cc9-5481-4ce7-99c7-54b5d064384b-1Vaquiro Hererra, Eliana0f0c5b33-df6c-4bd5-a22b-aeef2b30fc6c-1Grupo de Investigacion en CardiologiaRangel Rivera, Diego AlejandroEspecialista en CardiologíaMaestríaFull timeabe1bed0-9022-43bd-bd74-81cee61fd740-12024-01-11T19:02:21Z2024-01-11T19:02:21Z2023La cardiopatía Chagásica crónica (CCC) es una antropozoonosis causada por el Trypanosoma cruzi (T. cruzi) y en Colombia se estima una prevalencia entre el 1-2%. La resonancia magnética cardíaca (RMNC) es el estándar de oro para la evaluación de la función y tamaño cardíaco. Métodos: Este es un estudio observacional, analítico de casos y controles anidado en una cohorte retrospectiva. Se incluyeron todos los pacientes con diagnóstico de CCC que se sometieron a RMNC en la Fundación Cardioinfantil-laCardio entre el 2016 hasta el 2022. Se evaluó un desenlace compuesto (mortalidad por todas las causas, hospitalización por causa cardiovascular, trasplante cardíaco y evento cerebrovascular). Resultados: Se incluyeron un total de 133 pacientes. La mediana de edad de los pacientes fue de 64 años (IQR: 12) con un predominio de mujeres (53,4%). El 97,0% de los pacientes tenían RTG en al menos un segmento miocárdico, siendo de predominio transmural e inferolateral. Durante una mediana de seguimiento de 554 días (IQR: 960) se documentó el evento compuesto en 63 sujetos (47,4%). Se encontró que la FEVI ≤ a 40% tuvo asociación significativa en el análisis multivariado con el primario compuesto (OR: 2,81; p=0,028). Conclusión: Los pacientes de nuestro estudio presentaron una alta incidencia de eventos cardiovasculares y la reducción de la FEVI fue un predictor independiente para su desarrollo.Chronic Chagasic heart disease (CCC) is an anthropozoonosis caused by Trypanosoma cruzi (T. cruzi) and in Colombia a prevalence between 1-2% is estimated. Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac evaluation. Methods: This is an analytical, cohort-type, retrospective study. All patients diagnosed with CHD who underwent CMR at Fundación Cardioinfantil-laCardio from January 2016 to April 2022 were included. A composite outcome (all-cause mortality, hospitalization for cardiovascular causes, heart transplantation, and cerebrovascular event) was evaluated. Results: A total of 133 patients were included. The median age of the patients was 64 years (IQR: 12) with a predominance of women (53.4%). 97.0% of patients had LGE in at least one myocardial segment, predominantly transmural and inferolateral. During a median follow-up of 554 days (IQR: 960), the composite event was documented in 63 subjects (47.4%). LVEF ≤ 40% had a significant association in the multivariate analysis with the primary composite (OR: 2.81; p=0.028). Conclusion: The patients in our study had a high incidence of cardiovascular events and the reduction in LVEF was an independent predictor for their development.62 ppapplication/pdfhttps://repository.urosario.edu.co/handle/10336/41965spaUniversidad del RosarioEscuela de Medicina y Ciencias de la SaludEspecialización en CardiologíaAttribution-NoDerivatives 4.0 InternationalAbierto (Texto Completo)EL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. 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